@@ -44,15 +44,15 @@ tutorial is available `online <https://github.com/PEtab-dev/PEtab/tree/b50d000a5
4444 == ========================== =============================================
4545 ID Reaction Rate law
4646 == ========================== =============================================
47- R1 2 STAT5A -> pApA cyt \* BaF3_Epo \* STAT5A^2 \* k_phos
48- R2 STAT5A + STAT5B -> pApB cyt \* BaF3_Epo \* STAT5A \* STAT5B \* k_phos
49- R3 2 STAT5B -> pBpB cyt \* BaF3_Epo \* STAT5B^2 \* k_phos
50- R4 pApA -> nucpApA cyt \* k_imp_homo \* pApA
51- R5 pApB -> nucpApB cyt \* k_imp_hetero \* pApB
52- R6 pBpB -> nucpBpB cyt \* k_imp_homo \* pBpB
53- R7 nucpApA -> 2 STAT5A nuc \* k_exp_homo \* nucpApA
54- R8 nucpApB -> STAT5A + STAT5B nuc \* k_exp_hetero \* nucpApB
55- R9 nucpBpB -> 2 STAT5B nuc \* k_exp_homo \* nucpBpB
47+ R1 2 STAT5A → pApA cyt \* BaF3_Epo \* STAT5A^2 \* k_phos
48+ R2 STAT5A + STAT5B → pApB cyt \* BaF3_Epo \* STAT5A \* STAT5B \* k_phos
49+ R3 2 STAT5B → pBpB cyt \* BaF3_Epo \* STAT5B^2 \* k_phos
50+ R4 pApA → nucpApA cyt \* k_imp_homo \* pApA
51+ R5 pApB → nucpApB cyt \* k_imp_hetero \* pApB
52+ R6 pBpB → nucpBpB cyt \* k_imp_homo \* pBpB
53+ R7 nucpApA → 2 STAT5A nuc \* k_exp_homo \* nucpApA
54+ R8 nucpApB → STAT5A + STAT5B nuc \* k_exp_hetero \* nucpApB
55+ R9 nucpBpB → 2 STAT5B nuc \* k_exp_homo \* nucpBpB
5656 == ========================== =============================================
5757
58582. Linking model and measurements
@@ -79,21 +79,22 @@ experimental conditions under which a measurement was performed.
79792.1 Specifying experimental conditions
8080--------------------------------------
8181
82- The measurements were collected under the same experimental condition,
82+ All measurements were collected under the same experimental condition,
8383which is a stimulation with Epo. This is specified in the experimental
8484condition PEtab file, a tab-separated values (TSV) file\ [#f1 ]_,
8585by providing a condition identifier and listing all condition-specific
8686parameters and their respective values.
8787
8888In the problem considered here, the relevant parameter is
8989``Epo_concentration `` which we want to set to a value of 1.25E-7, as the
90- only condition-specific parameter. In our example we include data from
91- only one single experiment, so we would not need to specify it here, but
92- could set the value in the model or in the parameter table. However,
93- having it would allow us to easily add measurements from other
90+ only condition-specific parameter. Since in this example we include data from
91+ only one single experiment, it would not be necessary to specify the condition
92+ parameter here, but instead the value could have been also set in the model or
93+ in the parameter table. However, the benefit of specifying it in the condition
94+ table is, that it allows us to easily add measurements from other
9495experiments performed with different Epo concentrations later on.
9596
96- The condition table would look as follows:
97+ The condition table looks as follows:
9798
9899.. table :: Conditions table ``experimental_conditions.tsv``.
99100
@@ -189,16 +190,13 @@ file:
189190 containing any form of STAT5A.
190191
191192* *noiseFormula * is used to describe the formula for the measurement
192- noise. Together with *noiseDistribution *\ it defines the noise model. In
193- this example, we assume additive normally distributed measurement noise.
193+ noise. Together with *noiseDistribution *, it defines the noise model. In
194+ this example, we assume additive, normally distributed measurement noise.
194195 In this scenario, ``noiseParameter1_{observableId} `` is the standard
195196 deviation of the measurement noise. Parameters following this naming
196197 scheme are expected to be overridden in a measurement-specific manner in
197198 the *noiseParameters * column of the measurement table (see below).
198199
199- * *observableTransformation * defines the scale in which model observable
200- and measurement data are compared. Here, we assume a linear scale. Other
201- transformations, such as log10 can also be used.
202200
2032012.3 Specifying measurements
204202---------------------------
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