diff --git a/.github/workflows/build.yml b/.github/workflows/build.yml
index 68d62abd035..2a4db0e9ece 100644
--- a/.github/workflows/build.yml
+++ b/.github/workflows/build.yml
@@ -23,6 +23,10 @@ on:
         type: boolean
         default: false
 
+env:
+  NOX_DEFAULT_VENV_BACKEND: uv
+  UV_PYTHON: ${{ inputs.python-version }}
+
 jobs:
   build:
     continue-on-error: ${{ endsWith(inputs.python-version, '-dev') || contains(fromJSON('["3.7", "3.8"]'), inputs.python-version) || contains(fromJSON('["beta", "nightly"]'), inputs.rust) }}
@@ -48,8 +52,7 @@ jobs:
           # PyPy can have FFI changes within Python versions, which creates pain in CI
           check-latest: ${{ startsWith(inputs.python-version, 'pypy') }}
 
-      - name: Install nox
-        run: python -m pip install --upgrade pip && pip install nox
+      - uses: astral-sh/setup-uv@v6
 
       - name: Install Rust toolchain
         uses: dtolnay/rust-toolchain@master
@@ -90,7 +93,7 @@ jobs:
 
       - if: inputs.rust == inputs.MSRV
         name: Prepare MSRV package versions
-        run: nox -s set-msrv-package-versions
+        run: uvx nox -s set-msrv-package-versions
 
       - if: inputs.rust != 'stable'
         name: Ignore changed error messages when using trybuild
@@ -112,7 +115,7 @@ jobs:
       - name: Run pyo3-ffi-check
         # pypy 3.9 on windows is not PEP 3123 compliant, nor is graalpy
         if: ${{ endsWith(inputs.python-version, '-dev') || (steps.ffi-changes.outputs.changed == 'true' && inputs.rust == 'stable' && !startsWith(inputs.python-version, 'graalpy') && !(inputs.python-version == 'pypy3.9' && contains(inputs.os, 'windows'))) }}
-        run: nox -s ffi-check
+        run: uvx nox -s ffi-check
 
       - if: ${{ github.event_name != 'merge_group' }}
         name: Install cargo-llvm-cov
@@ -122,17 +125,17 @@ jobs:
         name: Prepare coverage environment
         run: |
           cargo llvm-cov clean --workspace --profraw-only
-          nox -s set-coverage-env
+          uvx nox -s set-coverage-env
 
       - name: Build docs
-        run: nox -s docs
+        run: uvx nox -s docs
 
       - name: Run Rust tests
-        run: nox -s test-rust
+        run: uvx nox -s test-rust
 
       - name: Test python examples and tests
         shell: bash
-        run: nox -s test-py
+        run: uvx nox -s test-py
         env:
           CARGO_TARGET_DIR: ${{ github.workspace }}/target