diff --git a/pkg/clusteragent/admission/mutate/autoinstrumentation/target_mutator.go b/pkg/clusteragent/admission/mutate/autoinstrumentation/target_mutator.go
index 05d9caba9358b5..46b40f94501174 100644
--- a/pkg/clusteragent/admission/mutate/autoinstrumentation/target_mutator.go
+++ b/pkg/clusteragent/admission/mutate/autoinstrumentation/target_mutator.go
@@ -23,6 +23,7 @@ import (
 	"github.com/DataDog/datadog-agent/pkg/clusteragent/admission/metrics"
 	"github.com/DataDog/datadog-agent/pkg/clusteragent/admission/mutate/autoinstrumentation/annotation"
 	"github.com/DataDog/datadog-agent/pkg/clusteragent/admission/mutate/autoinstrumentation/imageresolver"
+	"github.com/DataDog/datadog-agent/pkg/clusteragent/admission/mutate/autoinstrumentation/libraryinjection"
 	mutatecommon "github.com/DataDog/datadog-agent/pkg/clusteragent/admission/mutate/common"
 	"github.com/DataDog/datadog-agent/pkg/util/log"
 )
@@ -185,12 +186,18 @@ func (m *TargetMutator) MutatePod(pod *corev1.Pod, ns string, _ dynamic.Interfac
 	log.Debugf("Mutating pod in target mutator %q", mutatecommon.PodString(pod))
 
 	// The admission can be re-run for the same pod. Fast return if we injected the library already.
+	// Check for the init_container mode's per-language init containers.
 	for _, lang := range supportedLanguages {
 		if containsInitContainer(pod, initContainerName(lang)) {
 			log.Debugf("Init container %q already exists in pod %q", initContainerName(lang), mutatecommon.PodString(pod))
 			return false, nil
 		}
 	}
+	// Check for the image_volume mode's init container.
+	if containsInitContainer(pod, libraryinjection.InjectLDPreloadInitContainerName) {
+		log.Debugf("Init container %q already exists in pod %q", libraryinjection.InjectLDPreloadInitContainerName, mutatecommon.PodString(pod))
+		return false, nil
+	}
 
 	// Get the target to inject. If there is not target, we should not mutate the pod.
 	target := m.getTarget(pod)
diff --git a/pkg/clusteragent/admission/mutate/autoinstrumentation/target_mutator_test.go b/pkg/clusteragent/admission/mutate/autoinstrumentation/target_mutator_test.go
index 1565855a41077e..839d5bd6c6f12c 100644
--- a/pkg/clusteragent/admission/mutate/autoinstrumentation/target_mutator_test.go
+++ b/pkg/clusteragent/admission/mutate/autoinstrumentation/target_mutator_test.go
@@ -26,6 +26,7 @@ import (
 	"github.com/DataDog/datadog-agent/pkg/clusteragent/admission/common"
 	"github.com/DataDog/datadog-agent/pkg/clusteragent/admission/mutate/autoinstrumentation/annotation"
 	"github.com/DataDog/datadog-agent/pkg/clusteragent/admission/mutate/autoinstrumentation/imageresolver"
+	"github.com/DataDog/datadog-agent/pkg/clusteragent/admission/mutate/autoinstrumentation/libraryinjection"
 	mutatecommon "github.com/DataDog/datadog-agent/pkg/clusteragent/admission/mutate/common"
 	configmock "github.com/DataDog/datadog-agent/pkg/config/mock"
 	"github.com/DataDog/datadog-agent/pkg/languagedetection/languagemodels"
@@ -142,6 +143,34 @@ func TestMutatePod(t *testing.T) {
 			},
 			expectNoChange: true,
 		},
+		// Re-admission guard: when the webhook runs again on an already-injected pod we must not
+		// mutate further (e.g. must not append to LD_PRELOAD or add duplicate init containers).
+		"re-admission with init_container mode init container already present does not mutate": {
+			configPath: "testdata/filter_simple_namespace.yaml",
+			in: mutatecommon.FakePodSpec{
+				NS: "application",
+				InitContainers: []corev1.Container{
+					{Name: "datadog-lib-python-init", Image: "registry/dd-lib-python-init:v3"},
+				},
+			}.Create(),
+			namespaces: []workloadmeta.KubernetesMetadata{
+				newTestNamespace("application", nil),
+			},
+			expectNoChange: true,
+		},
+		"re-admission with image_volume mode init container already present does not mutate": {
+			configPath: "testdata/filter_simple_namespace.yaml",
+			in: mutatecommon.FakePodSpec{
+				NS: "application",
+				InitContainers: []corev1.Container{
+					{Name: libraryinjection.InjectLDPreloadInitContainerName, Image: "registry/apm-inject:0"},
+				},
+			}.Create(),
+			namespaces: []workloadmeta.KubernetesMetadata{
+				newTestNamespace("application", nil),
+			},
+			expectNoChange: true,
+		},
 		"tracer configs get applied": {
 			configPath: "testdata/filter_simple_configs.yaml",
 			in: mutatecommon.WithLabels(
diff --git a/releasenotes/notes/guard-readmission-ssi-imgvol-e9dfef7c4b5b8b0d.yaml b/releasenotes/notes/guard-readmission-ssi-imgvol-e9dfef7c4b5b8b0d.yaml
new file mode 100644
index 00000000000000..97c1923281251a
--- /dev/null
+++ b/releasenotes/notes/guard-readmission-ssi-imgvol-e9dfef7c4b5b8b0d.yaml
@@ -0,0 +1,3 @@
+fixes:
+  - |
+    Fixes a bug in the admission controller webhook that allowed admission to re-run for pods that already had APM injection in image-volume mode.