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3 | 3 | <p><strong>Changing the conductance densities</strong></p> |
4 | 4 |
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5 | 5 |
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6 | | - <p>Change...</p> |
| 6 | + <p>Try changing the conductance densities of some of the ion channels below.</p> |
7 | 7 |
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8 | 8 | <div class="tutorialForm center"> |
9 | 9 |
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10 | | - <div class="tutorialLabel" style="width:300px">Transient Na<sup>+</sup> current on <strong>axon</strong> (S/cm2) <input id="axonal_gNaTa_tbar_NaTa_t" type="text" value="3.429725" style="width:200px"></input></div> |
11 | | - <div class="tutorialLabel" style="width:300px">Persistent Na<sup>+</sup> current on <strong>axon</strong> (S/cm2) <input id="axonal_gNap_Et2bar_Nap_Et2" type="text" value="0.009803" style="width:100px"></input></div></br> |
| 10 | + <div class="tutorialLabel" style="width:300px">Fast, transient Na<sup>+</sup> conductance on <strong>axon</strong> (S/cm2) <input id="axonal_gNaTa_tbar_NaTa_t" type="text" value="3.429725"></input></div> |
| 11 | + <div class="tutorialLabel" style="width:300px">Persistent Na<sup>+</sup> conductance on <strong>axon</strong> (S/cm2) <input id="axonal_gNap_Et2bar_Nap_Et2" type="text" value="0.009803"></input></div> |
12 | 12 |
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13 | | - <div class="tutorialLabel" style="width:400px">Persistent K<sup>+</sup> current on <strong>axon</strong> (S/cm2)</div> <input id="axonal_gK_Pstbar_K_Pst" type="text" value="0.959296"></input></br> |
| 13 | + <div class="tutorialLabel" style="width:300px">Persistent K<sup>+</sup> conductance on <strong>axon</strong> (S/cm2)<input id="axonal_gK_Pstbar_K_Pst" type="text" value="0.959296"></input></div> |
14 | 14 |
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15 | 15 |
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16 | | - |
17 | | - <div class="tutorialLabel">Input current (pA)</div> <input id="iAmp" type="text" value="180"></input></br> |
18 | | - <div class="tutorialLabel">Delay (ms)</div> <input id="iDel" type="text" value="700"></input></br> |
19 | | - <div class="tutorialLabel">Duration (ms)</div> <input id="iDur" type="text" value="2000"></input></br> |
| 16 | + <div class="tutorialLabel">Input current (pA) <input id="iAmp" type="text" value="180"> </input></div> |
| 17 | + <div class="tutorialLabel">Delay (ms) <input id="iDel" type="text" value="700"></input></div> |
| 18 | + <div class="tutorialLabel">Duration (ms) <input id="iDur" type="text" value="2000"></input></div> |
20 | 19 |
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21 | 20 | <button class="btn" id="changeConds" onclick="quickExperiment('ConductanceDensities', |
22 | 21 | { |
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31 | 30 | );"><i class="fa fa-exclamation-circle" aria-hidden="true" style="color:#dd0000"></i> Try it!</button><br/> |
32 | 31 | </div> |
33 | 32 |
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| 33 | + <p>Some configurations to try:</p> |
| 34 | + |
| 35 | + <p><strong> > Remove the high transient Na<sup>+</sup> conductance on the axon</strong> <br/> |
| 36 | + Setting this value to 0 should lead to reduced firing frequency. However there is still a persistent Na<sup>+</sup> and so a gradual depolarisation leading to spiking...</p> |
| 37 | + |
| 38 | + <p><strong> > Remove the persistent Na<sup>+</sup> conductance on the axon</strong> <br/> |
| 39 | + This removes all spiking in the cell.</p> |
| 40 | + |
| 41 | + |
34 | 42 | </div> |
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