MSIO_OBI_import.owl

<?xml version="1.0"?>
<rdf:RDF xmlns="http://purl.obolibrary.org/obo/MSIO_OBI_import.owl#"
     xml:base="http://purl.obolibrary.org/obo/MSIO_OBI_import.owl"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:xml="http://www.w3.org/XML/1998/namespace"
     xmlns:protege="http://protege.stanford.edu/plugins/owl/protege#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:obo="http://purl.obolibrary.org/obo/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/">
    <owl:Ontology rdf:about="http://purl.obolibrary.org/obo/MSIO_OBI_import.owl"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://protege.stanford.edu/plugins/owl/protege#defaultLanguage -->

    <owl:AnnotationProperty rdf:about="http://protege.stanford.edu/plugins/owl/protege#defaultLanguage"/>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000179 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000179">
        <obo:IAO_0000115 xml:lang="en">Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification.</obo:IAO_0000115>
        <obo:IAO_0000232 xml:lang="en">Really of interest to developers only</obo:IAO_0000232>
        <rdfs:label xml:lang="en">BFO OWL specification label</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://www.w3.org/2000/01/rdf-schema#label"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000180 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000180">
        <obo:IAO_0000115 xml:lang="en">Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2</obo:IAO_0000115>
        <obo:IAO_0000119>Person:Alan Ruttenberg</obo:IAO_0000119>
        <obo:IAO_0000232 xml:lang="en">Really of interest to developers only</obo:IAO_0000232>
        <rdfs:label xml:lang="en">BFO CLIF specification label</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://www.w3.org/2000/01/rdf-schema#label"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000111 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000111">
        <obo:IAO_0000111>editor preferred label</obo:IAO_0000111>
        <obo:IAO_0000111 xml:lang="en">editor preferred label</obo:IAO_0000111>
        <obo:IAO_0000111>editor preferred term</obo:IAO_0000111>
        <obo:IAO_0000111 xml:lang="en">editor preferred term</obo:IAO_0000111>
        <obo:IAO_0000111>editor preferred term~editor preferred label</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERSON:Daniel Schober</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">GROUP:OBI:&lt;http://purl.obolibrary.org/obo/obi&gt;</obo:IAO_0000119>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/iao.owl"/>
        <rdfs:label>editor preferred label</rdfs:label>
        <rdfs:label xml:lang="en">editor preferred label</rdfs:label>
        <rdfs:label>editor preferred term</rdfs:label>
        <rdfs:label xml:lang="en">editor preferred term</rdfs:label>
        <rdfs:label>editor preferred term~editor preferred label</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000112 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000112">
        <obo:IAO_0000111 xml:lang="en">example</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERSON:Daniel Schober</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">GROUP:OBI:&lt;http://purl.obolibrary.org/obo/obi&gt;</obo:IAO_0000119>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/iao.owl"/>
        <rdfs:label xml:lang="en">example of usage</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000114 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000114">
        <obo:IAO_0000111 xml:lang="en">has curation status</obo:IAO_0000111>
        <obo:IAO_0000117 xml:lang="en">PERSON:Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON:Bill Bug</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON:Melanie Courtot</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">OBI_0000281</obo:IAO_0000119>
        <rdfs:label xml:lang="en">has curation status</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000115 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115">
        <obo:IAO_0000111>definition</obo:IAO_0000111>
        <obo:IAO_0000111 xml:lang="en">definition</obo:IAO_0000111>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">definition</obo:IAO_0000111>
        <obo:IAO_0000111>textual definition</obo:IAO_0000111>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">textual definition</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.</obo:IAO_0000115>
        <obo:IAO_0000115 xml:lang="en">The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2012-04-05: 
Barry Smith

The official OBI definition, explaining the meaning of a class or property: &apos;Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions&apos;  is terrible.

Can you fix to something like:

A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.

Alan Ruttenberg

Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can&apos;t be evaluated by those criteria. 

On the specifics of the proposed definition:

We don&apos;t have definitions of &apos;meaning&apos; or &apos;expression&apos; or &apos;property&apos;. For &apos;reference&apos; in the intended sense I think we use the term &apos;denotation&apos;. For &apos;expression&apos;, I think we you mean symbol, or identifier. For &apos;meaning&apos; it differs for class and property. For class we want documentation that let&apos;s the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let&apos;s the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The &apos;intended reader&apos; part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. 

Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. 

We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.  </obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">PERSON:Daniel Schober</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">GROUP:OBI:&lt;http://purl.obolibrary.org/obo/obi&gt;</obo:IAO_0000119>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/iao.owl"/>
        <rdfs:label>definition</rdfs:label>
        <rdfs:label xml:lang="en">definition</rdfs:label>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">definition</rdfs:label>
        <rdfs:label>textual definition</rdfs:label>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">textual definition</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000116 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000116">
        <obo:IAO_0000111 xml:lang="en">editor note</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERSON:Daniel Schober</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">GROUP:OBI:&lt;http://purl.obfoundry.org/obo/obi&gt;</obo:IAO_0000119>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/iao.owl"/>
        <rdfs:label xml:lang="en">editor note</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000117 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000117">
        <obo:IAO_0000111 xml:lang="en">term editor</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">20110707, MC: label update to term editor and definition modified accordingly. See https://github.com/information-artifact-ontology/IAO/issues/115.</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">PERSON:Daniel Schober</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">GROUP:OBI:&lt;http://purl.obolibrary.org/obo/obi&gt;</obo:IAO_0000119>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/iao.owl"/>
        <rdfs:label xml:lang="en">term editor</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000118 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000118">
        <obo:IAO_0000111 xml:lang="en">alternative term</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent)</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERSON:Daniel Schober</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">GROUP:OBI:&lt;http://purl.obolibrary.org/obo/obi&gt;</obo:IAO_0000119>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/iao.owl"/>
        <rdfs:label xml:lang="en">alternative term</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000119 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000119">
        <obo:IAO_0000111 xml:lang="en">definition source</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERSON:Daniel Schober</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w</obo:IAO_0000119>
        <obo:IAO_0000119 xml:lang="en">GROUP:OBI:&lt;http://purl.obolibrary.org/obo/obi&gt;</obo:IAO_0000119>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/iao.owl"/>
        <rdfs:label xml:lang="en">definition source</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000232 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000232">
        <obo:IAO_0000111 xml:lang="en">curator note</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">An administrative note of use for a curator but of no use for a user</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERSON:Alan Ruttenberg</obo:IAO_0000117>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/iao.owl"/>
        <rdfs:label xml:lang="en">curator note</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000412 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000412">
        <obo:IAO_0000111 xml:lang="en">imported from</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">For external terms/classes, the ontology from which the term was imported</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERSON:Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON:Melanie Courtot</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">GROUP:OBI:&lt;http://purl.obolibrary.org/obo/obi&gt;</obo:IAO_0000119>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/iao.owl"/>
        <rdfs:label xml:lang="en">imported from</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000600 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000600">
        <obo:IAO_0000111 xml:lang="en">elucidation</obo:IAO_0000111>
        <obo:IAO_0000117 xml:lang="en">person:Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">Person:Barry Smith</obo:IAO_0000119>
        <obo:IAO_0000600 xml:lang="en">Primitive terms in a highest-level ontology such as BFO are terms which are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms</obo:IAO_0000600>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/iao.owl"/>
        <rdfs:label xml:lang="en">elucidation</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000601 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000601">
        <obo:IAO_0000111 xml:lang="en">has associated axiom(nl)</obo:IAO_0000111>
        <obo:IAO_0000117 xml:lang="en">Person:Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">Person:Alan Ruttenberg</obo:IAO_0000119>
        <obo:IAO_0000600 xml:lang="en">An axiom associated with a term expressed using natural language</obo:IAO_0000600>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/iao.owl"/>
        <rdfs:label xml:lang="en">has associated axiom(nl)</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000602 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000602">
        <obo:IAO_0000111 xml:lang="en">has associated axiom(fol)</obo:IAO_0000111>
        <obo:IAO_0000117 xml:lang="en">Person:Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">Person:Alan Ruttenberg</obo:IAO_0000119>
        <obo:IAO_0000600 xml:lang="en">An axiom expressed in first order logic using CLIF syntax</obo:IAO_0000600>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/iao.owl"/>
        <rdfs:label xml:lang="en">has associated axiom(fol)</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001847 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0001847">
        <obo:IAO_0000111 xml:lang="en">ISA alternative term</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115>An alternative term used by the ISA tools project (http://isa-tools.org).</obo:IAO_0000115>
        <obo:IAO_0000116>Requested by Alejandra Gonzalez-Beltran
https://sourceforge.net/tracker/?func=detail&amp;aid=3603413&amp;group_id=177891&amp;atid=886178</obo:IAO_0000116>
        <obo:IAO_0000117>Person: Alejandra Gonzalez-Beltran</obo:IAO_0000117>
        <obo:IAO_0000117>Person: Philippe Rocca-Serra</obo:IAO_0000117>
        <obo:IAO_0000119>ISA tools project (http://isa-tools.org)</obo:IAO_0000119>
        <rdfs:label xml:lang="en">ISA alternative term</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000118"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/OBI_9991118 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/OBI_9991118">
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">IEDB alternative term</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An alternative term used by the IEDB.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">IEDB</obo:IAO_0000119>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">IEDB alternative term</rdfs:label>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000118"/>
    </owl:AnnotationProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0001900 -->

    <owl:AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/RO_0001900">
        <rdfs:label xml:lang="en">temporal interpretation</rdfs:label>
        <foaf:page rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/oborel/obo-relations/wiki/ROAndTime</foaf:page>
    </owl:AnnotationProperty>
    


    <!-- http://purl.org/dc/elements/1.1/contributor -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/contributor">
        <dc:description xml:lang="en-us">Examples of a Contributor include a person, an 
         organisation, or a service.  Typically, the name of a 
         Contributor should be used to indicate the entity.</dc:description>
        <rdfs:comment xml:lang="en-us">An entity responsible for making contributions to the
         content of the resource.</rdfs:comment>
        <rdfs:isDefinedBy rdf:resource="http://purl.org/dc/elements/1.1/"/>
        <rdfs:label>Contributor</rdfs:label>
        <rdfs:label xml:lang="en-us">Contributor</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.org/dc/elements/1.1/creator -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/creator">
        <dc:description xml:lang="en-us">Examples of a Creator include a person, an organisation,
         or a service.  Typically, the name of a Creator should 
         be used to indicate the entity.</dc:description>
        <rdfs:comment xml:lang="en-us">An entity primarily responsible for making the content 
         of the resource.</rdfs:comment>
        <rdfs:isDefinedBy rdf:resource="http://purl.org/dc/elements/1.1/"/>
        <rdfs:label>Creator</rdfs:label>
        <rdfs:label xml:lang="en-us">Creator</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.org/dc/elements/1.1/date -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/date">
        <dc:description xml:lang="en-us">Typically, Date will be associated with the creation or
         availability of the resource.  Recommended best practice
         for encoding the date value is defined in a profile of
         ISO 8601 [W3CDTF] and follows the YYYY-MM-DD format.</dc:description>
        <rdfs:comment xml:lang="en-us">A date associated with an event in the life cycle of the
         resource.</rdfs:comment>
        <rdfs:isDefinedBy rdf:resource="http://purl.org/dc/elements/1.1/"/>
        <rdfs:label>Date</rdfs:label>
        <rdfs:label xml:lang="en-us">Date</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.org/dc/elements/1.1/description -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/description">
        <dc:description xml:lang="en-us">Description may include but is not limited to: an abstract,
         table of contents, reference to a graphical representation
         of content or a free-text account of the content.</dc:description>
        <rdfs:comment xml:lang="en-us">An account of the content of the resource.</rdfs:comment>
        <rdfs:isDefinedBy rdf:resource="http://purl.org/dc/elements/1.1/"/>
        <rdfs:label>Description</rdfs:label>
        <rdfs:label xml:lang="en-us">Description</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.org/dc/elements/1.1/format -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/format">
        <dc:description xml:lang="en-us">Typically, Format may include the media-type or dimensions of
         the resource. Format may be used to determine the software,
         hardware or other equipment needed to display or operate the
         resource. Examples of dimensions include size and duration.
         Recommended best practice is to select a value from a
         controlled vocabulary (for example, the list of Internet Media
         Types [MIME] defining computer media formats).</dc:description>
        <rdfs:comment xml:lang="en-us">The physical or digital manifestation of the resource.</rdfs:comment>
        <rdfs:isDefinedBy rdf:resource="http://purl.org/dc/elements/1.1/"/>
        <rdfs:label>Format</rdfs:label>
        <rdfs:label xml:lang="en-us">Format</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.org/dc/elements/1.1/license -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/license"/>
    


    <!-- http://purl.org/dc/elements/1.1/source -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/source">
        <dc:description xml:lang="en-us">The present resource may be derived from the Source resource
         in whole or in part.  Recommended best practice is to reference
         the resource by means of a string or number conforming to a
         formal identification system.</dc:description>
        <rdfs:comment xml:lang="en-us">A reference to a resource from which the present resource
         is derived.</rdfs:comment>
        <rdfs:isDefinedBy rdf:resource="http://purl.org/dc/elements/1.1/"/>
        <rdfs:label>Source</rdfs:label>
        <rdfs:label xml:lang="en-us">Source</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.org/dc/elements/1.1/subject -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/subject">
        <dc:description xml:lang="en-us">Typically, a Subject will be expressed as keywords,
         key phrases or classification codes that describe a topic
         of the resource.  Recommended best practice is to select 
         a value from a controlled vocabulary or formal 
         classification scheme.</dc:description>
        <rdfs:comment xml:lang="en-us">The topic of the content of the resource.</rdfs:comment>
        <rdfs:isDefinedBy rdf:resource="http://purl.org/dc/elements/1.1/"/>
        <rdfs:label>Subject and Keywords</rdfs:label>
        <rdfs:label xml:lang="en-us">Subject and Keywords</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://purl.org/dc/elements/1.1/title -->

    <owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/title">
        <dc:description xml:lang="en-us">
        Typically, a Title will be a name by which the resource is
         formally known.
    </dc:description>
        <rdfs:comment xml:lang="en-us">A name given to the resource.</rdfs:comment>
        <rdfs:isDefinedBy rdf:resource="http://purl.org/dc/elements/1.1/"/>
        <rdfs:label>Title</rdfs:label>
        <rdfs:label xml:lang="en-us">Title</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://www.w3.org/2000/01/rdf-schema#comment -->

    <owl:AnnotationProperty rdf:about="http://www.w3.org/2000/01/rdf-schema#comment"/>
    


    <!-- http://www.w3.org/2000/01/rdf-schema#isDefinedBy -->

    <owl:AnnotationProperty rdf:about="http://www.w3.org/2000/01/rdf-schema#isDefinedBy"/>
    


    <!-- http://www.w3.org/2000/01/rdf-schema#label -->

    <owl:AnnotationProperty rdf:about="http://www.w3.org/2000/01/rdf-schema#label">
        <obo:IAO_0000111>label</obo:IAO_0000111>
        <rdfs:label>label</rdfs:label>
    </owl:AnnotationProperty>
    


    <!-- http://www.w3.org/2000/01/rdf-schema#seeAlso -->

    <owl:AnnotationProperty rdf:about="http://www.w3.org/2000/01/rdf-schema#seeAlso"/>
    


    <!-- http://xmlns.com/foaf/0.1/page -->

    <owl:AnnotationProperty rdf:about="http://xmlns.com/foaf/0.1/page"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://www.w3.org/2001/XMLSchema#date -->

    <rdfs:Datatype rdf:about="http://www.w3.org/2001/XMLSchema#date"/>
    


    <!-- http://www.w3.org/2001/XMLSchema#float -->

    <rdfs:Datatype rdf:about="http://www.w3.org/2001/XMLSchema#float"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/BFO_0000050 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000050">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <obo:IAO_0000111 xml:lang="en">is part of</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">my brain is part of my body (continuant parthood, two material entities)</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this day is part of this year (occurrent parthood)</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a core relation that holds between a part and its whole</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)

A continuant cannot be part of an occurrent: use &apos;participates in&apos;. An occurrent cannot be part of a continuant: use &apos;has participant&apos;. A material entity cannot be part of an immaterial entity: use &apos;has location&apos;. A specifically dependent continuant cannot be part of an independent continuant: use &apos;inheres in&apos;. An independent continuant cannot be part of a specifically dependent continuant: use &apos;bearer of&apos;.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">part_of</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <rdfs:label xml:lang="en">part of</rdfs:label>
        <rdfs:seeAlso>http://www.obofoundry.org/ro/#OBO_REL:part_of</rdfs:seeAlso>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000051 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000051">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <obo:IAO_0000111 xml:lang="en">has part</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">my body has part my brain (continuant parthood, two material entities)</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this year has part this day (occurrent parthood)</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a core relation that holds between a whole and its part</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.)

A continuant cannot have an occurrent as part: use &apos;participates in&apos;. An occurrent cannot have a continuant as part: use &apos;has participant&apos;. An immaterial entity cannot have a material entity as part: use &apos;location of&apos;. An independent continuant cannot have a specifically dependent continuant as part: use &apos;bearer of&apos;. A specifically dependent continuant cannot have an independent continuant as part: use &apos;inheres in&apos;.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">has_part</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <rdfs:label xml:lang="en">has part</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000054 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000054">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000111 xml:lang="en">realized in</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">this disease is realized in this disease course</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this fragility is realized in this shattering</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this investigator role is realized in this investigation</obo:IAO_0000112>
        <obo:IAO_0000118 xml:lang="en">is realized by</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">realized_in</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000600 xml:lang="en">[copied from inverse property &apos;realizes&apos;] to say that b realizes c at t is to assert that there is some material entity d &amp; b is a process which has participant d at t &amp; c is a disposition or role of which d is bearer_of at t&amp; the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])</obo:IAO_0000600>
        <rdfs:comment>Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process</rdfs:comment>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">realized in</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000055 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000055">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000054"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <obo:IAO_0000111 xml:lang="en">realizes</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">this disease course realizes this disease</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this investigation realizes this investigator role</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this shattering realizes this fragility</obo:IAO_0000112>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000600 xml:lang="en">to say that b realizes c at t is to assert that there is some material entity d &amp; b is a process which has participant d at t &amp; c is a disposition or role of which d is bearer_of at t&amp; the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])</obo:IAO_0000600>
        <rdfs:comment>Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process</rdfs:comment>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/iao.owl"/>
        <rdfs:label xml:lang="en">realizes</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000062 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000062">
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000063"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000111 xml:lang="en">preceded by</obo:IAO_0000111>
        <obo:IAO_0000116 xml:lang="en">An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C.    The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">is preceded by</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">preceded_by</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <dc:source>http://www.obofoundry.org/ro/#OBO_REL:preceded_by</dc:source>
        <rdfs:label xml:lang="en">preceded by</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000063 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000063">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0002222"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000111 xml:lang="en">precedes</obo:IAO_0000111>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">precedes</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000039 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000039">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/IAO_0000003"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">has measurement unit label</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000136 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000136">
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
        <obo:IAO_0000112 xml:lang="en">This document is about information artifacts and their representations</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">is_about is a (currently) primitive relation that relates an information artifact to an entity.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of &quot;mentions&quot; relation. Weaken the is_about relationship to be primitive. 

We will try to build it back up by elaborating the various subproperties that are more precisely defined.

Some currently missing phenomena that should be considered &quot;about&quot; are predications - &quot;The only person who knows the answer is sitting beside me&quot; , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic.</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">person:Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">Smith, Ceusters, Ruttenberg, 2000 years of philosophy</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">is about</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000219 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000219">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
        <obo:IAO_0000112 xml:lang="en">A person&apos;s name denotes the person. A variable name in a computer program denotes some piece of memory. Lexically equivalent strings can denote different things, for instance &quot;Alan&quot; can denote different people. In each case of use, there is a case of the denotation relation obtaining, between &quot;Alan&quot; and the person that is being named.</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">denotes is a primitive, instance-level, relation obtaining between an information content entity and some portion of reality. Denotation is what happens when someone creates an information content entity E in order to specifically refer to something. The only relation between E and the thing is that E can be used to &apos;pick out&apos; the thing. This relation connects those two together. Freedictionary.com sense 3: To signify directly; refer to specifically</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2009-11-10 Alan Ruttenberg. Old definition said the following to emphasize the generic nature of this relation. We no longer have &apos;specifically denotes&apos;, which would have been primitive, so make this relation primitive.
g denotes r =def 
r is a portion of reality
there is some c that is a concretization of g 
every c that is a concretization of g specifically denotes r</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">person:Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">Conversations with Barry Smith, Werner Ceusters, Bjoern Peters, Michel Dumontier, Melanie Courtot, James Malone, Bill Hogan</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:comment xml:lang="en"></rdfs:comment>
        <rdfs:label xml:lang="en">denotes</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000221 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000221">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000417"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000417"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/IAO_0000109"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000019"/>
        <obo:IAO_0000115 xml:lang="en">m is a quality measurement of q at t when
q is a quality 
there is a measurement process p that has specified output m, a measurement datum, that is about q</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">8/6/2009 Alan Ruttenberg: The strategy is to be rather specific with this relationship. There are other kinds of measurements that are not of qualities, such as those that measure time. We will add these as separate properties for the moment and see about generalizing later</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">From the second IAO workshop [Alan Ruttenberg 8/6/2009: not completely current, though bringing in comparison is probably important]

This one is the one we are struggling with at the moment. The issue is what a measurement measures. On the one hand saying that it measures the quality would include it &quot;measuring&quot; the bearer = referring to the bearer in the measurement. However this makes comparisons of two different things not possible. On the other hand not having it inhere in the bearer, on the face of it, breaks the audit trail.

