Is there a params file for sarcosine (N-methyl glycine) in the Rosetta database?

[rkgasn]

Hello Rosetta Community,

I'm working with peptoids and notice that the Rosetta database contains sarcosine Ramachandran tables.

Does a sarcosine/N-methyl glycine {CNCC(=O)O} params file exist in the standard Rosetta database?
If yes, what is it called?
If not, is there a recommended way to generate it?

I've checked the peptoid params directory (database/chemical/residue_type_sets/fa_standard/residue_types/peptoid/) but haven't found one that matches the simple sarcosine structure.

Thank you for any guidance!

Thanks
Rittik

[vmullig]

Use the N_METHYLATION patch and the ModifyVariantType mover to apply it to glycine.

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On Thu, Oct 2, 2025 at 11:36 PM Rittik Ghosh ***@***.***> wrote: Hello Rosetta Community, I'm working with peptoids and notice that the Rosetta database contains sarcosine Ramachandran tables. Does a sarcosine/N-methyl glycine {CNCC(=O)O} params file exist in the standard Rosetta database? If yes, what is it called? If not, is there a recommended way to generate it? I've checked the peptoid params directory (database/chemical/residue_type_sets/fa_standard/residue_types/peptoid/) but haven't found one that matches the simple sarcosine structure. Thank you for any guidance! Thanks Rittik — Reply to this email directly, view it on GitHub <#535>, or unsubscribe <https://github.com/notifications/unsubscribe-auth/ABACZUDBGFTCAW7HVLV6Y2D3VXVK3AVCNFSM6AAAAACIFK5VGWVHI2DSMVQWIX3LMV43ERDJONRXK43TNFXW4OZYHE3TMMRRGY> . You are receiving this because you are subscribed to this thread.Message ID: ***@***.***>

[rkgasn]

Thank you, will do.

[rkgasn]

It worked, thanks again.