diff --git a/package.json b/package.json
index 06f489c9..a2be59bd 100644
--- a/package.json
+++ b/package.json
@@ -60,7 +60,6 @@
     "@types/minimatch": "^5.1.2",
     "@types/node": "^24.3.0",
     "@types/ts-expose-internals": "npm:ts-expose-internals@4.9.5",
-    "@types/ts-node": "npm:ts-node@^10.9.2",
     "changelogen": "^0.6.2",
     "eslint": "9.x",
     "globals": "^16.4.0",
@@ -73,11 +72,6 @@
   "peerDependencies": {
     "typescript": ">=5"
   },
-  "peerDependenciesMeta": {
-    "ts-node": {
-      "optional": true
-    }
-  },
   "dependencies": {
     "minimatch": "^10.1.1"
   },
diff --git a/src/transformer.ts b/src/transformer.ts
index e819501e..75f1fe73 100755
--- a/src/transformer.ts
+++ b/src/transformer.ts
@@ -11,7 +11,7 @@ import {
   type TsTransformPathsContext,
   type VisitorContext,
 } from "./types.ts";
-import { createSyntheticEmitHost, getTsNodeRegistrationProperties } from "./utils/ts-helpers.ts";
+import { createSyntheticEmitHost } from "./utils/ts-helpers.ts";
 import { nodeVisitor } from "./visitor.ts";
 
 function getTsProperties(args: Parameters<typeof transformer>) {
@@ -25,15 +25,10 @@ function getTsProperties(args: Parameters<typeof transformer>) {
   const tsInstance = extras?.ts ?? ts;
 
   if (program) compilerOptions = program.getCompilerOptions();
-  const tsNodeProps = getTsNodeRegistrationProperties(tsInstance);
 
   /* Determine RunMode & Setup */
-  // Note: ts-node passes a Program with the paths property stripped, so we do some comparison to determine if it's the caller
-  const isTsNode =
-    tsNodeProps && (!program || compilerOptions!.configFilePath === tsNodeProps.compilerOptions.configFilePath);
-
   // RunMode: Program
-  if (program && !isTsNode) {
+  if (program) {
     runMode = RunMode.Program;
     compilerOptions = compilerOptions!;
   }
@@ -42,30 +37,10 @@ function getTsProperties(args: Parameters<typeof transformer>) {
     runMode = RunMode.Manual;
     fileNames = manualTransformOptions.fileNames;
     compilerOptions = manualTransformOptions.compilerOptions!;
-  }
-  // RunMode: TsNode
-  else if (isTsNode) {
-    fileNames = tsNodeProps.fileNames;
-    runMode = RunMode.TsNode;
-
-    tsNodeState =
-      !program ||
-      (fileNames.length > 1 && program?.getRootFileNames().length === 1) ||
-      (!compilerOptions!.paths && tsNodeProps!.compilerOptions.paths)
-        ? TsNodeState.Stripped
-        : TsNodeState.Full;
-
-    compilerOptions =
-      tsNodeState === TsNodeState.Full
-        ? compilerOptions!
-        : {
-            ...program?.getCompilerOptions(),
-            ...tsNodeProps!.compilerOptions,
-          };
   } else {
     throw new Error(
-      `Cannot transform without a Program, ts-node instance, or manual parameters supplied. ` +
-        `Make sure you're using ts-patch or ts-node with transpileOnly.`,
+      `Cannot transform without a Program or manual parameters supplied. ` +
+        `Make sure you're using ts-patch with transpileOnly.`,
     );
   }
 
diff --git a/src/types.ts b/src/types.ts
index 2ac1a938..09644a06 100755
--- a/src/types.ts
+++ b/src/types.ts
@@ -62,7 +62,6 @@ export interface VisitorContext extends TsTransformPathsContext {
 /* ****************************************************************************************************************** */
 
 export const RunMode = {
-  TsNode: "ts-node",
   Manual: "manual",
   Program: "program",
 };
diff --git a/src/utils/ts-helpers.ts b/src/utils/ts-helpers.ts
index a1d42514..cdc45ce7 100755
--- a/src/utils/ts-helpers.ts
+++ b/src/utils/ts-helpers.ts
@@ -1,6 +1,5 @@
 import path from "node:path";
 
-import type { REGISTER_INSTANCE } from "ts-node";
 import type ts from "typescript";
 import type { GetCanonicalFileName, SourceFile } from "typescript";
 
@@ -74,28 +73,4 @@ export function createSyntheticEmitHost(
   } as ts.EmitHost;
 }
 