Werner suggests a solution based on &quot;Magnitudes&quot; a proposal for which we are awaiting details.
--
From the second IAO workshop, various comments, [commented on by Alan Ruttenberg 8/6/2009]

unit of measure is a quality, e.g. the length of a ruler.

[We decided to hedge on what units of measure are, instead talking about measurement unit labels, which are the information content entities that are about whatever measurement units are. For IAO we need that information entity in any case. See the term measurement unit label]

[Some struggling with the various subflavors of is_about. We subsequently removed the relation represents, and describes until and only when we have a better theory]

a represents b means either a denotes b or a describes

describe:
a describes b means a is about b and a allows an inference of at least one quality of b

We have had a long discussion about denotes versus describes.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">From the second IAO workshop: An attempt at tieing the quality to the measurement datum more carefully.

a is a magnitude means a is a determinate quality particular inhering in some bearer b existing at a time t that can be represented/denoted by an information content entity e that has parts denoting a unit of measure, a number, and b. The unit of measure is an instance of the determinable quality.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">From the second meeting on IAO:

An attempt at defining assay using Barry&apos;s &quot;reliability&quot; wording

assay:
process and has_input some material entity
and has_output some information content entity 
and which is such that instances of this process type reliably generate 
outputs that describes the input.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">This one is the one we are struggling with at the moment. The issue is what a measurement measures. On the one hand saying that it measures the quality would include it &quot;measuring&quot; the bearer = referring to the bearer in the measurement. However this makes comparisons of two different things not possible. On the other hand not having it inhere in the bearer, on the face of it, breaks the audit trail.

Werner suggests a solution based on &quot;Magnitudes&quot; a proposal for which we are awaiting details.</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">is quality measurement of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000407 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000407">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/IAO_0000400"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/UO_0000001"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:comment xml:lang="en">relating a cartesian spatial coordinate datum to a unit label that together with the values represent a point</rdfs:comment>
        <rdfs:label xml:lang="en">has coordinate unit label</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000413 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000413">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/IAO_0000416"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">relates a process to a time-measurement-datum that represents the duration of the process</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Person:Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">is duration of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000417 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000417">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000221"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">inverse of the relation of is quality measurement of</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2009/10/19 Alan Ruttenberg. Named &apos;junk&apos; relation useful in restrictions, but not a real instance relationship</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">Person:Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">is quality measured as</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000581 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000581">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/IAO_0000582"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/IAO_0000416"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 xml:lang="en">relates a time stamped measurement datum to the time measurement datum that denotes the time when the measurement was taken</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">has time stamp</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000583 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000583">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/IAO_0000582"/>
        <rdfs:range>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000109"/>
                    <owl:Class>
                        <owl:complementOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000416"/>
                    </owl:Class>
                </owl:intersectionOf>
            </owl:Class>
        </rdfs:range>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 xml:lang="en">relates a time stamped measurement datum to the measurement datum that was measured</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">has measurement datum</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000124 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0000124">
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OBI_0001909"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">is_supported_by_data</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The relation between the conclusion &quot;Gene tpbA is involved in EPS production&quot; and the data items produced using two sets of organisms, one being a tpbA knockout, the other being tpbA wildtype tested in polysacharide production assays and analyzed using an ANOVA. </obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The relation between a data item and a conclusion where the conclusion is the output of a data interpreting process and the data item is used as an input to that process</obo:IAO_0000115>
        <obo:IAO_0000117>OBI</obo:IAO_0000117>
        <obo:IAO_0000119>OBI</obo:IAO_0000119>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Philly 2011 workshop</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">is_supported_by_data</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000293 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0000293">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000295"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000295"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
        <obo:IAO_0000111 xml:lang="en">has_specified_input</obo:IAO_0000111>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_specified_input</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">see is_input_of example_of_usage</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A relation between a planned process and a continuant participating in that process that is not created during  the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of.</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">8/17/09: specified inputs of one process are not necessarily specified inputs of a larger process that it is part of. This is in contrast to how &apos;has participant&apos; works.</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">PERSON: Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Larry Hunter</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Melanie Coutot</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">has_specified_input</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000295 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0000295">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">is_specified_input_of</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">some Autologous EBV(Epstein-Barr virus)-transformed B-LCL (B lymphocyte cell line) is_input_for instance of Chromum Release Assay described at https://wiki.cbil.upenn.edu/obiwiki/index.php/Chromium_Release_assay</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A relation between a planned process and a continuant participating in that process that is not created during  the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON:Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">is_specified_input_of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000299 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0000299">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
        <obo:IAO_0000111 xml:lang="en">has_specified_output</obo:IAO_0000111>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has_specified_output</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERSON: Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Larry Hunter</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Melanie Courtot</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">has_specified_output</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000312 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0000312">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
        <obo:IAO_0000111 xml:lang="en">is_specified_output_of</obo:IAO_0000111>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">is_specified_output_of</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON:Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">is_specified_output_of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000314 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0000314">
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">is_proxy_for</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">position on a gel is_proxy_for mass and charge of molecule in an western blot. Florescent intensity is_proxy_for amount of protein labeled with GFP. Examples:
A260/A280 (of a DNA sample) is_proxy_for DNA-purity. NMR Sample scan is a proxy for sample quality.

Within the assay mentioned here: https://wiki.cbil.upenn.edu/obiwiki/index.php/Chromium_Release_assay
level of radioactivity is_proxy_for level of toxicity</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 xml:lang="en">A relation between continuant instances c1 and c2 where within an experiment/ protocol application,  measurement of c1 is used to determine what a measurement of c2 would be.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">A relation between continuant instances c1 and c2 where within a protocol 
    application, measurement of c1 is related to a what would be the 
    measurement of c2.
(another definition)</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">is_proxy_for</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000417 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0000417">
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000833"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/IAO_0000005"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">achieves_planned_objective</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A cell sorting process achieves the objective specification &apos;material separation objective&apos;</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">BP, AR, PPPB branch</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PPPB branch derived</obo:IAO_0000119>
        <obo:IAO_0000232 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">modified according to email thread from 1/23/09 in accordince with DT and PPPB branch</obo:IAO_0000232>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">achieves_planned_objective</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000643 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0000643">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has grain</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">the relation of the cells in the finger of the skin to the finger, in which an indeterminate number of grains are parts of the whole by virtue of being grains in a collective that is part of the whole, and in which removing one granular part does not nec- essarily damage or diminish the whole. Ontological Whether there is a fixed, or nearly fixed number of parts - e.g. fingers of the hand, chambers of the heart, or wheels of a car - such that there can be a notion of a single one being missing, or whether, by contrast, the number of parts is indeterminate - e.g., cells in the skin of the hand, red cells in blood, or rubber molecules in the tread of the tire of the wheel of the car.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">Discussion in Karslruhe with, among others, Alan Rector, Stefan Schulz, Marijke Keet, Melanie Courtot, and Alan Ruttenberg. Definition take from the definition of granular parthood in the cited paper. Needs work to put into standard form</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">PERSON: Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PAPER: Granularity, scale and collectivity: When size does and does not matter, Alan Rector, Jeremy Rogers, Thomas Bittner, Journal of Biomedical Informatics 39 (2006) 333-349</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">has grain</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000833 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0000833">
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/IAO_0000005"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">objective_achieved_by</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">This relation obtains between a a objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process.</obo:IAO_0000115>
        <obo:IAO_0000117>OBI</obo:IAO_0000117>
        <obo:IAO_0000119>OBI</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">objective_achieved_by</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000846 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0000846">
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0001688"/>
        <rdfs:domain>
            <owl:Class>
                <owl:unionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_9606"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000245"/>
                </owl:unionOf>
            </owl:Class>
        </rdfs:domain>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/OBI_0000245"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">is member of organization</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Relating a legal person or organization to an organization in the case where the legal person or organization has a role as member of the organization.</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2009/10/01 Alan Ruttenberg. Barry prefers generic is-member-of. Question of what the range should be. For now organization. Is organization a population? Would the same relation be used to record members of a population</obo:IAO_0000116>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">JZ: Discussed on May 7, 2012 OBI dev call. Bjoern points out that we need to allow for organizations to be members of organizations. And agreed by the other OBI developers. So, human and organization were specified in &apos;Domains&apos;. The textual definition was updated based on it.</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Person:Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Person:Helen Parkinson</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Person:Alan Ruttenberg</obo:IAO_0000119>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Person:Helen Parkinson</obo:IAO_0000119>
        <obo:IAO_0000232 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2009/09/28 Alan Ruttenberg. Fucoidan-use-case</obo:IAO_0000232>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">is member of organization</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001688 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0001688">
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OBI_0000245"/>
        <rdfs:range>
            <owl:Class>
                <owl:unionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_9606"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000245"/>
                </owl:unionOf>
            </owl:Class>
        </rdfs:range>
        <obo:IAO_0000111 xml:lang="en">has organization member</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Relating an organization to a legal person or organization.</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">See tracker:
https://sourceforge.net/tracker/index.php?func=detail&amp;aid=3512902&amp;group_id=177891&amp;atid=886178</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Person: Jie Zheng</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">has organization member</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001927 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0001927">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OBI_0001933"/>
        <obo:IAO_0000111>specifies value of</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115>A relation between a value specification and an entity which the specification is about.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label>specifies value of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001938 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0001938">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/OBI_0001933"/>
        <obo:IAO_0000111>has value specification</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115>A relation between an information content entity and a value specification that specifies its value.</obo:IAO_0000115>
        <obo:IAO_0000117>PERSON: James A. Overton</obo:IAO_0000117>
        <obo:IAO_0000119>OBI</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label>has value specification</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000052 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000052">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
        <obo:IAO_0000111 xml:lang="en">inheres in</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">this fragility inheres in this vase</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this red color inheres in this apple</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">A dependent inheres in its bearer at all times for which the dependent exists.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">inheres_in</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <rdfs:label xml:lang="en">inheres in</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000053 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000053">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <obo:IAO_0000111 xml:lang="en">bearer of</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">this apple is bearer of this red color</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this vase is bearer of this fragility</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">bearer_of</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">is bearer of</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:RO_0001900 rdf:resource="http://purl.obolibrary.org/obo/RO_0001901"/>
        <rdfs:label xml:lang="en">bearer of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000056 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000056">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000111 xml:lang="en">participates in</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">this blood clot participates in this blood coagulation</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this input material (or this output material) participates in this process</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this investigator participates in this investigation</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between a continuant and a process, in which the continuant is somehow involved in the process</obo:IAO_0000115>
        <obo:IAO_0000118 xml:lang="en">participates_in</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">participates in</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000057 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000057">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <obo:IAO_0000111 xml:lang="en">has participant</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">this blood coagulation has participant this blood clot</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this investigation has participant this investigator</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this process has participant this input material (or this output material)</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between a process and a continuant, in which the continuant is somehow involved in the process</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">has_participant</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <dc:source>http://www.obofoundry.org/ro/#OBO_REL:has_participant</dc:source>
        <rdfs:label xml:lang="en">has participant</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000058 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000058">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000031"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <obo:IAO_0000112 xml:lang="en">A journal article is an information artifact that inheres in some number of printed journals. For each copy of the printed journal there is some quality that carries the journal article, such as a pattern of ink. The journal article (a generically dependent continuant) is concretized as the quality (a specifically dependent continuant), and both depend on that copy of the printed journal (an independent continuant).</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">An investigator reads a protocol and forms a plan to carry out an assay. The plan is a realizable entity (a specifically dependent continuant) that concretizes the protocol (a generically dependent continuant), and both depend on the investigator (an independent continuant). The plan is then realized by the assay (a process).</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">A relationship between a generically dependent continuant and a specifically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. A generically dependent continuant may be concretized as multiple specifically dependent continuants.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">is concretized as</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000059 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000059">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000058"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000031"/>
        <obo:IAO_0000112 xml:lang="en">A journal article is an information artifact that inheres in some number of printed journals. For each copy of the printed journal there is some quality that carries the journal article, such as a pattern of ink. The quality (a specifically dependent continuant) concretizes the journal article (a generically dependent continuant), and both depend on that copy of the printed journal (an independent continuant).</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">An investigator reads a protocol and forms a plan to carry out an assay. The plan is a realizable entity (a specifically dependent continuant) that concretizes the protocol (a generically dependent continuant), and both depend on the investigator (an independent continuant). The plan is then realized by the assay (a process).</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">concretizes</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000079 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000079">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000085"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000085"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000034"/>
        <obo:IAO_0000112 xml:lang="en">this catalysis function is a function of this enzyme</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">A function inheres in its bearer at all times for which the function exists, however the function need not be realized at all the times that the function exists.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">function_of</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">is function of</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">function of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000080 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000080">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000086"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000086"/>
        <obo:IAO_0000112 xml:lang="en">this red color is a quality of this apple</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">A quality inheres in its bearer at all times for which the quality exists.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">is quality of</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">quality_of</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">quality of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000081 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000081">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
        <obo:IAO_0000112 xml:lang="en">this investigator role is a role of this person</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">is role of</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">role_of</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">role of</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000085 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000085">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000079"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000034"/>
        <obo:IAO_0000112 xml:lang="en">this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function)</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">has_function</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">has function</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000086 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000086">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000080"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000019"/>
        <obo:IAO_0000112 xml:lang="en">this apple has quality this red color</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">has_quality</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">has quality</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000087 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000087">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000081"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
        <obo:IAO_0000112 xml:lang="en">this person has role this investigator role (more colloquially: this person has this role of investigator)</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">has_role</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">has role</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0001000 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0001000">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0001001"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
        <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0001001"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">derives from</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">this cell derives from this parent cell (cell division)</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this nucleus derives from this parent nucleus (nuclear division)</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">This is a very general relation. More specific relations are preferred when applicable, such as &apos;directly develops from&apos;.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">derives_from</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ro.owl"/>
        <rdfs:label xml:lang="en">derives from</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0001001 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0001001">
        <owl:equivalentProperty>
            <rdf:Description>
                <owl:inverseOf rdf:resource="http://purl.obolibrary.org/obo/RO_0001000"/>
            </rdf:Description>
        </owl:equivalentProperty>
        <obo:IAO_0000112 xml:lang="en">this parent cell derives into this cell (cell division)</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">this parent nucleus derives into this nucleus (nuclear division)</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">This is a very general relation. More specific relations are preferred when applicable, such as &apos;directly develops into&apos;. To avoid making statements about a future that may not come to pass, it is often better to use the backward-looking &apos;derives from&apos; rather than the forward-looking &apos;derives into&apos;.</obo:IAO_0000116>
        <obo:IAO_0000118 xml:lang="en">derives_into</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">derives into</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002222 -->

    <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002222">
        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000116>move to BFO?</obo:IAO_0000116>
        <obo:IAO_0000119>Allen</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:comment>A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations.</rdfs:comment>
        <rdfs:label xml:lang="en">temporal relation</rdfs:label>
    </owl:ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Data properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/IAO_0000004 -->

    <owl:DatatypeProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000004">
        <rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topDataProperty"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/IAO_0000032"/>
        <rdfs:range rdf:resource="http://www.w3.org/2001/XMLSchema#double"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">has measurement value</rdfs:label>
    </owl:DatatypeProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000404 -->

    <owl:DatatypeProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000404">
        <rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topDataProperty"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/IAO_0000400"/>
        <rdfs:range rdf:resource="http://www.w3.org/2001/XMLSchema#float"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">has x coordinate value</rdfs:label>
    </owl:DatatypeProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000406 -->

    <owl:DatatypeProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000406">
        <rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topDataProperty"/>
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#FunctionalProperty"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/IAO_0000400"/>
        <rdfs:range rdf:resource="http://www.w3.org/2001/XMLSchema#float"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">has y coordinate value</rdfs:label>
    </owl:DatatypeProperty>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001937 -->

    <owl:DatatypeProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0001937">
        <rdfs:subPropertyOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0002135"/>
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OBI_0001933"/>
        <rdfs:range rdf:resource="http://www.w3.org/2002/07/owl#real"/>
        <obo:IAO_0000111>has specified numeric value</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115>A relation between a value specification and a number that quantifies it.</obo:IAO_0000115>
        <obo:IAO_0000116>A range of &apos;real&apos; might be better than &apos;float&apos;. For now we follow &apos;has measurement value&apos; until we can consider technical issues with SPARQL queries and reasoning.</obo:IAO_0000116>
        <obo:IAO_0000117>PERSON: James A. Overton</obo:IAO_0000117>
        <obo:IAO_0000119>OBI</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label>has specified numeric value</rdfs:label>
    </owl:DatatypeProperty>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0002135 -->

