diff --git a/cmake/dependencies/python3.cmake b/cmake/dependencies/python3.cmake
index f3cb2e3c1..6730d9832 100644
--- a/cmake/dependencies/python3.cmake
+++ b/cmake/dependencies/python3.cmake
@@ -31,7 +31,6 @@ SET(RV_DEPS_PYTHON_VERSION_SHORT
 )
 
 # This version is used for generating src/build/requirements.txt from requirements.txt.in template
-# All platforms install OpenTimelineIO from git to ensure consistent source builds.
 SET(_opentimelineio_version
     "${RV_DEPS_OTIO_VERSION}"
 )
@@ -39,11 +38,6 @@ SET(_opentimelineio_version
 SET(_pyside_version 
     "${RV_DEPS_PYSIDE_VERSION}"
 )
-# Construct the full git URL for pip to use in requirements.txt
-# Using this avoids @ symbol conflicts in CONFIGURE_FILE
-SET(_opentimelineio_pip_url
-    "git+https://github.com/AcademySoftwareFoundation/OpenTimelineIO@v${_opentimelineio_version}#egg=OpenTimelineIO"
-)
 
 SET(_python3_download_url
     "https://github.com/python/cpython/archive/refs/tags/v${_python3_version}.zip"
@@ -79,9 +73,6 @@ SET(_build_dir
     ${RV_DEPS_BASE_DIR}/${_python3_target}/build
 )
 
-# Note: OpenTimelineIO is now installed via requirements.txt from git URL for all platforms.
-# This ensures consistent source builds across Windows, Mac, and Linux.
-
 FETCHCONTENT_DECLARE(
   ${_pyside_target}
   URL ${_pyside_archive_url}
@@ -283,12 +274,13 @@ ELSE()
   SET(_otio_debug_env "")
 ENDIF()
 
-# Single unified command for all platforms and build types
+# Using --no-binary :all: to ensure all packages with native extensions are built from source
+# against our custom Python build, preventing ABI compatibility issues.
 SET(_requirements_install_command
     ${CMAKE_COMMAND} -E env
     ${_otio_debug_env}
     "CMAKE_ARGS=-DPYTHON_LIBRARY=${_python3_cmake_library} -DPYTHON_INCLUDE_DIR=${_include_dir} -DPYTHON_EXECUTABLE=${_python3_executable}"
-    "${_python3_executable}" -m pip install --upgrade --no-cache-dir --force-reinstall -r "${_requirements_output_file}"
+    "${_python3_executable}" -m pip install --upgrade --no-cache-dir --force-reinstall --no-binary :all: -r "${_requirements_output_file}"
 )
 
 IF(RV_TARGET_WINDOWS)
diff --git a/src/build/requirements.txt.in b/src/build/requirements.txt.in
index d354ac868..2be3bf364 100644
--- a/src/build/requirements.txt.in
+++ b/src/build/requirements.txt.in
@@ -1,10 +1,11 @@
 # This file contains all the packages that will be packaged with RV. Please add the license next to the package.
 # NOTE: This is a CMake template file. The actual requirements.txt is generated during CMake configuration.
 #       To update OpenTimelineIO version, edit _opentimelineio_version in cmake/dependencies/python3.cmake
+# NOTE: Using --no-binary :all: in pip install ensures all packages are built from source against our custom Python.
 
 pip                     # License: MIT License (MIT)
 setuptools              # License: MIT License
-@_opentimelineio_pip_url@ # License: Other/Proprietary License (Modified Apache 2.0 License)
+opentimelineio==@_opentimelineio_version@ # License: Other/Proprietary License (Modified Apache 2.0 License)
 PyOpenGL                # License: BSD License (BSD)
 
 # MacOS only - PyOpenGL_accelerate is built from source in python3.cmake as a workaround until the fix