diff --git a/Il2CppInterop.Runtime/Runtime/ClassInjectorBase.cs b/Il2CppInterop.Runtime/Runtime/ClassInjectorBase.cs
index 1fc35b5f..96ea8d05 100644
--- a/Il2CppInterop.Runtime/Runtime/ClassInjectorBase.cs
+++ b/Il2CppInterop.Runtime/Runtime/ClassInjectorBase.cs
@@ -13,9 +13,30 @@ public static class ClassInjectorBase
     public static object GetMonoObjectFromIl2CppPointer(IntPtr pointer)
     {
         var gcHandle = GetGcHandlePtrFromIl2CppObject(pointer);
+
+        if (gcHandle == IntPtr.Zero) // The Garbage collector handle might return a null pointer
+        {
+            gcHandle = FallbackGetGcHandlePtrFromIl2CppDelegateMTarget(pointer);
+        }
+
         return GCHandle.FromIntPtr(gcHandle).Target;
     }
 
+    /// <summary>
+    /// Tries to get the Garbage collector pointer from the m_target object from the m_target of the delegate.
+    /// Fixes Harmony in Unity 2021.2.x .
+    /// </summary>
+    private static IntPtr FallbackGetGcHandlePtrFromIl2CppDelegateMTarget(IntPtr pointer)
+    {
+        if (IL2CPP.il2cpp_class_is_assignable_from(Il2CppClassPointerStore<Il2CppSystem.MulticastDelegate>.NativeClassPtr, IL2CPP.il2cpp_object_get_class(pointer)))
+        {
+            var delegateObject = new Il2CppSystem.Delegate(pointer);
+            if (delegateObject.m_target != null && delegateObject.m_target.Pointer != IntPtr.Zero)
+                return GetGcHandlePtrFromIl2CppObject(delegateObject.m_target.Pointer);
+        }
+        return IntPtr.Zero;
+    }
+
     public static unsafe IntPtr GetGcHandlePtrFromIl2CppObject(IntPtr pointer)
     {
         return GetInjectedData(pointer)->managedGcHandle;