diff --git a/profiling/src/lib.rs b/profiling/src/lib.rs
index f32b883e1c..7ef94bae7d 100644
--- a/profiling/src/lib.rs
+++ b/profiling/src/lib.rs
@@ -577,7 +577,6 @@ extern "C" fn rinit(_type: c_int, _module_number: c_int) -> ZendResult {
     let result = REQUEST_LOCALS.try_with_borrow_mut(|locals| {
         // SAFETY: we are in rinit on a PHP thread.
         locals.vm_interrupt_addr = unsafe { zend::datadog_php_profiling_vm_interrupt_addr() };
-        locals.interrupt_count.store(0, Ordering::SeqCst);
 
         // SAFETY: We are after first rinit and before mshutdown.
         unsafe {
diff --git a/profiling/src/profiling/interrupts.rs b/profiling/src/profiling/interrupts.rs
index ab69b11034..bd1e32107e 100644
--- a/profiling/src/profiling/interrupts.rs
+++ b/profiling/src/profiling/interrupts.rs
@@ -46,6 +46,12 @@ impl InterruptManager {
     pub(super) fn remove_interrupt(&self, interrupt: VmInterrupt) {
         let mut vm_interrupts = self.vm_interrupts.lock().unwrap();
         vm_interrupts.remove(&interrupt);
+        unsafe {
+            // Reset interrupt counter to prevent sampling during `mshutdown` (PHP 8.0 bug with
+            // userland destructors), but leave the interrupt flag unchanged as other extensions
+            // may have raised it.
+            (*interrupt.interrupt_count_ptr).store(0, Ordering::SeqCst);
+        }
     }
 
     #[inline]