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defender-endpoint/api/isolate-machine.md

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audience: ITPro
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ms.collection:
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- m365-security
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- tier3
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- must-keep
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ms.topic: reference
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ms.subservice: reference
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ms.custom: api
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search.appverid: met150
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ms.date: 09/26/2024
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ms.date: 02/28/2025
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---
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# Isolate machine API
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[!INCLUDE [Microsoft Defender XDR rebranding](../../includes/microsoft-defender.md)]
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**Applies to:**
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- [Microsoft Defender for Endpoint Plan 1](../microsoft-defender-endpoint.md)
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- [Microsoft Defender for Endpoint](../microsoft-defender-endpoint.md)
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- [Microsoft Defender for Endpoint Plan 1 or Plan 2](/defender-endpoint/microsoft-defender-endpoint)
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- [Microsoft Defender XDR](/defender-xdr)
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> Want to experience Defender for Endpoint? [Sign up for a free trial.](https://go.microsoft.com/fwlink/p/?linkid=2225630)
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- [Microsoft Defender for Business](/defender-business)
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[!include[Microsoft Defender for Endpoint API URIs for US Government](../../includes/microsoft-defender-api-usgov.md)]
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> [!IMPORTANT]
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> - Full isolation is available for devices on Windows 10, version 1703, and on Windows 11.
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> - Full isolation is available in **public preview** for all supported Microsoft Defender for Endpoint on Linux listed in [System requirements](../microsoft-defender-endpoint-linux.md#system-requirements).
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> - Full isolation is available for all supported Linux devices. See [Microsoft Defender for Endpoint on Linux](/defender-endpoint/microsoft-defender-endpoint-linux).
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> - Selective isolation is available for devices on Windows 10, version 1709 or later, and on Windows 11.
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> - When isolating a device, only certain processes and destinations are allowed. Therefore, devices that are behind a full VPN tunnel won't be able to reach the Microsoft Defender for Endpoint cloud service after the device is isolated. We recommend using a split-tunneling VPN for Microsoft Defender for Endpoint and Microsoft Defender Antivirus cloud-based protection-related traffic.
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> - Calling this API on unmanaged devices triggers the [contain device from the network](../respond-machine-alerts.md#contain-devices-from-the-network) action.
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## Permissions
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One of the following permissions is required to call this API. To learn more, including how to choose permissions, see [Use Microsoft Defender for Endpoint APIs](apis-intro.md)

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