-/** Get ts-node register info */
-export function getTsNodeRegistrationProperties(tsInstance: typeof ts) {
-  let tsNodeSymbol: typeof REGISTER_INSTANCE;
-  try {
-    // eslint-disable-next-line @typescript-eslint/no-require-imports
-    tsNodeSymbol = require("ts-node")?.["REGISTER_INSTANCE"];
-  } catch {
-    return;
-  }
-
-  if (!global.process[tsNodeSymbol]) return;
-
-  const { config, options } = global.process[tsNodeSymbol]!;
-
-  const { configFilePath } = config.options;
-  // @ts-expect-error TS(2345) FIXME: Argument of type 'System' is not assignable to parameter of type 'ParseConfigFileHost'.
-  const pcl = configFilePath ? tsInstance.getParsedCommandLineOfConfigFile(configFilePath, {}, tsInstance.sys) : void 0;
-
-  const fileNames = pcl?.fileNames || config.fileNames;
-  const compilerOptions = Object.assign({}, config.options, options.compilerOptions, { outDir: pcl?.options.outDir });
-
-  return { compilerOptions, fileNames, tsNodeOptions: options };
-}
-
 // endregion
diff --git a/test/projects/extras/tsconfig.json b/test/projects/extras/tsconfig.json
index edd6eb8b..ee670fa3 100755
--- a/test/projects/extras/tsconfig.json
+++ b/test/projects/extras/tsconfig.json
@@ -1,10 +1,6 @@
 {
   "include": ["src"],
 
-  "ts-node": {
-    "require": ["typescript-transform-paths/register"]
-  },
-
   "compilerOptions": {
     "noEmit": true,
     "outDir": "dist",
diff --git a/test/yarn.lock b/test/yarn.lock
index cf4b0899..321e19d6 100644
--- a/test/yarn.lock
+++ b/test/yarn.lock
@@ -1334,9 +1334,6 @@ __metadata:
     minimatch: "npm:^10.1.1"
   peerDependencies:
     typescript: ">=5"
-  peerDependenciesMeta:
-    ts-node:
-      optional: true
   languageName: node
   linkType: soft
 
diff --git a/yarn.lock b/yarn.lock
index ddb3b621..18f9f47d 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -5,15 +5,6 @@ __metadata:
   version: 8
   cacheKey: 10c0
 
-"@cspotcode/source-map-support@npm:^0.8.0":
-  version: 0.8.1
-  resolution: "@cspotcode/source-map-support@npm:0.8.1"
-  dependencies:
-    "@jridgewell/trace-mapping": "npm:0.3.9"
-  checksum: 10c0/05c5368c13b662ee4c122c7bfbe5dc0b613416672a829f3e78bc49a357a197e0218d6e74e7c66cfcd04e15a179acab080bd3c69658c9fbefd0e1ccd950a07fc6
-  languageName: node
-  linkType: hard
-
 "@eslint-community/eslint-utils@npm:^4.2.0, @eslint-community/eslint-utils@npm:^4.7.0":
   version: 4.7.0
   resolution: "@eslint-community/eslint-utils@npm:4.7.0"
@@ -161,30 +152,6 @@ __metadata:
   languageName: node
   linkType: hard
 
-"@jridgewell/resolve-uri@npm:^3.0.3":
-  version: 3.1.2
-  resolution: "@jridgewell/resolve-uri@npm:3.1.2"
-  checksum: 10c0/d502e6fb516b35032331406d4e962c21fe77cdf1cbdb49c6142bcbd9e30507094b18972778a6e27cbad756209cfe34b1a27729e6fa08a2eb92b33943f680cf1e
-  languageName: node
-  linkType: hard
-
-"@jridgewell/sourcemap-codec@npm:^1.4.10":
-  version: 1.5.0
-  resolution: "@jridgewell/sourcemap-codec@npm:1.5.0"
-  checksum: 10c0/2eb864f276eb1096c3c11da3e9bb518f6d9fc0023c78344cdc037abadc725172c70314bdb360f2d4b7bffec7f5d657ce006816bc5d4ecb35e61b66132db00c18
-  languageName: node
-  linkType: hard
-
-"@jridgewell/trace-mapping@npm:0.3.9":
-  version: 0.3.9
-  resolution: "@jridgewell/trace-mapping@npm:0.3.9"
-  dependencies:
-    "@jridgewell/resolve-uri": "npm:^3.0.3"
-    "@jridgewell/sourcemap-codec": "npm:^1.4.10"
-  checksum: 10c0/fa425b606d7c7ee5bfa6a31a7b050dd5814b4082f318e0e4190f991902181b4330f43f4805db1dd4f2433fd0ed9cc7a7b9c2683f1deeab1df1b0a98b1e24055b
-  languageName: node
-  linkType: hard
-
 "@nodelib/fs.scandir@npm:2.1.5":
   version: 2.1.5
   resolution: "@nodelib/fs.scandir@npm:2.1.5"
@@ -219,34 +186,6 @@ __metadata:
   languageName: node
   linkType: hard
 
