diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 00000000..679960ee
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,73 @@
+[build-system]
+requires = ["setuptools>=78.0.2", "wheel"]
+build-backend = "setuptools.build_meta"
+
+[project]
+name = "nixio"
+version = "1.5.4"
+description = "Python reimplementation of NIXIO (http://g-node.github.io/nix/)"
+readme = "README.rst"
+license-files = ["LICENSE"]
+authors = [
+    { name = "Christian Kellner" },
+    { name = "Adrian Stoewer" },
+    { name = "Andrey Sobolev" },
+    { name = "Jan Grewe" },
+    { name = "Balint Morvai" },
+    { name = "Achilleas Koutsou" }
+]
+maintainers = [
+    { name = "Christian Kellner", email = "dev@g-node.org" },
+    { name = "Adrian Stoewer", email = "dev@g-node.org" },
+    { name = "Andrey Sobolev", email = "dev@g-node.org" },
+    { name = "Jan Grewe", email = "dev@g-node.org" },
+    { name = "Balint Morvai", email = "dev@g-node.org" },
+    { name = "Achilleas Koutsou", email = "dev@g-node.org" }
+]
+requires-python = ">=3.9"
+dependencies = [
+    "numpy >= 1.26.0",
+    "h5py>= 2.0.0"
+]
+classifiers = [
+    "Development Status :: 5 - Production/Stable",
+    "Programming Language :: Python",
+    "Programming Language :: Python :: 3.9",
+    "Programming Language :: Python :: 3.10",
+    "Programming Language :: Python :: 3.11",
+    "Programming Language :: Python :: 3.12",
+    "Topic :: Scientific/Engineering"
+]
+
+[project.urls]
+Homepage = "https://github.com/G-Node/nixpy"
+Documentation= "https://nixpy.readthedocs.io/en/latest/install.html"
+
+[project.optional-dependencies]
+dev = [
+    "coveralls",
+    "pytest",
+    "pytest-cov",
+    "pillow",
+    "matplotlib",
+    "scipy",
+    "sphinx",
+    "sphinx_rtd_theme"
+]
+
+[tool.setuptools]
+include-package-data = true
+zip-safe = false
+
+[tool.setuptools.packages.find]
+where = ["."]
+include = [
+    "nixio",
+    "nixio.hdf5",
+    "nixio.util",
+    "nixio.exceptions",
+    "nixio.cmd"
+]
+
+[project.scripts]
+nixio = "nixio.cmd.main:main"
diff --git a/setup.cfg b/setup.cfg
index 94c44805..2b4b225b 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -9,9 +9,6 @@ all_files  = 1
 [upload_sphinx]
 upload-dir = build/docs
 
-[metadata]
-description_file = README.rst
-
 [aliases]
 test=pytest
 
diff --git a/setup.py b/setup.py
deleted file mode 100644
index 63c58640..00000000
--- a/setup.py
+++ /dev/null
@@ -1,94 +0,0 @@
-#!/usr/bin/env python
-import sys
-import os
-import json
-from setuptools import setup
-
-__author__ = 'Christian Kellner, Achilleas Koutsou'
-
-if sys.version_info.major < 3 or (sys.version_info.major > 2 and sys.version_info.minor < 6):
-    sys.exit('Sorry, nixio requires python >= 3.6!')
-
-with open('README.rst') as f:
-    description_text = f.read()
-
-with open('LICENSE') as f:
-    license_text = f.read()
-
-
-is_win = os.name == 'nt'
-
-# load info from nixio/info.json
-with open(os.path.join("nixio", "info.json")) as infofile:
-    infodict = json.load(infofile)
-
-VERSION = infodict["VERSION"]
-AUTHOR = infodict["AUTHOR"]
-CONTACT = infodict["CONTACT"]
-BRIEF = infodict["BRIEF"]
-HOMEPAGE = infodict["HOMEPAGE"]
-
-
-if "dev" in VERSION:
-    if is_win:
-        colorcodes = ("", "")
-    else:
-        colorcodes = ("\033[93m", "\033[0m")
-    sys.stderr.write("{}WARNING: You are building a development version "
-                     "of nixpy.{}\n".format(*colorcodes))
-
-
-def get_wheel_data():
-    data = []
-    bin = os.environ.get('NIXPY_WHEEL_BINARIES', '')
-    if bin and os.path.isdir(bin):
-        data.append(
-            ('share/nixio/bin',
-             [os.path.join(bin, f) for f in os.listdir(bin)]))
-    return data
-
-
-classifiers = [
-    'Development Status :: 5 - Production/Stable',
-    'Programming Language :: Python',
-    'Programming Language :: Python :: 3.6',
-    'Programming Language :: Python :: 3.7',
-    'Programming Language :: Python :: 3.8',
-    'Programming Language :: Python :: 3.9',
-    'Programming Language :: Python :: 3.10',
-    'Programming Language :: Python :: 3.11',
-    'Programming Language :: Python :: 3.12',
-    'Topic :: Scientific/Engineering'
-]
-
-packages = ['nixio',
-            'nixio.hdf5',
-            'nixio.util',
-            'nixio.exceptions',
-            'nixio.cmd']
-
-setup(
-    name='nixio',
-    version=VERSION,
-    author=AUTHOR,
-    author_email=CONTACT,
-    url=HOMEPAGE,
-    description=BRIEF,
-    long_description=description_text,
-    classifiers=classifiers,
-    license='BSD',
-    packages=packages,
-    scripts=[],
-    python_requires=">=3.6",
-    tests_require=['pytest', 'scipy', 'pillow', 'matplotlib'],
-    test_suite='pytest',
-    setup_requires=['pytest-runner'],
-    install_requires=['numpy', 'h5py'],
-    package_data={'nixio': [license_text, description_text]},
-    include_package_data=True,
-    zip_safe=False,
-    data_files=get_wheel_data(),
-    entry_points={'console_scripts': [
-        'nixio=nixio.cmd.main:main'
-    ]}
-)