-From within the operating system of a VM, you shouldn't statically assign the *private* IP that's assigned to the Azure VM. Only do static assignment of a private IP when it's necessary, such as when [assigning many IP addresses to VMs](virtual-network-multiple-ip-addresses-portal.md). If you manually set the private IP address within the operating system, make sure it matches the private IP address assigned to the Azure [network interface](virtual-network-network-interface-addresses.md#change-ip-address-settings.md). Otherwise, you can lose connectivity to the VM. Learn more about [private IP address](virtual-network-network-interface-addresses.md#private) settings.
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