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We use the caret package which doesn't support any GPU backend for parallel processing, as far as I'm aware of. See topepo/caret#391

You should be able to get reasonably fast run times with multicore processing on an HPC cluster. We have an example Snakemake workflow which is great for running jobs in parallel on HPCs: https://github.com/SchlossLab/mikropml-snakemake-workflow

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Answer selected by kelly-sovacool
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