diff --git a/docs/src/API/model_building.md b/docs/src/API/model_building.md
index 28069b535e..c9d7c2f249 100644
--- a/docs/src/API/model_building.md
+++ b/docs/src/API/model_building.md
@@ -226,6 +226,7 @@ change_independent_variable
 add_accumulations
 noise_to_brownians
 convert_system_indepvar
+subset_tunables
 ```
 
 ## Hybrid systems
diff --git a/src/ModelingToolkit.jl b/src/ModelingToolkit.jl
index 26efc0c7a9..bb2ba0285d 100644
--- a/src/ModelingToolkit.jl
+++ b/src/ModelingToolkit.jl
@@ -265,7 +265,8 @@ export isinput, isoutput, getbounds, hasbounds, getguess, hasguess, isdisturbanc
        istunable, getdist, hasdist,
        tunable_parameters, isirreducible, getdescription, hasdescription,
        hasunit, getunit, hasconnect, getconnect,
-       hasmisc, getmisc, state_priority
+       hasmisc, getmisc, state_priority,
+       subset_tunables
 export liouville_transform, change_independent_variable, substitute_component,
        add_accumulations, noise_to_brownians, Girsanov_transform, change_of_variables
 export PDESystem
diff --git a/src/parameters.jl b/src/parameters.jl
index 7633d8c1b7..93c74e36a9 100644
--- a/src/parameters.jl
+++ b/src/parameters.jl
@@ -147,3 +147,42 @@ function split_parameters_by_type(ps)
         end
     end
 end
+
+"""
+    $(TYPEDSIGNATURES)
+
+Change the tunable parameters of a system to a new set of tunables.
+
+The new tunable parameters must be a subset of the current tunables as discovered by [`tunable_parameters`](@ref).
+The remaining parameters will be set as constants in the system.
+"""
+function subset_tunables(sys, new_tunables)
+    if !iscomplete(sys)
+        throw(ArgumentError("System must be `complete` before changing tunables."))
+    end
+    if !is_split(sys)
+        throw(ArgumentError("Tunable parameters can only be changed for split systems."))
+    end
+
+    cur_tunables = tunable_parameters(sys, parameters(sys))
+    diff_params = setdiff(cur_tunables, new_tunables)
+
+    if !isempty(setdiff(new_tunables, cur_tunables))
+        throw(ArgumentError("""New tunable parameters must be a subset of the current tunable parameters. Found tunable parameters not in the system: $(setdiff(new_tunables, cur_tunables)).
+        Note that array parameters can only be set as tunable or non-tunable, not partially tunable. They should be specified in the un-scalarized form.
+        """))
+    end
+    cur_ps = get_ps(sys)
+    const_ps = toconstant.(diff_params)
+
+    for (idx, p) in enumerate(cur_ps)
+        for (d, c) in zip(diff_params, const_ps)
+            if isequal(p, d)
+                setindex!(cur_ps, c, idx)
+                break
+            end
+        end
+    end
+    @set! sys.ps = cur_ps
+    complete(sys)
+end
diff --git a/test/parameter_dependencies.jl b/test/parameter_dependencies.jl
index 627df5913f..7316a59bc4 100644
--- a/test/parameter_dependencies.jl
+++ b/test/parameter_dependencies.jl
@@ -173,6 +173,33 @@ end
     @test SciMLBase.successful_retcode(sol)
 end
 
+@testset "Change Tunables" begin
+    @variables θ(t)=π/6 ω(t)=0.
+    @parameters g=9.81 L=1.0 b=0.1 errp=1
+    eqs = [
+        D(θ) ~ ω,
+        D(ω) ~ -(g/L)*sin(θ) - b*ω
+    ]
+    @named pendulum_sys = System(eqs, t, [θ, ω], [g, L, b])
+    sys = mtkcompile(pendulum_sys)
+
+    new_tunables = [L, b]
+    sys2 = ModelingToolkit.subset_tunables(sys, new_tunables)
+    sys2_tunables = ModelingToolkit.tunable_parameters(sys2, ModelingToolkit.parameters(sys2))
+    @test length(sys2_tunables) == 2
+    @test isempty(setdiff(sys2_tunables, new_tunables))
+    @test_throws ArgumentError ModelingToolkit.subset_tunables(sys, [errp])
+    @test_throws ArgumentError ModelingToolkit.subset_tunables(sys, [θ, L])
+    sys3 = ModelingToolkit.subset_tunables(sys, [])
+    sys3_tunables = ModelingToolkit.tunable_parameters(sys3, ModelingToolkit.parameters(sys3))
+    @test length(sys3_tunables) == 0
+
+    sys_incomplete = pendulum_sys
+    @test_throws ArgumentError ModelingToolkit.subset_tunables(sys_incomplete, new_tunables)
+    sys_nonsplit = mtkcompile(pendulum_sys; split = false)
+    @test_throws ArgumentError ModelingToolkit.subset_tunables(sys_nonsplit, new_tunables)
+end
+
 struct CallableFoo
     p::Any
 end