-"@tsconfig/node10@npm:^1.0.7":
-  version: 1.0.11
-  resolution: "@tsconfig/node10@npm:1.0.11"
-  checksum: 10c0/28a0710e5d039e0de484bdf85fee883bfd3f6a8980601f4d44066b0a6bcd821d31c4e231d1117731c4e24268bd4cf2a788a6787c12fc7f8d11014c07d582783c
-  languageName: node
-  linkType: hard
-
-"@tsconfig/node12@npm:^1.0.7":
-  version: 1.0.11
-  resolution: "@tsconfig/node12@npm:1.0.11"
-  checksum: 10c0/dddca2b553e2bee1308a056705103fc8304e42bb2d2cbd797b84403a223b25c78f2c683ec3e24a095e82cd435387c877239bffcb15a590ba817cd3f6b9a99fd9
-  languageName: node
-  linkType: hard
-
-"@tsconfig/node14@npm:^1.0.0":
-  version: 1.0.3
-  resolution: "@tsconfig/node14@npm:1.0.3"
-  checksum: 10c0/67c1316d065fdaa32525bc9449ff82c197c4c19092b9663b23213c8cbbf8d88b6ed6a17898e0cbc2711950fbfaf40388938c1c748a2ee89f7234fc9e7fe2bf44
-  languageName: node
-  linkType: hard
-
-"@tsconfig/node16@npm:^1.0.2":
-  version: 1.0.4
-  resolution: "@tsconfig/node16@npm:1.0.4"
-  checksum: 10c0/05f8f2734e266fb1839eb1d57290df1664fe2aa3b0fdd685a9035806daa635f7519bf6d5d9b33f6e69dd545b8c46bd6e2b5c79acb2b1f146e885f7f11a42a5bb
-  languageName: node
-  linkType: hard
-
 "@types/debug@npm:^4.0.0":
   version: 4.1.12
   resolution: "@types/debug@npm:4.1.12"
@@ -319,44 +258,6 @@ __metadata:
   languageName: node
   linkType: hard
 
-"@types/ts-node@npm:ts-node@^10.9.2":
-  version: 10.9.2
-  resolution: "ts-node@npm:10.9.2"
-  dependencies:
-    "@cspotcode/source-map-support": "npm:^0.8.0"
-    "@tsconfig/node10": "npm:^1.0.7"
-    "@tsconfig/node12": "npm:^1.0.7"
-    "@tsconfig/node14": "npm:^1.0.0"
-    "@tsconfig/node16": "npm:^1.0.2"
-    acorn: "npm:^8.4.1"
-    acorn-walk: "npm:^8.1.1"
-    arg: "npm:^4.1.0"
-    create-require: "npm:^1.1.0"
-    diff: "npm:^4.0.1"
-    make-error: "npm:^1.1.1"
-    v8-compile-cache-lib: "npm:^3.0.1"
-    yn: "npm:3.1.1"
-  peerDependencies:
-    "@swc/core": ">=1.2.50"
-    "@swc/wasm": ">=1.2.50"
-    "@types/node": "*"
-    typescript: ">=2.7"
-  peerDependenciesMeta:
-    "@swc/core":
-      optional: true
-    "@swc/wasm":
-      optional: true
-  bin:
-    ts-node: dist/bin.js
-    ts-node-cwd: dist/bin-cwd.js
-    ts-node-esm: dist/bin-esm.js
-    ts-node-script: dist/bin-script.js
-    ts-node-transpile-only: dist/bin-transpile.js
-    ts-script: dist/bin-script-deprecated.js
-  checksum: 10c0/5f29938489f96982a25ba650b64218e83a3357d76f7bede80195c65ab44ad279c8357264639b7abdd5d7e75fc269a83daa0e9c62fd8637a3def67254ecc9ddc2
-  languageName: node
-  linkType: hard
-
 "@types/unist@npm:*, @types/unist@npm:^3.0.0":
   version: 3.0.3
   resolution: "@types/unist@npm:3.0.3"
@@ -510,16 +411,7 @@ __metadata:
   languageName: node
   linkType: hard
 
-"acorn-walk@npm:^8.1.1":
-  version: 8.3.3
-  resolution: "acorn-walk@npm:8.3.3"
-  dependencies:
-    acorn: "npm:^8.11.0"
-  checksum: 10c0/4a9e24313e6a0a7b389e712ba69b66b455b4cb25988903506a8d247e7b126f02060b05a8a5b738a9284214e4ca95f383dd93443a4ba84f1af9b528305c7f243b
-  languageName: node
-  linkType: hard
-
-"acorn@npm:^8.11.0, acorn@npm:^8.15.0, acorn@npm:^8.4.1":
+"acorn@npm:^8.15.0":
   version: 8.15.0
   resolution: "acorn@npm:8.15.0"
   bin:
@@ -556,13 +448,6 @@ __metadata:
   languageName: node
   linkType: hard
 
