diff --git a/modules/openapi-generator/src/main/java/org/openapitools/codegen/languages/AbstractTypeScriptClientCodegen.java b/modules/openapi-generator/src/main/java/org/openapitools/codegen/languages/AbstractTypeScriptClientCodegen.java
index 69a5a6240a22..03fd19bd3b9d 100644
--- a/modules/openapi-generator/src/main/java/org/openapitools/codegen/languages/AbstractTypeScriptClientCodegen.java
+++ b/modules/openapi-generator/src/main/java/org/openapitools/codegen/languages/AbstractTypeScriptClientCodegen.java
@@ -942,9 +942,13 @@ public String toEnumVarName(String name, String datatype) {
         }
 
         // string
+        // Handle + and - signs to prevent duplicate enum keys (e.g., "Etc/GMT+12" vs "Etc/GMT-12")
+        // Replace them with descriptive names before sanitization to avoid collisions
+        varName = varName.replaceAll("\\+", "Plus");
+        varName = varName.replaceAll("-", "Minus");
+        
         if (isEnumPropertyNamingReplaceSpecialChar()) {
-            varName = varName.replaceAll("-", "_minus_");
-            varName = varName.replaceAll("\\+", "_plus_");
+            // Apply additional special character replacements if the option is enabled
             varName = varName.replaceAll("_+", "_");
         }
         varName = sanitizeName(varName);
diff --git a/modules/openapi-generator/src/test/java/org/openapitools/codegen/typescript/axios/TypeScriptAxiosEnumCollisionTest.java b/modules/openapi-generator/src/test/java/org/openapitools/codegen/typescript/axios/TypeScriptAxiosEnumCollisionTest.java
new file mode 100644
index 000000000000..632db013dfb5
--- /dev/null
+++ b/modules/openapi-generator/src/test/java/org/openapitools/codegen/typescript/axios/TypeScriptAxiosEnumCollisionTest.java
@@ -0,0 +1,40 @@
+package org.openapitools.codegen.typescript.axios;
+
+import org.openapitools.codegen.languages.TypeScriptAxiosClientCodegen;
+import org.openapitools.codegen.typescript.TypeScriptGroups;
+import org.testng.annotations.Test;
+
+import static org.testng.Assert.assertNotEquals;
+import static org.testng.Assert.assertEquals;
+
+@Test(groups = {TypeScriptGroups.TYPESCRIPT, TypeScriptGroups.TYPESCRIPT_AXIOS})
+public class TypeScriptAxiosEnumCollisionTest {
+
+    @Test
+    public void testTimezoneEnumsDontCollide() {
+        TypeScriptAxiosClientCodegen codegen = new TypeScriptAxiosClientCodegen();
+        codegen.processOpts();
+
+        // Test the problematic timezone values from issue #22074
+        String plusTwelve = codegen.toEnumVarName("Etc/GMT+12", "string");
+        String minusTwelve = codegen.toEnumVarName("Etc/GMT-12", "string");
+        
+        // These should produce different enum variable names to avoid TS1117 error
+        assertNotEquals(plusTwelve, minusTwelve, 
+            "Enum variable names for 'Etc/GMT+12' and 'Etc/GMT-12' should be different to avoid TS1117 error");
+        
+        // Test a few more cases to ensure we handle the pattern correctly
+        String plusOne = codegen.toEnumVarName("Etc/GMT+1", "string");
+        String minusOne = codegen.toEnumVarName("Etc/GMT-1", "string");
+        
+        assertNotEquals(plusOne, minusOne, 
+            "Enum variable names for 'Etc/GMT+1' and 'Etc/GMT-1' should be different");
+
+        // Verify the expected output format with our fix (using default PascalCase naming)
+        // The + and - should be converted to descriptive names
+        assertEquals(plusTwelve, "EtcGmtPlus12", "Etc/GMT+12 should become EtcGmtPlus12");
+        assertEquals(minusTwelve, "EtcGmtMinus12", "Etc/GMT-12 should become EtcGmtMinus12");
+        assertEquals(plusOne, "EtcGmtPlus1", "Etc/GMT+1 should become EtcGmtPlus1");
+        assertEquals(minusOne, "EtcGmtMinus1", "Etc/GMT-1 should become EtcGmtMinus1");
+    }
+}