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- Full isolation is available for devices on Windows 10, version 1703, and on Windows 11.
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> - Full isolation is available for devices on Windows 10, version 1703, and on Windows 11.
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> - Full isolation is available for all supported Microsoft Defender for Endpoint on Linux listed in [System requirements](../microsoft-defender-endpoint-linux.md#system-requirements).
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- Selective isolation is available for devices on Windows 10, version 1709 or later, and on Windows 11.
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- When isolating a device, only certain processes and destinations are allowed. Therefore, devices that are behind a full VPN tunnel won't be able to reach the Microsoft Defender for Endpoint cloud service after the device is isolated. We recommend using a split-tunneling VPN for Microsoft Defender for Endpoint and Microsoft Defender Antivirus cloud-based protection-related traffic.
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- Calling this API on unmanaged devices triggers the [contain device from the network](../respond-machine-alerts.md#contain-devices-from-the-network) action.
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> - Selective isolation is available for devices on Windows 10, version 1709 or later, and on Windows 11.
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> - When isolating a device, only certain processes and destinations are allowed. Therefore, devices that are behind a full VPN tunnel won't be able to reach the Microsoft Defender for Endpoint cloud service after the device is isolated. We recommend using a split-tunneling VPN for Microsoft Defender for Endpoint and Microsoft Defender Antivirus cloud-based protection-related traffic.
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> - Calling this API on unmanaged devices triggers the [contain device from the network](../respond-machine-alerts.md#contain-devices-from-the-network) action.
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