diff --git a/.github/workflows/base-e2e-backendtest.yml b/.github/workflows/base-e2e-backendtest.yml
index 537955857..bdc2489eb 100644
--- a/.github/workflows/base-e2e-backendtest.yml
+++ b/.github/workflows/base-e2e-backendtest.yml
@@ -78,8 +78,6 @@ jobs:
       - name: Get E2e Test Variables
         run: |
           AWS_WORKSPACE="${SANDBOX}"
-          API_URL="api-${SANDBOX}.access-request-fulfilment.patient-deductions.nhs.uk"
-          echo "NDR_API_ENDPOINT=$API_URL" >> $GITHUB_ENV
           echo "AWS_WORKSPACE=$AWS_WORKSPACE" >> $GITHUB_ENV
         env:
           SANDBOX: ${{ inputs.sandbox }}
diff --git a/.github/workflows/full-deploy-to-pre-prod.yml b/.github/workflows/full-deploy-to-pre-prod.yml
index 51e97fea3..d1b261cb9 100644
--- a/.github/workflows/full-deploy-to-pre-prod.yml
+++ b/.github/workflows/full-deploy-to-pre-prod.yml
@@ -135,3 +135,15 @@ jobs:
       sandbox: pre-prod
     secrets:
       AWS_ASSUME_ROLE: ${{ secrets.AWS_ASSUME_ROLE }}
+
+  run_backend_e2e_tests:
+    name: Run E2E Tests
+    needs: ["deploy_all_lambdas"]
+    uses: ./.github/workflows/ndr-e2e-test-sandbox.yml
+    with:
+      build_branch: ${{ needs.tag_and_release.outputs.version }}
+      environment: pre-prod
+      sandbox: pre-prod
+    secrets:
+      AWS_ASSUME_ROLE: ${{ secrets.AWS_ASSUME_ROLE }}
+  
diff --git a/.github/workflows/lambdas-deploy-to-pre-prod.yml b/.github/workflows/lambdas-deploy-to-pre-prod.yml
index 2f68fb87c..2398bdbc0 100644
--- a/.github/workflows/lambdas-deploy-to-pre-prod.yml
+++ b/.github/workflows/lambdas-deploy-to-pre-prod.yml
@@ -65,3 +65,15 @@ jobs:
       environment: pre-prod
     secrets:
       AWS_ASSUME_ROLE: ${{ secrets.AWS_ASSUME_ROLE }}
+
+  run_backend_e2e_tests:
+    name: Run E2E Tests
+    needs: ["deploy_all"]
+    uses: ./.github/workflows/ndr-e2e-test-sandbox.yml
+    with:
+      build_branch: ${{ needs.tag_and_release.outputs.version }}
+      environment: pre-prod
+      sandbox: pre-prod
+    secrets:
+      AWS_ASSUME_ROLE: ${{ secrets.AWS_ASSUME_ROLE }}
+        
diff --git a/.github/workflows/ndr-e2e-test-sandbox.yml b/.github/workflows/ndr-e2e-test-sandbox.yml
index 458de390f..6d61a4ff0 100644
--- a/.github/workflows/ndr-e2e-test-sandbox.yml
+++ b/.github/workflows/ndr-e2e-test-sandbox.yml
@@ -19,6 +19,21 @@ on:
         type: string
         default: development
 
+  workflow_call:
+    inputs:
+      build_branch:
+        required: true
+        type: string
+      sandbox:
+        required: true
+        type: string
+      environment:
+        required: true
+        type: string
+    secrets:
+      AWS_ASSUME_ROLE:
+        required: true
+
 permissions:
   pull-requests: write
   id-token: write
diff --git a/lambdas/tests/e2e/api/fhir/conftest.py b/lambdas/tests/e2e/api/fhir/conftest.py
index 66eb02546..28e759e12 100644
--- a/lambdas/tests/e2e/api/fhir/conftest.py
+++ b/lambdas/tests/e2e/api/fhir/conftest.py
@@ -11,10 +11,10 @@
 
 pdm_data_helper = PdmDataHelper()
 
