diff --git a/Makefile b/Makefile
index 146f24b..2071da2 100644
--- a/Makefile
+++ b/Makefile
@@ -1,15 +1,14 @@
 init:
-	pip install numpy ; \
-  pip install -r requirements.txt
+	poetry install
 
 test:
-	python -m unittest discover
+	poetry run pytest
 
 install_develop:
-	python setup.py develop
+	poetry install
 
 install:
-	python setup.py install
+	poetry install --no-dev
 
 documentation:
-	sphinx-apidoc -e -f DeepLearningBatchGeneratorUtils -o doc/
+	poetry run sphinx-apidoc -e -f DeepLearningBatchGeneratorUtils -o doc/
diff --git a/poetry.lock b/poetry.lock
new file mode 100644
index 0000000..c773874
--- /dev/null
+++ b/poetry.lock
@@ -0,0 +1,1037 @@
+[[package]]
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+description = "A configurable sidebar-enabled Sphinx theme"
+category = "dev"
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+
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+optional = false
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+
+[[package]]
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+version = "20.3.0"
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+category = "dev"
+optional = false
+python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*"
+
+[package.extras]
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+tests_no_zope = ["coverage[toml] (>=5.0.2)", "hypothesis", "pympler", "pytest (>=4.3.0)", "six"]
+
+[[package]]
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+version = "2.9.0"
+description = "Internationalization utilities"
+category = "dev"
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+
+[package.dependencies]
+pytz = ">=2015.7"
+
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+name = "certifi"
+version = "2020.12.5"
+description = "Python package for providing Mozilla's CA Bundle."
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+
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+version = "4.0.0"
+description = "Universal encoding detector for Python 2 and 3"
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+optional = false
+python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*"
+
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+[package.dependencies]
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+version = "20.9"
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+[package.dependencies]
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+description = "World timezone definitions, modern and historical"
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+
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+
+[[package]]
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+sphinxcontrib-qthelp = "*"
+sphinxcontrib-serializinghtml = "*"
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+[package.extras]
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+    {file = "sphinxcontrib-qthelp-1.0.3.tar.gz", hash = "sha256:4c33767ee058b70dba89a6fc5c1892c0d57a54be67ddd3e7875a18d14cba5a72"},
+    {file = "sphinxcontrib_qthelp-1.0.3-py2.py3-none-any.whl", hash = "sha256:bd9fc24bcb748a8d51fd4ecaade681350aa63009a347a8c14e637895444dfab6"},
+]
+sphinxcontrib-serializinghtml = [
+    {file = "sphinxcontrib-serializinghtml-1.1.4.tar.gz", hash = "sha256:eaa0eccc86e982a9b939b2b82d12cc5d013385ba5eadcc7e4fed23f4405f77bc"},
+    {file = "sphinxcontrib_serializinghtml-1.1.4-py2.py3-none-any.whl", hash = "sha256:f242a81d423f59617a8e5cf16f5d4d74e28ee9a66f9e5b637a18082991db5a9a"},
+]
+threadpoolctl = [
+    {file = "threadpoolctl-2.1.0-py3-none-any.whl", hash = "sha256:38b74ca20ff3bb42caca8b00055111d74159ee95c4370882bbff2b93d24da725"},
+    {file = "threadpoolctl-2.1.0.tar.gz", hash = "sha256:ddc57c96a38beb63db45d6c159b5ab07b6bced12c45a1f07b2b92f272aebfa6b"},
+]
+tifffile = [
+    {file = "tifffile-2021.4.8-py3-none-any.whl", hash = "sha256:1cfc55f5b728e200142580a7bf108b72775c4097d007b4111876559fa1fb7432"},
+    {file = "tifffile-2021.4.8.tar.gz", hash = "sha256:55aa8baad38e1567c9fe450fff52160e4a21294a612f241c5e414da80f87209b"},
+]
+toml = [
+    {file = "toml-0.10.2-py2.py3-none-any.whl", hash = "sha256:806143ae5bfb6a3c6e736a764057db0e6a0e05e338b5630894a5f779cabb4f9b"},
