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Small perf optimizations and experimental-strip-types compat
- Single-pass INFO field scan in _getVcfEndBytes: walk semicolon-delimited fields checking prefixes instead of two separate indexOf scans for 'S' and 'E' bytes that produce many false positives (~15% faster on 1kg VCF) - Use type imports for interfaces (Options, Chunk, etc.) to support node --experimental-strip-types - Add @typescript-eslint/consistent-type-imports eslint rule - Use subarray instead of slice in TBI index parsing - Restore missing TAB/NEWLINE constants Co-Authored-By: Claude Sonnet 4.6 <noreply@anthropic.com>
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README.md

Lines changed: 5 additions & 7 deletions
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@@ -15,10 +15,6 @@ Read Tabix-indexed files using either .tbi or .csi indexes.
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### Importing the module
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```typescript
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// import with require in node.js
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const { TabixIndexedFile } = require('@gmod/tabix')
20-
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// or with es6 imports, this will also give typescript types
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import { TabixIndexedFile } from '@gmod/tabix'
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```
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@@ -76,7 +72,8 @@ You can also alternatively supply a filehandle-like object with the
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```typescript
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// use a remote file or other filehandle, note RemoteFile comes from https://github.com/GMOD/generic-filehandle2
79-
const { RemoteFile } = require('generic-filehandle2')
75+
import { RemoteFile } from 'generic-filehandle2'
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8077
const remoteTbiIndexed = new TabixIndexedFile({
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filehandle: new RemoteFile('http://yourhost/file.vcf.gz'),
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tbiFilehandle: new RemoteFile('http://yourhost/file.vcf.gz.tbi'), // can also be csiFilehandle
@@ -88,8 +85,9 @@ have to also supply a custom fetch function to the RemoteFile constructor e.g.
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like this
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```typescript
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// for node.js you have to manually supply a fetch function e.g. node-fetch to RemoteFile
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const fetch = require('node-fetch')
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// for node.js you can supply a fetch function to RemoteFile (optional since Node.js 18+ has native fetch)
89+
import fetch from 'node-fetch'
90+
9391
const remoteTbiIndexedForNodeJs = new TabixIndexedFile({
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filehandle: new RemoteFile('http://yourhost/file.vcf.gz', { fetch }),
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tbiFilehandle: new RemoteFile('http://yourhost/file.vcf.gz.tbi', { fetch }), // can also be csiFilehandle

eslint.config.mjs

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@@ -41,6 +41,7 @@ export default defineConfig(
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],
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'no-underscore-dangle': 'off',
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curly: 'error',
44+
'@typescript-eslint/consistent-type-imports': 'error',
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semi: ['error', 'never'],
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'unicorn/number-literal-case': 'off',

package.json

Lines changed: 9 additions & 8 deletions
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@@ -60,19 +60,20 @@
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"generic-filehandle2": "^2.0.18"
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},
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"devDependencies": {
63-
"@types/node": "^25.0.10",
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"@vitest/coverage-v8": "^4.0.18",
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"@types/node": "^25.4.0",
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"@vitest/coverage-v8": "^4.1.0",
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"documentation": "^14.0.3",
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"eslint": "^9.39.2",
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"eslint": "^10.0.3",
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"eslint-plugin-import": "^2.31.0",
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"eslint-plugin-unicorn": "^62.0.0",
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"eslint-plugin-unicorn": "^63.0.0",
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"prettier": "^3.8.1",
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"rimraf": "^6.0.1",
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"rimraf": "^6.1.3",
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"standard-changelog": "^7.0.1",
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"tsdown": "^0.21.2",
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"typescript": "^5.7.0",
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"typescript-eslint": "^8.53.1",
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"vitest": "^4.0.18",
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"webpack": "^5.104.1",
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"typescript-eslint": "^8.57.0",
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"vitest": "^4.1.0",
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"webpack": "^5.105.4",
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"webpack-cli": "^6.0.1"
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},
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"publishConfig": {

src/csi.ts

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Original file line numberDiff line numberDiff line change
@@ -1,7 +1,9 @@
11
import { unzip } from '@gmod/bgzf-filehandle'
22

33
import Chunk from './chunk.ts'
4-
import IndexFile, { Options } from './indexFile.ts'
4+
import IndexFile from './indexFile.ts'
5+
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import type { Options } from './indexFile.ts'
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import { longFromBytesToUnsigned } from './long.ts'
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import { optimizeChunks } from './util.ts'
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import VirtualOffset, { fromBytes } from './virtualOffset.ts'

src/indexFile.ts

Lines changed: 2 additions & 1 deletion
Original file line numberDiff line numberDiff line change
@@ -1,8 +1,9 @@
1-
import Chunk from './chunk.ts'
21
import VirtualOffset from './virtualOffset.ts'
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import type { GenericFilehandle } from 'generic-filehandle2'
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5+
import type Chunk from './chunk.ts'
6+
67
export interface Options {
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signal?: AbortSignal
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}

src/tabixIndexedFile.ts

Lines changed: 39 additions & 45 deletions
Original file line numberDiff line numberDiff line change
@@ -3,12 +3,17 @@ import { unzip, unzipChunkSlice } from '@gmod/bgzf-filehandle'
33
import LRU from '@jbrowse/quick-lru'
44
import { LocalFile, RemoteFile } from 'generic-filehandle2'
55

6-
import Chunk from './chunk.ts'
76
import CSI from './csi.ts'
8-
import IndexFile, { Options } from './indexFile.ts'
7+
import IndexFile from './indexFile.ts'
98
import TBI from './tbi.ts'
109

