diff --git a/newsfragments/5121.added.md b/newsfragments/5121.added.md
new file mode 100644
index 00000000000..fd79e5a8ea7
--- /dev/null
+++ b/newsfragments/5121.added.md
@@ -0,0 +1 @@
+Add `PyBytes_AS_STRING`
diff --git a/newsfragments/5121.changed.md b/newsfragments/5121.changed.md
new file mode 100644
index 00000000000..49b317cb96b
--- /dev/null
+++ b/newsfragments/5121.changed.md
@@ -0,0 +1,2 @@
+Enable vectorcall methods on GraalPy
+Call Py_Is function on GraalPy
diff --git a/pyo3-ffi/src/abstract_.rs b/pyo3-ffi/src/abstract_.rs
index 84fb98a1b4e..59639d14de8 100644
--- a/pyo3-ffi/src/abstract_.rs
+++ b/pyo3-ffi/src/abstract_.rs
@@ -25,7 +25,6 @@ pub unsafe fn PyObject_DelAttr(o: *mut PyObject, attr_name: *mut PyObject) -> c_
 extern "C" {
     #[cfg(all(
         not(PyPy),
-        not(GraalPy),
         any(Py_3_10, all(not(Py_LIMITED_API), Py_3_9)) // Added to python in 3.9 but to limited API in 3.10
     ))]
     #[cfg_attr(PyPy, link_name = "PyPyObject_CallNoArgs")]
@@ -94,7 +93,7 @@ extern "C" {
         kwnames: *mut PyObject,
     ) -> *mut PyObject;
 
-    #[cfg(any(Py_3_12, all(Py_3_9, not(any(Py_LIMITED_API, PyPy, GraalPy)))))]
+    #[cfg(any(Py_3_12, all(Py_3_9, not(any(Py_LIMITED_API, PyPy)))))]
     pub fn PyObject_VectorcallMethod(
         name: *mut PyObject,
         args: *const *mut PyObject,
diff --git a/pyo3-ffi/src/compat/py_3_9.rs b/pyo3-ffi/src/compat/py_3_9.rs
index 285f2b2ae7e..6b3521cc167 100644
--- a/pyo3-ffi/src/compat/py_3_9.rs
+++ b/pyo3-ffi/src/compat/py_3_9.rs
@@ -1,7 +1,6 @@
 compat_function!(
     originally_defined_for(all(
         not(PyPy),
-        not(GraalPy),
         any(Py_3_10, all(not(Py_LIMITED_API), Py_3_9)) // Added to python in 3.9 but to limited API in 3.10
     ));
 
@@ -12,7 +11,7 @@ compat_function!(
 );
 
 compat_function!(
-    originally_defined_for(all(Py_3_9, not(any(Py_LIMITED_API, PyPy, GraalPy))));
+    originally_defined_for(all(Py_3_9, not(any(Py_LIMITED_API, PyPy))));
 
     #[inline]
     pub unsafe fn PyObject_CallMethodNoArgs(obj: *mut crate::PyObject, name: *mut crate::PyObject) -> *mut crate::PyObject {
diff --git a/pyo3-ffi/src/cpython/abstract_.rs b/pyo3-ffi/src/cpython/abstract_.rs
index 6ada1a754ef..b9d9dd47dc9 100644
--- a/pyo3-ffi/src/cpython/abstract_.rs
+++ b/pyo3-ffi/src/cpython/abstract_.rs
@@ -1,12 +1,12 @@
 use crate::{PyObject, Py_ssize_t};
-#[cfg(any(all(Py_3_8, not(any(PyPy, GraalPy))), not(Py_3_11)))]
+#[cfg(any(all(Py_3_8, not(PyPy)), not(Py_3_11)))]
 use std::os::raw::c_char;
 use std::os::raw::c_int;
 
 #[cfg(not(Py_3_11))]
 use crate::Py_buffer;
 
