diff --git a/src/bloqade/pyqrack/qasm2/core.py b/src/bloqade/pyqrack/qasm2/core.py
index 45f4baa1..aacad31d 100644
--- a/src/bloqade/pyqrack/qasm2/core.py
+++ b/src/bloqade/pyqrack/qasm2/core.py
@@ -51,12 +51,30 @@ def creg_get(
     def measure(
         self, interp: PyQrackInterpreter, frame: interp.Frame, stmt: core.Measure
     ):
-        qarg: PyQrackQubit = frame.get(stmt.qarg)
-        carg: CBitRef = frame.get(stmt.carg)
-        if qarg.is_active():
-            carg.set_value(Measurement(qarg.sim_reg.m(qarg.addr)))
+        qarg: PyQrackQubit | PyQrackReg = frame.get(stmt.qarg)
+        carg: CBitRef | CRegister = frame.get(stmt.carg)
+
+        if isinstance(qarg, PyQrackQubit) and isinstance(carg, CBitRef):
+            if qarg.is_active():
+                carg.set_value(Measurement(qarg.sim_reg.m(qarg.addr)))
+            else:
+                carg.set_value(interp.loss_m_result)
+        elif isinstance(qarg, PyQrackReg) and isinstance(carg, CRegister):
+            # TODO: clean up iteration after PyQrackReg is refactored
+            for i in range(qarg.size):
+                qubit = qarg[i]
+
+                # TODO: make this consistent with PyQrackReg __getitem__ ?
+                cbit = CBitRef(carg, i)
+
+                if qubit.is_active():
+                    cbit.set_value(Measurement(qarg.sim_reg.m(qubit.addr)))
+                else:
+                    cbit.set_value(interp.loss_m_result)
         else:
-            carg.set_value(interp.loss_m_result)
+            raise RuntimeError(
+                f"Expected measure call on either a single qubit and classical bit, or two registers, but got the types {type(qarg)} and {type(carg)}"
+            )
 
         return ()
 
diff --git a/src/bloqade/qasm2/_wrappers.py b/src/bloqade/qasm2/_wrappers.py
index 4fed2a8b..79e30cba 100644
--- a/src/bloqade/qasm2/_wrappers.py
+++ b/src/bloqade/qasm2/_wrappers.py
@@ -1,3 +1,5 @@
+from typing import overload
+
 from kirin.lowering import wraps
 
 from .types import Bit, CReg, QReg, Qubit
@@ -58,7 +60,7 @@ def reset(qarg: Qubit) -> None:
     ...
 
 
-@wraps(core.Measure)
+@overload
 def measure(qarg: Qubit, cbit: Bit) -> None:
     """
     Measure the qubit `qarg` and store the result in the classical bit `cbit`.
@@ -70,6 +72,22 @@ def measure(qarg: Qubit, cbit: Bit) -> None:
     ...
 
 
+@overload
+def measure(qarg: QReg, carg: CReg) -> None:
+    """
+    Measure each qubit in the quantum register `qarg` and store the result in the classical register `carg`.
+
+    Args:
+        qarg: The quantum register to measure.
+        carg: The classical bit to store the result in.
+    """
+    ...
+
+
+@wraps(core.Measure)
+def measure(qarg, carg) -> None: ...
+
+
 @wraps(uop.CX)
 def cx(ctrl: Qubit, qarg: Qubit) -> None:
     """
diff --git a/src/bloqade/qasm2/dialects/core/stmts.py b/src/bloqade/qasm2/dialects/core/stmts.py
index 7231bada..75fec223 100644
--- a/src/bloqade/qasm2/dialects/core/stmts.py
+++ b/src/bloqade/qasm2/dialects/core/stmts.py
@@ -46,10 +46,21 @@ class Measure(ir.Statement):
 
     name = "measure"
     traits = frozenset({lowering.FromPythonCall()})
-    qarg: ir.SSAValue = info.argument(QubitType)
-    """qarg (Qubit): The qubit to measure."""
-    carg: ir.SSAValue = info.argument(BitType)
-    """carg (Bit): The bit to store the result in."""
+    qarg: ir.SSAValue = info.argument(QubitType | QRegType)
+    """qarg (Qubit | QReg): The qubit or quantum register to measure."""
+    carg: ir.SSAValue = info.argument(BitType | CRegType)
+    """carg (Bit | CReg): The bit or register to store the result in."""
+
+    def check_type(self) -> None:
+        qarg_is_qubit = self.qarg.type.is_subseteq(QubitType)
+        carg_is_bit = self.carg.type.is_subseteq(BitType)
+        if (qarg_is_qubit and not carg_is_bit) or (not qarg_is_qubit and carg_is_bit):
+            raise ir.TypeCheckError(
+                self,
+                "Can't perform measurement with single (qu)bit and an entire register!",
+                help="Instead of `measure(qreg[i], creg)` or `measure(qreg, creg[i])`"
+                "use `measure(qreg[i], creg[j])` or `measure(qreg, creg)`, respectively.",
+            )
 
 
 @statement(dialect=dialect)
diff --git a/test/pyqrack/test_target.py b/test/pyqrack/test_target.py
index 58d3413e..56156dad 100644
--- a/test/pyqrack/test_target.py
+++ b/test/pyqrack/test_target.py
@@ -1,5 +1,8 @@
 import math
 
+import pytest
+from kirin import ir
+
 from bloqade import qasm2
 from bloqade.pyqrack import PyQrack, reg
 
@@ -111,4 +114,37 @@ def multiple_registers():
     assert True
 
 
-test_target_glob()
+def test_measurement():
+
+    @qasm2.main
+    def measure_register():
+        q = qasm2.qreg(2)
+        c = qasm2.creg(2)
+        qasm2.x(q[0])
+        qasm2.cx(q[0], q[1])
+        qasm2.measure(q, c)
+        return c
+
+    @qasm2.main
+    def measure_single_qubits():
+        q = qasm2.qreg(2)
+        c = qasm2.creg(2)
+        qasm2.x(q[0])
+        qasm2.cx(q[0], q[1])
+        qasm2.measure(q[0], c[0])
+        qasm2.measure(q[1], c[1])
+        return c
+
+    target = PyQrack(2)
+    result_single = target.run(measure_single_qubits)
+    result_reg = target.run(measure_register)
+
+    assert result_single == result_reg == [reg.Measurement.One, reg.Measurement.One]
+
+    with pytest.raises(ir.ValidationError):
+
+        @qasm2.main
+        def measurement_that_errors():
+            q = qasm2.qreg(1)
+            c = qasm2.creg(1)
+            qasm2.measure(q[0], c)