-PDM_SNOMED = 717391000000106
+PDM_SNOMED = pdm_data_helper.snomed_code
 PDM_METADATA_TABLE = pdm_data_helper.dynamo_table
 PDM_S3_BUCKET = pdm_data_helper.s3_bucket
-MTLS_ENDPOINT = os.environ.get("MTLS_ENDPOINT")
+MTLS_ENDPOINT = pdm_data_helper.mtls_endpoint
 CLIENT_CERT_PATH = os.environ.get("CLIENT_CERT_PATH")
 CLIENT_KEY_PATH = os.environ.get("CLIENT_KEY_PATH")
 
diff --git a/lambdas/tests/e2e/api/fhir/test_search_patient_fhir_api.py b/lambdas/tests/e2e/api/fhir/test_search_patient_fhir_api.py
index 1b60fda4e..3d24b0907 100644
--- a/lambdas/tests/e2e/api/fhir/test_search_patient_fhir_api.py
+++ b/lambdas/tests/e2e/api/fhir/test_search_patient_fhir_api.py
@@ -2,10 +2,11 @@
 
 from lambdas.tests.e2e.api.fhir.conftest import (
     MTLS_ENDPOINT,
+    PDM_SNOMED,
     create_and_store_pdm_record,
     create_mtls_session,
 )
-from lambdas.tests.e2e.conftest import APIM_ENDPOINT, PDM_SNOMED
+from lambdas.tests.e2e.conftest import APIM_ENDPOINT
 from lambdas.tests.e2e.helpers.data_helper import PdmDataHelper
 
 pdm_data_helper = PdmDataHelper()
@@ -31,7 +32,7 @@ def search_document_reference(nhs_number, client_cert_path=None, client_key_path
 
 
 def test_search_nonexistent_document_references_for_patient_details():
-    response = search_document_reference("9912003071")
+    response = search_document_reference("9449305943")
     assert response.status_code == 200
 
     bundle = response.json()
diff --git a/lambdas/tests/e2e/api/fhir/test_upload_document_fhir_api_success.py b/lambdas/tests/e2e/api/fhir/test_upload_document_fhir_api_success.py
index 0cdbcbad2..47ac4320d 100644
--- a/lambdas/tests/e2e/api/fhir/test_upload_document_fhir_api_success.py
+++ b/lambdas/tests/e2e/api/fhir/test_upload_document_fhir_api_success.py
@@ -4,10 +4,11 @@
 
 from lambdas.tests.e2e.api.fhir.conftest import (
     MTLS_ENDPOINT,
+    PDM_SNOMED,
     create_mtls_session,
     fetch_with_retry_mtls,
 )
-from lambdas.tests.e2e.conftest import APIM_ENDPOINT, PDM_SNOMED
+from lambdas.tests.e2e.conftest import APIM_ENDPOINT
 from lambdas.tests.e2e.helpers.data_helper import PdmDataHelper
 
 pdm_data_helper = PdmDataHelper()
diff --git a/lambdas/tests/e2e/api/test_login_api.py b/lambdas/tests/e2e/api/test_login_api.py
index 5fed15af8..107dbc082 100644
--- a/lambdas/tests/e2e/api/test_login_api.py
+++ b/lambdas/tests/e2e/api/test_login_api.py
@@ -1,9 +1,15 @@
 import pytest
+from tests.e2e.helpers.data_helper import LloydGeorgeDataHelper
 from tests.e2e.helpers.lloyd_george_mockcis2_helper import LloydGeorgeMockcis2Helper
 
 # Note this is testing a mock, but this test is valuable to ensure the login code is working for other tests
 
+data_helper = LloydGeorgeDataHelper()
 
+
+@pytest.mark.skipif(
+    data_helper.workspace == "pre-prod", reason="CIS2 login is not mocked in pre-prod"
+)
 @pytest.mark.parametrize(
     "ods_code, role_to_assume, expected_granted_role",
     [
diff --git a/lambdas/tests/e2e/api/test_upload_document_api.py b/lambdas/tests/e2e/api/test_upload_document_api.py
index e2181977b..cc9319bc2 100644
--- a/lambdas/tests/e2e/api/test_upload_document_api.py
+++ b/lambdas/tests/e2e/api/test_upload_document_api.py
@@ -165,7 +165,9 @@ def test_create_document_virus(test_data, snapshot_json):
     lloyd_george_record["nhs_number"] = "9730154260"
 
