diff --git a/src/parameter_indexing.jl b/src/parameter_indexing.jl
index de21a38..b441070 100644
--- a/src/parameter_indexing.jl
+++ b/src/parameter_indexing.jl
@@ -531,27 +531,39 @@ function (mpg::OnlyTimeseriesMPG)(
     throw(ParameterTimeseriesValueIndexMismatchError{NotTimeseries}(prob, mpg))
 end
 
-struct AsParameterTupleWrapper{N, G <: AbstractParameterGetIndexer} <:
+struct AsParameterTupleWrapper{N, A, G <: AbstractParameterGetIndexer} <:
        AbstractParameterGetIndexer
     getter::G
 end
 
-AsParameterTupleWrapper{N}(getter::G) where {N, G} = AsParameterTupleWrapper{N, G}(getter)
+function AsParameterTupleWrapper{N}(getter::G) where {N, G}
+    AsParameterTupleWrapper{N, Nothing, G}(getter)
+end
+function AsParameterTupleWrapper{N, A}(getter::G) where {N, A, G}
+    AsParameterTupleWrapper{N, A, G}(getter)
+end
 
-function is_indexer_timeseries(::Type{AsParameterTupleWrapper{N, G}}) where {N, G}
+function is_indexer_timeseries(::Type{AsParameterTupleWrapper{N, A, G}}) where {N, A, G}
     is_indexer_timeseries(G)
 end
 function indexer_timeseries_index(atw::AsParameterTupleWrapper)
     indexer_timeseries_index(atw.getter)
 end
-function as_timeseries_indexer(::IndexerBoth, atw::AsParameterTupleWrapper{N}) where {N}
-    AsParameterTupleWrapper{N}(as_timeseries_indexer(atw.getter))
+function as_timeseries_indexer(
+        ::IndexerBoth, atw::AsParameterTupleWrapper{N, A}) where {N, A}
+    AsParameterTupleWrapper{N, A}(as_timeseries_indexer(atw.getter))
 end
-function as_not_timeseries_indexer(::IndexerBoth, atw::AsParameterTupleWrapper{N}) where {N}
-    AsParameterTupleWrapper{N}(as_not_timeseries_indexer(atw.getter))
+function as_not_timeseries_indexer(
+        ::IndexerBoth, atw::AsParameterTupleWrapper{N, A}) where {N, A}
+    AsParameterTupleWrapper{N, A}(as_not_timeseries_indexer(atw.getter))
 end
 
-wrap_tuple(::AsParameterTupleWrapper{N}, val) where {N} = ntuple(i -> val[i], Val(N))
+function wrap_tuple(::AsParameterTupleWrapper{N, Nothing}, val) where {N}
+    ntuple(i -> val[i], Val(N))
+end
+function wrap_tuple(::AsParameterTupleWrapper{N, A}, val) where {N, A}
+    NamedTuple{A}(ntuple(i -> val[i], Val(N)))
+end
 
 function (atw::AsParameterTupleWrapper)(ts::IsTimeseriesTrait, prob, args...)
     atw(ts, is_indexer_timeseries(atw), prob, args...)
@@ -591,19 +603,24 @@ is_observed_getter(mpg::MultipleParametersGetter) = any(is_observed_getter, mpg.
 for (t1, t2) in [
     (ArraySymbolic, Any),
     (ScalarSymbolic, Any),
-    (NotSymbolic, Union{<:Tuple, <:AbstractArray})
+    (NotSymbolic, Union{<:Tuple, <:NamedTuple, <:AbstractArray})
 ]
     @eval function _getp(sys, ::NotSymbolic, ::$t1, p::$t2)
         # We need to do it this way because if an `ODESystem` has `p[1], p[2], p[3]` as
         # parameters (all scalarized) then `is_observed(sys, p[2:3]) == true`. Then,
         # `getp` errors on older MTK that doesn't support `parameter_observed`.
-        getters = getp.((sys,), p)
+        _p = p isa NamedTuple ? Tuple(p) : p
+        getters = getp.((sys,), _p)
         num_observed = count(is_observed_getter, getters)
         supports_tuple = supports_tuple_observed(sys)
-        p_arr = p isa Tuple ? collect(p) : p
+        p_arr = p isa Union{Tuple, NamedTuple} ? collect(p) : p
 
