@@ -199,7 +199,7 @@ Note that [Maq] internally rounds base qualities to the nearest 10 and
199199rounds qualities greater than 30 to 30. To maintain compatibility,
200200Bowtie does the same. Rounding can be suppressed with the
201201`--nomaqround` option.
202-
202+
203203Bowtie is not fully sensitive in `-n` 2 and `-n` 3 modes by default.
204204In these modes Bowtie imposes a "backtracking limit" to limit effort
205205spent trying to find valid alignments for low-quality reads unlikely to
@@ -352,7 +352,7 @@ output no alignments.
352352Specifying `-m` 5 instructs bowtie to refrain from reporting any
353353alignments for reads having more than 5 reportable alignments. Since
354354the read has exactly 5 reportable alignments, the `-m` 5 limit allows
355- `bowtie` to print them as usual.
355+ `bowtie` to print them as usual.
356356
357357 Example 9: `-a -m 3 --best --strata`
358358
@@ -383,7 +383,7 @@ A valid paired-end alignment satisfies these criteria:
383383 defined by the `-v`/`-n`/`-e`/`-l` options.
3843842. The relative orientation and position of the mates satisfy the
385385 constraints defined by the `-I`/`-X`/`--fr`/`--rf`/`--ff`
386- options.
386+ options.
387387
388388Policies governing which paired-end alignments are reported for a
389389given read are specified using the `-k`, `-a` and `-m` options as
@@ -798,7 +798,7 @@ versions prior to 1.3. Default: off.
798798 --solexa1.3-quals
799799
800800Same as `--phred64-quals`. This is usually the right option for use
801- with (unconverted) reads emitted by GA Pipeline version 1.3 or later.
801+ with (unconverted) reads emitted by GA Pipeline version 1.3 or later.
802802Default: off.
803803
804804 --integer-quals
@@ -1037,7 +1037,7 @@ disallowed via the `-k` option) and they fall into more than one
10371037alignment "stratum", report only those alignments that fall into the
10381038best stratum. By default, Bowtie reports all reportable alignments
10391039regardless of whether they fall into multiple strata. When
1040- `--strata` is specified, `--best` must also be specified.
1040+ `--strata` is specified, `--best` must also be specified.
10411041
10421042 Output
10431043
@@ -1283,7 +1283,7 @@ Default `bowtie` output
12831283 character of the alignment occurs
12841284
128512855. Read sequence (reverse-complemented if orientation is `-`).
1286-
1286+
12871287 If the read was in colorspace, then the sequence shown in this
12881288 column is the sequence of *decoded nucleotides*, not the original
12891289 colors. See the [Colorspace alignment] section for details about
@@ -1292,7 +1292,7 @@ Default `bowtie` output
129212926. ASCII-encoded read qualities (reversed if orientation is `-`). The
12931293 encoded quality values are on the Phred scale and the encoding is
12941294 ASCII-offset by 33 (ASCII char `!`).
1295-
1295+
12961296 If the read was in colorspace, then the qualities shown in this
12971297 column are the *decoded qualities*, not the original qualities.
12981298 See the [Colorspace alignment] section for details about decoding.
@@ -1302,7 +1302,7 @@ Default `bowtie` output
13021302 this read, this column contains the value of the ceiling,
13031303 indicating that at least that many valid alignments were found in
13041304 addition to the one reported.
1305-
1305+
13061306 Otherwise, this column contains the number of other instances where
13071307 the same sequence aligned against the same reference characters as
13081308 were aligned against in the reported alignment. This is *not* the
@@ -1316,7 +1316,7 @@ Default `bowtie` output
13161316 mismatches in the alignment, this field is empty. A single
13171317 descriptor has the format offset:reference-base>read-base. The
13181318 offset is expressed as a 0-based offset from the high-quality (5')
1319- end of the read.
1319+ end of the read.
13201320
13211321SAM `bowtie` output
13221322-------------------
@@ -1402,7 +1402,7 @@ right, the fields are:
1402140211. ASCII-encoded read qualities (reverse-complemented if the read
14031403 aligned to the reverse strand). The encoded quality values are on
14041404 the [Phred quality] scale and the encoding is ASCII-offset by 33
1405- (ASCII char `!`), similarly to a [FASTQ] file.
1405+ (ASCII char `!`), similarly to a [FASTQ] file.
14061406
1407140712. Optional fields. Fields are tab-separated. For descriptions of
14081408 all possible optional fields, see the SAM format specification.
@@ -1453,10 +1453,10 @@ The `bowtie-build` indexer
14531453`bowtie-build` outputs a set of 6 files with suffixes `.1.ebwt`,
14541454`.2.ebwt`, `.3.ebwt`, `.4.ebwt`, `.rev.1.ebwt`, and `.rev.2.ebwt`. (If
14551455the total length of all the input sequences is greater than about 4
1456- billion, then the index files will end in `ebwtl` instead of `ebwt`.)
1456+ billion, then the index files will end in `ebwtl` instead of `ebwt`.)
14571457These files together constitute the index: they are all that is needed
14581458to align reads to that reference. The original sequence files are no
1459- longer used by Bowtie once the index is built.
1459+ longer used by Bowtie once the index is built.
14601460
14611461Use of Karkkainen's [blockwise algorithm] allows `bowtie-build` to
14621462trade off between running time and memory usage. `bowtie-build` has
@@ -1592,7 +1592,7 @@ governs how many rows get marked: the indexer will mark every 2^`<int>`
15921592rows. Marking more rows makes reference-position lookups faster, but
15931593requires more memory to hold the annotations at runtime. The default
15941594is 5 (every 32nd row is marked; for human genome, annotations occupy
1595- about 340 megabytes).
1595+ about 340 megabytes).
15961596
15971597 -t/--ftabchars <int>
15981598
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