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@@ -337,7 +337,7 @@ The leading edge column has three values:
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- signal: They contribute 40% of the enrichment signal, highlighting their importance in driving the association between this gene set and the biological phenotype being studied.
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#### **Challenge:** How different ranking metrics impact the output? {- .challenge}
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#### **Challenge:** How do different ranking metrics impact the output? {- .challenge}
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Run GSEA analysis using Hallmark gene sets with two metrics (tTest and Ratio_of_Classes). What are the upregulated terms (FDR < 0.1) in the `Diff` class, based on the t-test and Ratio of Classes metrics?
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@@ -358,3 +358,10 @@ Why might the HALLMARK_CHOLESTEROL_HOMEOSTASIS gene set be upregulated specifica
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Reactome is an open-source database of curated biological pathways across species, offering pathway maps and enrichment tools to analyse gene lists in a pathway-focused context. It’s ideal for visualising data within established biochemical and cellular processes.
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