fix(profiler): do not unload google.protobuf in module clean-up [backport #5747 to 1.12] (#5749)

Backport of #5747 to 1.12

When cleaning up the modules as part of the support for gevent, we also
unload google.protobuf. However, starting with version 4.21, the new
default upb backend does not tolerate being unloaded, which resulted in
segfaults in applications with a runtime dependency on protobuf.

## Checklist

- [x] Change(s) are motivated and described in the PR description.
- [x] Testing strategy is described if automated tests are not included
in the PR.
- [x] Risk is outlined (performance impact, potential for breakage,
maintainability, etc).
- [x] Change is maintainable (easy to change, telemetry, documentation).
- [x] [Library release note
guidelines](https://ddtrace.readthedocs.io/en/stable/contributing.html#Release-Note-Guidelines)
are followed.
- [x] Documentation is included (in-code, generated user docs, [public
corp docs](https://github.com/DataDog/documentation/)).
- [x] PR description includes explicit acknowledgement/acceptance of the
performance implications of this PR as reported in the benchmarks PR
comment.

## Reviewer Checklist

- [x] Title is accurate.
- [x] No unnecessary changes are introduced.
- [x] Description motivates each change.
- [x] Avoids breaking
[API](https://ddtrace.readthedocs.io/en/stable/versioning.html#interfaces)
changes unless absolutely necessary.
- [x] Testing strategy adequately addresses listed risk(s).
- [x] Change is maintainable (easy to change, telemetry, documentation).
- [x] Release note makes sense to a user of the library.
- [x] Reviewer has explicitly acknowledged and discussed the performance
implications of this PR as reported in the benchmarks PR comment.

Author: P403n1x87

ddtrace/bootstrap/sitecustomize.py

@@ -129,6 +129,7 @@ def drop(module_name):
             "typing",
             "logging",
             "attr",
+            "google.protobuf",  # the upb backend in >= 4.21 does not like being unloaded
         ]
     )
     if PY2:

releasenotes/notes/fix-profiler-segfault-in-protobuf-apps-032558829864cdfe.yaml

@@ -0,0 +1,5 @@
+---
+fixes:
+  - |
+    profiler: Fixed a bug that caused segmentation faults in applications that
+    use protobuf as a runtime dependency.

tests/profiling/test_main.py

@@ -124,3 +124,20 @@ def test_memalloc_no_init_error_on_fork():
     if not pid:
         exit(0)
     os.waitpid(pid, 0)
+
+
+@pytest.mark.subprocess(
+    ddtrace_run=True,
+    env=dict(
+        DD_PROFILING_ENABLED="1",
+        DD_UNLOAD_MODULES_FROM_SITECUSTOMIZE="1",
+    ),
+    out="OK\n",
+    err=None,
+)
+def test_profiler_start_up_with_module_clean_up_in_protobuf_app():
+    # This can cause segfaults if we do module clean up with later versions of
+    # protobuf. This is a regression test.
+    from google.protobuf import empty_pb2  # noqa
+
+    print("OK")