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Matthias Heyden joined Arizona State University's School of Molecular Sciences in 2017. Prior appointments include a research group leader
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position at the Max-Planck-Institut für Kohlenforschung and the Cluster of Excellence RESOLV, and as a postdoctoral researcher at the University
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of California, Irvine.
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His group uses computer simulations to gain atomistic insights into molecular systems. A main focus of this work is to understand the process of
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solvation of small solutes (ions, alcohols and metabolites) up to large biopolymers (proteins and nucleic acids). Another avenue of his research
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is in the analysis of correlated vibrational motion in biomolecular liquids, which provide rich information on the propagation of energy and local
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density fluctuations within the system (i.e. sound propagation). These simulations can be compared to coherent scattering experiments with neutrons
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or x-rays, but the computer models allow further to isolate the correlations between specific components of the system and to follow time- and space
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correlations of atomic vibrations with spatial resolution. This provides entirely new insights into the dynamic coupling of low-frequency intermolecular
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vibrations in liquids and between biomolecules and their surrounding solvent. In addition, the Heyden lab develops novel methods to simulate biomolecular
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solutions on a large scale including 100s to 1000s of flexible proteins or polymers. These approaches provide insights into the complex interactions
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between biomolecules in realistic, crowded environments resembling the interior of living cells.
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