    <owl:DatatypeProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0002135">
        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/OBI_0001933"/>
        <obo:IAO_0000111 xml:lang="en">has specified value</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115>A relation between a value specification and a literal.</obo:IAO_0000115>
        <obo:IAO_0000116>This is not an RDF/OWL object property. It is intended to link a value found in e.g. a database column of &apos;M&apos; (the literal) to an instance of a value specification class, which can then be linked to indicate that this is about the biological gender of a human subject.</obo:IAO_0000116>
        <obo:IAO_0000119>OBI</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">has specified value</rdfs:label>
    </owl:DatatypeProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/BFO_0000001 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000001">
        <obo:BFO_0000179>entity</obo:BFO_0000179>
        <obo:BFO_0000180>Entity</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">Julius Caesar</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">Verdi’s Requiem</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the Second World War</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">your body mass index</obo:IAO_0000112>
        <obo:IAO_0000116 xml:lang="en">BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Entity doesn&apos;t have a closure axiom because the subclasses don&apos;t necessarily exhaust all possibilites. For example Werner Ceusters &apos;portions of reality&apos; include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, &apos;How to track absolutely everything&apos; at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf</obo:IAO_0000116>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000600 xml:lang="en">An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])</obo:IAO_0000600>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">entity</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000002 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000002">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000001"/>
        <obo:BFO_0000179>continuant</obo:BFO_0000179>
        <obo:BFO_0000180>Continuant</obo:BFO_0000180>
        <obo:IAO_0000115 xml:lang="en">An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Continuant doesn&apos;t have a closure axiom because the subclasses don&apos;t necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster&apos;s other portions of reality, questions are raised as to whether universals are continuants</obo:IAO_0000116>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000600 xml:lang="en">A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])</obo:IAO_0000600>
        <obo:IAO_0000601 xml:lang="en">if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])</obo:IAO_0000601>
        <obo:IAO_0000601 xml:lang="en">if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])</obo:IAO_0000601>
        <obo:IAO_0000601 xml:lang="en">if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])</obo:IAO_0000601>
        <obo:IAO_0000602>(forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] </obo:IAO_0000602>
        <obo:IAO_0000602>(forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] </obo:IAO_0000602>
        <obo:IAO_0000602>(forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] </obo:IAO_0000602>
        <obo:IAO_0000602>(forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">continuant</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000003 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000003">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000001"/>
        <obo:BFO_0000179>occurrent</obo:BFO_0000179>
        <obo:BFO_0000180>Occurrent</obo:BFO_0000180>
        <obo:IAO_0000115 xml:lang="en">An entity that has temporal parts and that happens, unfolds or develops through time.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Occurrent doesn&apos;t have a closure axiom because the subclasses don&apos;t necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process.</obo:IAO_0000116>
        <obo:IAO_0000116>Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by &apos;spn[e]&apos; and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write &apos;spr[e]&apos; and `spl[e]&apos; respectively for the spread and spell of e, omitting mention of the frame.</obo:IAO_0000116>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000600 xml:lang="en">An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])</obo:IAO_0000600>
        <obo:IAO_0000601 xml:lang="en">Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])</obo:IAO_0000601>
        <obo:IAO_0000601 xml:lang="en">b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])</obo:IAO_0000601>
        <obo:IAO_0000602>(forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] </obo:IAO_0000602>
        <obo:IAO_0000602>(forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">occurrent</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000004 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000004">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <obo:BFO_0000179>ic</obo:BFO_0000179>
        <obo:BFO_0000180>IndependentContinuant</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">a chair</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a heart</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a leg</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a molecule</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a spatial region</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">an atom</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">an orchestra.</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">an organism</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the bottom right portion of a human torso</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the interior of your mouth</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.</obo:IAO_0000115>
        <obo:IAO_0000115 xml:lang="en">b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000601 xml:lang="en">For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])</obo:IAO_0000601>
        <obo:IAO_0000601 xml:lang="en">For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])</obo:IAO_0000601>
        <obo:IAO_0000602>(forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] </obo:IAO_0000602>
        <obo:IAO_0000602>(forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] </obo:IAO_0000602>
        <obo:IAO_0000602>(iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">independent continuant</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000006 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000006">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000141"/>
        <obo:BFO_0000179>s-region</obo:BFO_0000179>
        <obo:BFO_0000180>SpatialRegion</obo:BFO_0000180>
        <obo:IAO_0000116 xml:lang="en">BFO 2 Reference: Spatial regions do not participate in processes.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Spatial region doesn&apos;t have a closure axiom because the subclasses don&apos;t exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn&apos;t overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional.</obo:IAO_0000116>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000600 xml:lang="en">A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001])</obo:IAO_0000600>
        <obo:IAO_0000601 xml:lang="en">All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001])</obo:IAO_0000601>
        <obo:IAO_0000602>(forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001] </obo:IAO_0000602>
        <obo:IAO_0000602>(forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">spatial region</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000009 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000009">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000006"/>
        <obo:BFO_0000179>2d-s-region</obo:BFO_0000179>
        <obo:BFO_0000180>TwoDimensionalSpatialRegion</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">an infinitely thin plane in space.</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the surface of a sphere-shaped part of space</obo:IAO_0000112>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000600 xml:lang="en">A two-dimensional spatial region is a spatial region that is of two dimensions. (axiom label in BFO2 Reference: [039-001])</obo:IAO_0000600>
        <obo:IAO_0000602>(forall (x) (if (TwoDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [039-001] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">two-dimensional spatial region</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000015 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000015">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000003"/>
        <obo:BFO_0000179>process</obo:BFO_0000179>
        <obo:BFO_0000180>Process</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">a process of cell-division, \ a beating of the heart</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a process of meiosis</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a process of sleeping</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the course of a disease</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the flight of a bird</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the life of an organism</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">your process of aging.</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.</obo:IAO_0000115>
        <obo:IAO_0000115 xml:lang="en">p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)</obo:IAO_0000116>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000602>(iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">process</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000016 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000016">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <obo:BFO_0000179>disposition</obo:BFO_0000179>
        <obo:BFO_0000180>Disposition</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">an atom of element X has the disposition to decay to an atom of element Y</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">certain people have a predisposition to colon cancer</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">children are innately disposed to categorize objects in certain ways.</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the cell wall is disposed to filter chemicals in endocytosis and exocytosis</obo:IAO_0000112>
        <obo:IAO_0000116 xml:lang="en">BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type.</obo:IAO_0000116>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000600 xml:lang="en">b is a disposition means: b is a realizable entity &amp; b’s bearer is some material entity &amp; b is such that if it ceases to exist, then its bearer is physically changed, &amp; b’s realization occurs when and because this bearer is in some special physical circumstances, &amp; this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])</obo:IAO_0000600>
        <obo:IAO_0000601 xml:lang="en">If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])</obo:IAO_0000601>
        <obo:IAO_0000602>(forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] </obo:IAO_0000602>
        <obo:IAO_0000602>(forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">disposition</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000017 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000017">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <obo:BFO_0000179>realizable</obo:BFO_0000179>
        <obo:BFO_0000180>RealizableEntity</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">the disposition of this piece of metal to conduct electricity.</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the disposition of your blood to coagulate</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the function of your reproductive organs</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the role of being a doctor</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the role of this boundary to delineate where Utah and Colorado meet</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">A specifically dependent continuant  that inheres in continuant  entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000600 xml:lang="en">To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])</obo:IAO_0000600>
        <obo:IAO_0000601 xml:lang="en">All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])</obo:IAO_0000601>
        <obo:IAO_0000602>(forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] </obo:IAO_0000602>
        <obo:IAO_0000602>(forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">realizable entity</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000018 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000018">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000006"/>
        <obo:BFO_0000179>0d-s-region</obo:BFO_0000179>
        <obo:BFO_0000180>ZeroDimensionalSpatialRegion</obo:BFO_0000180>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000600 xml:lang="en">A zero-dimensional spatial region is a point in space. (axiom label in BFO2 Reference: [037-001])</obo:IAO_0000600>
        <obo:IAO_0000602>(forall (x) (if (ZeroDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [037-001] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">zero-dimensional spatial region</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000019 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000019">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000020"/>
        <obo:BFO_0000179>quality</obo:BFO_0000179>
        <obo:BFO_0000180>Quality</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">the ambient temperature of this portion of air</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the color of a tomato</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the length of the circumference of your waist</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the mass of this piece of gold.</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the shape of your nose</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the shape of your nostril</obo:IAO_0000112>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000600 xml:lang="en">a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])</obo:IAO_0000600>
        <obo:IAO_0000601 xml:lang="en">If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])</obo:IAO_0000601>
        <obo:IAO_0000602>(forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] </obo:IAO_0000602>
        <obo:IAO_0000602>(forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">quality</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000020 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000020">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <obo:BFO_0000179>sdc</obo:BFO_0000179>
        <obo:BFO_0000180>SpecificallyDependentContinuant</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">of one-sided specifically dependent continuants: the mass of this tomato</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates.</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the disposition of this fish to decay</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the function of this heart: to pump blood</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the mutual dependence of proton donors and acceptors in chemical reactions [79</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the pink color of a medium rare piece of grilled filet mignon at its center</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the role of being a doctor</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the shape of this hole.</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the smell of this portion of mozzarella</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.</obo:IAO_0000115>
        <obo:IAO_0000115 xml:lang="en">b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n &amp;gt; 1 independent continuants c1, … cn which are not spatial regions are such that for all 1  i &amp;lt; j  n, ci  and cj share no common parts, are such that for each 1  i  n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004])</obo:IAO_0000115>
        <obo:IAO_0000115 xml:lang="en">b is a specifically dependent continuant = Def. b is a continuant &amp; there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">Specifically dependent continuant doesn&apos;t have a closure axiom because the subclasses don&apos;t necessarily exhaust all possibilites. We&apos;re not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc.</obo:IAO_0000116>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000602>(iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004] </obo:IAO_0000602>
        <obo:IAO_0000602>(iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">specifically dependent continuant</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000023 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000023">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
        <obo:BFO_0000179>role</obo:BFO_0000179>
        <obo:BFO_0000180>Role</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married.</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the priest role</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the role of a boundary to demarcate two neighboring administrative territories</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the role of a building in serving as a military target</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the role of a stone in marking a property boundary</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the role of subject in a clinical trial</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the student role</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">A realizable entity  the manifestation of which brings about some result or end that is not essential to a continuant  in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant  in some kinds of natural, social or institutional contexts.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role &amp; c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals –  professor, sergeant, nurse – only during certain phases in their lives.</obo:IAO_0000116>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000600 xml:lang="en">b is a role means: b is a realizable entity &amp; b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be&amp; b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])</obo:IAO_0000600>
        <obo:IAO_0000602>(forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">role</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000026 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000026">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000006"/>
        <obo:BFO_0000179>1d-s-region</obo:BFO_0000179>
        <obo:BFO_0000180>OneDimensionalSpatialRegion</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">an edge of a cube-shaped portion of space.</obo:IAO_0000112>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000600 xml:lang="en">A one-dimensional spatial region is a line or aggregate of lines stretching from one point in space to another. (axiom label in BFO2 Reference: [038-001])</obo:IAO_0000600>
        <obo:IAO_0000602>(forall (x) (if (OneDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [038-001] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">one-dimensional spatial region</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000028 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000028">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000006"/>
        <obo:BFO_0000179>3d-s-region</obo:BFO_0000179>
        <obo:BFO_0000180>ThreeDimensionalSpatialRegion</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">a cube-shaped region of space</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a sphere-shaped region of space,</obo:IAO_0000112>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000600 xml:lang="en">A three-dimensional spatial region is a spatial region that is of three dimensions. (axiom label in BFO2 Reference: [040-001])</obo:IAO_0000600>
        <obo:IAO_0000602>(forall (x) (if (ThreeDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [040-001] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">three-dimensional spatial region</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000031 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000031">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000002"/>
        <obo:BFO_0000179>gdc</obo:BFO_0000179>
        <obo:BFO_0000180>GenericallyDependentContinuant</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity.</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the pdf file on your laptop, the pdf file that is a copy thereof on my laptop</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule.</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time.</obo:IAO_0000115>
        <obo:IAO_0000115 xml:lang="en">b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000602>(iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">generically dependent continuant</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000034 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000034">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000016"/>
        <obo:BFO_0000179>function</obo:BFO_0000179>
        <obo:BFO_0000180>Function</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">the function of a hammer to drive in nails</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the function of a heart pacemaker to regulate the beating of a heart through electricity</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the function of amylase in saliva to break down starch into sugar</obo:IAO_0000112>
        <obo:IAO_0000116 xml:lang="en">BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc.</obo:IAO_0000116>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000600 xml:lang="en">A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001])</obo:IAO_0000600>
        <obo:IAO_0000602>(forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">function</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000040 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000040">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <obo:BFO_0000179>material</obo:BFO_0000179>
        <obo:BFO_0000180>MaterialEntity</obo:BFO_0000180>
        <obo:IAO_0000112 xml:lang="en">a flame</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a forest fire</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a human being</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a hurricane</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a photon</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a puff of smoke</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a sea wave</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a tornado</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">an aggregate of human beings.</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">an energy wave</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">an epidemic</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">the undetached arm of a human being</obo:IAO_0000112>
        <obo:IAO_0000115 xml:lang="en">An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here.</obo:IAO_0000116>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000600 xml:lang="en">A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])</obo:IAO_0000600>
        <obo:IAO_0000601 xml:lang="en">Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])</obo:IAO_0000601>
        <obo:IAO_0000601 xml:lang="en">every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])</obo:IAO_0000601>
        <obo:IAO_0000602>(forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] </obo:IAO_0000602>
        <obo:IAO_0000602>(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] </obo:IAO_0000602>
        <obo:IAO_0000602>(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] </obo:IAO_0000602>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">material entity</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000141 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/BFO_0000141">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000004"/>
        <obo:BFO_0000179>immaterial</obo:BFO_0000179>
        <obo:BFO_0000180>ImmaterialEntity</obo:BFO_0000180>
        <obo:IAO_0000116 xml:lang="en">BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10</obo:IAO_0000116>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:isDefinedBy rdf:resource="http://purl.obolibrary.org/obo/bfo.owl"/>
        <rdfs:label xml:lang="en">immaterial entity</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_16670 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_16670">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33839"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">peptide</obo:IAO_0000111>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/chebi.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">peptide</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_16991 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_16991">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33696"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">deoxyribonucleic acid</obo:IAO_0000111>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/chebi.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">deoxyribonucleic acid</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_23367 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_23367">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">molecular entity</obo:IAO_0000111>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">We are assuming that every molecular entity has to be completely connected by chemical bonds. This excludes protein complexes, which are comprised of minimally two separate molecular entities. We will follow up with Chebi to ensure this is their understanding as well</obo:IAO_0000116>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/chebi.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">molecular entity</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_33250 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33250">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">atom</obo:IAO_0000111>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A chemical entity constituting the smallest component of an element having the chemical properties of the element.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/chebi.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">atom</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_33696 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33696">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33839"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">nucleic acid</obo:IAO_0000111>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/chebi.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">nucleic acid</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_33697 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33697">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33696"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ribonucleic acid</obo:IAO_0000111>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/chebi.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ribonucleic acid</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_33839 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_33839">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_23367"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">macromolecule</obo:IAO_0000111>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.</obo:IAO_0000115>
        <obo:IAO_0000118 xml:lang="en">polymer</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/chebi.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">macromolecule</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000000 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CL_0000000">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000111 xml:lang="en">cell</obo:IAO_0000111>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cell</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">PMID:18089833.Cancer Res. 2007 Dec 15;67(24):12018-25. &quot;...Epithelial cells were harvested from histologically confirmed adenocarcinomas ..&quot;</obo:IAO_0000112>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/cl.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">cell</rdfs:label>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cell</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000010 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CL_0000010">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000578"/>
        <rdfs:subClassOf>
            <owl:Class>
                <owl:unionOf rdf:parseType="Collection">
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0600036"/>
                    </owl:Restriction>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0001000"/>
                        <owl:someValuesFrom>
                            <owl:Restriction>
                                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
                                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0600036"/>
                            </owl:Restriction>
                        </owl:someValuesFrom>
                    </owl:Restriction>
                </owl:unionOf>
            </owl:Class>
        </rdfs:subClassOf>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cultured cell</obo:IAO_0000111>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A cell in vitro that is or has been maintained or propagated as part of a cell culture.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/cl.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cultured cell</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000578 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/CL_0000578">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000000"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000047"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000094"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">experimentally modified cell in vitro</obo:IAO_0000111>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/cl.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">experimentally modified cell in vitro</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/GO_0003674 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0003674">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000034"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">molecular_function</obo:IAO_0000111>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/go.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">molecular_function</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/GO_0003824 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0003824">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0003674"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">catalytic activity</obo:IAO_0000111>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/go.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">catalytic activity</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/GO_0008150 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0008150">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</obo:IAO_0000111>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/go.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">biological_process</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/GO_0010467 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0010467">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/GO_0008150"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">gene expression</obo:IAO_0000111>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The process in which a gene&apos;s sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/go.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">gene expression</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/GO_0043234 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/GO_0043234">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000000001"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">protein complex</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A ribosome is a protein complex</obo:IAO_0000112>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/go.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">protein complex</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000001 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000001">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000033"/>
        <obo:IAO_0000111 xml:lang="en">conditional specification</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">a directive information entity that specifies what should happen if the trigger condition is fulfilled</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PlanAndPlannedProcess Branch</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">OBI branch derived</obo:IAO_0000119>
        <obo:IAO_0000119 xml:lang="en">OBI_0000349</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">conditional specification</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000003 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000003">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000009"/>
        <obo:IAO_0000111 xml:lang="en">measurement unit label</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">Examples of measurement unit labels are liters, inches, weight per volume.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">A measurement unit label is as a label that is part of a scalar measurement datum and denotes a unit of measure.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2009-03-16: provenance: a term measurement unit was
proposed for OBI (OBI_0000176) , edited by Chris Stoeckert and
Cristian Cocos, and subsequently moved to IAO where the objective for
which the original term was defined was satisfied with the definition
of this, different, term.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">2009-03-16: review of this term done during during the OBI workshop winter 2009 and the current definition was considered acceptable for use in OBI. If there is a need to modify this definition please notify OBI.</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">PERSON: Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Melanie Courtot</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">measurement unit label</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000005 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000005">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000033"/>
        <obo:IAO_0000111 xml:lang="en">objective specification</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">In the protocol of a ChIP assay the objective specification says to identify protein and DNA interaction.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">a directive information entity that describes an intended process endpoint. When part of a plan specification the concretization is realized in a planned process in which the bearer tries to effect the world so that the process endpoint is achieved.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2009-03-16: original definition when imported from OBI read: &quot;objective is an non realizable information entity which can serve as that  proper part of a plan towards which the realization of the plan is directed.&quot;</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">2014-03-31: In the example of usage (&quot;In the protocol of a ChIP assay the objective specification says to identify protein and DNA interaction&quot;) there is a protocol which is the ChIP assay protocol. In addition to being concretized on paper, the protocol can be concretized as a realizable entity, such as a plan that inheres in a person. The objective specification is the part that says that some protein and DNA interactions are identified. This is a specification of a process endpoint: the boundary in the process before which they are not identified and after which they are. During the realization of the plan, the goal is to get to the point of having the interactions, and participants in the realization of the plan try to do that.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Answers the question, why did you do this experiment?</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">PERSON: Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Barry Smith</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Jennifer Fostel</obo:IAO_0000117>
        <obo:IAO_0000118 xml:lang="en">goal specification</obo:IAO_0000118>
        <obo:IAO_0000119 xml:lang="en">OBI Plan and Planned Process/Roles Branch</obo:IAO_0000119>
        <obo:IAO_0000119 xml:lang="en">OBI_0000217</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">objective specification</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000007 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000007">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000033"/>
        <obo:IAO_0000112 xml:lang="en">Pour the contents of flask 1 into flask 2</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">a directive information entity that describes an action the bearer will take</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">OBI Plan and Planned Process branch</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">action specification</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000009 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000009">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
        <obo:IAO_0000111 xml:lang="en">datum label</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 xml:lang="en">A label is a symbol that is part of some other datum and is used to either partially define  the denotation of that datum or to provide a means for identifying the datum as a member of the set of data with the same label</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">http://www.golovchenko.org/cgi-bin/wnsearch?q=label#4n</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">GROUP: IAO</obo:IAO_0000117>
        <obo:IAO_0000232>9/22/11 BP: changed the rdfs:label for this class from &apos;label&apos; to &apos;datum label&apos; to convey that this class is not intended to cover all kinds of labels (stickers, radiolabels, etc.), and not even all kind of textual labels, but rather the kind of labels occuring in a datum. 
</obo:IAO_0000232>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">datum label</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000010 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000010">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000104"/>
        <obo:IAO_0000111 xml:lang="en">software</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">Software is a plan specification composed of a series of instructions that can be 
interpreted by or directly executed by a processing unit.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">see sourceforge tracker discussion at http://sourceforge.net/tracker/index.php?func=detail&amp;aid=1958818&amp;group_id=177891&amp;atid=886178</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">PERSON: Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Chris Stoeckert</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Melanie Courtot</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">GROUP: OBI</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">software</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000027 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000027">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
        <obo:IAO_0000111 xml:lang="en">data item</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">Data items include counts of things, analyte concentrations, and statistical summaries.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">a data item is an information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2/2/2009 Alan and Bjoern discussing FACS run output data. This is a data item because it is about the cell population. Each element records an event and is typically further composed a set of measurment data items that record the fluorescent intensity stimulated by one of the lasers.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">2009-03-16: data item deliberatly ambiguous: we merged data set and datum to be one entity, not knowing how to define singular versus plural. So data item is more general than datum.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">2009-03-16: removed datum as alternative term as datum specifically refers to singular form, and is thus not an exact synonym.</obo:IAO_0000116>
        <obo:IAO_0000116>2014-03-31: See discussion at http://odontomachus.wordpress.com/2014/03/30/aboutness-objects-propositions/</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">JAR: datum     -- well, this will be very tricky to define, but maybe some 
information-like stuff that might be put into a computer and that is 
meant, by someone, to denote and/or to be interpreted by some 
process... I would include lists, tables, sentences... I think I might 
defer to Barry, or to Brian Cantwell Smith

JAR: A data item is an approximately justified approximately true approximate belief</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">PERSON: Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Chris Stoeckert</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Jonathan Rees</obo:IAO_0000117>
        <obo:IAO_0000118 xml:lang="en">data</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">data item</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000028 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000028">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
        <obo:IAO_0000111 xml:lang="en">symbol</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">a serial number such as &quot;12324X&quot;</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a stop sign</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">a written proper name such as &quot;OBI&quot;</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">An information content entity that is a mark(s) or character(s) used as a conventional representation of another entity.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">20091104, MC: this needs work and will most probably change</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">2014-03-31: We would like to have a deeper analysis of &apos;mark&apos; and &apos;sign&apos; in the future (see https://github.com/information-artifact-ontology/IAO/issues/154).</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">PERSON: James A. Overton</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Jonathan Rees</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">based on Oxford English Dictionary</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">symbol</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000030 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000030">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000031"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000001"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">information content entity</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">Examples of information content entites include journal articles, data, graphical layouts, and graphs.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A generically dependent continuant that is about some thing.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2014-03-10: The use of &quot;thing&quot; is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ).</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">information_content_entity &apos;is_encoded_in&apos; some digital_entity in obi before split (040907). information_content_entity &apos;is_encoded_in&apos; some physical_document in obi before split (040907).

