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@@ -60,7 +60,7 @@ The workflow is built using [snakemake](https://snakemake.readthedocs.io/en/stab
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6. Return report as HTML and PDF files (`weasyprint`)
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7. Export module logs and versions
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If you want to contribute, report issues, or suggest features, please get in touch on [github](https://github.com/MPUSP/snakemake-crispr-guides).
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If you want to contribute, report issues, or suggest features, please get in touch on [GitHub](https://github.com/MPUSP/snakemake-crispr-guides).
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## Deployment options
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@@ -134,7 +134,7 @@ The list of available on-target scores in the [R crisprScore package](https://gi
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Another good reason to exclude some scores are the computational resources they require. Particularly deep learning-derived scores are calculated by machine learning models that require both a lot of extra resources in terms of disk space (downloaded and installed _via_`basilisk` and `conda` environments) and processing power (orders of magnitude longer computation time).
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Users can look up all available scores on the [R crisprScore github page](https://github.com/crisprVerse/crisprScore) and decide which ones should be included. In addition, the default behavior of the pipeline is to compute an average score and select the top N guides based on it. The average score is the _weighted mean_ of all single scores and the `score_weights` can be defined in the `config/config.yml` file. If a score should be excluded from the ranking, it's weight can simply be set to zero.
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Users can look up all available scores on the [R crisprScore GitHub page](https://github.com/crisprVerse/crisprScore) and decide which ones should be included. In addition, the default behavior of the pipeline is to compute an average score and select the top N guides based on it. The average score is the _weighted mean_ of all single scores and the `score_weights` can be defined in the `config/config.yml` file. If a score should be excluded from the ranking, it's weight can simply be set to zero.
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The default scores are:
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@@ -201,7 +201,7 @@ The workflow generates the following output from its modules:
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- Dr. Michael Jahn
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- Affiliation: [Max-Planck-Unit for the Science of Pathogens](https://www.mpusp.mpg.de/) (MPUSP), Berlin, Germany
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@@ -78,7 +78,7 @@ The list of available on-target scores in the [R crisprScore package](https://gi
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Another good reason to exclude some scores are the computational resources they require. Particularly deep learning-derived scores are calculated by machine learning models that require both a lot of extra resources in terms of disk space (downloaded and installed _via_`basilisk` and `conda` environments) and processing power (orders of magnitude longer computation time).
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Users can look up all available scores on the [R crisprScore github page](https://github.com/crisprVerse/crisprScore) and decide which ones should be included. In addition, the default behavior of the pipeline is to compute an average score and select the top N guides based on it. The average score is the _weighted mean_ of all single scores and the `score_weights` can be defined in the `config/config.yml` file. If a score should be excluded from the ranking, it's weight can simply be set to zero.
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Users can look up all available scores on the [R crisprScore GitHub page](https://github.com/crisprVerse/crisprScore) and decide which ones should be included. In addition, the default behavior of the pipeline is to compute an average score and select the top N guides based on it. The average score is the _weighted mean_ of all single scores and the `score_weights` can be defined in the `config/config.yml` file. If a score should be excluded from the ranking, it's weight can simply be set to zero.
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