diff --git a/newsfragments/5333.removed.md b/newsfragments/5333.removed.md
new file mode 100644
index 00000000000..421ae3cda8b
--- /dev/null
+++ b/newsfragments/5333.removed.md
@@ -0,0 +1,3 @@
+removed `Py_DebugFlag`, `Py_VerboseFlag`, `Py_QuietFlag`, `Py_InteractiveFlag`, `Py_InspectFlag`, `Py_OptimizeFlag`, `Py_NoSiteFlag`, `Py_BytesWarningFlag`, `Py_UseClassExceptionsFlag`, `Py_FrozenFlag`, `Py_IgnoreEnvironmentFlag`, `Py_DontWriteBytecodeFlag`, `Py_NoUserSiteDirectory`, `Py_UnbufferedStdioFlag`, `Py_HashRandomizationFlag`, `Py_IsolatedFlag`, `Py_LegacyWindowsFSEncodingFlag`, `Py_LegacyWindowsStdioFlag`, `Py_FileSystemDefaultEncoding`, `Py_FileSystemDefaultEncodeErrors`, `Py_HasFileSystemDefaultEncoding`
+
+these have all been deprecated in CPython since 3.12, will be removed in 3.14, and we've deprecated them for more than 2 years.
diff --git a/pyo3-ffi/src/cpython/pydebug.rs b/pyo3-ffi/src/cpython/pydebug.rs
index 6878554aead..8cd662c7915 100644
--- a/pyo3-ffi/src/cpython/pydebug.rs
+++ b/pyo3-ffi/src/cpython/pydebug.rs
@@ -1,58 +1,12 @@
-use std::ffi::{c_char, c_int};
+use std::ffi::c_char;
+#[cfg(all(not(Py_LIMITED_API), not(Py_3_11)))]
+use std::ffi::c_int;
 
-#[cfg(not(Py_LIMITED_API))]
+#[cfg(all(not(Py_LIMITED_API), not(Py_3_11)))]
 #[cfg_attr(windows, link(name = "pythonXY"))]
 extern "C" {
-    #[deprecated(note = "Python 3.12")]
-    #[cfg_attr(PyPy, link_name = "PyPy_DebugFlag")]
-    pub static mut Py_DebugFlag: c_int;
-    #[deprecated(note = "Python 3.12")]
-    #[cfg_attr(PyPy, link_name = "PyPy_VerboseFlag")]
-    pub static mut Py_VerboseFlag: c_int;
-    #[deprecated(note = "Python 3.12")]
-    pub static mut Py_QuietFlag: c_int;
-    #[deprecated(note = "Python 3.12")]
-    #[cfg_attr(PyPy, link_name = "PyPy_InteractiveFlag")]
-    pub static mut Py_InteractiveFlag: c_int;
-    #[deprecated(note = "Python 3.12")]
-    #[cfg_attr(PyPy, link_name = "PyPy_InspectFlag")]
-    pub static mut Py_InspectFlag: c_int;
-    #[deprecated(note = "Python 3.12")]
-    #[cfg_attr(PyPy, link_name = "PyPy_OptimizeFlag")]
-    pub static mut Py_OptimizeFlag: c_int;
-    #[deprecated(note = "Python 3.12")]
-    #[cfg_attr(PyPy, link_name = "PyPy_NoSiteFlag")]
-    pub static mut Py_NoSiteFlag: c_int;
-    #[deprecated(note = "Python 3.12")]
-    #[cfg_attr(PyPy, link_name = "PyPy_BytesWarningFlag")]
-    pub static mut Py_BytesWarningFlag: c_int;
-    #[deprecated(note = "Python 3.12")]
-    #[cfg_attr(PyPy, link_name = "PyPy_UseClassExceptionsFlag")]
-    pub static mut Py_UseClassExceptionsFlag: c_int;
-    #[deprecated(note = "Python 3.12")]
-    #[cfg_attr(PyPy, link_name = "PyPy_FrozenFlag")]
-    pub static mut Py_FrozenFlag: c_int;
-    #[deprecated(note = "Python 3.12")]
     #[cfg_attr(PyPy, link_name = "PyPy_IgnoreEnvironmentFlag")]
     pub static mut Py_IgnoreEnvironmentFlag: c_int;
-    #[deprecated(note = "Python 3.12")]
-    #[cfg_attr(PyPy, link_name = "PyPy_DontWriteBytecodeFlag")]
-    pub static mut Py_DontWriteBytecodeFlag: c_int;
-    #[deprecated(note = "Python 3.12")]
-    #[cfg_attr(PyPy, link_name = "PyPy_NoUserSiteDirectory")]
-    pub static mut Py_NoUserSiteDirectory: c_int;
-    #[deprecated(note = "Python 3.12")]
-    pub static mut Py_UnbufferedStdioFlag: c_int;
-    #[cfg_attr(PyPy, link_name = "PyPy_HashRandomizationFlag")]
-    pub static mut Py_HashRandomizationFlag: c_int;
-    #[deprecated(note = "Python 3.12")]
-    pub static mut Py_IsolatedFlag: c_int;
-    #[cfg(windows)]
-    #[deprecated(note = "Python 3.12")]
-    pub static mut Py_LegacyWindowsFSEncodingFlag: c_int;
-    #[cfg(windows)]
-    #[deprecated(note = "Python 3.12")]
-    pub static mut Py_LegacyWindowsStdioFlag: c_int;
 }
 
 extern "C" {
@@ -63,7 +17,6 @@ extern "C" {
 #[cfg(not(Py_3_11))]
 #[inline(always)]
 pub unsafe fn Py_GETENV(name: *const c_char) -> *mut c_char {
-    #[allow(deprecated)]
     if Py_IgnoreEnvironmentFlag != 0 {
         std::ptr::null_mut()
     } else {
diff --git a/pyo3-ffi/src/fileobject.rs b/pyo3-ffi/src/fileobject.rs
index ec3a0409930..4faf58c2b15 100644
--- a/pyo3-ffi/src/fileobject.rs
+++ b/pyo3-ffi/src/fileobject.rs
@@ -24,15 +24,4 @@ extern "C" {
     pub fn PyObject_AsFileDescriptor(arg1: *mut PyObject) -> c_int;
 }
 
-#[cfg_attr(windows, link(name = "pythonXY"))]
-extern "C" {
-    #[deprecated(note = "Python 3.12")]
-    pub static mut Py_FileSystemDefaultEncoding: *const c_char;
-    #[deprecated(note = "Python 3.12")]
-    pub static mut Py_FileSystemDefaultEncodeErrors: *const c_char;
-    #[deprecated(note = "Python 3.12")]
-    pub static mut Py_HasFileSystemDefaultEncoding: c_int;
-    // skipped 3.12-deprecated Py_UTF8Mode
-}
-
 // skipped _PyIsSelectable_fd