Previous. An information content entity is a non-realizable information entity that &apos;is encoded in&apos; some digital or physical entity.</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">PERSON: Chris Stoeckert</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">OBI_0000142</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">information content entity</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000032 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000032">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000109"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0001938"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001931"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000039"/>
                <owl:minCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:minCardinality>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000004"/>
                <owl:minCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:minCardinality>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000112 xml:lang="en">10 feet. 3 ml.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">a scalar measurement datum is a measurement datum that is composed of two parts, numerals and a unit label.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2009-03-16: we decided to keep datum singular in scalar measurement datum, as in
this case we explicitly refer to the singular form</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Would write this as: has_part some &apos;measurement unit label&apos; and has_part some numeral and has_part exactly 2, except for the fact that this won&apos;t let us take advantage of OWL reasoning over the numbers. Instead use has measurment value property to represent the same. Use has measurement unit label (subproperty of has_part) so we can easily say that there is only one of them.</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">PERSON: Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Melanie Courtot</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">scalar measurement datum</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000033 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000033">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000017"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">An information content entity whose concretizations indicate to their bearer how to realize them in a process.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2009-03-16: provenance: a term realizable information entity was proposed for OBI (OBI_0000337) , edited by the PlanAndPlannedProcess branch. Original definition was  &quot;is the specification of a process that can be concretized and realized by an actor&quot; with alternative term  &quot;instruction&quot;.It has been subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definitionof this, different, term.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">2013-05-30 Alan Ruttenberg: What differentiates a directive information entity from an information concretization is that it can have concretizations that are either qualities or realizable entities. The concretizations that are realizable entities are created when an individual chooses to take up the direction, i.e. has the intention to (try to) realize it.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">8/6/2009 Alan Ruttenberg: Changed label from &quot;information entity about a realizable&quot; after discussions at ICBO</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Werner pushed back on calling it realizable information entity as it isn&apos;t realizable. However this name isn&apos;t right either. An example would be a recipe. The realizable entity would be a plan, but the information entity isn&apos;t about the plan, it, once concretized, *is* the plan. -Alan</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">PERSON: Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">directive information entity</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000038 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000038">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000309"/>
        <obo:IAO_0000111 xml:lang="en">graph</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">A diagram that presents one or more tuples of information by mapping those tuples in to a two dimensional space in a non arbitrary way.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERSON: Lawrence Hunter</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">person:Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">person:Allyson Lister</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">OBI_0000240</obo:IAO_0000119>
        <obo:IAO_0000119 xml:lang="en">group:OBI</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">graph</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000055 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000055">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000001"/>
        <obo:IAO_0000111 xml:lang="en">rule</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">example to be added</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 xml:lang="en">a rule is an executable which guides, defines, restricts actions</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">MSI</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">PRS</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">OBI_0500021</obo:IAO_0000119>
        <obo:IAO_0000119 xml:lang="en">PRS</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">rule</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000064 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000064">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000104"/>
        <obo:IAO_0000111 xml:lang="en">algorithm</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">PMID: 18378114.Genomics. 2008 Mar 28. LINKGEN: A new algorithm to process data in genetic linkage studies.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">A plan specification which describes the inputs and output of mathematical functions as well as workflow of execution for achieving an predefined objective. Algorithms are realized usually by means of implementation as computer programs for execution by automata.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Philippe Rocca-Serra</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PlanAndPlannedProcess Branch</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">OBI_0000270</obo:IAO_0000119>
        <obo:IAO_0000119 xml:lang="en">adapted from discussion on OBI list (Matthew Pocock, Christian Cocos, Alan Ruttenberg)</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">algorithm</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000078 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000078">
        <owl:equivalentClass>
            <owl:Class>
                <owl:oneOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000002"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000120"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000121"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000122"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000123"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000124"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000125"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000423"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000428"/>
                </owl:oneOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000102"/>
        <obo:IAO_0000111 xml:lang="en">curation status specification</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting)</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">PERSON:Bill Bug</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">GROUP:OBI:&lt;http://purl.obolibrary.org/obo/obi&gt;</obo:IAO_0000119>
        <obo:IAO_0000119 xml:lang="en">OBI_0000266</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">curation status specification</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000100 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000100">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
        <obo:IAO_0000111 xml:lang="en">data set</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">Intensity values in a CEL file or from multiple CEL files comprise a data set (as opposed to the CEL files themselves).</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">A data item that is an aggregate of other data items of the same type that have something in common. Averages and distributions can be determined for data sets.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2009/10/23 Alan Ruttenberg. The intention is that this term represent collections of like data. So this isn&apos;t for, e.g. the whole contents of a cel file, which includes parameters, metadata etc. This is more like java arrays of a certain rather specific type</obo:IAO_0000116>
        <obo:IAO_0000116>2014-05-05: Data sets are aggregates and thus must include two or more data items. We have chosen not to add logical axioms to make this restriction.</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">person:Allyson Lister</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">person:Chris Stoeckert</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">OBI_0000042</obo:IAO_0000119>
        <obo:IAO_0000119 xml:lang="en">group:OBI</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">data set</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000101 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000101">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000308"/>
        <obo:IAO_0000111 xml:lang="en">image</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">An image is an affine projection to a two dimensional surface, of measurements of some quality of an entity or entities repeated at regular intervals across a spatial range, where the measurements are represented as color and luminosity on the projected on surface.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">person:Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">person:Allyson</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">person:Chris Stoeckert</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">OBI_0000030</obo:IAO_0000119>
        <obo:IAO_0000119 xml:lang="en">group:OBI</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">image</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000102 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000102">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
        <obo:IAO_0000115 xml:lang="en">data about an ontology part is a data item about a part of an ontology, for example a term</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Person:Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">data about an ontology part</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000104 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000104">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000033"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000005"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000007"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">plan specification</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">PMID: 18323827.Nat Med. 2008 Mar;14(3):226.New plan proposed to help resolve conflicting medical advice.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A directive information entity with action specifications and objective specifications as parts that, when concretized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2009-03-16: provenance: a term a plan was proposed for OBI (OBI_0000344) , edited by the PlanAndPlannedProcess branch. Original definition was &quot; a plan is a specification of a process that is realized by an actor to achieve the objective specified as part of the plan&quot;. It has been subsequently moved to IAO where the objective for which the original term was defined was satisfied with the definitionof this, different, term.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">2014-03-31: A plan specification can have other parts, such as conditional specifications.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Alternative previous definition: a plan is a set of instructions that specify how an objective should be achieved</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">OBI Plan and Planned Process branch</obo:IAO_0000119>
        <obo:IAO_0000119 xml:lang="en">OBI_0000344</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:comment xml:lang="en">2/3/2009 Comment from OBI review.

Action specification not well enough specified.
Conditional specification not well enough specified.
Question whether all plan specifications have objective specifications.

Request that IAO either clarify these or change definitions not to use them</rdfs:comment>
        <rdfs:label xml:lang="en">plan specification</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000109 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000109">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0001938"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001933"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">measurement datum</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">Examples of measurement data are the recoding of the weight of a mouse as {40,mass,&quot;grams&quot;}, the recording of an observation of the behavior of the mouse {,process,&quot;agitated&quot;}, the recording of the expression level of a gene as measured through the process of microarray experiment {3.4,luminosity,}.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2/2/2009 is_specified_output of some assay?</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">person:Chris Stoeckert</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">OBI_0000305</obo:IAO_0000119>
        <obo:IAO_0000119 xml:lang="en">group:OBI</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">measurement datum</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000129 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000129">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000028"/>
        <obo:IAO_0000111 xml:lang="en">version number</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 xml:lang="en">A version number is an information content entity which is a sequence of characters borne by part of each of a class of manufactured products or its packaging and indicates its order within a set of other products having the same name.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">Note: we feel that at the moment we are happy with a general version number, and that we will subclass as needed in the future. For example, see 7. genome sequence version</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">GROUP: IAO</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">version number</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000144 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000144">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000300"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0001909"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000124"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000338"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">conclusion textual entity</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">that fucoidan has a small statistically significant effect on AT3 level but no useful clinical effect as in-vivo anticoagulant, a paraphrase of part of the last paragraph of the discussion section of the paper &apos;Pilot clinical study to evaluate the anticoagulant activity of fucoidan&apos;, by Lowenthal et. al.PMID:19696660</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">A textual entity that expresses the results of reasoning about a problem, for instance as typically found towards the end of scientific papers.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2009/09/28 Alan Ruttenberg. Fucoidan-use-case</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">2009/10/23 Alan Ruttenberg: We need to work on the definition still</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">Person:Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">conclusion textual entity</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000300 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000300">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
        <obo:IAO_0000111 xml:lang="en">textual entity</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">Words, sentences, paragraphs, and the written (non-figure) parts of publications are all textual entities</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 xml:lang="en">A textual entity is a part of a manifestation (FRBR sense), a generically dependent continuant whose concretizations are patterns of glyphs intended to be interpreted as words, formulas, etc.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">AR, (IAO call 2009-09-01): a document as a whole is not typically a textual entity, because it has pictures in it - rather there are parts of it that are textual entities. Examples: The title, paragraph 2 sentence 7, etc.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">MC, 2009-09-14 (following IAO call 2009-09-01): textual entities live at the FRBR (http://en.wikipedia.org/wiki/Functional_Requirements_for_Bibliographic_Records) manifestation level. Everything is significant: line break, pdf and html versions of same document are different textual entities.</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">PERSON: Lawrence Hunter</obo:IAO_0000117>
        <obo:IAO_0000118 xml:lang="en">text</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">textual entity</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000306 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000306">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000300"/>
        <obo:IAO_0000111 xml:lang="en">table</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">| T     F
--+-----
T   | T     F
F   |  F    F</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">A textual entity that contains a two-dimensional arrangement of texts repeated at regular intervals across a spatial range, such that the spatial relationships among the constituent texts expresses propositions</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERSON: Lawrence Hunter</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">table</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000308 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000308">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
        <obo:IAO_0000111 xml:lang="en">figure</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">Any picture, diagram or table</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">An information content entity consisting of a two dimensional arrangement of information content entities such that the arrangement itself is about something.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERSON: Lawrence Hunter</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">figure</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000309 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000309">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000308"/>
        <obo:IAO_0000111 xml:lang="en">diagram</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">A molecular structure ribbon cartoon showing helices, turns and sheets and their relations to each other in space.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">A figure that expresses one or more propositions</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERSON: Lawrence Hunter</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">diagram</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000310 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000310">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
        <obo:IAO_0000111 xml:lang="en">document</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">A journal article, patent application, laboratory notebook, or a book</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">A collection of information content entities intended to be understood together as a whole</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERSON: Lawrence Hunter</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">document</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000400 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000400">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000219"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000018"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000407"/>
                <owl:cardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:cardinality>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">A cartesian spatial coordinate datum is a representation of a point in a spatial region, in which equal changes in the magnitude of a coordinate value denote length qualities with the same magnitude</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2009-08-18 Alan Ruttenberg - question to BFO list about whether the BFO sense of the lower dimensional regions is that they are always part of actual space (the three dimensional sort) http://groups.google.com/group/bfo-discuss/browse_thread/thread/9d04e717e39fb617</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000232>AR notes: We need to discuss whether it should include site.</obo:IAO_0000232>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">cartesian spatial coordinate datum</rdfs:label>
        <rdfs:seeAlso xml:lang="en">http://groups.google.com/group/bfo-discuss/browse_thread/thread/9d04e717e39fb617</rdfs:seeAlso>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000401 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000401">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000400"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000219"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:intersectionOf rdf:parseType="Collection">
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000018"/>
                            <owl:Restriction>
                                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000026"/>
                            </owl:Restriction>
                        </owl:intersectionOf>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000404"/>
                <owl:cardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:cardinality>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 xml:lang="en">A cartesion spatial coordinate datum that  uses one value to specify a position along a one dimensional spatial region</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">one dimensional cartesian spatial coordinate datum</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000402 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000402">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000400"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000219"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:intersectionOf rdf:parseType="Collection">
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000018"/>
                            <owl:Restriction>
                                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000009"/>
                            </owl:Restriction>
                        </owl:intersectionOf>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000404"/>
                <owl:cardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:cardinality>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000406"/>
                <owl:cardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:cardinality>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 xml:lang="en">A cartesion spatial coordinate datum that  uses two values to specify a position within a two dimensional spatial region</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">two dimensional cartesian spatial coordinate datum</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000414 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000414">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000032"/>
        <rdfs:subClassOf>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000039"/>
                        <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UO_0000002"/>
                    </owl:Restriction>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000221"/>
                        <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PATO_0000125"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </rdfs:subClassOf>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 xml:lang="en">A scalar measurement datum that is the result of measurement of mass quality</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2009/09/28 Alan Ruttenberg. Fucoidan-use-case</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">Person:Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">mass measurement datum</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000416 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000416">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000032"/>
        <rdfs:subClassOf>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000039"/>
                        <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UO_0000003"/>
                    </owl:Restriction>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000413"/>
                        <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </rdfs:subClassOf>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 xml:lang="en">A scalar measurement datum that is the result of measuring a temporal interval</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2009/09/28 Alan Ruttenberg. Fucoidan-use-case</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">Person:Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">time measurement datum</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000572 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000572">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000310"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000112 xml:lang="en">Recording the current temperature in a laboratory notebook. Writing a journal article. Updating a patient record in a database.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">a planned process in which a document is created or added to by including the specified input in it.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">6/11/9: Edited at OBI workshop. We need to be able identify a child form of information artifact which corresponds to something enduring (not brain like). This used to be restricted to physical document or digital entity as the output, but that excludes e.g. an audio cassette tape</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">wikipedia http://en.wikipedia.org/wiki/Documenting</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">documenting</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000573 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000573">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000038"/>
        <obo:IAO_0000111 xml:lang="en">line graph</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A line graph is a type of graph created by connecting a series of data
points together with a line.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERSON:Chris Stoeckert</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON:Melanie Courtot</obo:IAO_0000117>
        <obo:IAO_0000118 xml:lang="en">line chart</obo:IAO_0000118>
        <obo:IAO_0000119 xml:lang="en">GROUP:OBI</obo:IAO_0000119>
        <obo:IAO_0000119 xml:lang="en">WEB: http://en.wikipedia.org/wiki/Line_chart</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">line graph</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000577 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000577">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000028"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000578"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000112 xml:lang="en">The sentence &quot;The article has Pubmed ID 12345.&quot; contains a CRID that has two parts: one part is the CRID symbol, which is &apos;12345&apos;; the other part denotes the CRID registry, which is Pubmed.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">A symbol that is part of a CRID and that is sufficient to look up a record from the CRID&apos;s registry.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERSON: Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Bill Hogan</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Melanie Courtot</obo:IAO_0000117>
        <obo:IAO_0000118>CRID symbol</obo:IAO_0000118>
        <obo:IAO_0000119 xml:lang="en">Original proposal from Bjoern, discussions at IAO calls</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">centrally registered identifier symbol</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000578 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000578">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000577"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                <owl:someValuesFrom>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000219"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000579"/>
                    </owl:Restriction>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000112 xml:lang="en">The sentence &quot;The article has Pubmed ID 12345.&quot; contains a CRID that has two parts: one part is the CRID symbol, which is &apos;12345&apos;; the other part denotes the CRID registry, which is Pubmed.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">An information content entity that consists of a CRID symbol and additional information about the CRID registry to which it belongs.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2014-05-05: In defining this term we take no position on what the CRID denotes. In particular do not assume it denotes a *record* in the CRID registry (since the registry might not have &apos;records&apos;).</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Alan, IAO call 20101124: potentially the CRID denotes the instance it was associated with during creation. 
</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Note, IAO call 20101124: URIs are not always CRID, as not centrally registered. We acknowledge that CRID is a subset of a larger identifier class, but this subset fulfills our current needs. OBI PURLs are CRID as they are registered with OCLC. UPCs (Universal Product Codes from AC Nielsen)are not CRID as they are not centrally registered.</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">PERSON: Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Bill Hogan</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Melanie Courtot</obo:IAO_0000117>
        <obo:IAO_0000118>CRID</obo:IAO_0000118>
        <obo:IAO_0000119 xml:lang="en">Original proposal from Bjoern, discussions at IAO calls</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">centrally registered identifier</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000579 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000579">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000100"/>
        <obo:IAO_0000112 xml:lang="en">PubMed is a CRID registry. It has a dataset of PubMed identifiers associated with journal articles. </obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">A CRID registry is a dataset of CRID records, each consisting of a CRID symbol and additional information which was recorded in the dataset through a assigning a centrally registered identifier process.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERSON: Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Bill Hogan</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">PERSON: Melanie Courtot</obo:IAO_0000117>
        <obo:IAO_0000118>CRID registry</obo:IAO_0000118>
        <obo:IAO_0000119 xml:lang="en">Original proposal from Bjoern, discussions at IAO calls</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">centrally registered identifier registry</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000582 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000582">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000109"/>
        <rdfs:subClassOf>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000581"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000416"/>
                    </owl:Restriction>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000583"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000109"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </rdfs:subClassOf>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">time stamped measurement datum</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000584 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/IAO_0000584">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000100"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000582"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000112 xml:lang="en">pmid:20604925 - time-lapse live cell microscopy</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">A data set that is an aggregate of data recording some measurement at a number of time points. The time series data set is an ordered list of pairs of time measurement data and the corresponding measurement data acquired at that time.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000118 xml:lang="en">experimental time series</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">time sampled measurement data set</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_10239 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_10239">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Viruses</obo:IAO_0000111>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Viruses</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_117571 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_117571">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_7742"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Euteleostomi</obo:IAO_0000111>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">bony vertebrates</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Euteleostomi</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_2 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_2">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bacteria</obo:IAO_0000111>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">eubacteria</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bacteria</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_2157 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_2157">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Archaea</obo:IAO_0000111>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Archaea</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_2759 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_2759">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Eukaryota</obo:IAO_0000111>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">eucaryotes</obo:IAO_0000118>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">eukaryotes</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Eukaryota</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_314146 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_314146">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_40674"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Euarchontoglires</obo:IAO_0000111>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Euarchontoglires</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_32523 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_32523">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_117571"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tetrapoda</obo:IAO_0000111>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">tetrapods</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tetrapoda</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_32524 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_32524">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_32523"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Amniota</obo:IAO_0000111>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">amniotes</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Amniota</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_33154 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_33154">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2759"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Opisthokonta</obo:IAO_0000111>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Opisthokonta</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_33213 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_33213">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33154"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bilateria</obo:IAO_0000111>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bilateria</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_40674 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_40674">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_32524"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mammalia</obo:IAO_0000111>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mammals</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mammalia</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_7742 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_7742">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_33213"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vertebrata &lt;Metazoa&gt;</obo:IAO_0000111>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vertebrata</obo:IAO_0000118>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">vertebrates</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vertebrata &lt;Metazoa&gt;</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_9606 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_9606">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_314146"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Homo sapiens</obo:IAO_0000111>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">human</obo:IAO_0000118>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">human being</obo:IAO_0000118>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">man</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ncbitaxon.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Homo sapiens</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000011 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000011">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
                <owl:someValuesFrom>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000104"/>
                    </owl:Restriction>
                </owl:someValuesFrom>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <obo:IAO_0000111 xml:lang="en">planned process</obo:IAO_0000111>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">planned process</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Injecting mice with a vaccine in order to test its efficacy</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A processual entity that realizes a plan which is the concretization of a plan specification.</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">&apos;Plan&apos; includes a future direction sense. That can be problematic if plans are changed during their execution. There are however implicit contingencies for protocols that an agent has in his mind that can be considered part of the plan, even if the agent didn&apos;t have them in mind before. Therefore, a planned process can diverge from what the agent would have said the plan was before executing it, by adjusting to problems encountered during execution (e.g. choosing another reagent with equivalent properties, if the originally planned one has run out.)</obo:IAO_0000116>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">We are only considering successfully completed planned processes. A plan may be modified, and details added during execution. For a given planned process, the associated realized plan specification is the one encompassing all changes made during execution. This means that all processes in which an agent acts towards achieving some 
objectives is a planned process.</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">branch derived</obo:IAO_0000119>
        <obo:IAO_0000232 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6/11/9: Edited at workshop. Used to include: is initiated by an agent</obo:IAO_0000232>
        <obo:IAO_0000232 xml:lang="en">This class merges the previously separated objective driven process and planned process, as they the separation proved hard to maintain. (1/22/09, branch call)</obo:IAO_0000232>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">planned process</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000047 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000047">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000040"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000094"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000111 xml:lang="en">processed material</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">Examples include gel matrices, filter paper, parafilm and buffer solutions, mass spectrometer, tissue samples</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">Is a material entity that is created or changed during material processing.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERSON: Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">processed material</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000066 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000066">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000572"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000338"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000471"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:intersectionOf rdf:parseType="Collection">
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000339"/>
                            <owl:Restriction>
                                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
                            </owl:Restriction>
                        </owl:intersectionOf>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">investigation</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lung cancer investigation using expression profiling, a stem cell transplant investigation, biobanking is not an investigation, though it may be part of an investigation</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">a planned process that consists of parts: planning, study design execution, documentation and which produce conclusion(s).</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">OBI branch derived</obo:IAO_0000119>
        <obo:IAO_0000232 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Could add specific objective specification</obo:IAO_0000232>
        <obo:IAO_0000232 xml:lang="en">Following OBI call November 2012,26th: it was decided there was no need for adding &quot;achieves objective of drawing conclusion&quot; as existing relations were providing equivalent ability. this note closes the issue and validates the class definition to be part of the OBI core
editor = PRS</obo:IAO_0000232>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:OBI_0001847 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">study</obo:OBI_0001847>
        <rdfs:label xml:lang="en">investigation</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000067 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000067">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000054"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000070"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">evaluant role</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">When a specimen of blood is assayed for glucose concentration, the blood has the evaluant role. When measuring the mass of a mouse, the evaluant is the mouse. When measuring the time of DNA replication, the evaluant is the DNA. When measuring the intensity of light on a surface, the evaluant is the light source.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">a role that inheres in a material entity that is realized in an assay in which data is generated about the bearer of the evaluant role</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">Role call - 17nov-08: JF and MC think an evaluant role is always specified input of a process. Even in the case where we have an assay taking blood as evaluant and outputting blood, the blood is not the specified output at the end of the assay (the concentration of glucose in the blood is)</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">examples of features that could be described in an evaluant: quality.... e.g. &quot;contains 10 pg/ml IL2&quot;, or &quot;no glucose detected&quot;)</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GROUP:  Role Branch</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OBI</obo:IAO_0000119>
        <obo:IAO_0000232 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Feb 10, 2009.  changes after discussion at OBI Consortium Workshop Feb 2-6, 2009.  accepted as core term.</obo:IAO_0000232>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">evaluant role</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000070 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000070">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000441"/>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000067"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:intersectionOf rdf:parseType="Collection">
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000040"/>
                            <owl:Restriction>
                                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000067"/>
                            </owl:Restriction>
                        </owl:intersectionOf>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:intersectionOf rdf:parseType="Collection">
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000030"/>
                            <owl:Restriction>
                                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
                                <owl:someValuesFrom>
                                    <owl:Class>
                                        <owl:intersectionOf rdf:parseType="Collection">
                                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000040"/>
                                            <owl:Restriction>
                                                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                                                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000067"/>
                                            </owl:Restriction>
                                        </owl:intersectionOf>
                                    </owl:Class>
                                </owl:someValuesFrom>
                            </owl:Restriction>
                        </owl:intersectionOf>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">assay</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Assay the wavelength of light emitted by excited Neon atoms. Count of geese flying over a house.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A planned process with the objective to produce information about the material entity that is the evaluant, by physically examining it or its proxies.</obo:IAO_0000115>
        <obo:IAO_0000116>12/3/12: BP: the reference to the &apos;physical examination&apos; is included to point out that a prediction is not an assay, as that does not require physical examiniation. </obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">PlanAndPlannedProcess Branch</obo:IAO_0000117>
        <obo:IAO_0000118 xml:lang="en">measuring</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">scientific observation</obo:IAO_0000118>
        <obo:IAO_0000119 xml:lang="en">OBI branch derived</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:OBI_0001847 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">study assay</obo:OBI_0001847>
        <obo:OBI_9991118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">any method</obo:OBI_9991118>
        <rdfs:label xml:lang="en">assay</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000071 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000071">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
        <obo:IAO_0000111 xml:lang="en">quantitative confidence value</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">A data item which is used to indicate the degree of uncertainty about a measurement.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">person:Chris Stoeckert</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">group:OBI</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">quantitative confidence value</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000079 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000079">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000047"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">culture medium</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">A growth medium or culture medium is a substance in which microorganisms or cells can grow.  Wikipedia, growth medium, Feb 29, 2008</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">a processed material that provides the needed nourishment for microorganisms or cells grown in vitro.</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">changed from a role to a processed material based on on Aug 22, 2011 dev call. Details see the tracker item: http://sourceforge.net/tracker/?func=detail&amp;aid=3325270&amp;group_id=177891&amp;atid=886178
Modification made by JZ.</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">Person: Jennifer Fostel, Jie Zheng</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">OBI</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">culture medium</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000086 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000086">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">reagent role</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">Buffer, dye, a catalyst, a solvating agent.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">A role inhering in a biological or chemical entity that is intended to be applied in a scientific technique to participate (or have molecular components that participate) in a chemical reaction that facilitates the generation of data about some entity distinct from the bearer, or the generation of some specified material output distinct from the bearer.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERSON:Matthew Brush</obo:IAO_0000117>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">reagent</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON:Matthew Brush</obo:IAO_0000119>
        <obo:IAO_0000232 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Feb 10, 2009.  changes after discussion at OBI Consortium Workshop Feb 2-6, 2009.  accepted as core term.

