High memory and runtime requirements when adding scRNA-seq data

Hello, 

I’m trying to run Segger with the tutorial data. The pipeline runs fine (with reasonable memory and runtime) when I exclude the scRNA-seq data, but when I include it, the run requires significantly more disk space, memory, and time.

I extracted the scRNA-seq data from the Xenium example dataset. Could you clarify why this might be happening or how best to handle it?

Thank you!
