diff --git a/src/PhpSpreadsheet/Reader/Xlsx.php b/src/PhpSpreadsheet/Reader/Xlsx.php
index f8a0b11324..53bb7ed752 100644
--- a/src/PhpSpreadsheet/Reader/Xlsx.php
+++ b/src/PhpSpreadsheet/Reader/Xlsx.php
@@ -1206,6 +1206,8 @@ protected function loadSpreadsheetFromFile(string $filename): Spreadsheet
                                     foreach ($shapes as $shape) {
                                         /** @var SimpleXMLElement $shape */
                                         $shape->registerXPathNamespace('v', Namespaces::URN_VML);
+                                        $shape->registerXPathNamespace('x', Namespaces::URN_VML);
+                                        $shape->registerXPathNamespace('o', Namespaces::URN_MSOFFICE);
 
                                         if (isset($shape['style'])) {
                                             $style = (string) $shape['style'];
diff --git a/tests/PhpSpreadsheetTests/Reader/Xlsx/Issue4505Test.php b/tests/PhpSpreadsheetTests/Reader/Xlsx/Issue4505Test.php
new file mode 100644
index 0000000000..fc859bf578
--- /dev/null
+++ b/tests/PhpSpreadsheetTests/Reader/Xlsx/Issue4505Test.php
@@ -0,0 +1,80 @@
+<?php
+
+declare(strict_types=1);
+
+namespace PhpOffice\PhpSpreadsheetTests\Reader\Xlsx;
+
+use PhpOffice\PhpSpreadsheet\Reader\Xlsx as XlsxReader;
+use PhpOffice\PhpSpreadsheet\Reader\Xlsx\Namespaces as XlsxNamespaces;
+use PHPUnit\Framework\TestCase;
+use SimpleXMLElement;
+
+class Issue4505Test extends TestCase
+{
+    private static string $file = 'tests/data/Reader/XLSX/issue.4505.xlsx';
+
+    public function testVmlProcessingWithXAndONamespaces(): void
+    {
+        $reader = new XlsxReader();
+        $spreadsheet = $reader->load(self::$file);
+        $sheet = $spreadsheet->getActiveSheet();
+
+        $comments = $sheet->getComments();
+        self::assertSame('Sheet1', $sheet->getTitle());
+
+        if (!empty($comments)) {
+            $comment = reset($comments);
+            $comment->getText();
+        }
+
+        $spreadsheet->disconnectWorksheets();
+    }
+
+    public function testVmlFileContainsRequiredNamespaces(): void
+    {
+        $file = 'zip://' . self::$file . '#xl/drawings/vmlDrawing1.vml';
+        $data = file_get_contents($file);
+
+        if ($data === false) {
+            self::markTestSkipped('Test file issue.4505.xlsx not found or VML file missing.');
+        }
+
+        self::assertStringContainsString('<v:shape', $data);
+        self::assertStringContainsString('o:shapelayout', $data);
+        self::assertStringContainsString('x:ClientData', $data);
+        self::assertStringContainsString('o:insetmode', $data);
+    }
+
+    public function testXPathQueriesWithNamespaceRegistration(): void
+    {
+        $vmlContent = '<?xml version="1.0" encoding="UTF-8"?>
+        <v:shape xmlns:v="urn:schemas-microsoft-com:vml"
+                 xmlns:x="urn:schemas-microsoft-com:office:excel"
+                 xmlns:o="urn:schemas-microsoft-com:office:office">
+            <v:fill o:relid="rId1" o:title="Test Image"/>
+            <x:ClientData ObjectType="Note">
+                <x:Row>5</x:Row>
+                <x:Column>2</x:Column>
+                <x:TextHAlign>left</x:TextHAlign>
+            </x:ClientData>
+        </v:shape>';
+
+        $shape = new SimpleXMLElement($vmlContent);
+
+        $shape->registerXPathNamespace('v', XlsxNamespaces::URN_VML);
+        $shape->registerXPathNamespace('x', XlsxNamespaces::URN_VML);
+        $shape->registerXPathNamespace('o', XlsxNamespaces::URN_MSOFFICE);
+
+        $clientData = $shape->xpath('.//x:ClientData');
+        self::assertNotEmpty($clientData, 'XPath with x: prefix works with namespace registration');
+
+        $relid = $shape->xpath('.//v:fill/@o:relid');
+        self::assertNotEmpty($relid, 'XPath with o: prefix works with namespace registration');
+
+        $row = $clientData[0]->xpath('.//x:Row');
+        self::assertNotEmpty($row, 'Can access nested x: elements');
+        self::assertEquals('5', (string) $row[0], 'Row value is correct');
+
+        self::assertEquals('rId1', (string) $relid[0], 'RelId value is correct');
+    }
+}
diff --git a/tests/data/Reader/XLSX/issue.4505.xlsx b/tests/data/Reader/XLSX/issue.4505.xlsx
new file mode 100644
index 0000000000..9b0a417b59
Binary files /dev/null and b/tests/data/Reader/XLSX/issue.4505.xlsx differ