         if num_observed == 0
-            return MultipleParametersGetter(getters)
+            getter = MultipleParametersGetter(getters)
+            if p isa NamedTuple
+                getter = AsParameterTupleWrapper{length(p), keys(p)}(getter)
+            end
+            return getter
         else
             pofn = supports_tuple ? parameter_observed(sys, p) :
                    parameter_observed(sys, p_arr)
@@ -617,8 +634,12 @@ for (t1, t2) in [
             else
                 getter = GetParameterObservedNoTime(pofn)
             end
-            return p isa Tuple && !supports_tuple ?
-                   AsParameterTupleWrapper{length(p)}(getter) : getter
+            if p isa Tuple && !supports_tuple
+                getter = AsParameterTupleWrapper{length(p)}(getter)
+            elseif p isa NamedTuple
+                getter = AsParameterTupleWrapper{length(p), keys(p)}(getter)
+            end
+            return getter
         end
     end
 end
@@ -698,9 +719,13 @@ end
 for (t1, t2) in [
     (ArraySymbolic, Any),
     (ScalarSymbolic, Any),
-    (NotSymbolic, Union{<:Tuple, <:AbstractArray})
+    (NotSymbolic, Union{<:Tuple, <:NamedTuple, <:AbstractArray})
 ]
     @eval function _setp(sys, ::NotSymbolic, ::$t1, p::$t2)
+        if p isa NamedTuple
+            setters = NamedTuple{keys(p)}(setp.((sys,), values(p); run_hook = false))
+            return NamedTupleSetter(setters)
+        end
         setters = setp.((sys,), p; run_hook = false)
         return MultipleSetters(setters)
     end
diff --git a/src/state_indexing.jl b/src/state_indexing.jl
index dc381ea..a8bb306 100644
--- a/src/state_indexing.jl
+++ b/src/state_indexing.jl
@@ -221,13 +221,17 @@ function (mg::MultipleGetters)(::NotTimeseries, ::IndexerMixedTimeseries, prob,
     return map(g -> g(prob), mg.getters)
 end
 
-struct AsTupleWrapper{N, G} <: AbstractStateGetIndexer
+struct AsTupleWrapper{N, A, G} <: AbstractStateGetIndexer
     getter::G
 end
 
-AsTupleWrapper{N}(getter::G) where {N, G} = AsTupleWrapper{N, G}(getter)
+AsTupleWrapper{N}(getter::G) where {N, G} = AsTupleWrapper{N, Nothing, G}(getter)
+AsTupleWrapper{N, A}(getter::G) where {N, A, G} = AsTupleWrapper{N, A, G}(getter)
 
-wrap_tuple(::AsTupleWrapper{N}, val) where {N} = ntuple(i -> val[i], Val(N))
+wrap_tuple(::AsTupleWrapper{N, Nothing}, val) where {N} = ntuple(i -> val[i], Val(N))
+function wrap_tuple(::AsTupleWrapper{N, A}, val) where {N, A}
+    NamedTuple{A}(ntuple(i -> val[i], Val(N)))
+end
 
 function (atw::AsTupleWrapper)(::Timeseries, prob)
     return wrap_tuple.((atw,), atw.getter(prob))
@@ -245,13 +249,13 @@ end
 for (t1, t2) in [
     (ScalarSymbolic, Any),
     (ArraySymbolic, Any),
-    (NotSymbolic, Union{<:Tuple, <:AbstractArray})
+    (NotSymbolic, Union{<:Tuple, <:NamedTuple, <:AbstractArray})
 ]
     @eval function _getsym(sys, ::NotSymbolic, elt::$t1, sym::$t2)
         if isempty(sym)
             return MultipleGetters(ContinuousTimeseries(), sym)
         end
-        sym_arr = sym isa Tuple ? collect(sym) : sym
+        sym_arr = sym isa Union{Tuple, NamedTuple} ? collect(sym) : sym
         supports_tuple = supports_tuple_observed(sys)
         num_observed = 0
         for s in sym
@@ -266,6 +270,8 @@ for (t1, t2) in [
                 getter = TimeIndependentObservedFunction(obs)
                 if sym isa Tuple
                     getter = AsTupleWrapper{length(sym)}(getter)
+                elseif sym isa NamedTuple
+                    getter = AsTupleWrapper{length(sym), keys(sym)}(getter)
                 end
                 return getter
             end
@@ -280,9 +286,14 @@ for (t1, t2) in [
             ts_idxs = collect(ts_idxs)
         end
 
-        if num_observed == 0 || num_observed == 1 && sym isa Tuple
-            getters = getsym.((sys,), sym)
-            return MultipleGetters(ts_idxs, getters)
+        if num_observed == 0 || num_observed == 1 && sym isa Union{Tuple, NamedTuple}
+            _sym = sym isa NamedTuple ? Tuple(sym) : sym
+            getters = getsym.((sys,), _sym)
+            getter = MultipleGetters(ts_idxs, getters)
+            if sym isa NamedTuple
+                getter = AsTupleWrapper{length(sym), keys(sym)}(getter)
+            end
+            return getter
         else
             obs = supports_tuple ? observed(sys, sym) : observed(sys, sym_arr)
             getter = if is_time_dependent(sys)
@@ -292,6 +303,8 @@ for (t1, t2) in [
             end
             if sym isa Tuple && !supports_tuple
                 getter = AsTupleWrapper{length(sym)}(getter)
+            elseif sym isa NamedTuple
+                getter = AsTupleWrapper{length(sym), keys(sym)}(getter)
             end
             return getter
         end
@@ -351,12 +364,39 @@ function _setsym(sys, ::ScalarSymbolic, ::SymbolicTypeTrait, sym)
     error("Invalid symbol $sym for `setsym`")
 end
 
