diff --git a/.github/workflows/test.yaml b/.github/workflows/test.yaml
index f77ea93..52a03bf 100644
--- a/.github/workflows/test.yaml
+++ b/.github/workflows/test.yaml
@@ -22,16 +22,15 @@ jobs:
 
     steps:
     - uses: actions/checkout@v3
-    - name: Setup conda
-      uses: conda-incubator/setup-miniconda@v3
-      with:
-        auto-update-conda: true
-        python-version: ${{ matrix.python-version }}
-        environment-file: conda-env.yml
-        channels: conda-forge
-    - name: Install pytest
-      run: |
-        conda install pytest --yes
+
+    - name: Install uv
+      uses: astral-sh/setup-uv@v2
+
+    - name: Set up Python ${{ matrix.python-version }}
+      run: uv python install ${{ matrix.python-version }}
+
+    - name: Install the project
+      run: uv sync --dev
+
     - name: Run tests
-      run: |
-        python -m pytest
+      run: uv run pytest
diff --git a/.gitignore b/.gitignore
index 044ba5f..e2e35ba 100644
--- a/.gitignore
+++ b/.gitignore
@@ -161,3 +161,6 @@ cython_debug/
 
 # macOS
 .DS_Store
+
+# uv
+uv.lock
diff --git a/.python-version b/.python-version
new file mode 100644
index 0000000..e4fba21
--- /dev/null
+++ b/.python-version
@@ -0,0 +1 @@
+3.12
diff --git a/README.md b/README.md
index 11b4064..fcd1a4b 100644
--- a/README.md
+++ b/README.md
@@ -11,8 +11,10 @@ Once you have a terminal (or "Anaconda prompt" on Windows) open after installati
 1. Change to a directory where you want to download this code.
 2. `git clone https://github.com/HiPCTProject/rebin`
 3. `cd rebin`
-4. `conda env create -f conda-env.yml`
+4. `conda env create --name rebin`
 5. `conda activate rebin`
+6. `conda install uv`
+7. `uv sync`
 
 Now you should be able to run the rebinning code using the example below.
 
diff --git a/conda-env.yml b/conda-env.yml
deleted file mode 100644
index 21ed59f..0000000
--- a/conda-env.yml
+++ /dev/null
@@ -1,9 +0,0 @@
-name: rebin
-channels:
-  - conda-forge
-dependencies:
-  - click
-  - dask
-  - glymur
-  - numpy
-  - scikit-image
diff --git a/pyproject.toml b/pyproject.toml
index da503bc..4dc1dae 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -1,12 +1,19 @@
-[tool.mypy]
-ignore_missing_imports = true
-no_implicit_optional = false
+[project]
+name = "rebin"
+version = "0.1.0"
+description = "Re-bin JPEG2000 images"
+readme = "README.md"
+requires-python = ">=3.9"
+dependencies = [
+    "click",
+    "dask",
+    "glymur",
+    "joblib",
+    "numpy",
+    "scikit-image",
+]
 
-[tool.ruff]
-fix = true
-force-exclude = true
-select = [
-    "F401", # Remove unused imports
-    "I", # Sort imports
-    "UP", # Update Python syntax
+[tool.uv]
+dev-dependencies = [
+    "pytest",
 ]
diff --git a/requirements-dev.txt b/requirements-dev.txt
deleted file mode 100644
index 26b77f6..0000000
--- a/requirements-dev.txt
+++ /dev/null
@@ -1,2 +0,0 @@
--r requirements.txt
-pytest
diff --git a/requirements.txt b/requirements.txt
deleted file mode 100644
index 03674a1..0000000
--- a/requirements.txt
+++ /dev/null
@@ -1,5 +0,0 @@
-click
-dask
-glymur
-numpy
-scikit-image