diff --git a/ddtrace/debugging/_expressions.py b/ddtrace/debugging/_expressions.py
index 71dc13654b6..1efa4238aa0 100644
--- a/ddtrace/debugging/_expressions.py
+++ b/ddtrace/debugging/_expressions.py
@@ -39,6 +39,7 @@
 from typing import Tuple
 from typing import Union
 
+from bytecode import BinaryOp
 from bytecode import Bytecode
 from bytecode import Compare
 from bytecode import Instr
@@ -301,7 +302,12 @@ def _compile_arg_operation(self, ast: DDASTType) -> Optional[List[Instr]]:
                 raise ValueError("Invalid argument: %r" % a)
             if cb is None:
                 raise ValueError("Invalid argument: %r" % b)
-            return cv + ca + cb + [Instr("BUILD_SLICE", 2), Instr("BINARY_SUBSCR")]
+
+            if PY >= (3, 14):
+                subscr_instruction = Instr("BINARY_OP", BinaryOp.SUBSCR)
+            else:
+                subscr_instruction = Instr("BINARY_SUBSCR")
+            return cv + ca + cb + [Instr("BUILD_SLICE", 2), subscr_instruction]
 
         if _type == "filter":
             a, b = args
diff --git a/ddtrace/internal/assembly.py b/ddtrace/internal/assembly.py
index c1740192540..0d099ed9af2 100644
--- a/ddtrace/internal/assembly.py
+++ b/ddtrace/internal/assembly.py
@@ -46,7 +46,7 @@ def transform_instruction(opcode: str, arg: t.Any) -> t.Tuple[str, t.Any]:
             opcode = "LOAD_ATTR"
             arg = (True, arg)
         elif opcode.upper() == "LOAD_ATTR" and not isinstance(arg, tuple):
-            arg = (False, arg)
+            arg = (sys.version_info >= (3, 14), arg)
 
     return opcode, arg
 
@@ -157,6 +157,11 @@ def parse_try_end(self, line: str) -> t.Optional[bc.TryEnd]:
 
     def parse_opcode(self, text: str) -> str:
         opcode = text.upper()
+
+        # `dis` doesn't include `LOAD_METHOD` in 3.14.0rc1
+        if sys.version_info >= (3, 14) and opcode == "LOAD_METHOD":
+            return opcode
+
         if opcode not in dis.opmap:
             raise ValueError("unknown opcode %s" % opcode)
 
diff --git a/ddtrace/internal/bytecode_injection/__init__.py b/ddtrace/internal/bytecode_injection/__init__.py
index b31e52e3140..a151fbea654 100644
--- a/ddtrace/internal/bytecode_injection/__init__.py
+++ b/ddtrace/internal/bytecode_injection/__init__.py
@@ -30,8 +30,8 @@ class InvalidLine(Exception):
 # the stack to the state prior to the call.
 
 INJECTION_ASSEMBLY = Assembly()
-if PY >= (3, 14):
-    raise NotImplementedError("Python >= 3.14 is not supported yet")
+if PY >= (3, 15):
+    raise NotImplementedError("Python >= 3.15 is not supported yet")
 elif PY >= (3, 13):
     INJECTION_ASSEMBLY.parse(
         r"""
diff --git a/ddtrace/internal/symbol_db/symbols.py b/ddtrace/internal/symbol_db/symbols.py
index 803ce59cd11..050e9655902 100644
--- a/ddtrace/internal/symbol_db/symbols.py
+++ b/ddtrace/internal/symbol_db/symbols.py
@@ -96,7 +96,8 @@ def get_fields(cls: type) -> t.Set[str]:
         return {
             code.co_names[b.arg]
             for a, b in zip(*(islice(t, i, None) for i, t in enumerate(tee(dis.get_instructions(code), 2))))
-            if a.opname == "LOAD_FAST" and a.arg == 0 and b.opname == "STORE_ATTR"
+            # Python 3.14 changed this to LOAD_FAST_BORROW
+            if a.opname.startswith("LOAD_FAST") and a.arg & 15 == 0 and b.opname == "STORE_ATTR"
         }
     except AttributeError:
         return set()
diff --git a/ddtrace/internal/wrapping/asyncs.py b/ddtrace/internal/wrapping/asyncs.py
index 66341657ca4..e6288eb9175 100644
--- a/ddtrace/internal/wrapping/asyncs.py
+++ b/ddtrace/internal/wrapping/asyncs.py
@@ -34,7 +34,133 @@
 ASYNC_GEN_ASSEMBLY = Assembly()
 ASYNC_HEAD_ASSEMBLY = None
 