+struct NamedTupleSetter{S <: NamedTuple} <: AbstractSetIndexer
+    setter::S
+end
+
+function (nts::NamedTupleSetter)(prob, val)
+    _generated_setter(nts, prob, val)
+end
+
+@generated function _generated_setter(
+        nts::NamedTupleSetter{<:NamedTuple{N1}}, prob, val::NamedTuple{N2}) where {N1, N2}
+    expr = Expr(:block)
+    for (i, name) in enumerate(N2)
+        idx = findfirst(isequal(name), N1)
+        if idx === nothing
+            throw(ArgumentError("""
+            Invalid name $(name) in value. Must be one of $(N1).
+            """))
+        end
+        push!(expr.args, :(nts.setter[$idx](prob, val[$i])))
+    end
+    return expr
+end
+
 for (t1, t2) in [
     (ScalarSymbolic, Any),
     (ArraySymbolic, Any),
-    (NotSymbolic, Union{<:Tuple, <:AbstractArray})
+    (NotSymbolic, Union{<:Tuple, <:NamedTuple, <:AbstractArray})
 ]
     @eval function _setsym(sys, ::NotSymbolic, ::$t1, sym::$t2)
+        if sym isa NamedTuple
+            setters = NamedTuple{keys(sym)}(setsym.((sys,), values(sym)))
+            return NamedTupleSetter(setters)
+        end
         setters = setsym.((sys,), sym)
         return MultipleSetters(setters)
     end
diff --git a/test/parameter_indexing_test.jl b/test/parameter_indexing_test.jl
index 7017b74..b3d6e73 100644
--- a/test/parameter_indexing_test.jl
+++ b/test/parameter_indexing_test.jl
@@ -55,7 +55,10 @@ for sys in [
             ([1, [:b, :c]], [p[1], p[2:3]], [new_p[1], new_p[2:3]], false),
             ([1, (:b, :c)], [p[1], (p[2], p[3])], [new_p[1], (new_p[2], new_p[3])], false),
             ((1, [:b, :c]), (p[1], p[2:3]), (new_p[1], new_p[2:3]), true),
-            ((1, (:b, :c)), (p[1], (p[2], p[3])), (new_p[1], (new_p[2], new_p[3])), true)]
+            ((1, (:b, :c)), (p[1], (p[2], p[3])), (new_p[1], (new_p[2], new_p[3])), true),
+            ((a = :a, b = [:a, :b], c = (d = :c, e = :a)),
+                (a = p[1], b = p[1:2], c = (d = p[3], e = p[1])),
+                (a = new_p[1], b = new_p[1:2], c = (d = new_p[3], e = new_p[1])), true)]
             get = getp(sys, sym)
             set! = setp(sys, sym)
             if check_inference
diff --git a/test/state_indexing_test.jl b/test/state_indexing_test.jl
index e52276f..b2db2f7 100644
--- a/test/state_indexing_test.jl
+++ b/test/state_indexing_test.jl
@@ -50,7 +50,12 @@ for (sym, val, newval, check_inference) in [(:x, u[1], 4.0, true)
                                             ((1, (:y, :z)), (u[1], (u[2], u[3])),
                                                 (4.0, (5.0, 6.0)), true)
                                             ((:x, [:y], (:z,)), (u[1], [u[2]], (u[3],)),
-                                                (4.0, [5.0], (6.0,)), true)]
+                                                (4.0, [5.0], (6.0,)), true)
+                                            ((a = :x, b = [:x, :y], c = (d = :z, e = :x)),
+                                                (a = u[1], b = u[1:2],
+                                                    c = (d = u[3], e = u[1])),
+                                                (a = 4.0, b = [4.0, 5.0],
+                                                    c = (d = 6.0, e = 4.0)), true)]
     get = getsym(sys, sym)
     set! = setsym(sys, sym)
     if check_inference
@@ -86,12 +91,14 @@ for (sym, val, newval, check_inference) in [(:x, u[1], 4.0, true)
         continue
     end
 
-    setter = setsym_oop(sys, sym)
-    svals, pvals = setter(fi, newval)
-    @test svals ≈ new_states
-    @test pvals == parameter_values(fi)
-    @test_throws ArgumentError setter(state_values(fi), newval)
-    @test_throws ArgumentError setter(parameter_values(fi), newval)
+    if !(sym isa NamedTuple)
+        setter = setsym_oop(sys, sym)
+        svals, pvals = setter(fi, newval)
+        @test svals ≈ new_states
+        @test pvals == parameter_values(fi)
+        @test_throws ArgumentError setter(state_values(fi), newval)
+        @test_throws ArgumentError setter(parameter_values(fi), newval)
+    end
 end
 
 for (sym, val, check_inference) in [