     # Attach EICAR data
-    eicar_string = r"X5O!P%@AP[4\PZX54(P^)7CC)7}$EICAR-STANDARD-ANTIVIRUS-TEST-FILE!$H+H*"
+    eicar_string = (
+        r"X5O!P%@AP[4\PZX54(P^)7CC)7}$EICAR-STANDARD-ANTIVIRUS-TEST-FILE!$H+H*"
+    )
     lloyd_george_record["data"] = base64.b64encode(eicar_string.encode()).decode()
 
     payload = create_upload_payload(lloyd_george_record)
@@ -185,14 +187,16 @@ def test_create_document_virus(test_data, snapshot_json):
     def condition(response_json):
         logging.info(response_json)
         return response_json.get("docStatus") in (
-        "cancelled",
-        "final",
+            "cancelled",
+            "final",
         )
 
     raw_retrieve_response = fetch_with_retry(retrieve_url, condition)
     retrieve_response = raw_retrieve_response.json()
 
-    assert upload_response == snapshot_json(exclude=paths("id", "date", "content.0.attachment.url"))
+    assert upload_response == snapshot_json(
+        exclude=paths("id", "date", "content.0.attachment.url")
+    )
     assert retrieve_response == snapshot_json(exclude=paths("id", "date"))
 
 
diff --git a/lambdas/tests/e2e/apim/conftest.py b/lambdas/tests/e2e/apim/conftest.py
index 9c583975e..251935e84 100644
--- a/lambdas/tests/e2e/apim/conftest.py
+++ b/lambdas/tests/e2e/apim/conftest.py
@@ -1,15 +1,11 @@
-import os
-
 import pytest
 
 from lambdas.tests.e2e.helpers.data_helper import PdmDataHelper
 
 pdm_data_helper = PdmDataHelper()
 
-PDM_METADATA_TABLE = (
-    os.environ.get("PDM_METADATA_TABLE") or "ndr-dev_COREDocumentMetadata"
-)
-PDM_S3_BUCKET = os.environ.get("PDM_S3_BUCKET") or "ndr-dev-pdm-document-store"
+PDM_METADATA_TABLE = pdm_data_helper.dynamo_table
+PDM_S3_BUCKET = pdm_data_helper.s3_bucket
 
 
 @pytest.fixture
diff --git a/lambdas/tests/e2e/apim/test_apim_client.py b/lambdas/tests/e2e/apim/test_apim_client.py
index 279afd0fc..5a7c78443 100644
--- a/lambdas/tests/e2e/apim/test_apim_client.py
+++ b/lambdas/tests/e2e/apim/test_apim_client.py
@@ -6,9 +6,8 @@
 import requests
 from tests.e2e.helpers.data_helper import PdmDataHelper
 
-from lambdas.tests.e2e.conftest import PDM_SNOMED
-
 pdm_data_helper = PdmDataHelper()
+PDM_SNOMED = pdm_data_helper.snomed_code
 
 
 def test_ping(nhsd_apim_proxy_url):
diff --git a/lambdas/tests/e2e/conftest.py b/lambdas/tests/e2e/conftest.py
index be0105915..49dcbc54e 100644
--- a/lambdas/tests/e2e/conftest.py
+++ b/lambdas/tests/e2e/conftest.py
@@ -8,18 +8,14 @@
 
 data_helper = LloydGeorgeDataHelper()
 
-LLOYD_GEORGE_SNOMED = 16521000000101
-API_ENDPOINT = os.environ.get("NDR_API_ENDPOINT")
+LLOYD_GEORGE_SNOMED = data_helper.snomed_code
+API_ENDPOINT = data_helper.api_endpoint
 API_KEY = os.environ.get("NDR_API_KEY")
 LG_METADATA_TABLE = data_helper.dynamo_table
 LG_UNSTITCHED_TABLE = os.environ.get("LG_UNSTITCHED_TABLE")
 BULK_REPORT_TABLE = os.environ.get("BULK_REPORT_TABLE")
 LLOYD_GEORGE_S3_BUCKET = data_helper.s3_bucket
 APIM_ENDPOINT = data_helper.apim_url
-PDM_SNOMED = 717391000000106
-MTLS_ENDPOINT = os.environ.get("MTLS_ENDPOINT")
-CLIENT_CERT_PATH = os.environ.get("CLIENT_CERT_PATH")
-CLIENT_KEY_PATH = os.environ.get("CLIENT_KEY_PATH")
 
 
 @pytest.fixture
diff --git a/lambdas/tests/e2e/helpers/data_helper.py b/lambdas/tests/e2e/helpers/data_helper.py
index b7b3f69d5..20656bb88 100644
--- a/lambdas/tests/e2e/helpers/data_helper.py
+++ b/lambdas/tests/e2e/helpers/data_helper.py
@@ -25,6 +25,8 @@ def __init__(
         self.dynamo_service = DynamoDBService()
         self.s3_service = S3Service()
         self.apim_url = None
+        self.api_endpoint = None
+        self.mtls_endpoint = None
 
         self.build_env(table_name, bucket_name)
 
