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NeuroML2/osbSessions/15.html

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<p><strong>Changing the conductance densities</strong></p>
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<p>Change...</p>
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<p>Try changing the conductance densities of some of the ion channels below.</p>
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<div class="tutorialForm center">
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<div class="tutorialLabel" style="width:300px">Transient Na<sup>+</sup> current on <strong>axon</strong> (S/cm2) <input id="axonal_gNaTa_tbar_NaTa_t" type="text" value="3.429725" style="width:200px"></input></div>
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<div class="tutorialLabel" style="width:300px">Persistent Na<sup>+</sup> current on <strong>axon</strong> (S/cm2) <input id="axonal_gNap_Et2bar_Nap_Et2" type="text" value="0.009803" style="width:100px"></input></div></br>
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<div class="tutorialLabel" style="width:300px">Fast, transient Na<sup>+</sup> conductance on <strong>axon</strong> (S/cm2) <input id="axonal_gNaTa_tbar_NaTa_t" type="text" value="3.429725"></input></div>
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<div class="tutorialLabel" style="width:300px">Persistent Na<sup>+</sup> conductance on <strong>axon</strong> (S/cm2) <input id="axonal_gNap_Et2bar_Nap_Et2" type="text" value="0.009803"></input></div>
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<div class="tutorialLabel" style="width:400px">Persistent K<sup>+</sup> current on <strong>axon</strong> (S/cm2)</div> <input id="axonal_gK_Pstbar_K_Pst" type="text" value="0.959296"></input></br>
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<div class="tutorialLabel" style="width:300px">Persistent K<sup>+</sup> conductance on <strong>axon</strong> (S/cm2)<input id="axonal_gK_Pstbar_K_Pst" type="text" value="0.959296"></input></div>
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<div class="tutorialLabel">Input current (pA)</div> <input id="iAmp" type="text" value="180"></input></br>
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<div class="tutorialLabel">Delay (ms)</div> <input id="iDel" type="text" value="700"></input></br>
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<div class="tutorialLabel">Duration (ms)</div> <input id="iDur" type="text" value="2000"></input></br>
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<div class="tutorialLabel">Input current (pA) <input id="iAmp" type="text" value="180"> </input></div>
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<div class="tutorialLabel">Delay (ms) <input id="iDel" type="text" value="700"></input></div>
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<div class="tutorialLabel">Duration (ms) <input id="iDur" type="text" value="2000"></input></div>
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<button class="btn" id="changeConds" onclick="quickExperiment('ConductanceDensities',
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);"><i class="fa fa-exclamation-circle" aria-hidden="true" style="color:#dd0000"></i> Try it!</button><br/>
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</div>
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<p>Some configurations to try:</p>
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<p><strong>&nbsp;> Remove the high transient Na<sup>+</sup> conductance on the axon</strong> <br/>
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Setting this value to 0 should lead to reduced firing frequency. However there is still a persistent Na<sup>+</sup> and so a gradual depolarisation leading to spiking...</p>
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<p><strong>&nbsp;> Remove the persistent Na<sup>+</sup> conductance on the axon</strong> <br/>
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This removes all spiking in the cell.</p>
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</div>

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