The PaddleHelix team is working on [HelixFold3](./helixfold3_report.pdf) to replicate the advanced capabilities of AlphaFold3. Insights from the AlphaFold3 paper inform our approach and build on our prior work with [HelixFold](https://arxiv.org/abs/2207.05477), [HelixFold-Single](https://doi.org/10.1038/s42256-023-00721-6), [HelixFold-Multimer](https://arxiv.org/abs/2404.10260), and [HelixDock](https://arxiv.org/abs/2310.13913). Currently, HelixFold3's accuracy in predicting the structures of small molecule ligands, nucleic acids (including DNA and RNA), and proteins is comparable to that of AlphaFold3. We are committed to continuously enhancing the model's performance and rigorously evaluating it across a broader range of biological molecules. Please refer to our [HelixFold3 technical report](https://arxiv.org/pdf/2408.16975) for more details.
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