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NeuroML2/osbSessions/15.html

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<p><strong>Changing the conductance densities</strong></p>
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<p>Try changing the conductance densities of some of the ion channels below. Some scenarios to try:</p>
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<p>Try changing the conductance densities of some of the ion channels and other cellular properties below. Some scenarios to try:</p>
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<p><strong>&nbsp;> Remove the high transient Na<sup>+</sup> conductance on the axon</strong> <br/>
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Setting this value to 0 should lead to reduced firing frequency. However there is still a persistent Na<sup>+</sup> and so a gradual depolarisation leading to spiking...</p>
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Setting this value to 0 should lead to reduced firing frequency. However there is still a persistent Na<sup>+</sup> conductance on the axon and so a gradual depolarisation leading to spiking...</p>
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<p><strong>&nbsp;> Remove the persistent Na<sup>+</sup> conductance on the axon</strong> <br/>
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This removes all spiking in the cell.</p>
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<p><strong>&nbsp;> Remove the persistent Na<sup>+</sup> conductance on the axon also</strong> <br/>
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This removes all spiking in the cell</p>
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<p><strong>&nbsp;> Change the axial resistance of the cytoplasm</strong> <br/>
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Increasing this (e.g. to 100 Ohm cm) will confine spiking to axon/soma and suppress spread to rest of cell.</p>
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Increasing this (e.g. to 100 Ohm cm) will confine spiking to axon/soma and suppress spread to rest of cell</p>
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<div class="tutorialForm center">
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<div class="tutorialLabel" style="width:400px">Axial resistance (resistivity) on whole cell (ohm cm)<input id="resistivity" type="text" value="100"></input></div>
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<div class="tutorialLabel" style="width:400px">Input current (pA) <input id="iAmp" type="text" value="180"> </input></div>
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<div class="tutorialLabel" style="width:400px">Input current (pA) <input id="iAmp" type="text" value="180"></input></div>
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<div class="tutorialLabel" style="width:400px">Delay (ms) <input id="iDel" type="text" value="700"></input></div>
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<div class="tutorialLabel" style="width:400px">Duration (ms) <input id="iDur" type="text" value="2000"></input></div>
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