May 28 2013. Updated definition taken from ReO based on discussions initiated in Philly 2011 workshop.  Former defnition described a narrower view of reagents in chemistry that restricts bearers of the role to be chemical entities (&quot;a role played by a molecular entity used to produce a chemical reaction to detect, measure, or produce other substances&quot;).  Updated definition allows for broader view of reagents in the domain of biomedical research to include larger materials that have parts that participate chemically in a molecular reaction or interaction.
</obo:IAO_0000232>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:comment>(copied from ReO)
Reagents are distinguished from instruments or devices that also participate in scientific techniques by the fact that reagents are chemical or biological in nature and necessarily participate in or have parts that participate in some chemical interaction or reaction during their intended participation in some technique.  By contrast, instruments do not participate in a chemical reaction/interaction during the technique.

Reagents are distinguished from study subjects/evaluants in that study subjects and evaluants are that about which conclusions are drawn and knowledge is sought in an investigation - while reagents, by definition, are not.  It should be noted, however, that reagent and study subject/evaluant roles can be borne by instances of the same type of material entity - but a given instance will realize only one of these roles in the execution of a given assay or technique. For example, taq polymerase can bear a reagent role or an evaluant role.  In a DNA sequencing assay aimed at generating sequence data about some plasmid, the reagent role of the taq polymerase is realized. In an assay to evaluate the quality of the taq polymerase itself, the evaluant/study subject role of the taq is realized, but not the reagent role since the taq is the subject about which data is generated.

In regard to the statement that reagents are &apos;distinct&apos; from the specified outputs of a technique, note that a reagent may be incorporated into a material output of a technique, as long as the IDENTITY of this output is distinct from that of the bearer of the reagent role.  For example, dNTPs input into a PCR are reagents that become part of the material output of this technique, but this output has a new identity (ie that of a &apos;nucleic acid molecule&apos;) that is distinct from the identity of the dNTPs that comprise it.  Similarly, a biotin molecule input into a cell labeling technique are reagents that become part of the specified output, but the identity of the output is that of some modified cell specimen which shares identity with the input unmodified cell specimen, and not with the biotin label. Thus, we see that an important criteria of &apos;reagent-ness&apos; is that it is a facilitator, and not the primary focus of an investigation or material processing technique (ie not the specified subject/evaluant about which knowledge is sought, or the specified output material of the technique).</rdfs:comment>
        <rdfs:label xml:lang="en">reagent role</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000094 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000094">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000456"/>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000047"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material processing</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A cell lysis, production of a cloning vector, creating a buffer.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A planned process which results in physical changes in a specified input material</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERSON: Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Frank Gibson</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Jennifer Fostel</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Melanie Courtot</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Philippe Rocca Serra</obo:IAO_0000117>
        <obo:IAO_0000118 xml:lang="en">material transformation</obo:IAO_0000118>
        <obo:IAO_0000119 xml:lang="en">OBI branch derived</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">material processing</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000097 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000097">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000054"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000471"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">study subject role</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Human subjects in a clinical trial, rats in a toxicogenomics study, tissue cutlures subjected to drug tests, fish observed in an ecotoxicology study. 
Parasite example: people are infected with a parasite which is then extracted; the particpant under investigation could be the parasite, the people, or a population of which the people are members, depending on the nature of the study.
Lake example: a lake could realize this role in an investigation that assays pollution levels in samples of water taken from the lake.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A role that is realized through the execution of a study design in which the bearer of the role participates and in which data about that bearer is collected.</obo:IAO_0000115>
        <obo:IAO_0000116>A participant can realize both &quot;specimen role&quot; and &quot;participant under investigation role&quot; at the same time. However &quot;participant under investigation role&quot; is distinct from &quot;specimen role&quot;, since a specimen could somehow be involved in an investigation without being the thing that is under investigation.</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">GROUP:  Role Branch</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OBI</obo:IAO_0000119>
        <obo:IAO_0000232 xml:lang="en">Following OBI call November 2012,26th:
 
1. it was decided there was no need for moving the children class and making them siblings of study subject role.
2. it also settles the disambiguation about &apos;study subject&apos;. This is about the individual participating in the investigation/study, Not the &apos;topic&apos; (as in &apos;toxicity study&apos;) of the investigation/study

This note closes the issue and validates the class definition to be part of the OBI core
editor = PRS
</obo:IAO_0000232>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">participant under investigation role</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000112 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000112">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:intersectionOf rdf:parseType="Collection">
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000040"/>
                            <owl:Restriction>
                                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
                                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000659"/>
                            </owl:Restriction>
                        </owl:intersectionOf>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">specimen role</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">liver section; a portion of a culture of cells; a nemotode or other animal once no longer a subject (generally killed); portion of blood from a patient.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">a role borne by a material entity that is gained during a specimen collection process and that can be realized by use of the specimen in an investigation</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">22Jun09.  The definition includes whole organisms, and can include a human.  The link between specimen role and study subject role has been removed.  A specimen taken as part of a case study is not considered to be a population representative, while a specimen taken as representing a population, e.g. person taken from a cohort, blood specimen taken from an animal) would be considered a population representative and would also bear material sample role.</obo:IAO_0000116>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">blood taken from animal: animal continues in study, whereas blood has role specimen.
something taken from study subject, leaves the study and becomes the specimen.</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">parasite example
- when parasite in people we study people, people are subjects and parasites are specimen
- when parasite extracted, they become subject in the following study
specimen can later be subject.</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GROUP:  Role Branch</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OBI</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">specimen role</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000115 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000115">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0500000"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                        <owl:someValuesFrom>
                            <owl:Class>
                                <owl:intersectionOf rdf:parseType="Collection">
                                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000750"/>
                                    <owl:Restriction>
                                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
                                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000931"/>
                                    </owl:Restriction>
                                </owl:intersectionOf>
                            </owl:Class>
                        </owl:someValuesFrom>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
        <obo:IAO_0000111 xml:lang="en">intervention design</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">PMID: 18208636.Br J Nutr. 2008 Jan 22;:1-11.Effect of vitamin D supplementation on bone and vitamin D status among Pakistani immigrants in Denmark: a randomised double-blinded placebo-controlled intervention study.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">An intervention design is a study design in which a controlled process applied to the subjects (the intervention) serves as the independent variable manipulated by the experimentalist. The treatment (perturbation or intervention) defined can be defined as a combination of values taken by independent variable manipulated by the experimentalists are applied to the recruited subjects assigned (possibly by applying specific methods) to treatment groups. The specificity of intervention design is the fact that independent variables are being manipulated and a response of the biological system is evaluated via response variables as monitored by possibly a series of assays.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Philppe Rocca-Serra</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">OBI branch derived</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">intervention design</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000175 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000175">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000071"/>
        <obo:IAO_0000111 xml:lang="en">p-value</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID:19696660
in contrast to the in-vivo data AT-III increased significantly from
113.5% at baseline to 117% after 4 days (n = 10, P-value= 0.02; Table 2).</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000121"/>
        <obo:IAO_0000115 xml:lang="en">A quantitative confidence value that represents the probability of obtaining a result at least as extreme as that actually obtained, assuming that the actual value was the result of chance alone.</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">May be outside the scope of OBI long term, is needed so is retained</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">PERSON:Chris Stoeckert</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">WEB: http://en.wikipedia.org/wiki/P-value</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">p-value</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000181 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000181">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000111 xml:lang="en">population</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">PMID12564891. Environ Sci Technol. 2003 Jan 15;37(2):223-8. Effects of historic PCB exposures on the reproductive success of the Hudson River striped bass population.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">a population is a collection of individuals from the same taxonomic class living, counted or sampled at a particular site or in a particular area</obo:IAO_0000115>
        <obo:IAO_0000116>1/28/2013, BP, on the call it was raised that we may want to switch to an external ontology for all populatin terms: 
http://code.google.com/p/popcomm-ontology/</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">PERSON: Philippe Rocca-Serra</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">adapted from Oxford English Dictionnary</obo:IAO_0000119>
        <obo:IAO_0000232 xml:lang="en">rem1: collection somehow always involve a selection process</obo:IAO_0000232>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">population</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000185 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000185">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000070"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000101"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000441"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">imaging assay</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">An imaging assay is an assay to produce a picture of an entity. definition_source: OBI.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PlanAndPlannedProcess Branch</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">OBI branch derived</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">imaging assay</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000245 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000245">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000111 xml:lang="en">organization</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">PMID: 16353909.AAPS J. 2005 Sep 22;7(2):E274-80. Review. The joint food and agriculture organization of the United Nations/World Health Organization Expert Committee on Food Additives and its role in the evaluation of the safety of veterinary drug residues in foods.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">An entity that can bear roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">BP: The definition summarizes long email discussions on the OBI developer, roles, biomaterial and denrie branches. It leaves open if an organization is a material entity or a dependent continuant, as no consensus was reached on that.  The current placement as material is therefore temporary, in order to move forward with development. Here is the entire email summary, on which the definition is based:

1) there are organization_member_roles (president, treasurer, branch
editor), with individual persons as bearers

2) there are organization_roles (employer, owner, vendor, patent holder)

3) an organization has a charter / rules / bylaws, which specify what roles
there are, how they should be realized, and how to modify the
charter/rules/bylaws themselves.

It is debatable what the organization itself is (some kind of dependent
continuant or an aggregate of people). This also determines who/what the
bearer of organization_roles&apos; are. My personal favorite is still to define
organization as a kind of &apos;legal entity&apos;, but thinking it through leads to
all kinds of questions that are clearly outside the scope of OBI.

Interestingly enough, it does not seem to matter much where we place
organization itself, as long as we can subclass it (University, Corporation,
Government Agency, Hospital), instantiate it (Affymetrix, NCBI, NIH, ISO,
W3C, University of Oklahoma), and have it play roles.

This leads to my proposal: We define organization through the statements 1 -
3 above, but without an &apos;is a&apos; statement for now. We can leave it in its
current place in the is_a hierarchy (material entity) or move it up to
&apos;continuant&apos;. We leave further clarifications to BFO, and close this issue
for now.</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Philippe Rocca-Serra</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Susanna Sansone</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GROUP: OBI</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">organization</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000250 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000250">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/REO_0000171"/>
        <obo:IAO_0000111 xml:lang="en">dye role</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A molecular label role which inheres in a material entity and which is realized in the process of detecting a molecular dye that imparts color to some material of interest. </obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Jennifer Fostel</obo:IAO_0000117>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dye</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A substance used to color materials  www.answers.com/topic/dye  19feb09</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">dye role</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000272 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000272">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000104"/>
        <obo:IAO_0000111 xml:lang="en">protocol</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">PCR protocol, has objective specification, amplify DNA fragment of interest, and has action specification describes the amounts of experimental reagents used (e..g. buffers, dNTPS, enzyme), and the temperature and cycle time settings for running the PCR.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A plan specification which has sufficient level of detail and quantitative information to communicate it between investigation agents, so that different investigation agents will reliably be able to independently reproduce the process.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PlanAndPlannedProcess Branch</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">OBI branch derived + wikipedia (http://en.wikipedia.org/wiki/Protocol_%28natural_sciences%29)</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:OBI_0001847 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">study protocol</obo:OBI_0001847>
        <rdfs:label xml:lang="en">protocol</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000275 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000275">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000081"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:unionOf rdf:parseType="Collection">
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_23367"/>
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_33250"/>
                        </owl:unionOf>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000054"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000443"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">analyte role</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Glucose in blood (measured in an assay to determine the concentration of glucose).</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A role borne by a molecular entity or an atom and realized in an analyte assay which achieves the objective to measure the magnitude/concentration/amount of the analyte in the entity bearing evaluant role</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">interestingly, an analyte is still an analyte even if it is not detected.  for this reason it does not bear a specified input role</obo:IAO_0000116>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">pH (technically the inverse log of [H+]) may be considered a quality; this remains to be tested.</obo:IAO_0000116>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">qualities such as weight, color are not assayed but measured, so they do not fall into this category.</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GROUP: Role Branch</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OBI</obo:IAO_0000119>
        <obo:IAO_0000232 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Feb 10, 2009.  changes after discussion at OBI Consortium Workshop Feb 2-6, 2009.  accepted as core term.</obo:IAO_0000232>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">analyte role</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000338 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000338">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001909"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">interpreting data</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Concluding that a gene is upregulated in a tissue sample based on the band intensity in a western blot.  Concluding that a patient has a infection based on measurement of an elevated body temperature and reported headache. Concluding that there were problems in an investigation because data from PCR and microarray are conflicting. Concluding that &apos;defects in gene XYZ cause cancer due to improper DNA repair&apos; based on data from experiments in that study that gene XYZ is involved in DNA repair, and the conclusion of a previous study that cancer patients have an increased number of mutations in this gene. </obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A planned process in which data gathered in an investigation is evaluated in the context of existing knowledge with the objective to generate more general conclusions or to conclude that the data does not allow one to draw general conclusion</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Jennifer Fostel</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bjoern Peters</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">drawing a conclusion based on data</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000339 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000339">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000015"/>
        <rdfs:subClassOf>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000015"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000104"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </rdfs:subClassOf>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">planning</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The process of a scientist thinking about and deciding what reagents to use as part of a protocol for an experiment. Note that the scientist could be human or a &quot;robot scientist&quot; executing software.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">a process of creating or modifying a plan specification</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7/18/2011 BP: planning used to itself be a planned process. Barry Smith pointed out that this would lead to an infinite regression, as there would have to be a plan to conduct a planning process, which in itself would be the result of planning etc. Therefore, the restrictions on &apos;planning&apos; were loosened to allow for informal processes that result in an &apos;ad hoc plan &apos;. This required changing from &apos;has_specified_output some plan specifiction&apos; to &apos;has_participant some plan specification&apos;. </obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bjoern Peters</obo:IAO_0000119>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Plans and Planned Processes Branch</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">planning</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000370 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000370">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000034"/>
        <obo:IAO_0000111 xml:lang="en">contain function</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A syringe, a beaker</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A contain function is a function to constrain a material entities location in space</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bill Bug</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Daniel Schober</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Frank Gibson</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Melanie Courtot</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">contain function</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000372 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000372">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000034"/>
        <obo:IAO_0000111 xml:lang="en">material separation function</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A material separation function is a function that increases the resolution between two or more material entities. The  to distinction between the entities is usually based on some associated physical quality.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bill Bug</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Daniel Schober</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Frank Gibson</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Melanie Courtot</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">material separation function</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000425 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000425">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0200166"/>
        <obo:IAO_0000111 xml:lang="en">averaging objective</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">A mean calculation which has averaging objective is a descriptive statistics calculation in which the mean is calculated by taking the sum of all of the observations in a data set divided by the total number of observations. It gives a measure of the &apos;center of gravity&apos; for the data set. It is also known as the first moment.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">An averaging objective is a data transformation objective where the aim is to perform mean calculations on the input of the data transformation.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Elisabetta Manduchi</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">James Malone</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Elisabetta Manduchi</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">averaging objective</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000427 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000427">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000040"/>
                    <owl:Class>
                        <owl:unionOf rdf:parseType="Collection">
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_33697"/>
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0043234"/>
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/PR_000000001"/>
                            <owl:Restriction>
                                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_33697"/>
                            </owl:Restriction>
                            <owl:Restriction>
                                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0043234"/>
                            </owl:Restriction>
                            <owl:Restriction>
                                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000000001"/>
                            </owl:Restriction>
                        </owl:unionOf>
                    </owl:Class>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000085"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0003824"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000111 xml:lang="en">enzyme</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">(protein or rna) or has_part (protein or rna) and
has_function some GO:0003824 (catalytic activity)</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MC: known issue: enzyme doesn&apos;t classify under material entity for now as it isn&apos;t stated that anything
that has_part some material entity is a material entity. If we add as equivalent classes to material entity has_part some material entity and part_of some material entity  (each one in his own necessary and sufficient block) Pellet in P3 doesn&apos;t classify any more.</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">person: Melanie Courtot</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GROUP:OBI</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">enzyme</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000437 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000437">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000441"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">analyte measurement objective</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The objective to measure the concentration of glucose in a blood sample</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">an assay objective to determine the presence or concentration of an analyte in the evaluant</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PPPB branch</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">analyte measurement objective</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000441 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000441">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000005"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">assay objective</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">the objective to determine the weight of a mouse.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">an objective specification to determine a specified type of information about an evaluated entity (the material entity bearing evaluant role)</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PPPB branch</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PPPB branch</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">assay objective</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000443 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000443">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000437"/>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000070"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000275"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000109"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">analyte assay</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">example of usage: In lab test for blood glucose, the test is the assay, the blood bears evaluant_role and glucose bears the analyte role. The evaluant is considered an input to the assay and the information entity that records the measurement of glucose concentration the output</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">An assay with the objective to capture information about the presence, concentration, or amount of an analyte in an evaluant.</obo:IAO_0000115>
        <obo:IAO_0000116>2013-09-23: simplify equivalent axiom</obo:IAO_0000116>
        <obo:IAO_0000116 xml:lang="en">Note: is_realization of some analyte role isn&apos;t always true, for example when there is none of the analyte in the evaluant. For the moment we are writing it this way, but when the information ontology is further worked out this will be replaced with a condition discussing the measurement.</obo:IAO_0000116>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">logical def modified to remove expression below, as some analyte assays report below the level of detection, and therefore not a scalar measurement datum, replaced by measurement datum

