diff --git a/packages/wasm-miniscript/js/ast/fromWasmNode.ts b/packages/wasm-miniscript/js/ast/fromWasmNode.ts
index b9364b3..7d7d7a9 100644
--- a/packages/wasm-miniscript/js/ast/fromWasmNode.ts
+++ b/packages/wasm-miniscript/js/ast/fromWasmNode.ts
@@ -78,6 +78,8 @@ function fromUnknown(v: unknown): Node | Node[] {
         return wrap("v", value);
       case "ZeroNotEqual":
         return wrap("n", value);
+      case "Drop":
+        return wrap("r", value);
 
       // Conjunctions
       case "AndV":
diff --git a/packages/wasm-miniscript/test/descriptorFixtures.ts b/packages/wasm-miniscript/test/descriptorFixtures.ts
index 05c1336..411dcb7 100644
--- a/packages/wasm-miniscript/test/descriptorFixtures.ts
+++ b/packages/wasm-miniscript/test/descriptorFixtures.ts
@@ -351,6 +351,12 @@ export const fixtures = {
       script: "51207e8c409f0ab01197f9676efc3a9505f1f09ed0f21693e46a3aa3b6b54d437aa2",
       checksumRequired: true,
     },
+    {
+      descriptor:
+        "wsh(and_v(r:after(1),pkh(03cdabb7f2dce7bfbd8a0b9570c6fd1e712e5d64045e9d6b517b3d5072251dc204)))",
+      script: "0020823bcb22035958d32afe8ec04357535a3e73da3ed9cd90a4251970f9995077a5",
+      checksumRequired: false,
+    },
   ],
   invalid: [
     {
diff --git a/packages/wasm-miniscript/test/fixtures.ts b/packages/wasm-miniscript/test/fixtures.ts
new file mode 100644
index 0000000..1e917a9
--- /dev/null
+++ b/packages/wasm-miniscript/test/fixtures.ts
@@ -0,0 +1,11 @@
+import * as fs from "fs/promises";
+export async function getFixture(path: string, defaultValue: unknown): Promise<unknown> {
+  try {
+    return JSON.parse(await fs.readFile(path, "utf8"));
+  } catch (e) {
+    if (e.code === "ENOENT") {
+      await fs.writeFile(path, JSON.stringify(defaultValue, null, 2));
+      throw new Error(`Fixture not found at ${path}, created a new one`);
+    }
+  }
+}
diff --git a/packages/wasm-miniscript/test/fixtures/59.json b/packages/wasm-miniscript/test/fixtures/59.json
new file mode 100644
index 0000000..9e26dfe
--- /dev/null
+++ b/packages/wasm-miniscript/test/fixtures/59.json
@@ -0,0 +1 @@
+{}
\ No newline at end of file
diff --git a/packages/wasm-miniscript/test/fixtures/opdrop.json b/packages/wasm-miniscript/test/fixtures/opdrop.json
new file mode 100644
index 0000000..23427e0
--- /dev/null
+++ b/packages/wasm-miniscript/test/fixtures/opdrop.json
@@ -0,0 +1 @@
+"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"
\ No newline at end of file
diff --git a/packages/wasm-miniscript/test/opdrop.ts b/packages/wasm-miniscript/test/opdrop.ts
new file mode 100644
index 0000000..6bd2d44
--- /dev/null
+++ b/packages/wasm-miniscript/test/opdrop.ts
@@ -0,0 +1,99 @@
+import * as assert from "assert";
+import * as utxolib from "@bitgo/utxo-lib";
+import { Descriptor } from "../js";
+import { finalizePsbt, updateInputWithDescriptor } from "./psbt.util";
+import { getFixture } from "./fixtures";
+
+const rootWalletKeys = new utxolib.bitgo.RootWalletKeys(utxolib.testutil.getKeyTriple("wasm"));
+
+function getDescriptorOpDropP2ms(locktime: number, keys: utxolib.BIP32Interface[]) {
+  const xpubs = keys.map((key) => key.toBase58() + "/*");
+  // the `r:` prefix is a custom BitGo modification of miniscript to allow OP_DROP
+  return `wsh(and_v(r:after(${locktime}),multi(2,${xpubs.join(",")})))`;
+}
+
+describe("CLV with OP_DROP", function () {
+  // OP_DROP not enabled on main branch
+  return;
+
+  const locktime = 1024;
+  const descriptor = Descriptor.fromString(
+    getDescriptorOpDropP2ms(locktime, rootWalletKeys.triple),
+    "derivable",
+  );
+  it("has expected AST", () => {
+    assert.deepStrictEqual(descriptor.node(), {
+      Wsh: {
+        Ms: {
+          AndV: [
+            {
