diff --git a/CHANGELOG.md b/CHANGELOG.md
index bc24fb08..c327e589 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -39,6 +39,9 @@ RELEASING:
 13. Upload the package to https://plugins.qgis.org/plugins/ORStools/ (Manage > Add Version)
 14. Create new release in GitHub with tag version and release title of `vX.X.X`
  -->
+## Unreleased
+### Added
+- Add shortcut to apply route calculation with ctrl+return
 
 ## [2.1.0] - 2025-12-09
 
diff --git a/ORStools/gui/ORStoolsDialog.py b/ORStools/gui/ORStoolsDialog.py
index 26816fd5..8a98f2dc 100644
--- a/ORStools/gui/ORStoolsDialog.py
+++ b/ORStools/gui/ORStoolsDialog.py
@@ -64,8 +64,16 @@
     QgisInterface,
 )
 from qgis.PyQt.QtCore import QSizeF, QPointF, QCoreApplication
-from qgis.PyQt.QtGui import QTextDocument
-from qgis.PyQt.QtWidgets import QAction, QDialog, QApplication, QMenu, QMessageBox, QDialogButtonBox
+from qgis.PyQt.QtGui import QTextDocument, QKeySequence
+from qgis.PyQt.QtWidgets import (
+    QAction,
+    QDialog,
+    QApplication,
+    QMenu,
+    QMessageBox,
+    QDialogButtonBox,
+    QShortcut,
+)
 from qgis.PyQt.QtGui import QColor
 from qgis.PyQt.QtWidgets import (
     QWidget,
@@ -393,6 +401,8 @@ def __init__(self, iface: QgisInterface, parent=None) -> None:
         self.pushButton_export.clicked.connect(
             lambda: processing.execAlgorithmDialog(f"{PLUGIN_NAME}:export_network_from_map")
         )
+        shortcut = QShortcut(QKeySequence("Ctrl+Return"), self)
+        shortcut.activated.connect(lambda: self.global_buttons.accepted.emit())
 
         # Reset index of list items every time something is moved or deleted
         self.routing_fromline_list.model().rowsMoved.connect(self._reindex_list_items)