and 
(&apos;has measurement unit label&apos; some &apos;measurement unit label&apos;) and 
(&apos;is quality measurement of&apos; some &apos;molecular concentration&apos;))</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON:Bjoern Peters, Helen Parkinson, Philippe Rocca-Serra, Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON:Bjoern Peters
PERSON:Helen Parkinson
PERSON:Philippe Rocca-Serra
PERSON:Alan Ruttenberg
GROUP:OBI Planned process branch</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">analyte assay</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000451 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000451">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0200169"/>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000100"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">normalized data set</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">A data set that is produced as the output of a normalization data transformation.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: James Malone</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Melanie Courtot</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">normalized data set</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000453 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000453">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000034"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000079"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000047"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000054"/>
                <owl:allValuesFrom>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000109"/>
                    </owl:Restriction>
                </owl:allValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">measure function</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A glucometer measures blood glucose concentration, the glucometer has a measure function.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">Measure function is a function that is borne by a processed material  and realized in a process in which information about some entity is expressed relative to some reference.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Daniel Schober</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Helen Parkinson</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Melanie Courtot</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON:Frank Gibson</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">measure function</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000456 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000456">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000005"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material transformation objective</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The objective to create a mouse infected with LCM virus. The objective to create a defined solution of PBS.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">an objective specifiction that creates an specific output object from input materials.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Frank Gibson</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Jennifer Fostel</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Melanie Courtot</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Philippe Rocca-Serra</obo:IAO_0000117>
        <obo:IAO_0000118 xml:lang="en">artifact  creation objective</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GROUP: OBI PlanAndPlannedProcess Branch</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">material transformation objective</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000471 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000471">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000011"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
                        <owl:someValuesFrom>
                            <owl:Restriction>
                                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
                                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
                            </owl:Restriction>
                        </owl:someValuesFrom>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">study design execution</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">injecting a mouse with PBS solution, weighing it, and recording the weight according to a study design.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">a planned process that carries out a study design</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">removed axiom has_part some (assay or &apos;data transformation&apos;) per discussion on protocol application mailing list to improve reasoner performance. The axiom is still desired.</obo:IAO_0000116>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">branch derived</obo:IAO_0000119>
        <obo:IAO_0000232 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6/11/9: edited at workshop. Used to be: study design execution is a process with the objective to generate data according to a concretized study design. The execution of a study design is part of an investigation, and minimally consists of an assay or data transformation.</obo:IAO_0000232>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">study design execution</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000639 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000639">
        <owl:equivalentClass>
            <owl:Class>
                <owl:unionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000678"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000681"/>
                </owl:unionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000456"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material separation objective</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The objective to obtain multiple aliquots of an enzyme preparation. The objective to obtain cells contained in a sample of blood.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">is an objective to transform a material entity into spatially separated components.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PPPB branch</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PPPB branch</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material separation objective</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000652 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000652">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000686"/>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000094"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material combination</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mixing two fluids. Adding salt into water. Injecting a mouse with PBS.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">is a material processing with the objective to combine two or more material entities as input into a single material entity as output.</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">created at workshop as parent class for &apos;adding material into target&apos;, which is asymmetric, while combination encompasses all addition processes.</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">bp</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">bp</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material combination</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000659 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000659">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000011"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000684"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0100051"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">specimen collection process</obo:IAO_0000111>
        <obo:IAO_0000112>drawing blood from a patient for analysis, collecting a piece of a plant for depositing in a herbarium, buying meat from a butcher in order to measure its protein content in an investigation</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A planned process with the objective of collecting a specimen.</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation.</obo:IAO_0000116>
        <obo:IAO_0000116>Philly2013: A specimen collection can have as part a material entity acquisition, such as ordering from a bank. The distinction is that specimen collection necessarily involves the creation of a specimen role. However ordering cell lines cells from ATCC for use in an investigation is NOT a specimen collection, because the cell lines already have a specimen role.</obo:IAO_0000116>
        <obo:IAO_0000116>Philly2013: The specimen_role for the specimen is created during the specimen collection process.</obo:IAO_0000116>
        <obo:IAO_0000116>label  changed to &apos;specimen collection process&apos; on 10/27/2014, details see tracker:
http://sourceforge.net/p/obi/obi-terms/716/</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000118>specimen collection</obo:IAO_0000118>
        <obo:IAO_0000232 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">5/31/2012: This process is not necessarily an acquisition, as specimens may be collected from materials already in posession</obo:IAO_0000232>
        <obo:IAO_0000232 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6/9/09: used at workshop</obo:IAO_0000232>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">specimen collection process</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000662 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000662">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000668"/>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000100"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">error corrected data set</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">A data set that is produced as the output of an error correction data transformation and consists of producing a data set which has had erroneous contributions from the input to the data transformation removed (corrected for).</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: James Malone</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Monnie McGee</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">error corrected data set</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000668 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000668">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0200186"/>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0200000"/>
        <obo:IAO_0000111 xml:lang="en">error correction data transformation</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">An error correction data transformation is a data transformation that has the objective of error correction, where the aim is to remove (correct for) erroneous contributions from the input to the data transformation.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">James Malone</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Monnie McGee</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">EDITORS</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">error correction data transformation</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000674 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000674">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0200181"/>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">center value</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">A data item that is produced as the output of a center calculation data transformation and represents the center value of the input data.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: James Malone</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Monnie McGee</obo:IAO_0000117>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">median</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">center value</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000678 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000678">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000639"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">portioning objective</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The objective to obtain multiple aliquots of an enzyme preparation.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A material separation objective aiming to separate material into multiple portions, each of which contains a similar composition of the input material.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">portioning objective</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000679 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000679">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0200170"/>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">average value</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">A  data item that is produced as the output of an averaging data transformation and represents the average value of the input data.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: James Malone</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Monnie McGee</obo:IAO_0000117>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">arithmetic mean</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">average value</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000681 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000681">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000639"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">separation into different composition objective</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The objective to obtain cells contained in a sample of blood.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A material separation objective aiming to separate a material entity that has parts of different types, and end with at least one output that is a material with parts of fewer types (modulo impurities).</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">We should be using has the grain relations or concentrations to distinguish the portioning and other sub-objectives</obo:IAO_0000116>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">separation into different composition objective</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000684 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000684">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000005"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">specimen collection objective</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The objective to collect bits of excrement in the rainforest. The objective to obtain a blood sample from a patient.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A objective specification to obtain a material entity for potential use as an input during an investigation.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bjoern Peters</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">specimen collection objective</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000686 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000686">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000456"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material combination objective</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">is an objective to obtain an output material that contains several input materials.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PPPB branch</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">bp</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material combination objective</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000740 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000740">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000112"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material sample role</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">a role borne by a portion of blood taken to represent all the blood in an organism; the role borne by a population of humans with HIV enrolled in a study taken to represent patients with HIV in general.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A material sample role is a specimen role borne by a material entity that is the output of a material sampling process.</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7/13/09: Note that this is a relational role: between the sample taken and the &apos;sampled&apos; material of which the sample is thought to be representative off.</obo:IAO_0000116>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material sample role</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000744 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000744">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000659"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
                    </owl:Restriction>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000747"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000659"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material sampling process</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A specimen gathering process with the objective to obtain a specimen that is representative of the input material entity</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material sampling process</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000747 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000747">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000040"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000740"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0100051"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material sample</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">blood drawn from patient to measure his systemic glucose level. A population of humans with HIV enrolled in a study taken to represent patients with HIV in general.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A material entity that has the material sample role</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OBI: workshop</obo:IAO_0000117>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">sample population</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:OBI_0001847 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">sample</obo:OBI_0001847>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material sample</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000750 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000750">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000033"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">independent variable specification</obo:IAO_0000111>
        <obo:IAO_0000112>In a study in which gene expression is measured in patients between 8 month to 4 years old that have mild or severe malaria and in which the hypothesis is that gene expression in that age group is a function of disease status, disease status is the independent variable.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">a directive information entity that is part of a study design. Independent variables are entities whose values are selected to determine its relationship to an observed phenomenon (the dependent variable). In such an experiment, an attempt is made to find evidence that the values of the independent variable determine the values of the dependent variable (that which is being measured). The independent variable can be changed as required, and its values do not represent a problem requiring explanation in an analysis, but are taken simply as given. The dependent variable on the other hand, usually cannot be directly controlled</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2/2/2009 Original definition - In the design of experiments, independent variables are those whose values are controlled or selected by the person experimenting (experimenter) to determine its relationship to an observed phenomenon (the dependent variable). In such an experiment, an attempt is made to find evidence that the values of the independent variable determine the values of the dependent variable (that which is being measured). The independent variable can be changed as required, and its values do not represent a problem requiring explanation in an analysis, but are taken simply as given. The dependent variable on the other hand, usually cannot be directly controlled.</obo:IAO_0000116>
        <obo:IAO_0000116>In the Philly 2013 workshop the label was chosen to distinguish it from &quot;dependent variable&quot; as used in statistical modelling. See: http://en.wikipedia.org/wiki/Statistical_modeling</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Chris Stoeckert</obo:IAO_0000117>
        <obo:IAO_0000118>experimental factor</obo:IAO_0000118>
        <obo:IAO_0000118>independent variable</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Web: http://en.wikipedia.org/wiki/Dependent_and_independent_variables</obo:IAO_0000119>
        <obo:IAO_0000232 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2009-03-16: work has been done on this term during during the OBI workshop winter 2009 and the current definition was considered acceptable for use in OBI. If there is a need to modify thisdefinition please notify OBI.</obo:IAO_0000232>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:OBI_0001847 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">study factor</obo:OBI_0001847>
        <rdfs:label xml:lang="en">study design independent variable</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000751 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000751">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000033"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dependent variable specification</obo:IAO_0000111>
        <obo:IAO_0000112>In a study in which gene expression is measured in patients between 8 month to 4 years old that have mild or severe malaria and in which the hypothesis is that gene expression in that age group is a function of disease status, the gene expression is the dependent variable. </obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">dependent variable specification is part of a study design. The dependent variable is the event studied and expected to change when the independent variable varies.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2/2/2009 In the design of experiments, independent variables are those whose values are controlled or selected by the person experimenting (experimenter) to determine its relationship to an observed phenomenon (the dependent variable). In such an experiment, an attempt is made to find evidence that the values of the independent variable determine the values of the dependent variable (that which is being measured). The independent variable can be changed as required, and its values do not represent a problem requiring explanation in an analysis, but are taken simply as given. The dependent variable on the other hand, usually cannot be directly controlled.</obo:IAO_0000116>
        <obo:IAO_0000116>In the Philly 2013 workshop the label was chosen to distinguish it from &quot;dependent variable&quot; as used in statistical modelling. See: http://en.wikipedia.org/wiki/Statistical_modeling</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Chris Stoeckert</obo:IAO_0000117>
        <obo:IAO_0000118>dependent variable</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">WEB: http://en.wikipedia.org/wiki/Dependent_and_independent_variables</obo:IAO_0000119>
        <obo:IAO_0000232 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2009-03-16: work has been done on this term during during the OBI workshop winter 2009 and the current definition was considered acceptable for use in OBI. If there is a need to modify thisdefinition please notify OBI.</obo:IAO_0000232>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">study design dependent variable</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000789 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000789">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000109"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">survival rate</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A measurement data that represents the percentage of people or animals in a study or treatment group who are alive for a given period of time after diagnosis or initiation of monitoring.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oliver He</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">adapted from wikipedia
http://en.wikipedia.org/wiki/Survival_rate</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">survival rate</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000791 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000791">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0200186"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">multiple testing correction objective</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Application of the Bonferroni correction</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A multiple testing correction objectives is a data transformation objective where the aim is to correct for a set of statistical inferences considered simultaneously</obo:IAO_0000115>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">multiple comparison correction objective</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">http://en.wikipedia.org/wiki/Multiple_Testing_Correction</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">multiple testing correction objective</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000806 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000806">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000005"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material maintenance objective</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An objective specification maintains some or all of the qualities of a material over time.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000119>PERSON: Bjoern Peters</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material maintenance objective</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000811 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000811">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000058"/>
                <owl:someValuesFrom>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16991"/>
                    </owl:Restriction>
                </owl:someValuesFrom>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/SO_0000001"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">primary structure of DNA macromolecule</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">a quality of a DNA molecule that inheres in its bearer due to the order of its DNA nucleotide residues.</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">placeholder for SO</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">BP et al</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">primary structure of DNA macromolecule</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000832 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000832">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000968"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000085"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000453"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000968"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">measurement device</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A ruler, a microarray scanner, a Geiger counter.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A device in which a measure function inheres.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GROUP:OBI Philly workshop</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OBI</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">measurement device</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000838 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000838">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000806"/>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material maintenance</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">a process with that achieves the objective to maintain some or all of the characteristics of an input material over time</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material maintenance</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000931 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000931">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
        <rdfs:subClassOf>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0100051"/>
                    </owl:Restriction>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0100051"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:intersectionOf rdf:parseType="Collection">
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000471"/>
                            <owl:Restriction>
                                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
                                <owl:someValuesFrom>
                                    <owl:Restriction>
                                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
                                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000115"/>
                                    </owl:Restriction>
                                </owl:someValuesFrom>
                            </owl:Restriction>
                        </owl:intersectionOf>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">study intervention</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">the part of the execution of an intervention design study which is varied between two or more subjects in the study</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GROUP: OBI</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">study intervention</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000932 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000932">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000085"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000372"/>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000968"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material separation device</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">flow cytometer</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A device with a separation function realized in a planed process</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">material separation device</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000938 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000938">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000109"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0001938"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001930"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">categorical measurement datum</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A measurement datum that is reported on a categorical scale</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">nominal mesurement datum</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bjoern Peters
</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">categorical measurement datum</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000963 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000963">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000009"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">categorical label</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The labels &apos;positive&apos; vs. &apos;negative&apos;, or &apos;left handed&apos;, &apos;right handed&apos;, &apos;ambidexterous&apos;, or &apos;strongly binding&apos;, &apos;weakly binding&apos; , &apos;not binding&apos;, or &apos;+++&apos;, &apos;++&apos;, &apos;+&apos;, &apos;-&apos; etc. form scales of categorical labels. </obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A label that is part of a categorical datum and that indicates the value of the data item on the categorical scale.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bjoern Peters</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">categorical label</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000967 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000967">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000085"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000370"/>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000968"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">container</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A device that can be used to restrict the location of material entities over time</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">03/21/2010: Added to allow classification of children (similar to what we want to do for &apos;measurement device&apos;. Lookint at what classifies here, we may want to reconsider a contain function assigned to a part of an entity is necessarily also a function of the whole (e.g. is a centrifuge a container because it has test tubes as parts?)</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">container</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000968 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000968">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000047"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000094"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000085"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000034"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">device</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A voltmeter is a measurement device which is intended to perform some measure function.</obo:IAO_0000112>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An autoclave is a device that sterlizes instruments or contaminated waste by applying high temperature and pressure.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A material entity that is designed to perform a function in a scientific investigation, but is not a reagent.</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012-12-17 JAO: In common lab usage, there is a distinction made between devices and reagents that is difficult to model. Therefore we have chosen to specifically exclude reagents from the definition of &quot;device&quot;, and are enumerating the types of roles that a reagent can perform.

2013-6-5 MHB: The following clarifications are outcomes of the May 2013 Philly Workshop. Reagents are distinguished from devices that also participate in scientific techniques by the fact that reagents are chemical or biological in nature and necessarily participate in some chemical interaction or reaction during the realization of their experimental role. By contrast, devices do not participate in such chemical reactions/interactions.  Note that there are cases where devices use reagent components during their operation, where the reagent-device distinction is less clear.  For example:

(1) An HPLC machine is considered a device, but has a column that holds a stationary phase resin as an operational component.  This resin qualifies as a device if it participates purely in size exclusion, but bears a reagent role that is realized in the running of a column if it interacts electrostatically or chemically with the evaluant. The container the resin is in (“the column”) considered alone is a device. So the entire column as well as the entire HPLC machine are devices that have a reagent as an operating part.

(2) A pH meter is a device, but its electrode component bears a reagent role in virtue of its interacting directly with the evaluant in execution of an assay.

(3) A gel running  box  is a device that has a metallic lead as a component that participates in a chemical reaction with the running buffer when a charge is passed through it.  This metallic lead is considered to have a reagent role as a component of this device realized in the running of a gel.

In the examples above, a reagent is an operational component of a device, but the device itself does not realize a reagent role (as bearing a reagent role is not transitive across the part_of relation).  In this way, the asserted disjointness between a reagent and device holds, as both roles are never realized in the same bearer during execution of an assay.  </obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Helen Parkinson</obo:IAO_0000117>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">instrument</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">OBI development call 2012-12-17.</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">device</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000984 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000984">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000109"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dose</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An organism has been injected 1ml of vaccine</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A measurement datum that measures the quantity of something that may be administered to an organism or that an organism may be exposed to. Quantities of nutrients, drugs, vaccines and toxins are referred to as doses.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dose</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001172 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001172">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000573"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dose response curve</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A data item of paired values, one indicating the dose of a material, the other quantitating a measured effect at that dose. The dosing intervals are chosen so that effect values be interpolated by a plotting a curve. </obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bjoern Peters; Randi Vita</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">dose response curve</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001225 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001225">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0001404"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001305"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">genetic population background information</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">genotype information &apos;C57BL/6J  Hnf1a+/-&apos; in this case, C57BL/6J is the genetic population background information</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">a genetic characteristics information which is a part of genotype information that identifies the population of organisms</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">proposed and discussed on San Diego OBI workshop, March 2011</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">Group: OBI group</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">Group: OBI group</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">genetic population background information</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001305 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001305">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0001404"/>
        <rdfs:subClassOf>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001225"/>
                    </owl:Restriction>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001364"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">genotype information</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">Genotype information can be: Mus musculus wild type (in this case the genetic population background information is Mus musculus), C57BL/6J  Hnf1a+/- (in this case, C57BL/6J is the genetic population background information and Hnf1a+/- is the allele information</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">a genetic characteristics information that is about the genetic material of an organism and minimally includes information about the genetic background and can in addition contain information about specific alleles, genetic modifications, etc.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">discussed on San Diego OBI workshop, March 2011</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">Group: OBI group</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">Group: OBI group</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">genotype information</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001352 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001352">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0001364"/>
        <rdfs:subClassOf>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001305"/>
                    </owl:Restriction>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/SO_0000001"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">allele information</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">genotype information &apos;C57BL/6J  Hnf1a+/-&apos; in this case, Hnf1a+/- is the allele information</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">a genetic alteration information that about one of two or more alternative forms of a gene or marker sequence and differing from other alleles at one or more mutational sites based on sequence. Polymorphisms are included in this definition.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">discussed on San Diego OBI workshop, March 2011</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MO_58 Allele</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">allele information</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001364 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001364">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0001404"/>
        <obo:IAO_0000111 xml:lang="en">genetic alteration information</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">a genetic characteristics information that is about known changes or the lack thereof from the genetic background, including allele information, duplication, insertion, deletion, etc.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">proposed and discussed on San Diego OBI workshop, March 2011</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">Group: OBI group</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">Group: OBI group</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">genetic alteration information</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001404 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001404">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:intersectionOf rdf:parseType="Collection">
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/SO_0000001"/>
                            <owl:Restriction>
                                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000058"/>
                                <owl:someValuesFrom>
                                    <owl:Restriction>
                                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
                                        <owl:someValuesFrom>
                                            <owl:Class>
                                                <owl:intersectionOf rdf:parseType="Collection">
                                                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_33696"/>
                                                    <owl:Restriction>
                                                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                                                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
                                                    </owl:Restriction>
                                                </owl:intersectionOf>
                                            </owl:Class>
                                        </owl:someValuesFrom>
                                    </owl:Restriction>
                                </owl:someValuesFrom>
                            </owl:Restriction>
                        </owl:intersectionOf>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">genetic characteristics information</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">a data item that is about genetic material including polymorphisms, disease alleles, and haplotypes.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Person: Chris Stoeckert, Jie Zheng</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">MO_66 IndividualGeneticCharacteristics</obo:IAO_0000119>
        <obo:IAO_0000232 xml:lang="en">MO definition:
The genotype of the individual organism from which the biomaterial was derived. Individual genetic characteristics include polymorphisms, disease alleles, and haplotypes.