-"arg@npm:^4.1.0":
-  version: 4.1.3
-  resolution: "arg@npm:4.1.3"
-  checksum: 10c0/070ff801a9d236a6caa647507bdcc7034530604844d64408149a26b9e87c2f97650055c0f049abd1efc024b334635c01f29e0b632b371ac3f26130f4cf65997a
-  languageName: node
-  linkType: hard
-
 "argparse@npm:^2.0.1":
   version: 2.0.1
   resolution: "argparse@npm:2.0.1"
@@ -762,13 +647,6 @@ __metadata:
   languageName: node
   linkType: hard
 
-"create-require@npm:^1.1.0":
-  version: 1.1.1
-  resolution: "create-require@npm:1.1.1"
-  checksum: 10c0/157cbc59b2430ae9a90034a5f3a1b398b6738bf510f713edc4d4e45e169bc514d3d99dd34d8d01ca7ae7830b5b8b537e46ae8f3c8f932371b0875c0151d7ec91
-  languageName: node
-  linkType: hard
-
 "cross-spawn@npm:^7.0.6":
   version: 7.0.6
   resolution: "cross-spawn@npm:7.0.6"
@@ -862,13 +740,6 @@ __metadata:
   languageName: node
   linkType: hard
 
-"diff@npm:^4.0.1":
-  version: 4.0.2
-  resolution: "diff@npm:4.0.2"
-  checksum: 10c0/81b91f9d39c4eaca068eb0c1eb0e4afbdc5bb2941d197f513dd596b820b956fef43485876226d65d497bebc15666aa2aa82c679e84f65d5f2bfbf14ee46e32c1
-  languageName: node
-  linkType: hard
-
 "dotenv@npm:^17.2.3":
   version: 17.2.3
   resolution: "dotenv@npm:17.2.3"
@@ -1380,13 +1251,6 @@ __metadata:
   languageName: node
   linkType: hard
 
-"make-error@npm:^1.1.1":
-  version: 1.3.6
-  resolution: "make-error@npm:1.3.6"
-  checksum: 10c0/171e458d86854c6b3fc46610cfacf0b45149ba043782558c6875d9f42f222124384ad0b468c92e996d815a8a2003817a710c0a160e49c1c394626f76fa45396f
-  languageName: node
-  linkType: hard
-
 "mdast-util-from-markdown@npm:^2.0.0":
   version: 2.0.1
   resolution: "mdast-util-from-markdown@npm:2.0.1"
@@ -2133,7 +1997,6 @@ __metadata:
     "@types/minimatch": "npm:^5.1.2"
     "@types/node": "npm:^24.3.0"
     "@types/ts-expose-internals": "npm:ts-expose-internals@4.9.5"
-    "@types/ts-node": "npm:ts-node@^10.9.2"
     changelogen: "npm:^0.6.2"
     eslint: "npm:9.x"
     globals: "npm:^16.4.0"
@@ -2145,9 +2008,6 @@ __metadata:
     typescript-eslint: "npm:^8.3.0"
   peerDependencies:
     typescript: ">=5"
-  peerDependenciesMeta:
-    ts-node:
-      optional: true
   languageName: unknown
   linkType: soft
 
@@ -2203,13 +2063,6 @@ __metadata:
   languageName: node
   linkType: hard
 
-"v8-compile-cache-lib@npm:^3.0.1":
-  version: 3.0.1
-  resolution: "v8-compile-cache-lib@npm:3.0.1"
-  checksum: 10c0/bdc36fb8095d3b41df197f5fb6f11e3a26adf4059df3213e3baa93810d8f0cc76f9a74aaefc18b73e91fe7e19154ed6f134eda6fded2e0f1c8d2272ed2d2d391
-  languageName: node
-  linkType: hard
-
 "which@npm:^2.0.1":
   version: 2.0.2
   resolution: "which@npm:2.0.2"
@@ -2248,13 +2101,6 @@ __metadata:
   languageName: node
   linkType: hard
 
-"yn@npm:3.1.1":
-  version: 3.1.1
-  resolution: "yn@npm:3.1.1"
-  checksum: 10c0/0732468dd7622ed8a274f640f191f3eaf1f39d5349a1b72836df484998d7d9807fbea094e2f5486d6b0cd2414aad5775972df0e68f8604db89a239f0f4bf7443
-  languageName: node
-  linkType: hard
-
 "yocto-queue@npm:^0.1.0":
   version: 0.1.0
   resolution: "yocto-queue@npm:0.1.0"