> **Defining exclusions reduces the level of protection offered by Defender for Endpoint and Microsoft Defender Antivirus**. Use exclusions as a last resort, and make sure to define only the exclusions that are necessary. Make sure to review your exclusions periodically, and remove the ones you no longer need. See [Important points about exclusions](configure-exclusions-microsoft-defender-antivirus.md#important-points-about-exclusions) and [Common mistakes to avoid](common-exclusion-mistakes-microsoft-defender-antivirus.md).
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