examples in ArrayExpress
wild_type
MutaMouse (CD2F1 mice with lambda-gt10LacZ integration)
AlfpCre; SNF5 flox/knockout
p53 knock out
C57Bl/6 gp130lox/lox MLC2vCRE/+
fer-15; fem-1
df/df
pat1-114/pat1-114 ade6-M210/ade6-M216 h+/h+ (cells are diploid)
</obo:IAO_0000232>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">genetic characteristics information</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001442 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001442">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000071"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">q-value</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PMID: 20483222. Comp Biochem Physiol Part D Genomics Proteomics. 2008 Sep;3(3):234-42. Analysis of Sus scrofa liver proteome and identification of proteins differentially expressed between genders, and conventional and genetically enhanced lines.
&quot;After controlling the false discovery rate (FDR&lt;/=0.1) using the Storey q value only four proteins (EPHX1, CAT, PAH, ST13) were shown to be differentially expressed between genders (Males/Females) and two proteins (SELENBP2, TAGLN) were differentially expressed between two lines (Transgenic/Conventional pigs)&quot;</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A quantitative confidence value that measures the minimum false discovery rate that is incurred when calling that test significant. 
To compute q-values, it is necessary to know the p-value produced by a test and possibly set a false discovery rate level.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PERS:Philippe Rocca-Serra</obo:IAO_0000117>
        <obo:IAO_0000118 xml:lang="en">FDR adjusted p-value</obo:IAO_0000118>
        <obo:IAO_0000119 xml:lang="en">Adapted from several sources, including
http://.en/wikipedia.org/wiki/False_discovery_rate
http://svitsrv25.epfl.ch/R-doc/library/qvalue.html</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">q-value</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001554 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001554">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000032"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">rate measurement datum</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The rate of disassociation of a peptide from a complex with an MHC molecule measured by the ratio of bound and unbound peptide per unit of time.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A scalar measurement datum that represents the number of events occuring over a time interval</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Bjoern Peters, Randi Vita</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">IEDB</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">rate measurement datum</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001755 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001755">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000033"/>
        <obo:IAO_0000111 xml:lang="en">selection criterion</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">rats should be aged between 6 and 8 weeks and weight between 180-250grams</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A directive information entity which defines and states a principle of standard by which selection process may take place.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Person: Philippe Rocca-Serra</obo:IAO_0000117>
        <obo:IAO_0000118 xml:lang="en">selection rule</obo:IAO_0000118>
        <obo:IAO_0000119 xml:lang="en">OBI discussion summarized under the following tracker item : http://sourceforge.net/p/obi/obi-terms/678/</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">selection criterion</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001834 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001834">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000144"/>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111>drawing a conclusion</obo:IAO_0000111>
        <obo:IAO_0000112>Concluding that the length of the hypotenuse is equal to the square root of the sum of squares of the other two sides in a right-triangle. 
Concluding that a gene is upregulated in a tissue sample based on the band intensity in a western blot.  Concluding that a patient has a infection based on measurement of an elevated body temperature and reported headache. Concluding that there were problems in an investigation because data from PCR and microarray are conflicting. 
</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115>A planned process in which new information is inferred from existing information.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label>drawing a conclusion</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001909 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001909">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000124"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000338"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111>conclusion based on data</obo:IAO_0000111>
        <obo:IAO_0000112>The conclusion that a gene is upregulated in a tissue sample based on the band intensity in a western blot. The conclusion that a patient has a infection based on measurement of an elevated body temperature and reported headache. The conclusion that there were problems in an investigation because data from PCR and microarray are conflicting.
The following are NOT conclusions based on data: data themselves; results from pure mathematics, e.g. &quot;13 is prime&quot;.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115>An information content entity that is inferred from data.</obo:IAO_0000115>
        <obo:IAO_0000116>In the Philly 2013 workshop, we recognized the limitations of &quot;conclusion textual entity&quot;, and we introduced this as more general. The need for the &apos;textual entity&apos; term going forward is up for future debate. </obo:IAO_0000116>
        <obo:IAO_0000117>Group:2013 Philly Workshop group</obo:IAO_0000117>
        <obo:IAO_0000119>Group:2013 Philly Workshop group</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label>conclusion based on data</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001912 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001912">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000047"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cell freezing medium</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A processed material that serves as a liquid vehicle for freezing cells for long term quiescent stroage, which contains chemicls needed to sustain cell viability across freeze-thaw cycles. </obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Matthew Brush</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">cell freezing medium</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001930 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001930">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0001933"/>
        <obo:IAO_0000111>categorical value specification</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115>A value specification that is specifies one category out of a fixed number of nominal categories</obo:IAO_0000115>
        <obo:IAO_0000117>PERSON:Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label>categorical value specification</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001931 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001931">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0001933"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000039"/>
                <owl:minCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:minCardinality>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0001937"/>
                <owl:minCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:minCardinality>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111>scalar value specification</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115>A value specification that consists of two parts: a numeral and a unit label</obo:IAO_0000115>
        <obo:IAO_0000117>PERSON:Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label>scalar value specification</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001933 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001933">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000030"/>
        <obo:IAO_0000111>value specification</obo:IAO_0000111>
        <obo:IAO_0000112>The value of &apos;positive&apos; in a classification scheme of &quot;positive or negative&quot;; the value of &apos;20g&apos; on the quantitative scale of mass.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115>An information content entity that specifies a value within a classification scheme or on a quantitative scale.</obo:IAO_0000115>
        <obo:IAO_0000116>This term is currently a descendant of &apos;information content entity&apos;, which requires that it &apos;is about&apos; something. A value specification of &apos;20g&apos; for a measurement data item of the mass of a particular mouse &apos;is about&apos; the mass of that mouse. However there are cases where a value specification is not clearly about any particular. In the future we may change &apos;value specification&apos; to remove the &apos;is about&apos; requirement.</obo:IAO_0000116>
        <obo:IAO_0000117>PERSON:Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label>value specification</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0100026 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0100026">
        <owl:equivalentClass>
            <owl:Class>
                <owl:unionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_10239"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_2"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_2157"/>
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_2759"/>
                </owl:unionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000111 xml:lang="en">organism</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">animal</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">fungus</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">plant</obo:IAO_0000112>
        <obo:IAO_0000112 xml:lang="en">virus</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs.</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10/21/09: This is a placeholder term, that should ideally be imported from the NCBI taxonomy, but the high level hierarchy there does not suit our needs (includes plasmids and &apos;other organisms&apos;)</obo:IAO_0000116>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">13-02-2009:
OBI doesn&apos;t take position as to  when an organism starts or ends being an organism - e.g. sperm, foetus.
This issue is outside the scope of OBI.</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GROUP: OBI Biomaterial Branch</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">WEB: http://en.wikipedia.org/wiki/Organism</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">organism</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0100051 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0100051">
        <owl:equivalentClass>
            <owl:Class>
                <owl:intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000040"/>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000112"/>
                    </owl:Restriction>
                </owl:intersectionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
        <obo:IAO_0000111 xml:lang="en">specimen</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biobanking of blood taken and stored in a freezer for potential future investigations stores specimen.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A material entity that has the specimen role.</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation.</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: James Malone</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Philippe Rocca-Serra</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">GROUP: OBI Biomaterial Branch</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">specimen</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0100060 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0100060">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000047"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000312"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0600024"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000643"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CL_0000010"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000643"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CL_0000010"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cultured cell population</obo:IAO_0000111>
        <obo:IAO_0000112>A cultured cell population applied in an experiment: &quot;293 cells expressing TrkA were serum-starved for 18 hours and then neurotrophins were added for 10 min before cell harvest.&quot;  (Lee, Ramee, et al. &quot;Regulation of cell survival by secreted proneurotrophins.&quot; Science 294.5548 (2001): 1945-1948).

A cultured cell population maintained in vitro: &quot;Rat cortical neurons from 15 day embryos are grown in dissociated cell culture and maintained in vitro for 8–12 weeks&quot; (Dichter, Marc A. &quot;Rat cortical neurons in cell culture: culture methods, cell morphology, electrophysiology, and synapse formation.&quot; Brain Research 149.2 (1978): 279-293).</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A processed material comprised of a collection of cultured cells that has been continuously maintained together in culture and shares a common propagation history.</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2013-6-5 MHB: This OBI class was formerly called &apos;cell culture&apos;, but label changed and definition updated following CLO alignment efforts in spring 2013, during which the intent of this class was clarified to refer to portions of a culture or line rather than a complete cell culture or line.</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON:Matthew Brush</obo:IAO_0000117>
        <obo:IAO_0000118>cell culture sample</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON:Matthew Brush</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The extent of a &apos;cultured cell population&apos; is restricted only in that all cell members must share a propagation history (ie be derived through a common lineage of passages from an initial culture). In being defined in this way, this class can be used to refer to the populations that researchers actually use in the practice of science - ie are the inputs to culturing, experimentation, and sharing. The cells in such populations will be a relatively uniform population as they have experienced similar selective pressures due to their continuous co-propagation. And this population will also have a single passage number, again owing to their common passaging history. Cultured cell populations represent only a collection of cells (ie do not include media, culture dishes, etc), and include populations of cultured unicellular organisms or cultured multicellular organism cells. They can exist under active culture, stored in a quiescent state for future use, or applied experimentally.</rdfs:comment>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cultured cell population</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0200000 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0200000">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0200166"/>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
                <owl:someValuesFrom>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
                        <owl:someValuesFrom>
                            <owl:Class>
                                <owl:intersectionOf rdf:parseType="Collection">
                                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000064"/>
                                    <owl:Restriction>
                                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000005"/>
                                    </owl:Restriction>
                                </owl:intersectionOf>
                            </owl:Class>
                        </owl:someValuesFrom>
                    </owl:Restriction>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">data transformation</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The application of a clustering protocol to microarray data or the application of a statistical testing method on a primary data set to determine a p-value.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A planned process that produces output data from input data.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Elisabetta Manduchi</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">Helen Parkinson</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">James Malone</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">Melanie Courtot</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Philippe Rocca-Serra</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">Richard Scheuermann</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">Ryan Brinkman</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">Tina Hernandez-Boussard</obo:IAO_0000117>
        <obo:IAO_0000118 xml:lang="en">data analysis</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">data processing</obo:IAO_0000118>
        <obo:IAO_0000119 xml:lang="en">Branch editors</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">data transformation</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0200036 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0200036">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0200163"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000175"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000662"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001442"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000791"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">Benjamini and Hochberg false discovery rate correction method</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Statistical significance of the 8 most represented biological processes (GO level 4) among E7 6 month upregulated genes following analysis with DAVID software; Benjamini-Hochberg FDR (false discovery rate)</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A data transformation process in which the Benjamini and Hochberg method sequential p-value procedure  is applied with the aim of correcting false discovery rate</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2011-03-31: [PRS]. 
specified input and output of dt which were missing</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Helen Parkinson</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">Philippe Rocca-Serra</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Helen Parkinson</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">Benjamini and Hochberg false discovery rate correction method</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0200049 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0200049">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0200163"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000175"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000662"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001442"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000791"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">Benjamini and Yekutieli false discovery rate correction method</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The expression set was compared univariately between the stroke patients and controls, gene list was generated using False Discovery Rate correction (Benjamini and Yekutieli)</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A data transformation in which the Benjamini and Yekutieli method is applied with the aim of correcting false discovery rate</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2011-03-31: [PRS]. 
specified input and output of dt which were missing</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Helen Parkinson</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">Philippe Rocca-Serra</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Helen Parkinson</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">Benjamini and Yekutieli false discovery rate correction method</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0200089 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0200089">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000791"/>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000668"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">multiple testing correction method</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A multiple testing correction method is a hypothesis test performed simultaneously on M &gt; 1 hypotheses.  Multiple testing procedures produce a set of rejected hypotheses that is an estimate for the set of false null hypotheses while controlling for a suitably define Type I error rate</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Monnie McGee</obo:IAO_0000117>
        <obo:IAO_0000118 xml:lang="en">multiple testing procedure</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PAPER: Dudoit, Sandrine and van der Laan, Mark J. (2008) Multiple Testing Procedures with Applications to Genomics.  New York: Springer , p. 9-10.</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">multiple testing correction method</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0200094 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0200094">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0200169"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0200167"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">logarithmic transformation</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A logarithmic transformation is a data transformation consisting in the application of the logarithm function with a given base a (where a&gt;0 and a is not equal to 1) to a (one dimensional) positive real number input. The logarithm function with base a can be defined as the inverse of the exponential function with the same base. See e.g. http://en.wikipedia.org/wiki/Logarithm.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Elisabetta Manduchi</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">WEB: http://en.wikipedia.org/wiki/Logarithm</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">logarithmic transformation</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0200102 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0200102">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0200000"/>
        <obo:IAO_0000111 xml:lang="en">regression analysis method</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">Regression analysis is a descriptive statistics technique that examines the relation of a dependent variable (response variable) to specified independent variables (explanatory variables). Regression analysis can be used as a descriptive method of data analysis (such as curve fitting) without relying on any assumptions about underlying processes generating the data.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Tina Hernandez-Boussard</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">BOOK: Richard A. Berk, Regression Analysis: A Constructive Critique, Sage Publications (2004) 978-0761929048</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">regression analysis method</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0200111 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0200111">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:unionOf rdf:parseType="Collection">
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000038"/>
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000101"/>
                        </owl:unionOf>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:allValuesFrom rdf:resource="http://purl.obolibrary.org/obo/IAO_0000027"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:allValuesFrom>
                    <owl:Class>
                        <owl:unionOf rdf:parseType="Collection">
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000038"/>
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/IAO_0000101"/>
                        </owl:unionOf>
                    </owl:Class>
                </owl:allValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">data visualization</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Generation of a heatmap from a microarray dataset</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">An planned process that creates images, diagrams or animations from the input data.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Elisabetta Manduchi</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">James Malone</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">Melanie Courtot</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">Tina Boussard</obo:IAO_0000117>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">data encoding as image</obo:IAO_0000118>
        <obo:IAO_0000118 xml:lang="en">visualization</obo:IAO_0000118>
        <obo:IAO_0000119 xml:lang="en">PERSON: Elisabetta Manduchi</obo:IAO_0000119>
        <obo:IAO_0000119 xml:lang="en">PERSON: James Malone</obo:IAO_0000119>
        <obo:IAO_0000119 xml:lang="en">PERSON: Melanie Courtot</obo:IAO_0000119>
        <obo:IAO_0000119 xml:lang="en">PERSON: Tina Boussard</obo:IAO_0000119>
        <obo:IAO_0000232 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Possible future hierarchy might include this:
information_encoding
&gt;data_encoding
&gt;&gt;image_encoding</obo:IAO_0000232>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">data visualization</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0200163 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0200163">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001442"/>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0200089"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000175"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000791"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">false discovery rate correction method</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The false discovery rate is a  data transformation used in multiple hypothesis testing to correct for multiple comparisons. It controls the expected proportion of incorrectly rejected null hypotheses (type I errors) in a list of rejected hypotheses. It is a less conservative comparison procedure with greater power than familywise error rate (FWER) control, at a cost of increasing the likelihood of obtaining type I errors. .</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">2011-03-31: [PRS]. 
creating a defined class by specifying the necessary output of dt
allows correct classification of FDR dt</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Monnie McGee</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">Philippe Rocca-Serra</obo:IAO_0000117>
        <obo:IAO_0000118 xml:lang="en">FDR correction method</obo:IAO_0000118>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dudoit, Sandrine and van der Laan, Mark J. (2008) Multiple Testing Procedures with Applications to Genomics.  New York: Springer , p. 21 and http://www.wikidoc.org/index.php/False_discovery_rate</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">false discovery rate correction method</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0200166 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0200166">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000005"/>
        <obo:IAO_0000111 xml:lang="en">data transformation objective</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">normalize objective</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">An objective specification to transformation input data into output data</obo:IAO_0000115>
        <obo:IAO_0000116>Modified definition in 2013 Philly OBI workshop</obo:IAO_0000116>
        <obo:IAO_0000117 xml:lang="en">James Malone</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">PERSON: James Malone</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">data transformation objective</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0200167 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0200167">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0200166"/>
        <obo:IAO_0000111 xml:lang="en">data normalization objective</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">Quantile transformation which has normalization objective can be used for expression microarray assay normalization and it is referred to as &quot;quantile normalization&quot;, according to the procedure described e.g. in PMID 12538238.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A normalization objective is a data transformation objective where the aim is to remove
systematic sources of variation to put the data on equal footing in order
to create a common base for comparisons.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Elisabetta Manduchi</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Helen Parkinson</obo:IAO_0000117>
        <obo:IAO_0000117 xml:lang="en">James Malone</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Elisabetta Manduchi</obo:IAO_0000119>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Helen Parkinson</obo:IAO_0000119>
        <obo:IAO_0000119 xml:lang="en">PERSON: James Malone</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">data normalization objective</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0200168 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0200168">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0200166"/>
        <obo:IAO_0000111 xml:lang="en">correction objective</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">Type I error correction</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 xml:lang="en">A correction objective is a data transformation objective where the aim is to correct for error, noise or other impairments to the input of the data transformation or derived from the data transformation itself</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">James Malone</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: James Malone</obo:IAO_0000119>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Melanie Courtot</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">correction objective</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0200169 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0200169">
        <owl:equivalentClass>
            <owl:Class>
                <owl:unionOf rdf:parseType="Collection">
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000451"/>
                    </owl:Restriction>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0200167"/>
                    </owl:Restriction>
                </owl:unionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0200000"/>
        <obo:IAO_0000111 xml:lang="en">normalization data transformation</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 xml:lang="en">A normalization data transformation is a data transformation that has objective normalization.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">James Malone</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">PERSON: James Malone</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">normalization data transformation</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0200170 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0200170">
        <owl:equivalentClass>
            <owl:Class>
                <owl:unionOf rdf:parseType="Collection">
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000679"/>
                    </owl:Restriction>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000425"/>
                    </owl:Restriction>
                </owl:unionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0200000"/>
        <obo:IAO_0000111 xml:lang="en">averaging data transformation</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 xml:lang="en">An averaging data transformation is a data transformation that has objective averaging.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">James Malone</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">PERSON: James Malone</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">averaging data transformation</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0200177 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0200177">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0200166"/>
        <obo:IAO_0000111 xml:lang="en">center calculation objective</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">A mean calculation which has center calculation objective is a data transformation in which the center of the input data is discovered through the calculation of a mean average.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">A center calculation objective is a data transformation objective where the aim is to calculate the center of an input data set.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">James Malone</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: James Malone</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">center calculation objective</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0200181 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0200181">
        <owl:equivalentClass>
            <owl:Class>
                <owl:unionOf rdf:parseType="Collection">
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000674"/>
                    </owl:Restriction>
                    <owl:Restriction>
                        <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                        <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0200177"/>
                    </owl:Restriction>
                </owl:unionOf>
            </owl:Class>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0200000"/>
        <obo:IAO_0000111 xml:lang="en">center calculation data transformation</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 xml:lang="en">A center calculation data transformation is a data transformation that has objective of center calculation.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">James Malone</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">PERSON: James Malone</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">center calculation data transformation</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0200186 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0200186">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0200168"/>
        <obo:IAO_0000111 xml:lang="en">error correction objective</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Application of a multiple testing correction method</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">An error correction objective is a data transformation objective where the aim is to remove (correct for) erroneous contributions arising from the input data, or the transformation itself.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">James Malone, Helen Parkinson</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: James Malone</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">error correction objective</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0300311 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0300311">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
        <obo:IAO_0000111 xml:lang="en">observation design</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">PMID: 12387964.Lancet. 2002 Oct 12;360(9340):1144-9.Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">observation design is a study design in which subjects are monitored in the absence of any active intervention by experimentalists.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Philippe Rocca-Serra</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">OBI branch derived</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">observation design</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0302884 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0302884">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0600014"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000681"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">extraction</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">nucleic acid extraction using phenol chloroform</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000123"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A material separation in which a desired component of an input material is separated from the remainder</obo:IAO_0000115>
        <obo:IAO_0000116 xml:lang="en">Current the output of material processing defined as the molecular entity, main component in the output material entity, rather than the material entity that have grain molecular entity. 
&apos;nucleic acid extract&apos; is the output of &apos;nucleic acid extraction&apos; and has grain &apos;nucleic acid&apos;. However, the output of &apos;nucleic acid extraction&apos; is &apos;nucleic acid&apos; rather than &apos;nucleic acid extract&apos;. We are aware of this issue and will work it out in the future.</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Person:Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Philippe Rocca-Serra</obo:IAO_0000117>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">extraction</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0302900 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0302900">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0600015"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">group randomization</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">PMID: 18349405. Randomization reveals unexpected acute leukemias in Southwest Oncology Group prostate cancer trial. J Clin Oncol. 2008 Mar 20;26(9):1532-6.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">A group assignment which relies on chance to assign materials to a group of materials in order to avoid bias in experimental set up.</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Philippe Rocca-Serra</obo:IAO_0000117>
        <obo:IAO_0000119 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">adapted from wikipedia [http://en.wikipedia.org/wiki/Randomization]</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">group randomization</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0500000 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0500000">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000104"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000051"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000272"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">study design</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">a matched pairs study design describes criteria by which subjects are identified as pairs which then undergo the same protocols, and the data generated is analyzed by comparing the differences between the paired subjects, which constitute the results of the executed study design.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A plan specification comprised of protocols (which may specify how and what kinds of data will be gathered) that are executed as part of an investigation and is realized during a study design execution.</obo:IAO_0000115>
        <obo:IAO_0000116 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Editor note: there is at least an implicit restriction on the kind of data transformations that can be done based on the measured data available.</obo:IAO_0000116>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON: Chris Stoeckert</obo:IAO_0000117>
        <obo:IAO_0000118 xml:lang="en">experimental design</obo:IAO_0000118>
        <obo:IAO_0000232 xml:lang="en">rediscussed at length (MC/JF/BP). 12/9/08). The definition was clarified to differentiate it from protocol.</obo:IAO_0000232>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">study design</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0500002 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0500002">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000115"/>
        <obo:IAO_0000111 xml:lang="en">repeated measure design</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">PMID: 10959922.J Biopharm Stat. 2000 Aug;10(3):433-45.Equivalence in test assay method comparisons for the repeated-measure, matched-pair design in medical device studies: statistical considerations.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">a study design which use the same individuals and exposure them to a set of conditions. The effect of order and practice can be confounding factor in such designs</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PlanAndPlannedProcess Branch</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">http://www.holah.karoo.net/experimentaldesigns.htm</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">repeated measure design</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0500003 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0500003">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500002"/>
        <obo:IAO_0000111 xml:lang="en">cross over design</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">PMID: 17601993-Objective: HIV-infected patients with lipodystrophy (HIV-lipodystrophy) are insulin resistant and have elevated plasma free fatty acid (FFA) concentrations. We aimed to explore the mechanisms underlying FFA-induced insulin resistance in patients with HIV-lipodystrophy. Research Design and Methods: Using a randomized placebo-controlled cross-over design, we studied the effects of an overnight acipimox-induced suppression of FFA on glucose and FFA metabolism by using stable isotope labelled tracer techniques during basal conditions and a two-stage euglycemic, hyperinsulinemic clamp (20 mU insulin/m(2)/min; 50 mU insulin/m(2)/min) in nine patients with nondiabetic HIV-lipodystrophy. All patients received antiretroviral therapy. Biopsies from the vastus lateralis muscle were obtained during each stage of the clamp. Results: Acipimox treatment reduced basal FFA rate of appearance by 68.9% (52.6%-79.5%) and decreased plasma FFA concentration by 51.6 % (42.0%-58.9%), (both, P &lt; 0.0001). Endogenous glucose production was not influenced by acipimox. During the clamp the increase in glucose-uptake was significantly greater after acipimox treatment compared to placebo (acipimox: 26.85 (18.09-39.86) vs placebo: 20.30 (13.67-30.13) mumol/kg/min; P &lt; 0.01). Insulin increased phosphorylation of Akt (Thr(308)) and GSK-3beta (Ser(9)), decreased phosphorylation of glycogen synthase (GS) site 3a+b and increased GS-activity (I-form) in skeletal muscle (P &lt; 0.01). Acipimox decreased phosphorylation of GS (site 3a+b) (P &lt; 0.02) and increased GS-activity (P &lt; 0.01) in muscle. Conclusion: The present study provides direct evidence that suppression of lipolysis in patients with HIV-lipodystrophy improves insulin-stimulated peripheral glucose-uptake. The increased glucose-uptake may in part be explained by increased dephosphorylation of GS (site 3a+b) resulting in increased GS activity.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115 xml:lang="en">a repeated measure design which ensures that experimental units receive, in sequence, the treatment (or the control), and then, after a specified time interval (aka *wash-out periods*), switch to the control (or treatment). In this design, subjects (patients in human context) serve as their own controls, and randomization may be used to determine the ordering which a subject receives the treatment and control</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Philippe Rocca-Serra</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">(source: http://www.sbu.se/Filer/Content0/publikationer/1/literaturesearching_1993/glossary.html)</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">cross over design</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0500020 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0500020">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
        <obo:IAO_0000111 xml:lang="en">time series design</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">PMID: 14744830-Microarrays are powerful tools for surveying the expression levels of many thousands of genes simultaneously. They belong to the new genomics technologies which have important applications in the biological, agricultural and pharmaceutical sciences. There are myriad sources of uncertainty in microarray experiments, and rigorous experimental design is essential for fully realizing the potential of these valuable resources. Two questions frequently asked by biologists on the brink of conducting cDNA or two-colour, spotted microarray experiments are &apos;Which mRNA samples should be competitively hybridized together on the same slide?&apos; and &apos;How many times should each slide be replicated?&apos; Early experience has shown that whilst the field of classical experimental design has much to offer this emerging multi-disciplinary area, new approaches which accommodate features specific to the microarray context are needed. In this paper, we propose optimal designs for factorial and time course experiments, which are special designs arising quite frequently in microarray experimentation. Our criterion for optimality is statistical efficiency based on a new notion of admissible designs; our approach enables efficient designs to be selected subject to the information available on the effects of most interest to biologists, the number of arrays available for the experiment, and other resource or practical constraints, including limitations on the amount of mRNA probe. We show that our designs are superior to both the popular reference designs, which are highly inefficient, and to designs incorporating all possible direct pairwise comparisons. Moreover, our proposed designs represent a substantial practical improvement over classical experimental designs which work in terms of standard interactions and main effects. The latter do not provide a basis for meaningful inference on the effects of most interest to biologists, nor make the most efficient use of valuable and limited resources.</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">Groups of assays that are related as part of a time series.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Philippe Rocca-Serra on behalf of MO</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">MO_887</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">time series design</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0600014 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0600014">
        <owl:equivalentClass>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000639"/>
            </owl:Restriction>
        </owl:equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000094"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/BFO_0000040"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">material component separation</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">Using a cell sorter to separate a mixture of T cells into two fractions; one with surface receptor CD8 and the other lacking the receptor, or purification</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">a material processing in which components of an input material become segregated in space</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Bjoern Peters</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">IEDB</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">material component separation</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0600015 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0600015">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000011"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:intersectionOf rdf:parseType="Collection">
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/BFO_0000023"/>
                            <owl:Restriction>
                                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000052"/>
                                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
                            </owl:Restriction>
                        </owl:intersectionOf>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">group assignment</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">Assigning&apos; to be treated with active ingredient role&apos; to an organism during group assignment. The group is those organisms that have the same role in the context of an investigation</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000122"/>
        <obo:IAO_0000115 xml:lang="en">group assignment is a process which has an organism as specified input and during which a role is assigned</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Philippe Rocca-Serra</obo:IAO_0000117>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cohort assignment</obo:IAO_0000118>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">study assignment</obo:IAO_0000118>
        <obo:IAO_0000119 xml:lang="en">OBI Plan</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">group assignment</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0600024 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0600024">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000838"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0100060"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:someValuesFrom>
                    <owl:Class>
                        <owl:unionOf rdf:parseType="Collection">
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000079"/>
                            <rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0001912"/>
                        </owl:unionOf>
                    </owl:Class>
                </owl:someValuesFrom>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0100060"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000806"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111 xml:lang="en">maintaining cell culture</obo:IAO_0000111>
        <obo:IAO_0000112 xml:lang="en">When harvesting blood from a human, isolating T cells, and then limited dilution cloning of the cells, the maintaining_cell_culture step comprises all steps after the initial dilution and plating of the cells into culture, e.g. placing the culture into an incubator, changing or adding media, and splitting a cell culture</obo:IAO_0000112>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000125"/>
        <obo:IAO_0000115 xml:lang="en">a protocol application in which cells are kept alive in a defined environment outside of an organism.  part of cell_culturing</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">PlanAndPlannedProcess Branch</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">OBI branch derived</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:label xml:lang="en">maintaining cell culture</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0600036 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0600036">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0000094"/>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CL_0000000"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000079"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000299"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0100060"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <owl:Restriction>
                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000417"/>
                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0000456"/>
            </owl:Restriction>
        </rdfs:subClassOf>
        <obo:IAO_0000111>&apos;establishing cell culture&apos;</obo:IAO_0000111>
        <obo:IAO_0000114 rdf:resource="http://purl.obolibrary.org/obo/IAO_0000120"/>
        <obo:IAO_0000115>a process through which a new type of cell culture or cell line is created, either through the isolation and culture of one or more cells from a fresh source, or the deliberate experimental modification of an existing cell culture (e.g passaging a primary culture to become a secondary culture or line, or the immortalization or stable genetic modification of an existing culture or line).</obo:IAO_0000115>
        <obo:IAO_0000117>PERSON:Matthew Brush</obo:IAO_0000117>
        <obo:IAO_0000119>PERSON:Matthew Brush</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <rdfs:comment>A &apos;cell culture&apos; as used here referes to a new lineage of cells in culture deriving from a single biological source.. New cultures are established through the initial isolation and culturing of cells from an organismal source, or through changes in an existing cell culture or line that result in a new culture with unique characteristics.  This can occur through the passaging/selection of a primary culture into a secondary culture or line, or experimental modifications of an existing cell culture or line such as an immortalization process or other stable genetic modification. This class covers establishment of cultures of either multicellular organism cells or unicellular organisms.</rdfs:comment>
        <rdfs:label>establishing cell culture</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/OGMS_0000023 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OGMS_0000023">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000019"/>
        <obo:IAO_0000111>phenotype</obo:IAO_0000111>
        <obo:IAO_0000115 xml:lang="en">A (combination of) quality(ies) of an organism determined by the interaction of its genetic make-up and environment that differentiates specific instances of a species from other instances of the same species.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/ogms.owl"/>
        <rdfs:label>phenotype</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/PATO_0000125 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PATO_0000125">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000019"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mass</obo:IAO_0000111>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A physical quality that inheres in a bearer by virtue of the proportion of the bearer&apos;s amount of matter.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/pato.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mass</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/PR_000000001 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/PR_000000001">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16670"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">protein</obo:IAO_0000111>
        <obo:IAO_0000112 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">antithrombin III is a protein</obo:IAO_0000112>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/pr.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">protein</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/REO_0000171 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/REO_0000171">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000023"/>
        <obo:IAO_0000111 xml:lang="en">molecular label role</obo:IAO_0000111>
        <obo:IAO_0000115>a reagent role inhering in a molecular entity intended to associate with some molecular target to serve as a proxy for the presence, abundance, or location of this target in a detection of molecular label assay.</obo:IAO_0000115>
        <obo:IAO_0000116>MHB (9-29-13): &apos;molecular label role&apos; imported from the Reagent Ontology and replaced OBI:OBI_0000140 (label role)</obo:IAO_0000116>
        <obo:IAO_0000118>molecular tracer role</obo:IAO_0000118>
        <obo:IAO_0000119>OBI developer call, 3-12-12</obo:IAO_0000119>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/reo.owl"/>
        <rdfs:label xml:lang="en">molecular label role</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/SO_0000001 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/SO_0000001">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/BFO_0000031"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">region</obo:IAO_0000111>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A sequence_feature with an extent greater than zero. A nucleotide region is composed of bases and a polypeptide region is composed of amino acids.</obo:IAO_0000115>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">primary structure of sequence macromolecule</obo:IAO_0000118>
        <obo:IAO_0000118 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">sequence</obo:IAO_0000118>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/so.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">region</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/UO_0000001 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UO_0000001">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000003"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">length unit</obo:IAO_0000111>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A unit which is a standard measure of the distance between two points.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/uo.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">length unit</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/UO_0000002 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UO_0000002">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000003"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mass unit</obo:IAO_0000111>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A unit which is a standard measure of the amount of matter/energy of a physical object.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/uo.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mass unit</rdfs:label>
    </owl:Class>
    