-#[cfg(all(Py_3_8, not(any(PyPy, GraalPy))))]
+#[cfg(all(Py_3_8, not(PyPy)))]
 use crate::{
     vectorcallfunc, PyCallable_Check, PyThreadState, PyThreadState_GET, PyTuple_Check,
     PyType_HasFeature, Py_TPFLAGS_HAVE_VECTORCALL,
@@ -23,7 +23,7 @@ extern "C" {
 const _PY_FASTCALL_SMALL_STACK: size_t = 5;
 
 extern "C" {
-    #[cfg(all(Py_3_8, not(any(PyPy, GraalPy))))]
+    #[cfg(all(Py_3_8, not(PyPy)))]
     pub fn _Py_CheckFunctionResult(
         tstate: *mut PyThreadState,
         callable: *mut PyObject,
@@ -31,7 +31,7 @@ extern "C" {
         where_: *const c_char,
     ) -> *mut PyObject;
 
-    #[cfg(all(Py_3_8, not(any(PyPy, GraalPy))))]
+    #[cfg(all(Py_3_8, not(PyPy)))]
     pub fn _PyObject_MakeTpCall(
         tstate: *mut PyThreadState,
         callable: *mut PyObject,
@@ -52,7 +52,7 @@ pub unsafe fn PyVectorcall_NARGS(n: size_t) -> Py_ssize_t {
     n.try_into().expect("cannot fail due to mask")
 }
 
-#[cfg(all(Py_3_8, not(any(PyPy, GraalPy))))]
+#[cfg(all(Py_3_8, not(PyPy)))]
 #[inline(always)]
 pub unsafe fn PyVectorcall_Function(callable: *mut PyObject) -> Option<vectorcallfunc> {
     assert!(!callable.is_null());
@@ -67,7 +67,7 @@ pub unsafe fn PyVectorcall_Function(callable: *mut PyObject) -> Option<vectorcal
     *ptr
 }
 
-#[cfg(all(Py_3_8, not(any(PyPy, GraalPy))))]
+#[cfg(all(Py_3_8, not(PyPy)))]
 #[inline(always)]
 pub unsafe fn _PyObject_VectorcallTstate(
     tstate: *mut PyThreadState,
@@ -148,7 +148,7 @@ pub unsafe fn _PyObject_FastCall(
     _PyObject_FastCallTstate(PyThreadState_GET(), func, args, nargs)
 }
 
-#[cfg(all(Py_3_8, not(any(PyPy, GraalPy))))]
+#[cfg(all(Py_3_8, not(PyPy)))]
 #[inline(always)]
 pub unsafe fn _PyObject_CallNoArg(func: *mut PyObject) -> *mut PyObject {
     _PyObject_VectorcallTstate(
@@ -166,7 +166,7 @@ extern "C" {
     pub fn _PyObject_CallNoArg(func: *mut PyObject) -> *mut PyObject;
 }
 
-#[cfg(all(Py_3_8, not(any(PyPy, GraalPy))))]
+#[cfg(all(Py_3_8, not(PyPy)))]
 #[inline(always)]
 pub unsafe fn PyObject_CallOneArg(func: *mut PyObject, arg: *mut PyObject) -> *mut PyObject {
     assert!(!arg.is_null());
@@ -177,7 +177,7 @@ pub unsafe fn PyObject_CallOneArg(func: *mut PyObject, arg: *mut PyObject) -> *m
     _PyObject_VectorcallTstate(tstate, func, args, nargsf, std::ptr::null_mut())
 }
 
-#[cfg(all(Py_3_9, not(any(PyPy, GraalPy))))]
+#[cfg(all(Py_3_9, not(PyPy)))]
 #[inline(always)]
 pub unsafe fn PyObject_CallMethodNoArgs(
     self_: *mut PyObject,
@@ -191,7 +191,7 @@ pub unsafe fn PyObject_CallMethodNoArgs(
     )
 }
 
