diff --git a/.github/workflows/ci.yaml b/.github/workflows/ci.yaml
index 6d87e8379e..8445e06fdc 100644
--- a/.github/workflows/ci.yaml
+++ b/.github/workflows/ci.yaml
@@ -144,6 +144,160 @@ jobs:
         run: |
           ./scripts/ci/run-nightly-make-task-if-exists.sh "${TASK}"
 
+  self-check:
+    needs: pre_job
+    name: '${{ matrix.name }} - Python ${{ matrix.python-version-short }}'
+    runs-on: ubuntu-20.04
+    strategy:
+      fail-fast: false
+      matrix:
+        include:
+         # TODO: Check if we want to fix the errors on Py 3.6 to have it tested as well
+         #- name: 'Self-check on Python 3.6'
+         #   python-version-short: '3.6'
+         #   python-version: '3.6.13'
+          - name: 'Self-check on Python 3.8'
+            python-version-short: '3.8'
+            python-version: '3.8.14'
+    services:
+      mongo:
+        image: mongo:4.4
+        ports:
+          - 27017:27017
+
+      rabbitmq:
+        image: rabbitmq:3.8-management
+        options: >-
+          --name rabbitmq
+        ports:
+            - 5671:5671/tcp   # AMQP SSL port
+            - 5672:5672/tcp   # AMQP standard port
+            - 15672:15672/tcp # Management: HTTP, CLI
+
+    env:
+      # CI st2.conf (with ST2_CI_USER user instead of stanley)
+      ST2_CONF: 'conf/st2.ci.conf'
+
+      # Name of the user who is running the CI (on GitHub Actions this is 'runner')
+      ST2_CI_USER: 'runner'
+
+      # GitHub is juggling how to set vars for multiple shells. Protect our PATH assumptions.
+      PATH: /home/runner/.local/bin:/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/sbin:/bin
+
+      # Space separated list of tests to be skipped if the self-check is running in GitHub Actions
+      TESTS_TO_SKIP: "tests.test_quickstart_rules tests.test_run_pack_tests_tool"
+    steps:
+      - name: Checkout repository
+        uses: actions/checkout@v2
+      - name: Custom Environment Setup
+        run: |
+          ./scripts/github/setup-environment.sh
+      - name: 'Set up Python (${{ matrix.python-version }})'
+        uses: actions/setup-python@v2
+        with:
+          python-version: '${{ matrix.python-version }}'
+      - name: Cache Python Dependencies
+        uses: actions/cache@v2
+        with:
+          path: |
+            ~/.cache/pip
+            virtualenv
+            ~/virtualenv
+          # TODO: maybe make the virtualenv a partial cache to exclude st2*?
+          # !virtualenv/lib/python*/site-packages/st2*
+          # !virtualenv/bin/st2*
+          key: ${{ runner.os }}-v3-python-${{ matrix.python-version }}-${{ hashFiles('requirements.txt', 'test-requirements.txt') }}
+          restore-keys: |
+            ${{ runner.os }}-python-${{ matrix.python }}-
+      - name: Cache APT Dependencies
+        id: cache-apt-deps
+        uses: actions/cache@v2
+        with:
+          path: |
+            ~/apt_cache
+          key: ${{ runner.os }}-apt-v5-${{ hashFiles('scripts/github/apt-packages.txt') }}
+          restore-keys: |
+            ${{ runner.os }}-apt-v5-
+      - name: Install APT Depedencies
+        env:
+          CACHE_HIT: ${{steps.cache-apt-deps.outputs.cache-hit}}
+        run: |
+          cat /etc/environment
+          # install dev dependencies for Python YAML and LDAP packages
+          # https://github.com/StackStorm/st2-auth-ldap
+          ./scripts/github/install-apt-packages-use-cache.sh
+      - name: Install virtualenv
+        run: |
+          ./scripts/github/install-virtualenv.sh
+      - name: Install requirements
+        run: |
+          ./scripts/ci/install-requirements.sh
+      - name: Run Redis Service Container
+        timeout-minutes: 2
+        run: |
+          docker run --rm --detach -p 127.0.0.1:6379:6379/tcp --name redis redis:latest
+          until [ "$(docker inspect -f {{.State.Running}} redis)" == "true" ]; do sleep 0.1; done
+      - name: Setup Tests
+        run: |
+          # prep a ci-specific dev conf file that uses runner instead of stanley
+          # this user is the username of the user in GitHub actions, used for SSH, etc during
+          # integration tests (important)
+          cp conf/st2.dev.conf "${ST2_CONF}"
+          sed -i -e "s,/home/vagrant/.ssh/stanley_rsa,/home/stanley/.ssh/stanley_rsa," "${ST2_CONF}"
+
+          sudo -E ./scripts/ci/add-itest-user-key.sh
+      - name: Permissions Workaround
+        run: |
+          sudo ST2_CI_REPO_PATH="${ST2_CI_REPO_PATH}" scripts/ci/permissions-workaround.sh
+      - name: Reconfigure RabbitMQ
+        # bitnami image allows (see bitnami/rabbitmq readme):
+        # Here we're copying a rabbitmq.config file which won't do anything.