    <!-- http://purl.obolibrary.org/obo/UO_0000003 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/UO_0000003">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/IAO_0000003"/>
        <obo:IAO_0000111 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">time unit</obo:IAO_0000111>
        <obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A unit which is a standard measure of the dimension in which events occur in sequence.</obo:IAO_0000115>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/uo.owl"/>
        <rdfs:label rdf:datatype="http://www.w3.org/2001/XMLSchema#string">time unit</rdfs:label>
    </owl:Class>
    


    <!-- http://www.w3.org/2002/07/owl#Thing -->

    <owl:Class rdf:about="http://www.w3.org/2002/07/owl#Thing">
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </owl:Class>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Individuals
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/IAO_0000002 -->

    <owl:NamedIndividual rdf:about="http://purl.obolibrary.org/obo/IAO_0000002">
        <rdf:type rdf:resource="http://purl.obolibrary.org/obo/IAO_0000078"/>
        <rdfs:label xml:lang="en">example to be eventually removed</rdfs:label>
    </owl:NamedIndividual>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000120 -->

    <owl:Thing rdf:about="http://purl.obolibrary.org/obo/IAO_0000120">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
        <rdf:type rdf:resource="http://purl.obolibrary.org/obo/IAO_0000078"/>
        <obo:IAO_0000115 xml:lang="en">Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">metadata complete</rdfs:label>
    </owl:Thing>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000121 -->

    <owl:Thing rdf:about="http://purl.obolibrary.org/obo/IAO_0000121">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
        <rdf:type rdf:resource="http://purl.obolibrary.org/obo/IAO_0000078"/>
        <obo:IAO_0000115 xml:lang="en">term created to ease viewing/sort terms for development purpose, and will not be included in a release</obo:IAO_0000115>
        <obo:IAO_0000117 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PERSON:Alan Ruttenberg</obo:IAO_0000117>
        <rdfs:label xml:lang="en">organizational term</rdfs:label>
    </owl:Thing>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000122 -->

    <owl:Thing rdf:about="http://purl.obolibrary.org/obo/IAO_0000122">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
        <rdf:type rdf:resource="http://purl.obolibrary.org/obo/IAO_0000078"/>
        <obo:IAO_0000115 xml:lang="en">Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking &quot;ready_for_release&quot; should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release.  Those classes deemed &quot;ready_for_release&quot; will also derived from a chain of ancestor classes that are also &quot;ready_for_release.&quot;</obo:IAO_0000115>
        <rdfs:label xml:lang="en">ready for release</rdfs:label>
    </owl:Thing>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000123 -->

    <owl:Thing rdf:about="http://purl.obolibrary.org/obo/IAO_0000123">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
        <rdf:type rdf:resource="http://purl.obolibrary.org/obo/IAO_0000078"/>
        <obo:IAO_0000115 xml:lang="en">Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">metadata incomplete</rdfs:label>
    </owl:Thing>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000124 -->

    <owl:Thing rdf:about="http://purl.obolibrary.org/obo/IAO_0000124">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
        <rdf:type rdf:resource="http://purl.obolibrary.org/obo/IAO_0000078"/>
        <obo:IAO_0000115 xml:lang="en">Nothing done yet beyond assigning a unique class ID and proposing a preferred term.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">uncurated</rdfs:label>
    </owl:Thing>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000125 -->

    <owl:Thing rdf:about="http://purl.obolibrary.org/obo/IAO_0000125">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#NamedIndividual"/>
        <rdf:type rdf:resource="http://purl.obolibrary.org/obo/IAO_0000078"/>
        <obo:IAO_0000115 xml:lang="en">All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor.</obo:IAO_0000115>
        <rdfs:label xml:lang="en">pending final vetting</rdfs:label>
    </owl:Thing>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000423 -->

    <owl:NamedIndividual rdf:about="http://purl.obolibrary.org/obo/IAO_0000423">
        <rdf:type rdf:resource="http://purl.obolibrary.org/obo/IAO_0000078"/>
        <obo:IAO_0000115 xml:lang="en">Terms with this status should eventually replaced with a term from another ontology.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">group:OBI</obo:IAO_0000119>
        <rdfs:label xml:lang="en">to be replaced with external ontology term</rdfs:label>
    </owl:NamedIndividual>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000428 -->

    <owl:NamedIndividual rdf:about="http://purl.obolibrary.org/obo/IAO_0000428">
        <rdf:type rdf:resource="http://purl.obolibrary.org/obo/IAO_0000078"/>
        <obo:IAO_0000115 xml:lang="en">A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues.</obo:IAO_0000115>
        <obo:IAO_0000117 xml:lang="en">Alan Ruttenberg</obo:IAO_0000117>
        <obo:IAO_0000119 xml:lang="en">group:OBI</obo:IAO_0000119>
        <rdfs:label xml:lang="en">requires discussion</rdfs:label>
    </owl:NamedIndividual>
    


    <!-- http://purl.obolibrary.org/obo/RO_0001901 -->

    <owl:NamedIndividual rdf:about="http://purl.obolibrary.org/obo/RO_0001901">
        <obo:IAO_0000115>

## Elucidation

This is used when the statement/axiom is assumed to hold true &apos;eternally&apos;

## How to interpret (informal)

First the &quot;atemporal&quot; FOL is derived from the OWL using the standard
interpretation. This axiom is temporalized by embedding the axiom
within a for-all-times quantified sentence. The t argument is added to
all instantiation predicates and predicates that use this relation.

## Example

    Class: nucleus
    SubClassOf: part_of some cell

    forall t :
      forall n :
        instance_of(n,Nucleus,t)
         implies
        exists c :
          instance_of(c,Cell,t)
          part_of(n,c,t)

## Notes

This interpretation is *not* the same as an at-all-times relation

</obo:IAO_0000115>
        <rdfs:label xml:lang="en">axiom holds for all times</rdfs:label>
    </owl:NamedIndividual>
    


    <!-- http://purl.obolibrary.org/obo/iao.owl -->

    <owl:NamedIndividual rdf:about="http://purl.obolibrary.org/obo/iao.owl"/>
    


    <!-- http://purl.obolibrary.org/obo/obi.owl -->

    <owl:NamedIndividual rdf:about="http://purl.obolibrary.org/obo/obi.owl">
        <protege:defaultLanguage rdf:datatype="http://www.w3.org/2001/XMLSchema#string">en</protege:defaultLanguage>
        <dc:contributor xml:lang="en">Advisors for this project come from the IFOMIS group, Saarbruecken and from the Co-ODE group in Manchester</dc:contributor>
        <dc:creator xml:lang="en">Alan Ruttenberg</dc:creator>
        <dc:creator xml:lang="en">Allyson Lister</dc:creator>
        <dc:creator xml:lang="en">Barry Smith</dc:creator>
        <dc:creator xml:lang="en">Bill Bug</dc:creator>
        <dc:creator xml:lang="en">Bjoern Peters</dc:creator>
        <dc:creator xml:lang="en">Carlo Torniai</dc:creator>
        <dc:creator xml:lang="en">Chris Mungall</dc:creator>
        <dc:creator xml:lang="en">Chris Stoeckert</dc:creator>
        <dc:creator xml:lang="en">Chris Taylor</dc:creator>
        <dc:creator xml:lang="en">Christian Bolling</dc:creator>
        <dc:creator xml:lang="en">Cristian Cocos</dc:creator>
        <dc:creator xml:lang="en">Daniel Rubin</dc:creator>
        <dc:creator xml:lang="en">Daniel Schober</dc:creator>
        <dc:creator xml:lang="en">Dawn Field</dc:creator>
        <dc:creator xml:lang="en">Dirk Derom</dc:creator>
        <dc:creator xml:lang="en">Elisabetta Manduchi</dc:creator>
        <dc:creator xml:lang="en">Eric Deutsch</dc:creator>
        <dc:creator xml:lang="en">Frank Gibson</dc:creator>
        <dc:creator xml:lang="en">Gilberto Fragoso</dc:creator>
        <dc:creator xml:lang="en">Helen C. Causton</dc:creator>
        <dc:creator xml:lang="en">Helen Parkinson</dc:creator>
        <dc:creator xml:lang="en">Holger Stenzhorn</dc:creator>
        <dc:creator xml:lang="en">James A. Overton</dc:creator>
        <dc:creator xml:lang="en">James Malone</dc:creator>
        <dc:creator xml:lang="en">Jay Greenbaum</dc:creator>
        <dc:creator xml:lang="en">Jeffrey Grethe</dc:creator>
        <dc:creator xml:lang="en">Jennifer Fostel</dc:creator>
        <dc:creator xml:lang="en">Jessica Turner</dc:creator>
        <dc:creator xml:lang="en">Jie Zheng</dc:creator>
        <dc:creator xml:lang="en">Joe White</dc:creator>
        <dc:creator xml:lang="en">John Westbrook</dc:creator>
        <dc:creator xml:lang="en">Kevin Clancy</dc:creator>
        <dc:creator xml:lang="en">Larisa Soldatova</dc:creator>
        <dc:creator xml:lang="en">Lawrence Hunter</dc:creator>
        <dc:creator xml:lang="en">Liju Fan</dc:creator>
        <dc:creator xml:lang="en">Luisa Montecchi</dc:creator>
        <dc:creator xml:lang="en">Matthew Brush</dc:creator>
        <dc:creator xml:lang="en">Matthew Pocock</dc:creator>
        <dc:creator xml:lang="en">Melanie Courtot</dc:creator>
        <dc:creator xml:lang="en">Melissa Haendel</dc:creator>
        <dc:creator xml:lang="en">Mervi Heiskanen</dc:creator>
        <dc:creator xml:lang="en">Monnie McGee</dc:creator>
        <dc:creator xml:lang="en">Norman Morrison</dc:creator>
        <dc:creator xml:lang="en">Philip Lord</dc:creator>
        <dc:creator xml:lang="en">Philippe Rocca-Serra</dc:creator>
        <dc:creator xml:lang="en">Pierre Grenon</dc:creator>
        <dc:creator xml:lang="en">Richard Bruskiewich</dc:creator>
        <dc:creator xml:lang="en">Richard Scheuermann</dc:creator>
        <dc:creator xml:lang="en">Robert Stevens</dc:creator>
        <dc:creator xml:lang="en">Ryan R. Brinkman</dc:creator>
        <dc:creator xml:lang="en">Stefan Wiemann</dc:creator>
        <dc:creator xml:lang="en">Susanna-Assunta Sansone</dc:creator>
        <dc:creator xml:lang="en">Tanya Gray</dc:creator>
        <dc:creator xml:lang="en">Tina Hernandez-Boussard</dc:creator>
        <dc:creator xml:lang="en">Trish Whetzel</dc:creator>
        <dc:creator xml:lang="en">Yongqun He</dc:creator>
        <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2009-07-31</dc:date>
        <dc:description xml:lang="en">The Ontology for Biomedical Investigations (OBI) is build in a collaborative, international effort and will serve as a resource for annotating biomedical investigations, including the study design, protocols and instrumentation used, the data generated and the types of analysis performed on the data. This ontology arose from the Functional Genomics Investigation Ontology (FuGO) and will contain both terms that are common to all biomedical investigations, including functional genomics investigations and those that are more domain specific.</dc:description>
        <dc:format xml:lang="en">OWL-DL</dc:format>
        <dc:license rdf:resource="http://creativecommons.org/licenses/by/3.0/"/>
        <dc:subject xml:lang="en">An ontology for the annotation of biomedical and functional genomics experiments.</dc:subject>
        <dc:title xml:lang="en">Ontology for Biomedical Investigation</dc:title>
        <rdfs:comment rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Please cite the OBI consortium http://purl.obolibrary.org/obo/obi where traditional citation is called for. However it is adequate that individual terms be attributed simply by use of the identifying PURL for the term, in projects that refer to them.</rdfs:comment>
        <owl:versionInfo rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017-09-03</owl:versionInfo>
    </owl:NamedIndividual>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
        <obo:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/obi.owl"/>
    </rdf:Description>
    <rdf:Description>
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<!-- Generated by the OWL API (version 4.2.3.20160319-0906) https://github.com/owlcs/owlapi -->