Occasionally sequencing providers return I1 and I2 FASTQ files (index and/or UMIs) along with the typical paired end R1/R2 files.
While some Laxy pipelines may accept these, the current nf-core/rnaseq pipeline does not.
For nf-core/rnaseq (and maybe others), if _I1_ or _I2_ is detected in the filename, show a prominent warning that these are likely not the files you should be using. Possibly with a "I'm sure, go ahead" checkbox that must be ticked to continue.