-#[cfg(all(Py_3_9, not(any(PyPy, GraalPy))))]
+#[cfg(all(Py_3_9, not(PyPy)))]
 #[inline(always)]
 pub unsafe fn PyObject_CallMethodOneArg(
     self_: *mut PyObject,
@@ -219,7 +219,7 @@ extern "C" {
     pub fn PyObject_LengthHint(o: *mut PyObject, arg1: Py_ssize_t) -> Py_ssize_t;
 
     #[cfg(not(Py_3_11))] // moved to src/buffer.rs from 3.11
-    #[cfg(all(Py_3_9, not(any(PyPy, GraalPy))))]
+    #[cfg(all(Py_3_9, not(PyPy)))]
     pub fn PyObject_CheckBuffer(obj: *mut PyObject) -> c_int;
 }
 
diff --git a/pyo3-ffi/src/cpython/bytesobject.rs b/pyo3-ffi/src/cpython/bytesobject.rs
index dd78e646a12..9e233311ac1 100644
--- a/pyo3-ffi/src/cpython/bytesobject.rs
+++ b/pyo3-ffi/src/cpython/bytesobject.rs
@@ -1,6 +1,6 @@
 use crate::object::*;
 use crate::Py_ssize_t;
-#[cfg(not(any(PyPy, GraalPy, Py_LIMITED_API)))]
+#[cfg(not(Py_LIMITED_API))]
 use std::os::raw::c_char;
 use std::os::raw::c_int;
 
@@ -23,3 +23,12 @@ extern "C" {
     #[cfg_attr(PyPy, link_name = "_PyPyBytes_Resize")]
     pub fn _PyBytes_Resize(bytes: *mut *mut PyObject, newsize: Py_ssize_t) -> c_int;
 }
+
+#[cfg(not(Py_LIMITED_API))]
+#[inline]
+pub unsafe fn PyBytes_AS_STRING(op: *mut PyObject) -> *const c_char {
+    #[cfg(not(any(PyPy, GraalPy)))]
+    return &(*op.cast::<PyBytesObject>()).ob_sval as *const c_char;
+    #[cfg(any(PyPy, GraalPy))]
+    return crate::PyBytes_AsString(op);
+}
diff --git a/pyo3-ffi/src/object.rs b/pyo3-ffi/src/object.rs
index 5fbf45db617..c4c5abc361c 100644
--- a/pyo3-ffi/src/object.rs
+++ b/pyo3-ffi/src/object.rs
@@ -147,13 +147,13 @@ pub struct PyVarObject {
 // skipped private _PyVarObject_CAST
 
 #[inline]
-#[cfg(not(all(PyPy, Py_3_10)))]
+#[cfg(not(any(GraalPy, all(PyPy, Py_3_10))))]
 #[cfg_attr(docsrs, doc(cfg(all())))]
 pub unsafe fn Py_Is(x: *mut PyObject, y: *mut PyObject) -> c_int {
     (x == y).into()
 }
 
-#[cfg(all(PyPy, Py_3_10))]
+#[cfg(any(GraalPy, all(PyPy, Py_3_10)))]
 #[cfg_attr(docsrs, doc(cfg(all())))]
 extern "C" {
     #[cfg_attr(PyPy, link_name = "PyPy_Is")]
diff --git a/src/types/bytes.rs b/src/types/bytes.rs
index 4e2ce9c96e7..16e0c42f8b1 100644
--- a/src/types/bytes.rs
+++ b/src/types/bytes.rs
@@ -365,4 +365,19 @@ mod tests {
             assert_eq!(*b, py_string);
         })
     }
+
+    #[test]
+    #[cfg(not(Py_LIMITED_API))]
+    fn test_as_string() {
+        Python::with_gil(|py| {
+            let b = b"hello, world".as_slice();
+            let py_bytes = PyBytes::new(py, b);
+            unsafe {
+                assert_eq!(
+                    ffi::PyBytes_AsString(py_bytes.as_ptr()) as *const std::os::raw::c_char,
+                    ffi::PyBytes_AS_STRING(py_bytes.as_ptr()) as *const std::os::raw::c_char
+                );
+            }
+        })
+    }
 }