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Merge pull request #4383 from paulinbar/painbar-isolation-exclusions-fixes
Isolation exclusions: misc fixes as per PM
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defender-endpoint/isolation-exclusions.md

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ms.topic: how-to
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ms.subservice: edr
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search.appverid: met150
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ms.date: 06/22/2025
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ms.date: 07/01/2025
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---
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# Isolation exclusions (preview)
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### Prerequisites
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* Isolation exclusion is available on Windows (minimum client version 10.8470) and macOS (minimum client version 101.240902).
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* Isolation exclusion is available on Windows 11, Windows 10 version 1703 or later, Windows Server 2025, Windows Server 2022, Windows Server 2019, Windows Server 2016, Windows Server 2012 R2, and macOS.
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* Isolation exclusion must be enabled. Enabling isolation exclusion requires Security Admin or Manage Security settings permissions or above. To enable isolation exclusion, sign in to the [Microsoft Defender portal](https://security.microsoft.com) and go to **Settings** > **Endpoints** > **Advanced features** and enable **Isolation Exclusion Rules** feature.
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:::image type="content" source="./media/isolation-exclusions/enable-exclusions.png" alt-text="Screenshot showing how to enable isolation exclusions." lightbox="./media/isolation-exclusions/enable-exclusions.png":::
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defender-endpoint/respond-machine-alerts.md

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ms.author: diannegali
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author: diannegali
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ms.localizationpriority: medium
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ms.date: 04/09/2025
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ms.date: 07/01/2025
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manager: deniseb
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audience: ITPro
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ms.collection:
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- `iptables`
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- `ip6tables`
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- Linux kernel with `CONFIG_NETFILTER`, `CONFID_IP_NF_IPTABLES`, and `CONFIG_IP_NF_MATCH_OWNER`
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- Selective isolation is available for devices running Windows 10, version 1709 or later, and Windows 11. For more information about selective isolation, see [Isolation exclusions](./isolation-exclusions.md).
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- Selective isolation is available for devices running on Windows 11, Windows 10 version 1703 or later, Windows Server 2025, Windows Server 2022, Windows Server 2019, Windows Server 2016, Windows Server 2012 R2, and macOS. For more information about selective isolation, see [Isolation exclusions](./isolation-exclusions.md).
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- When isolating a device, only certain processes and destinations are allowed. Therefore, devices that are behind a full VPN tunnel won't be able to reach the Microsoft Defender for Endpoint cloud service after the device is isolated. We recommend using a split-tunneling VPN for Microsoft Defender for Endpoint and Microsoft Defender Antivirus cloud-based protection-related traffic.
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- The feature supports VPN connection.
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- You must have at least the `Active remediation actions` role assigned. For more information, see [Create and manage roles](user-roles.md).

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