+    {file = "toml-0.10.2.tar.gz", hash = "sha256:b3bda1d108d5dd99f4a20d24d9c348e91c4db7ab1b749200bded2f839ccbe68f"},
+]
+typing-extensions = [
+    {file = "typing_extensions-3.7.4.3-py2-none-any.whl", hash = "sha256:dafc7639cde7f1b6e1acc0f457842a83e722ccca8eef5270af2d74792619a89f"},
+    {file = "typing_extensions-3.7.4.3-py3-none-any.whl", hash = "sha256:7cb407020f00f7bfc3cb3e7881628838e69d8f3fcab2f64742a5e76b2f841918"},
+    {file = "typing_extensions-3.7.4.3.tar.gz", hash = "sha256:99d4073b617d30288f569d3f13d2bd7548c3a7e4c8de87db09a9d29bb3a4a60c"},
+]
+urllib3 = [
+    {file = "urllib3-1.26.4-py2.py3-none-any.whl", hash = "sha256:2f4da4594db7e1e110a944bb1b551fdf4e6c136ad42e4234131391e21eb5b0df"},
+    {file = "urllib3-1.26.4.tar.gz", hash = "sha256:e7b021f7241115872f92f43c6508082facffbd1c048e3c6e2bb9c2a157e28937"},
+]
+zipp = [
+    {file = "zipp-3.4.1-py3-none-any.whl", hash = "sha256:51cb66cc54621609dd593d1787f286ee42a5c0adbb4b29abea5a63edc3e03098"},
+    {file = "zipp-3.4.1.tar.gz", hash = "sha256:3607921face881ba3e026887d8150cca609d517579abe052ac81fc5aeffdbd76"},
+]
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 0000000..dbb2b9b
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,34 @@
+[tool.poetry]
+name = "batchgenerators"
+version = "0.21"
+description = "Data augmentation toolkit"
+authors = ["Division of Medical Image Computing, German Cancer Research Center <f.isensee@dkfz-heidelberg.de>"]
+license = "Apache License Version 2.0, January 2004"
+readme = "Readme.md"
+repository = "https://github.com/MIC-DKFZ/batchgenerators"
+keywords=[
+    'deep learning',
+    'image segmentation',
+    'image classification',
+    'medical image analysis',
+    'medical image segmentation',
+    'data augmentation'
+]
+
+[tool.poetry.dependencies]
+python = "^3.7"
+Pillow = ">=7.1.2"
+numpy = ">=1.10.2"
+scipy = "*"
+scikit-image = "*"
+scikit-learn = "*"
+future = "*"
+threadpoolctl = "*"
+
+[tool.poetry.dev-dependencies]
+pytest = "^6.2.3"
+Sphinx = "^3.5.4"
+
+[build-system]
+requires = ["poetry-core>=1.0.0"]
+build-backend = "poetry.core.masonry.api"
diff --git a/requirements.txt b/requirements.txt
deleted file mode 100644
index 4eecc7c..0000000
--- a/requirements.txt
+++ /dev/null
@@ -1,7 +0,0 @@
-pillow>=7.1.2
-threadpoolctl
-scikit-learn
-numpy>=1.10.2
-scipy
-scikit-image
-scikit-learn
diff --git a/setup.cfg b/setup.cfg
deleted file mode 100644
index 224a779..0000000
--- a/setup.cfg
+++ /dev/null
@@ -1,2 +0,0 @@
-[metadata]
-description-file = README.md
\ No newline at end of file
diff --git a/setup.py b/setup.py
deleted file mode 100755
index ef0def0..0000000
--- a/setup.py
+++ /dev/null
@@ -1,24 +0,0 @@
-from setuptools import setup, find_packages
-
-setup(name='batchgenerators',
-      version='0.21',
-      description='Data augmentation toolkit',
-      url='https://github.com/MIC-DKFZ/batchgenerators',
-      author='Division of Medical Image Computing, German Cancer Research Center',
-      author_email='f.isensee@dkfz-heidelberg.de',
-      license='Apache License Version 2.0, January 2004',
-      packages=find_packages(exclude=["tests"]),
-      install_requires=[
-            "pillow>=7.1.2",
-            "numpy>=1.10.2",
-            "scipy",
-            "scikit-image",
-            "scikit-learn",
-            "future",
-            "unittest2",
-            "threadpoolctl"
-      ],
-      keywords=['deep learning', 'image segmentation', 'image classification', 'medical image analysis',
-                  'medical image segmentation', 'data augmentation'],
-      download_url="https://github.com/MIC-DKFZ/batchgenerators/archive/v0.19.5.tar.gz"
-      )
diff --git a/tests/test_axis_mirroring.py b/tests/test_axis_mirroring.py
index 1b4598c..19465e2 100644
--- a/tests/test_axis_mirroring.py
+++ b/tests/test_axis_mirroring.py
@@ -12,8 +12,6 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 import unittest
-
-import unittest2
 import numpy as np
 from skimage import data
 
@@ -22,7 +20,7 @@
 from batchgenerators.transforms.spatial_transforms import MirrorTransform
 
 
-class TestMirrorAxis(unittest2.TestCase):
+class TestMirrorAxis(unittest.TestCase):
     def setUp(self):
         self.seed = 1234