diff --git a/.github/workflows/ci-e2e.yml b/.github/workflows/ci-e2e.yml
new file mode 100644
index 000000000..ae992c652
--- /dev/null
+++ b/.github/workflows/ci-e2e.yml
@@ -0,0 +1,76 @@
+name: E2E testing
+
+on:
+  push:
+    branches: [main, "release/*"]
+  pull_request:
+    branches: [main, "release/*"]
+
+defaults:
+  run:
+    shell: bash
+
+jobs:
+  pytester:
+    runs-on: ${{ matrix.os }}
+    strategy:
+      fail-fast: false
+      matrix:
+        os: ["ubuntu-latest"]
+        python-version: ["3.9", "3.10", "3.11"]
+        include:
+          - { os: "macos-latest", python-version: "3.11" }
+          - { os: "windows-latest", python-version: "3.11" }
+
+    timeout-minutes: 35
+    env:
+      TORCH_URL: "https://download.pytorch.org/whl/cpu/torch_stable.html"
+
+    steps:
+      - uses: actions/checkout@v4
+      - name: Install uv and setup python
+        uses: astral-sh/setup-uv@v6
+        with:
+          activate-environment: true
+          python-version: ${{ matrix.python-version }}
+          enable-cache: true
+
+      - name: Install package
+        run: |
+          uv sync --all-extras --dev
+          uv pip list
+
+      - name: Tests
+        timeout-minutes: 15
+        run: |
+          pytest --cov=litserve src/ tests/e2e/ -v -s --durations=100
+
+      - name: Statistics
+        run: |
+          coverage report
+          coverage xml
+
+      # e2e's are server-client tests via REST, so we don't need to upload coverage to Codecov
+      # - name: Upload coverage to Codecov
+      #   uses: codecov/codecov-action@v5
+      #   with:
+      #     token: ${{ secrets.CODECOV_TOKEN }}
+      #     file: ./coverage.xml
+      #     flags: unittests
+      #     env_vars: OS,PYTHON
+      #     name: codecov-umbrella
+      #     fail_ci_if_error: false
+
+  tests-guardian:
+    runs-on: ubuntu-latest
+    needs: pytester
+    if: always()
+    steps:
+      - run: echo "${{ needs.pytester.result }}"
+      - name: failing...
+        if: needs.pytester.result == 'failure'
+        run: exit 1
+      - name: cancelled or skipped...
+        if: contains(fromJSON('["cancelled", "skipped"]'), needs.pytester.result)
+        timeout-minutes: 1
+        run: sleep 90
diff --git a/.github/workflows/ci-testing.yml b/.github/workflows/ci-testing.yml
index 3e0de0480..fc7491598 100644
--- a/.github/workflows/ci-testing.yml
+++ b/.github/workflows/ci-testing.yml
@@ -58,7 +58,7 @@ jobs:
       - name: Tests
         timeout-minutes: 15
         run: |
-          pytest --cov=litserve src/ tests/ -v -s --durations=100
+          pytest --cov=litserve src/ tests/ -v -s --durations=100 -m "not e2e"
 
       - name: Statistics
         run: |