diff --git a/.flake8 b/.flake8
new file mode 100644
index 0000000..090cb31
--- /dev/null
+++ b/.flake8
@@ -0,0 +1,4 @@
+[flake8]
+max-line-length = 80
+ignore = E121,E125,W504
+statistics = true
diff --git a/.github/workflows/publish.yml b/.github/workflows/publish.yml
new file mode 100644
index 0000000..664a605
--- /dev/null
+++ b/.github/workflows/publish.yml
@@ -0,0 +1,27 @@
+name: Build and Publish Client to PyPI
+on:
+  release:
+    types: [published]
+jobs:
+  build-and-publish-client:
+    runs-on: ubuntu-latest
+    environment:
+      name: pypi
+      url: https://pypi.org/p/dicomweb-client
+    permissions:
+      id-token: write
+    steps:
+      - name: Checkout repository
+        uses: actions/checkout@v4
+      - name: Install uv
+        uses: astral-sh/setup-uv@v6
+        with:
+          version: "0.7.2"
+      - name: Setup Python
+        uses: actions/setup-python@v5
+        with:
+          python-version-file: "pyproject.toml"
+      - name: Build wheel and sdist
+        run: uv build
+      - name: Publish package distributions to PyPI
+        uses: pypa/gh-action-pypi-publish@release/v1
diff --git a/.github/workflows/run_unit_tests.yml b/.github/workflows/run_unit_tests.yml
index 1f27534..04da15f 100644
--- a/.github/workflows/run_unit_tests.yml
+++ b/.github/workflows/run_unit_tests.yml
@@ -28,18 +28,16 @@ jobs:
     - name: Set up Python ${{ matrix.python-version }}
       uses: actions/setup-python@v2
       with:
-        python-version: ${{ matrix.python-version }}
+        python-version: ${{ matrix.python-version }} 
+    - name: Install uv
+      uses: astral-sh/setup-uv@v6
+      with:
+        version: "0.7.2"
     - name: Install dependencies
-      run: |
-        python -m pip install --upgrade pip setuptools
-        pip install '.[test]'
-        pip install .
+      run: uv sync
     - name: Lint with flake8
-      run: |
-        flake8 --exclude='bin,build,.eggs'
+      run: uv run flake8 src tests --exclude=.venv,build,.eggs  
     - name: Check type hints with mypy
-      run: |
-        mypy src tests
+      run: uv run mypy src tests
     - name: Test with pytest
-      run: |
-        pytest --cov=dicomweb_client --cov-fail-under=65 tests
+      run: uv run pytest --cov=dicomweb_client --cov-fail-under=65 tests
diff --git a/.gitignore b/.gitignore
index 5fee395..a4736c6 100644
--- a/.gitignore
+++ b/.gitignore
@@ -105,3 +105,6 @@ venv.bak/
 
 # pytest
 .pytest_cache
+
+# lock files
+*.lock
diff --git a/pyproject.toml b/pyproject.toml
index ffa4d87..eceacd1 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -1,16 +1,10 @@
-[build-system]
-requires = ["setuptools>=64"]
-build-backend = "setuptools.build_meta"
-
 [project]
 name = "dicomweb-client"
-version = "0.59.3"
+dynamic = ["version"]
 description = "Client for DICOMweb RESTful services."
 readme = "README.md"
-requires-python = ">=3.6"
-authors = [
-    { name = "Markus D. Herrmann" },
-]
+requires-python = ">=3.9"
+authors = [{ name = "Markus D. Herrmann" }]
 maintainers = [
     { name = "Markus D. Herrmann" },
     { name = "Christopher P. Bridge" },
@@ -28,9 +22,6 @@ classifiers = [
     "Topic :: Multimedia :: Graphics",
     "Topic :: Scientific/Engineering :: Information Analysis",
     "Programming Language :: Python :: 3",
-    "Programming Language :: Python :: 3.6",
-    "Programming Language :: Python :: 3.7",
-    "Programming Language :: Python :: 3.8",
     "Programming Language :: Python :: 3.9",
     "Programming Language :: Python :: 3.10",
     "Programming Language :: Python :: 3.11",
@@ -47,12 +38,12 @@ dependencies = [
 ]
 
 [project.optional-dependencies]
-gcp = [
-    "dataclasses>=0.8; python_version=='3.6'",
-    "google-auth>=1.6",
-]
+gcp = ["dataclasses>=0.8; python_version=='3.6'", "google-auth>=1.6"]
+
+[dependency-groups]
 test = [
     "mypy==0.982",
+    "flake8==6.1.0",
     "pytest==7.1.3",
     "pytest-cov==3.0.0",
     "pytest-flake8==1.1.3",
@@ -68,6 +59,9 @@ docs = [
     "sphinx-autodoc-typehints==1.12.0",
 ]
 
