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Initial Preprocessing
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^^^^^^^^^^^^^^^^^^^^^
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Initial preprocessing offers methods like `non-local means filtering <https://www.iro.umontreal.ca/~mignotte/IFT6150/Articles/Buades-NonLocal.pdf>`_ and `N4 bias field correction <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071855/>`_ to preprocess anatomical images.
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Initial preprocessing offers methods like `ACPC Alignment <https://doi.org/10.1016/j.neuroimage.2013.04.127>`_ , `non-local means filtering <https://www.iro.umontreal.ca/~mignotte/IFT6150/Articles/Buades-NonLocal.pdf>`_ and `N4 bias field correction <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071855/>`_ to preprocess anatomical images.
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C-PAC provides options for configuring initial preprocessing - users can select:
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.. figure:: /_images/anat_init_options.png
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#. **ACPC Alignment - [On,Off]:** Anterior Commissure - Posterior Comissure (ACPC) alignment. Default is Off. If choose 'on', clicking on the setting icon will bring up a dialog where you can set ACPC alignment parameters.
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#. **Non-Local Means Filtering - [On,Off]:** ANTs DenoiseImage. Default is Off.
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#. **N4 Bias Field Correction - [On,Off]:** ANTs N4BiasFieldCorrection - a variant of the popular N3 (nonparametric nonuniform normalization) retrospective bias correction algorithm. Default is Off.
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Configuring ACPC Alignment options:
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**Note:** These options are pre-set for ACPC Alignment's default values. These do not need to be modified unless you are looking to optimize the results of ACPC alignment for your particular dataset.
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.. figure:: /_images/acpc_gui.png
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#. **ACPC Brain Size - [150]:** ACPC size of brain in z-dimension in mm. Default: 150mm for human data, 70mm for macaque data.
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#. **ACPC Aligned Skull Template - [path]:** Skull template to be used for ACPC alignment. It is not necessary to change this path unless you intend to use a non-standard template.
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#. **ACPC Aligned Brain Template - [path]:** Brain template to be used for ACPC alignment. For human data, it can be 'None'. It is not necessary to change this path unless you intend to use a non-standard template.
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