-if PY >= (3, 12):
+if PY >= (3, 14):
+    ASYNC_HEAD_ASSEMBLY = Assembly()
+    ASYNC_HEAD_ASSEMBLY.parse(
+        r"""
+            return_generator
+            pop_top
+        """
+    )
+
+    COROUTINE_ASSEMBLY.parse(
+        r"""
+            get_awaitable                   0
+            load_const                      None
+
+        presend:
+            send                            @send
+            yield_value                     2
+            resume                          3
+            jump_backward_no_interrupt      @presend
+        send:
+            end_send
+        """
+    )
+
+    ASYNC_GEN_ASSEMBLY.parse(
+        r"""
+        try                                 @stopiter
+            copy                            1
+            store_fast                      $__ddgen
+            load_attr                       (False, 'asend')
+            store_fast                      $__ddgensend
+            load_fast                       $__ddgen
+            load_attr                       (True, '__anext__')
+            call                            0
+
+        loop:
+            get_awaitable                   0
+            load_const                      None
+        presend0:
+            send                            @send0
+        tried
+
+        try                                 @genexit lasti
+            yield_value                     3
+            resume                          3
+            jump_backward_no_interrupt      @loop
+        send0:
+            end_send
+
+        yield:
+            call_intrinsic_1                asm.Intrinsic1Op.INTRINSIC_ASYNC_GEN_WRAP
+            yield_value                     3
+            resume                          1
+            push_null
+            swap                            2
+            load_fast                       $__ddgensend
+            swap                            2
+            call                            1
+            jump_backward                   @loop
+        tried
+
+        genexit:
+        try                                 @stopiter
+            push_exc_info
+            load_const                      GeneratorExit
+            check_exc_match
+            pop_jump_if_false               @exc
+            pop_top
+            load_fast                       $__ddgen
+            load_attr                       (True, 'aclose')
+            call                            0
+            get_awaitable                   0
+            load_const                      None
+
+        presend1:
+            send                            @send1
+            yield_value                     4
+            resume                          3
+            jump_backward_no_interrupt      @presend1
+        send1:
+            end_send
+            pop_top
+            pop_except
+            load_const                      None
+            return_value
+
+        exc:
+            pop_top
+            push_null
+            load_fast                       $__ddgen
+            load_attr                       (False, 'athrow')
+            push_null
+            load_const                      sys.exc_info
+            call                            0
+            call_function_ex
+            get_awaitable                   0
+            load_const                      None
+
+        presend2:
+            send                            @send2
+            yield_value                     4
+            resume                          3
+            jump_backward_no_interrupt      @presend2
+        send2:
+            end_send
+            swap                            2
+            pop_except
+            jump_backward                   @yield
+        tried
+
+        stopiter:
+            push_exc_info
+            load_const                      StopAsyncIteration
+            check_exc_match
+            pop_jump_if_false               @propagate
+            pop_top
+            pop_except
+            load_const                      None
+            return_value
+
+        propagate:
+            reraise                         0
+        """
+    )
+
+
+elif PY >= (3, 12):
     ASYNC_HEAD_ASSEMBLY = Assembly()
     ASYNC_HEAD_ASSEMBLY.parse(
         r"""
diff --git a/ddtrace/internal/wrapping/context.py b/ddtrace/internal/wrapping/context.py
index 87ce3430855..2e5be4b1013 100644
--- a/ddtrace/internal/wrapping/context.py
+++ b/ddtrace/internal/wrapping/context.py
@@ -67,8 +67,8 @@
 CONTEXT_RETURN = Assembly()
 CONTEXT_FOOT = Assembly()
 
-if sys.version_info >= (3, 14):
-    raise NotImplementedError("Python >= 3.14 is not supported yet")
+if sys.version_info >= (3, 15):
+    raise NotImplementedError("Python >= 3.15 is not supported yet")
 elif sys.version_info >= (3, 13):
     CONTEXT_HEAD.parse(
         r"""
diff --git a/ddtrace/internal/wrapping/generators.py b/ddtrace/internal/wrapping/generators.py
index 91cbed49962..37b762b64e5 100644
--- a/ddtrace/internal/wrapping/generators.py
+++ b/ddtrace/internal/wrapping/generators.py
@@ -30,7 +30,85 @@
 GENERATOR_ASSEMBLY = Assembly()
 GENERATOR_HEAD_ASSEMBLY = None
 
-if PY >= (3, 12):
+if PY >= (3, 14):
+    GENERATOR_HEAD_ASSEMBLY = Assembly()
+    GENERATOR_HEAD_ASSEMBLY.parse(
+        r"""
+            return_generator
+            pop_top
+        """
+    )
+
+    GENERATOR_ASSEMBLY.parse(
+        r"""
+        try                             @stopiter
+            copy                        1
+            store_fast                  $__ddgen
+            load_attr                   $send
+            store_fast                  $__ddgensend
+            push_null
+            load_const                  next
+            load_fast                   $__ddgen
+
+        loop:
+            call                        1
+        tried
+
+        yield:
+        try                             @genexit lasti
+            yield_value                 3
+            resume                      1
+            push_null
+            swap                        2
+            load_fast                   $__ddgensend
+            swap                        2
+            jump_backward               @loop
+        tried
+
+        genexit:
+        try                             @stopiter
+            push_exc_info
+            load_const                  GeneratorExit
+            check_exc_match
+            pop_jump_if_false           @exc
+            pop_top
+            load_fast                   $__ddgen
+            load_method                 $close
+            call                        0
+            swap                        2
+            pop_except
+            return_value
+
+        exc:
+            pop_top
+            push_null
+            load_fast                   $__ddgen
+            load_attr                   $throw
+            push_null
+            load_const                  sys.exc_info
+            call                        0
+            call_function_ex
+            swap                        2
+            pop_except
+            jump_backward               @yield
+        tried
+
+        stopiter:
+            push_exc_info
+            load_const                  StopIteration
+            check_exc_match
+            pop_jump_if_false           @propagate
+            pop_top
+            pop_except
+            load_const                  None
+            return_value
+
+        propagate:
+            reraise                     0
+        """
+    )
+
+elif PY >= (3, 12):
     GENERATOR_HEAD_ASSEMBLY = Assembly()
     GENERATOR_HEAD_ASSEMBLY.parse(
         r"""