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template.qmd

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@@ -207,7 +207,7 @@ blue line shows the linear model fit.](`r params$fig_cor_snp`){#fig-fig_cor_snp}
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### Description of intra-host nucleotide variants
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A total of $`r n_SNV`$ different single nucleotide variants (SNV) and $`r n_INDELS`$
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A total of $`r n_SNV`$ different nucleotide variants (NV) and $`r n_INDELS`$
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insertions and deletions (indels) have been detected along the genome (@fig-SNV).
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::: {.panel-tabset}
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![Summary of the intra-host accumulation of nucleotide variants,
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using the reconstructed dataset ancestor as reference. A) Nucleotide
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variants per site along the SARS-CoV-2 genome. Relative abundance of NVs is calculated
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variants per site along the SARS-CoV-2 genome. Relative abundance of variants is calculated
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with a sliding window of width $`r nv.counts[["window"]]`$ nucleotides and a step of
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$`r nv.counts[["step"]]`$. Labels indicate the coding regions of the non structural
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proteins (NSP) within ORF1ab. B) Genome variation along the genome for each sample.
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![Summary of the intra-host accumulation of nucleotide variants
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in the spike sequence, using the reconstructed dataset ancestor as reference. A) Nucleotide
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variants per site along the S gene. Relative abundance of NVs is calculated
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variants per site along the S gene. Relative abundance of variants is calculated
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with a sliding window of width $`r nv.counts[["window"]]`$ nucleotides and a step of
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$`r nv.counts[["step"]]`$. B) Genome variation along the S gene for each sample.
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The Y-axis displays samples in chronological order, with the earliest collection date
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### Temporal signal of the intra-host mutations
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The correlation of the allele frequency of each NV with the time since the
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`r cor.method.name` correlation of the allele frequency of each variant with the time since the
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initial sampling has been calculated (@fig-volcano).
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![`r cor.method.name` correlation coefficients and adjusted p-values of

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