+              Drop: {
+                After: {
+                  absLockTime: 1024,
+                },
+              },
+            },
+            {
+              Multi: [
+                2,
+                {
+                  XPub: "xpub661MyMwAqRbcFNusVUbSN3nbanHMtJjLgZGrs1wxH6f77kKQd6Vq4HfkZQNPC1vSbN6RTiBWJJV6FwJtCfBon2SgaT2J3MSkydukstKjwbJ/*",
+                },
+                {
+                  XPub: "xpub661MyMwAqRbcFo3t7PUqvbgvAcEuuoeVib5aapsg52inrG6KGF5aNtR5ey1FNCt1zJpMQiNec5XpofQmLNRhHvQRbhkc8UsWwwMwsXW6ogU/*",
+                },
+                {
+                  XPub: "xpub661MyMwAqRbcGg7f22Kcg2gy1F4jBjWR3xQTECVeJPHmxvhg5gUAZC6EYFtnyi6aMDQir1kV8HzCqC2FzTowGgEZqRh7rinqUCDeNDdmYzH/*",
+                },
+              ],
+            },
+          ],
+        },
+      },
+    });
+  });
+
+  it("has expected asm", () => {
+    assert.deepStrictEqual(descriptor.atDerivationIndex(0).toAsmString().split(" "), [
+      "OP_PUSHBYTES_2",
+      "0004",
+      "OP_CLTV",
+      "OP_DROP",
+      "OP_PUSHNUM_2",
+      "OP_PUSHBYTES_33",
+      "02ae7c3c0ebc315a33151a1985ebb1fdcae72b3b91c38e3193c40ebabfffe9c343",
+      "OP_PUSHBYTES_33",
+      "0260ba2407f7c75d525db9f171e9b2f3cf5ba3f0d7fc6067b20d4b91585432f974",
+      "OP_PUSHBYTES_33",
+      "03eadd6e4300dac62f1d4cf1131a06c5e140911f04245c64934c27510e93dbe843",
+      "OP_PUSHNUM_3",
+      "OP_CHECKMULTISIG",
+    ]);
+  });
+
+  it("can be signed", async function () {
+    const psbt = Object.assign(new utxolib.Psbt({ network: utxolib.networks.bitcoin }), {
+      locktime,
+    });
+    const signers = rootWalletKeys.triple.slice(0, 2);
+    const descriptorAt0 = descriptor.atDerivationIndex(0);
+    const script = Buffer.from(descriptorAt0.scriptPubkey());
+    psbt.addInput({
+      hash: Buffer.alloc(32),
+      index: 0,
+      sequence: 0xfffffffe,
+      witnessUtxo: { script, value: BigInt(1e8) },
+    });
+    psbt.addOutput({ script, value: BigInt(1e8) });
+    updateInputWithDescriptor(psbt, 0, descriptorAt0);
+    for (const signer of signers) {
+      psbt.signAllInputsHD(signer);
+    }
+    finalizePsbt(psbt);
+    const signedTx = psbt.extractTransaction().toBuffer();
+    assert.strictEqual(
+      signedTx.toString("hex"),
+      await getFixture("test/fixtures/opdrop.json", signedTx.toString("hex")),
+    );
+  });
+});
diff --git a/packages/wasm-miniscript/test/test.ts b/packages/wasm-miniscript/test/test.ts
index 16f884f..034cac1 100644
--- a/packages/wasm-miniscript/test/test.ts
+++ b/packages/wasm-miniscript/test/test.ts
@@ -50,15 +50,33 @@ function assertKnownDescriptorType(descriptor: Descriptor) {
   }
 }
 
+function assertIsErrorUnknownWrapper(error: unknown, wrapper: string) {
+  assert.ok(error instanceof Error);
+  assert.ok(error.message.includes(`Error: unknown wrapper «${wrapper}»`));
+}
+
 describe("Descriptor fixtures", function () {
   fixtures.valid.forEach((fixture, i) => {
     describe("fixture " + i, function () {
+      const isOpDropFixture = i === 59;
       let descriptor: Descriptor;
 
       before("setup descriptor", function () {
-        descriptor = Descriptor.fromString(fixture.descriptor, "derivable");
+        try {
+          descriptor = Descriptor.fromString(fixture.descriptor, "derivable");
+        } catch (e) {
+          if (isOpDropFixture) {
+            assertIsErrorUnknownWrapper(e, "r:");
+            return;
+          }
+          throw e;
+        }
       });
 
+      if (isOpDropFixture) {
+        return;
+      }
+
       it("should round-trip (pkType string)", function () {
         let descriptorString = Descriptor.fromString(fixture.descriptor, "string").toString();
         if (fixture.checksumRequired === false) {