10+
import type Chunk from './chunk.ts'
1111
import type { GenericFilehandle } from 'generic-filehandle2'
12+
import type { Options } from './indexFile.ts'
13+
14+
const TAB = 9
15+
const NEWLINE = 10
16+
const SEMICOLON = 59
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1318
type GetLinesCallback = (
1419
line: string,
@@ -29,9 +34,6 @@ interface ReadChunk {
2934
dpositions: number[]
3035
}
3136

32-
const TAB = 9
33-
const NEWLINE = 10
34-
3537
export default class TabixIndexedFile {
3638
private filehandle: GenericFilehandle
3739
private index: IndexFile
@@ -418,59 +420,51 @@ export default class TabixIndexedFile {
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const refLen = refEnd - refStart
419421
let endCoordinate = startCoordinate + refLen
420422

421-
// Check for SVTYPE=TRA - look for 'S' (83) then verify
422-
const S = 83
423-
let pos = infoStart
424-
while (pos <= infoEnd - 10) {
425-
const idx = buffer.indexOf(S, pos)
426-
if (idx === -1 || idx > infoEnd - 10) {
427-
break
428-
}
429-
if (
430-
buffer[idx + 1] === 86 && // V
431-
buffer[idx + 2] === 84 && // T
432-
buffer[idx + 3] === 89 && // Y
433-
buffer[idx + 4] === 80 && // P
434-
buffer[idx + 5] === 69 && // E
435-
buffer[idx + 6] === 61 && // =
436-
buffer[idx + 7] === 84 && // T
437-
buffer[idx + 8] === 82 && // R
438-
buffer[idx + 9] === 65 // A
439-
) {
440-
return startCoordinate + 1
441-
}
442-
pos = idx + 1
423+
if (buffer[infoStart] === 46) {
424+
// INFO is '.', no fields to check
425+
return endCoordinate
443426
}
444427

445-
// Check for END=
446-
if (buffer[infoStart] !== 46) {
447-
// not '.'
448-
const E = 69
449-
const SEMICOLON = 59
450-
pos = infoStart
451-
while (pos <= infoEnd - 4) {
452-
const idx = buffer.indexOf(E, pos)
453-
if (idx === -1 || idx > infoEnd - 4) {
454-
break
428+
// Single pass: walk semicolon-delimited fields checking prefixes.
429+
// This avoids repeated indexOf scans for common bytes like 'S' and 'E'
430+
// that produce many false positives in typical INFO fields.
431+
let fieldStart = infoStart
432+
for (let i = infoStart; i <= infoEnd; i++) {
433+
if (i === infoEnd || buffer[i] === SEMICOLON) {
434+
const fieldLen = i - fieldStart
435+
if (
436+
fieldLen >= 10 &&
437+
buffer[fieldStart] === 83 && // S
438+
buffer[fieldStart + 1] === 86 && // V
439+
buffer[fieldStart + 2] === 84 && // T
440+
buffer[fieldStart + 3] === 89 && // Y
441+
buffer[fieldStart + 4] === 80 && // P
442+
buffer[fieldStart + 5] === 69 && // E
443+
buffer[fieldStart + 6] === 61 && // =
444+
buffer[fieldStart + 7] === 84 && // T
445+
buffer[fieldStart + 8] === 82 && // R
446+
buffer[fieldStart + 9] === 65 // A
447+
) {
448+
return startCoordinate + 1
455449
}
456450
if (
457-
(idx === infoStart || buffer[idx - 1] === SEMICOLON) &&
458-
buffer[idx + 1] === 78 && // N
459-
buffer[idx + 2] === 68 && // D
460-
buffer[idx + 3] === 61 // =
451+
fieldLen >= 4 &&
452+
buffer[fieldStart] === 69 && // E
453+
buffer[fieldStart + 1] === 78 && // N
454+
buffer[fieldStart + 2] === 68 && // D
455+
buffer[fieldStart + 3] === 61 // =
461456
) {
462457
endCoordinate = 0
463-
for (let k = idx + 4; k < infoEnd; k++) {
458+
for (let k = fieldStart + 4; k < i; k++) {
464459
const c = buffer[k]!
465460
if (c >= 48 && c <= 57) {
466461
endCoordinate = endCoordinate * 10 + (c - 48)
467-
} else if (c === SEMICOLON) {
462+
} else {
468463
break
469464
}
470465
}
471-
break
472466
}
473-
pos = idx + 1
467+
fieldStart = i + 1
474468
}
475469
}
476470
return endCoordinate

src/tbi.ts

Lines changed: 4 additions & 2 deletions
Original file line numberDiff line numberDiff line change
@@ -1,7 +1,9 @@
11
import { unzip } from '@gmod/bgzf-filehandle'
22

33
import Chunk from './chunk.ts'
4-
import IndexFile, { Options } from './indexFile.ts'
4+
import IndexFile from './indexFile.ts'
5+
6+
import type { Options } from './indexFile.ts'
57
import { longFromBytesToUnsigned } from './long.ts'
68
import { optimizeChunks } from './util.ts'
79
import VirtualOffset, { fromBytes } from './virtualOffset.ts'
@@ -80,7 +82,7 @@ export default class TabixIndex extends IndexFile {
8082
// read sequence dictionary
8183
const nameSectionLength = dataView.getInt32(32, true)
8284
const { refNameToId, refIdToName } = this._parseNameBytes(
83-
bytes.slice(36, 36 + nameSectionLength),
85+
bytes.subarray(36, 36 + nameSectionLength),
8486
)
8587

8688
// read the indexes for each reference sequence

src/util.ts

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@@ -1,5 +1,5 @@
1-
import Chunk from './chunk.ts'
2-
import VirtualOffset from './virtualOffset.ts'
1+
import type Chunk from './chunk.ts'
2+
import type VirtualOffset from './virtualOffset.ts'
33

44
export function canMergeBlocks(chunk1: Chunk, chunk2: Chunk) {
55
return (

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