@@ -219,6 +219,45 @@ The BioGears source is structured as follows:
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- sdk - Example code and scripts for the Toolkit and SDK
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- utils - Various utilities used in validation
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+ ## What's new in ver 6.3 (March 1, 2018)
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+ The latest deployment includes the following notable updates:
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+
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+ - General bug fixes, system improvements, and tools/solver improvements
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+ - Fasciculation patient event flags
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+ - Updated sweat methodology (fixes to ions lost in sweat)
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+ - Updated substance and compound infusion functionality
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+ - Added Ringers lactate and updated
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+ - Saline compound ion concentrations corrected
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+ - Hardened implementation
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+ - MuscleMass new patient data request
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+ - Muscle catabolism patient flag
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+ - Added dehydration condition
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+ - Implemented as scalar 0to1 representing fractional total body water lost
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+ - Fluid removed from patient compartments
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+ - Updated patient flag for event and track body weight change (validated)
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+ - Added totalbodyfluidVolume as data request
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+ - Updated patient weight as a function of condition
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+ - Added starvation condition
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+ - TimeSinceMeal determines how long since the patient's last meal
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+ - Scales internal nutrient storages from validated starvation data
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+ - Removed ConsumeMeal condition, now replaced by starvation condition
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+ - Validated blood concentrations for ketones, glucose, and amino acids
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+ - Updated patient weight as a function of condition
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+ - Intracellular ion transport
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+ - Model uses membrane potential (see @ref TissueMethodology for details)
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+ - Michaelis coefficient could support more ion regulation in the future
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+ - Gated ion transport allows for differences between intra/extracellular spaces
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+ - COPD now supports elevated anaerobic metabolism
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+ - Ion transport model in the small intestine
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+ - Updated drug library so all drugs support an effects site transport rate
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+ - Diabetes type 1 and type 2 conditions
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+ - insulin resistance and insulin production effects
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+ - Hemorrhage action now initialized with a 0-1 severity and a location (MCIS SDK example still exists)
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+ - New drug Vasopressin
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+ - New drug classifications in the CDM for better grouping in-code
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+ - Include anesthetic, sedative, opioid, and reversal agent
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+ - More grouping in future work
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+
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Tentative Near-Term Timeline
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============================
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Planned model updates Oct 2, 2017:
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