diff --git a/crates/full-node/sov-sequencer/src/preferred/initialization.rs b/crates/full-node/sov-sequencer/src/preferred/initialization.rs
index e94d098757..e55082c7fe 100644
--- a/crates/full-node/sov-sequencer/src/preferred/initialization.rs
+++ b/crates/full-node/sov-sequencer/src/preferred/initialization.rs
@@ -4,6 +4,7 @@ use crate::preferred::db::SequencerRole;
 use anyhow::Context;
 use anyhow::Result;
 use sov_db::ledger_db::LedgerDb;
+use sov_modules_api::capabilities::SequencerRemuneration;
 use sov_modules_api::rest::StateUpdateReceiver;
 use std::net::SocketAddr;
 use std::path::Path;
@@ -64,6 +65,10 @@ where
             .await
             .context("Sequencer must have DaService configured with submit support")?;
 
+        // Early check: verify that this node's DA signer matches the preferred
+        // sequencer registered in the runtime.
+        Self::check_runtime_address_match(&latest_state_update, da_address)?;
+
         debug!(
             ?latest_state_update,
             %da_address,
@@ -277,6 +282,35 @@ where
         Ok((seq, handles))
     }
 
+    fn check_runtime_address_match(
+        latest_state_update: &StateUpdateInfo<<S as Spec>::Storage>,
+        da_address: <<S as Spec>::Da as DaSpec>::Address,
+    ) -> anyhow::Result<()> {
+        let mut runtime: Rt = Default::default();
+        let mut checkpoint =
+            StateCheckpoint::new(latest_state_update.storage.clone(), &runtime.kernel(), None);
+        let registry_preferred = runtime
+            .sequencer_remuneration()
+            .preferred_sequencer(&mut checkpoint);
+        match registry_preferred {
+            Some(ref expected) if *expected == da_address => Ok(()),
+            Some(expected) => {
+                anyhow::bail!(
+                        "DA address mismatch: this node's DaService signer address is {da_address}, \
+                         but the preferred sequencer DA address in the sequencer registry is {expected}. \
+                         Check your DA service configuration."
+                    );
+            }
+            None => {
+                anyhow::bail!(
+                    "No preferred sequencer is registered in the sequencer registry, \
+                         but this node is configured as a preferred sequencer. \
+                         Check the sequencer registry genesis configuration."
+                );
+            }
+        }
+    }
+
     fn api_state(
         storage: S::Storage,
     ) -> (
@@ -285,9 +319,9 @@ where
     ) {
         let mut runtime: Rt = Default::default();
         assert!(
-                accepts_preferred_batches(runtime.blob_selector()),
-                "Attempting to use preferred sequencer with an incompatible rollup. Set your sequencer config to `standard` in your rollup's config.toml file or change your kernel to be compatible with soft confirmations."
-            );
+            accepts_preferred_batches(runtime.blob_selector()),
+            "Attempting to use preferred sequencer with an incompatible rollup. Set your sequencer config to `standard` in your rollup's config.toml file or change your kernel to be compatible with soft confirmations."
+        );
         let checkpoint = StateCheckpoint::new(storage, &runtime.kernel(), None);
         // Preferred sequencer deliberately treats the latest available slot as finalized
         // when initializing API state (soft-confirmation semantics).
diff --git a/crates/full-node/sov-sequencer/tests/integration/preferred_end_to_end.rs b/crates/full-node/sov-sequencer/tests/integration/preferred_end_to_end.rs
index 57c8e0e9ca..9a58ee11bb 100644
--- a/crates/full-node/sov-sequencer/tests/integration/preferred_end_to_end.rs
+++ b/crates/full-node/sov-sequencer/tests/integration/preferred_end_to_end.rs
@@ -33,7 +33,9 @@ use sov_rollup_interface::node::da::DaService;
 use sov_rollup_interface::node::ledger_api::IncludeChildren;
 use sov_sequencer::{SequencerKindConfig, StateUpdateNotification};
 use sov_test_modules::hooks_count::HooksCount;
-use sov_test_utils::runtime::genesis::optimistic::HighLevelOptimisticGenesisConfig;
+use sov_test_utils::runtime::genesis::optimistic::{
+    HighLevelOptimisticGenesisConfig, MinimalOptimisticGenesisConfig,
+};
 use sov_test_utils::test_rollup::FullNodeBlueprint;
 use sov_test_utils::test_rollup::StoragePath;
 use sov_test_utils::test_rollup::{GenesisSource, RollupBuilder, RollupProverConfig, TestRollup};
@@ -3725,6 +3727,74 @@ fn tx_assert_state_root(
     encode_call::<TestRuntime<TestSpec>>(key, nonce, &msg)
 }
 