+[tool.uv]
+default-groups = "all"
+
 [project.scripts]
 dicomweb_client = "dicomweb_client.cli:_main"
 
@@ -98,3 +92,10 @@ ignore_missing_imports = true
 [[tool.mypy.overrides]]
 module = "retrying.*"
 ignore_missing_imports = true
+
+[tool.hatch.version]
+source = "uv-dynamic-versioning"
+
+[build-system]
+requires = ["hatchling", "uv-dynamic-versioning"]
+build-backend = "hatchling.build"
diff --git a/setup.cfg b/setup.cfg
deleted file mode 100644
index 1340c5f..0000000
--- a/setup.cfg
+++ /dev/null
@@ -1,7 +0,0 @@
-[aliases]
-test=pytest
-
-[flake8]
-max_line_length = 80
-ignore = E121 E125 W504
-statistics = True
diff --git a/setup.py b/setup.py
deleted file mode 100644
index 97811ab..0000000
--- a/setup.py
+++ /dev/null
@@ -1,68 +0,0 @@
-#!/usr/bin/env python
-# -*- coding: utf-8 -*-
-import io
-import re
-
-import setuptools
-from pathlib import Path
-
-root_directory = Path(__file__).parent
-readme_filepath = root_directory.joinpath('README.md')
-long_description = readme_filepath.read_text()
-
-with io.open('src/dicomweb_client/__init__.py', 'rt', encoding='utf8') as f:
-    version = re.search(r'__version__ = \'(.*?)\'', f.read()).group(1)
-
-
-setuptools.setup(
-    name='dicomweb-client',
-    version=version,
-    description='Client for DICOMweb RESTful services.',
-    long_description=long_description,
-    long_description_content_type='text/markdown',
-    author='Markus D. Herrmann',
-    maintainer='Markus D. Herrmann',
-    url='https://github.com/ImagingDataCommons/dicomweb-client',
-    license='MIT',
-    platforms=['Linux', 'MacOS', 'Windows'],
-    classifiers=[
-        'Environment :: Web Environment',
-        'License :: OSI Approved :: MIT License',
-        'Operating System :: MacOS',
-        'Operating System :: Microsoft :: Windows',
-        'Operating System :: POSIX :: Linux',
-        'Intended Audience :: Science/Research',
-        'Topic :: Internet :: WWW/HTTP',
-        'Topic :: Multimedia :: Graphics',
-        'Topic :: Scientific/Engineering :: Information Analysis',
-        'Programming Language :: Python :: 3',
-        'Programming Language :: Python :: 3.6',
-        'Programming Language :: Python :: 3.7',
-        'Programming Language :: Python :: 3.8',
-        'Programming Language :: Python :: 3.9',
-        'Programming Language :: Python :: 3.10',
-        'Programming Language :: Python :: 3.11',
-        'Development Status :: 4 - Beta',
-    ],
-    entry_points={
-        'console_scripts': ['dicomweb_client = dicomweb_client.cli:_main'],
-    },
-    include_package_data=True,
-    packages=setuptools.find_packages('src'),
-    package_dir={'': 'src'},
-    extras_require={
-        'gcp': [
-            'dataclasses>=0.8; python_version=="3.6"',
-            'google-auth>=1.6',
-        ],
-    },
-    python_requires='>=3.6',
-    install_requires=[
-        'numpy>=1.19',
-        'requests>=2.18',
-        'retrying>=1.3.3',
-        'Pillow>=8.3',
-        'pydicom>=2.2',
-        'typing-extensions>=4.0; python_version < "3.8.0"'
-    ]
-)
diff --git a/src/dicomweb_client/__init__.py b/src/dicomweb_client/__init__.py
index c47651c..bbd97fe 100644
--- a/src/dicomweb_client/__init__.py
+++ b/src/dicomweb_client/__init__.py
@@ -1,9 +1,14 @@
-__version__ = '0.59.3'
+import importlib.metadata
 
 from dicomweb_client.api import DICOMwebClient, DICOMfileClient
 from dicomweb_client.protocol import DICOMClient
 from dicomweb_client.uri import URI, URISuffix, URIType
 
+try:
+    __version__ = importlib.metadata.version(__name__)
+except importlib.metadata.PackageNotFoundError:
+    __version__ = '0.0.0'
+
 __all__ = [
     'DICOMClient',
     'DICOMfileClient',