@@ -37,10 +39,25 @@ def build_env(self, table_name, bucket_name):
         apim_map = {
             "pre-prod": "int.api.service.nhs.uk",
             "ndr-test": "internal-qa.api.service.nhs.uk",
-            "ndr-dev":  "internal-dev.api.service.nhs.uk",
-            }
-        self.apim_url = apim_map.get(str(self.workspace), "internal-dev.api.service.nhs.uk")
+            "ndr-dev": "internal-dev.api.service.nhs.uk",
+        }
+        self.apim_url = apim_map.get(
+            str(self.workspace), "internal-dev.api.service.nhs.uk"
+        )
+
+        domain = (
+            "national-document-repository.nhs.uk"
+            if self.workspace == "pre-prod"
+            else "access-request-fulfilment.patient-deductions.nhs.uk"
+        )
+
+        self.api_endpoint = (
+            f"api.{self.workspace}.{domain}"
+            if self.workspace in {"pre-prod", "ndr-test"}
+            else f"api-{self.workspace}.{domain}"
+        )
 
+        self.mtls_endpoint = f"mtls.{self.workspace}.{domain}"
 
     def build_record(
         self, nhs_number="9912003071", data=None, doc_status=None, size=None
diff --git a/lambdas/tests/e2e/helpers/lloyd_george_mockcis2_helper.py b/lambdas/tests/e2e/helpers/lloyd_george_mockcis2_helper.py
index f8f4fd6d4..fbd153e3e 100644
--- a/lambdas/tests/e2e/helpers/lloyd_george_mockcis2_helper.py
+++ b/lambdas/tests/e2e/helpers/lloyd_george_mockcis2_helper.py
@@ -4,15 +4,17 @@
 from urllib.parse import parse_qs, quote, urlparse
 
 import requests
+from tests.e2e.helpers.data_helper import LloydGeorgeDataHelper
+
+data_helper = LloydGeorgeDataHelper()
 
 
 class LloydGeorgeMockcis2Helper:
     def __init__(self, ods, repository_role):
         self.mock_key = os.environ.get("MOCK_CIS2_KEY") or ""
-        self.api_endpoint = os.environ.get("NDR_API_ENDPOINT")
+        self.api_endpoint = data_helper.api_endpoint
         self.ods = ods
         self.repository_role = repository_role
-
         pass
 
     def generate_mockcis2_token(self):
diff --git a/scripts/test/run-e2e-fhir-api-tests.sh b/scripts/test/run-e2e-fhir-api-tests.sh
index 5c1ec4467..197040ed3 100755
--- a/scripts/test/run-e2e-fhir-api-tests.sh
+++ b/scripts/test/run-e2e-fhir-api-tests.sh
@@ -35,7 +35,6 @@ fi
 source ./scripts/test/set-e2e-env-vars.sh $WORKSPACE
 
 echo "Running FHIR api E2E tests on workspace $AWS_WORKSPACE with:"
-echo "MTLS_ENDPOINT=$MTLS_ENDPOINT"
 echo "CLIENT_CERT_PATH=$CLIENT_CERT_PATH"
 echo "CLIENT_KEY_PATH=$CLIENT_KEY_PATH"
 echo "UNAUTHORISED_CLIENT_CERT_PATH=$UNAUTHORISED_CLIENT_CERT_PATH"
diff --git a/scripts/test/set-e2e-env-vars.sh b/scripts/test/set-e2e-env-vars.sh
index e4a99f757..1b74a0050 100644
--- a/scripts/test/set-e2e-env-vars.sh
+++ b/scripts/test/set-e2e-env-vars.sh
@@ -8,17 +8,7 @@ if [[ "$#" -ne 1 ]]; then
 fi
 
 WORKSPACE="$1"
-
-# Set domain
-if [[ "$WORKSPACE" = "ndr-test" || "$WORKSPACE" = "pre-prod" ]]; then
-  DOMAIN="national-document-repository.nhs.uk"
-else
-  DOMAIN="access-request-fulfilment.patient-deductions.nhs.uk"
-fi
-
-# Set environment variables
 export AWS_WORKSPACE="${WORKSPACE}"
-export MTLS_ENDPOINT="mtls.${WORKSPACE}.${DOMAIN}"
 
 # Ensure Client certificates in place
 if ! make download-api-certs WORKSPACE="${WORKSPACE}"; then