+#[tokio::test(flavor = "multi_thread")]
+#[should_panic(expected = "DA address mismatch")]
+async fn preferred_sequencer_fails_on_da_address_mismatch() {
+    let genesis_config = HighLevelOptimisticGenesisConfig::generate();
+    let genesis_params = GenesisParams {
+        runtime: <TestRuntime<TestSpec> as Runtime<TestSpec>>::GenesisConfig::from_minimal_config(
+            genesis_config.into(),
+            ValueSetterConfig {
+                admin: sov_modules_api::Address::from([0; 28]),
+            },
+            (),
+            PaymasterConfig::default(),
+            (),
+            (),
+        ),
+    };
+
+    RollupBuilder::<TestBlueprint>::new(
+        GenesisSource::CustomParams(genesis_params),
+        DEFAULT_BLOCK_PRODUCING_CONFIG,
+        0,
+    )
+    .set_config(|conf| {
+        conf.sequencer_config = SequencerKindConfig::Preferred(Default::default());
+    })
+    .start()
+    .await
+    .unwrap();
+}
+
+#[tokio::test(flavor = "multi_thread")]
+#[should_panic(expected = "No preferred sequencer is registered in the sequencer registry")]
+async fn preferred_sequencer_fails_when_no_preferred_sequencer_in_registry() {
+    let genesis_config = HighLevelOptimisticGenesisConfig::generate();
+    let seq_da_address = HighLevelOptimisticGenesisConfig::<TestSpec>::sequencer_da_addr();
+    let mut minimal: MinimalOptimisticGenesisConfig<TestSpec> = genesis_config.into();
+    minimal
+        .config
+        .sequencer_registry
+        .sequencer_config
+        .is_preferred_sequencer = false;
+    let genesis_params = GenesisParams {
+        runtime: <TestRuntime<TestSpec> as Runtime<TestSpec>>::GenesisConfig::from_minimal_config(
+            minimal,
+            ValueSetterConfig {
+                admin: sov_modules_api::Address::from([0; 28]),
+            },
+            (),
+            PaymasterConfig::default(),
+            (),
+            (),
+        ),
+    };
+
+    RollupBuilder::<TestBlueprint>::new(
+        GenesisSource::CustomParams(genesis_params),
+        DEFAULT_BLOCK_PRODUCING_CONFIG,
+        0,
+    )
+    .set_config(|conf| {
+        conf.sequencer_config = SequencerKindConfig::Preferred(Default::default());
+    })
+    .set_da_config(|c| c.sender_address = seq_da_address)
+    .start()
+    .await
+    .unwrap();
+}
+
 mod tests_with_basic_kernel {
     use sov_modules_stf_blueprint::GenesisParams;
     use sov_test_utils::test_rollup::{GenesisSource, RollupBuilder};
@@ -3745,6 +3815,7 @@ mod tests_with_basic_kernel {
     )]
     async fn preferred_sequencer_panics_with_basic_kernel() {
         let genesis_config = HighLevelOptimisticGenesisConfig::generate();
+        let seq_da_address = HighLevelOptimisticGenesisConfig::<TestSpec>::sequencer_da_addr();
         let genesis_params = GenesisParams {
             runtime: GenesisConfig::from_minimal_config(genesis_config.into()),
         };
@@ -3758,6 +3829,7 @@ mod tests_with_basic_kernel {
             conf.sequencer_config =
                 sov_sequencer::SequencerKindConfig::Preferred(Default::default());
         })
+        .set_da_config(|c| c.sender_address = seq_da_address)
         .start()
         .await
         .unwrap();