diff --git a/scripts/nb-tester/requirements.txt b/scripts/nb-tester/requirements.txt
index bf48e91f78c..51a87a32820 100644
--- a/scripts/nb-tester/requirements.txt
+++ b/scripts/nb-tester/requirements.txt
@@ -1,7 +1,7 @@
 # We pin to exact versions for a more reproducible and
 # stable build.
 
-qiskit[all]~=2.1.2
+qiskit[all]~=2.2.1
 qiskit-ibm-runtime~=0.40.1
 qiskit-ibm-transpiler[ai-local-mode]~=0.14.2
 qiskit-aer~=0.17