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| 1 | +<?xml version="1.0" encoding="UTF-8"?> |
| 2 | + |
| 3 | +<neuroml xmlns="http://www.neuroml.org/schema/neuroml2" |
| 4 | + xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" |
| 5 | + xsi:schemaLocation="http://www.neuroml.org/schema/neuroml2 ../Schemas/NeuroML2/NeuroML_v2beta4.xsd" |
| 6 | + id="hhcell"> |
| 7 | + |
| 8 | + <!-- Single compartment cell with HH channels --> |
| 9 | + |
| 10 | + <!-- This is a "pure" NeuroML 2 file. It can be included in a LEMS file for use in a simulaton |
| 11 | + by the LEMS interpreter, see LEMS_NML2_Ex5_DetCell.xml --> |
| 12 | + |
| 13 | + <ionChannelHH id="passiveChan" conductance="10pS"> |
| 14 | + <notes>Leak conductance</notes> |
| 15 | + </ionChannelHH> |
| 16 | + |
| 17 | + |
| 18 | + <ionChannelHH id="naChan" conductance="10pS" species="na"> |
| 19 | + <notes>Na channel</notes> |
| 20 | + |
| 21 | + <gateHHrates id="m" instances="3"> |
| 22 | + <forwardRate type="HHExpLinearRate" rate="1per_ms" midpoint="-40mV" scale="10mV"/> |
| 23 | + <reverseRate type="HHExpRate" rate="4per_ms" midpoint="-65mV" scale="-18mV"/> |
| 24 | + </gateHHrates> |
| 25 | + |
| 26 | + <gateHHrates id="h" instances="1"> |
| 27 | + <forwardRate type="HHExpRate" rate="0.07per_ms" midpoint="-65mV" scale="-20mV"/> |
| 28 | + <reverseRate type="HHSigmoidRate" rate="1per_ms" midpoint="-35mV" scale="10mV"/> |
| 29 | + </gateHHrates> |
| 30 | + |
| 31 | + </ionChannelHH> |
| 32 | + |
| 33 | + |
| 34 | + <ionChannelHH id="kChan" conductance="10pS" species="k"> |
| 35 | + |
| 36 | + <gateHHrates id="n" instances="4"> |
| 37 | + <forwardRate type="HHExpLinearRate" rate="0.1per_ms" midpoint="-55mV" scale="10mV"/> |
| 38 | + <reverseRate type="HHExpRate" rate="0.125per_ms" midpoint="-65mV" scale="-80mV"/> |
| 39 | + </gateHHrates> |
| 40 | + |
| 41 | + </ionChannelHH> |
| 42 | + |
| 43 | + |
| 44 | + |
| 45 | + <cell id="hhcell"> |
| 46 | + |
| 47 | + <morphology id="morph1"> |
| 48 | + <segment id="0" name="soma"> |
| 49 | + <proximal x="0" y="0" z="0" diameter="17.841242"/> <!--Gives a convenient surface area of 1000.0 um^2--> |
| 50 | + <distal x="0" y="0" z="0" diameter="17.841242"/> |
| 51 | + </segment> |
| 52 | + |
| 53 | + <segmentGroup id="soma_group"> |
| 54 | + <member segment="0"/> |
| 55 | + </segmentGroup> |
| 56 | + |
| 57 | + </morphology> |
| 58 | + |
| 59 | + <biophysicalProperties id="bioPhys1"> |
| 60 | + |
| 61 | + <membraneProperties> |
| 62 | + |
| 63 | + <channelDensity id="leak" ionChannel="passiveChan" condDensity="3.0 S_per_m2" erev="-54.3mV" ion="non_specific"/> |
| 64 | + <channelDensity id="naChans" ionChannel="naChan" condDensity="120.0 mS_per_cm2" erev="50.0 mV" ion="na"/> |
| 65 | + <channelDensity id="kChans" ionChannel="kChan" condDensity="360 S_per_m2" erev="-77mV" ion="k"/> |
| 66 | + |
| 67 | + <spikeThresh value="-20mV"/> |
| 68 | + <specificCapacitance value="1.0 uF_per_cm2"/> |
| 69 | + <initMembPotential value="-65mV"/> |
| 70 | + |
| 71 | + </membraneProperties> |
| 72 | + |
| 73 | + <intracellularProperties> |
| 74 | + <resistivity value="0.03 kohm_cm"/> <!-- Note: not used in single compartment simulations --> |
| 75 | + </intracellularProperties> |
| 76 | + |
| 77 | + </biophysicalProperties> |
| 78 | + |
| 79 | + </cell> |
| 80 | + |
| 81 | +</neuroml> |
| 82 | + |
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