+        # We need to switch to custom.conf or advanced.config.
+        timeout-minutes: 2  # may die if rabbitmq fails to start
+        run: |
+          ./scripts/github/configure-rabbitmq.sh
+      - name: Print versions
+        run: |
+          ./scripts/ci/print-versions.sh
+      - name: make
+        timeout-minutes: 14  # may die if rabbitmq fails to start
+        # use: script -e -c to print colors
+        run: |
+          script -e -c "make .ci-prepare-integration" && exit 0
+      - name: Extend the path for upcoming tasks
+        run: |
+          echo ${HOME}/work/st2/st2/virtualenv/bin
+          echo ${HOME}/work/st2/st2/virtualenv/bin >> $GITHUB_PATH
+      - name: Create symlinks to find the binaries when running st2 actions
+        run: |
+          ln -s ${HOME}/work/st2/st2/virtualenv/bin/st2 /usr/local/bin/st2
+          ln -s ${HOME}/work/st2/st2/virtualenv/bin/st2-run-pack-tests /usr/local/bin/st2-run-pack-tests
+      - name: Install st2client
+        timeout-minutes: 5
+        run: |
+          cd ./st2client
+          pip3 install --upgrade pip
+          python3 setup.py develop
+      - name: Run self-verification script
+        env:
+          ST2_CONF: /home/runner/work/st2/st2/conf/st2.ci.conf
+        run: |
+          sudo -E ST2_AUTH_TOKEN=$(st2 auth testu -p 'testp' -t) PATH=${PATH} virtualenv/bin/st2-self-check
+      - name: Compress Service Logs Before upload
+        if: ${{ failure() }}
+        run: |
+          tar cvzpf logs.tar.gz logs/*
+      - name: Upload StackStorm services Logs
+        if: ${{ failure() }}
+        uses: actions/upload-artifact@v2
+        with:
+          name: logs
+          path: logs.tar.gz
+          retention-days: 7
+      - name: Stop Redis Service Container
+        if: "${{ always() }}"
+        run: docker rm --force redis || true
+
   unit-tests:
     needs: pre_job
     # NOTE: We always want to run job on master since we run some additional checks there (code
diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index a267a04fed..e3d6e797e7 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -43,6 +43,10 @@ Added
 * Python 3.9 support. #5730
   Contributed by Amanda McGuinness (@amanda11 intive)
 
+* Run the st2 self-check in Github Actions and support the environment variable `TESTS_TO_SKIP` to skip tests when running st2-self-check. #5609
+
+  Contributed by @winem
+
 Changed
 ~~~~~~~
 * Remove `distutils` dependencies across the project. #5992
diff --git a/st2common/bin/st2-self-check b/st2common/bin/st2-self-check
index d7d1a0b85a..1240b13fc7 100755
--- a/st2common/bin/st2-self-check
+++ b/st2common/bin/st2-self-check
@@ -29,6 +29,7 @@ function usage() {
 RUN_ORQUESTA_TESTS=true
 RUN_WINDOWS_TESTS=false
 ST2_TESTS_BRANCH="master"
+TESTS_TO_SKIP="${TESTS_TO_SKIP:-}"
 
 while getopts "b:wo" o
 do
@@ -101,10 +102,15 @@ if [ ${EXIT_CODE} -ne 0 ]; then
 fi
 
 echo "Copying asserts, fixtures, tests and examples packs."
-chown -R root:st2packs st2tests/packs/
-chmod -R 775 st2tests/packs/*
+if [ -n "${GITHUB_ACTIONS}" ]; then
+  cp -Rf --preserve /home/runner/work/st2/st2/contrib/examples /opt/stackstorm/packs/
+else
+  chmod -R 775 st2tests/packs/*
+  cp -Rf --preserve /usr/share/doc/st2/examples /opt/stackstorm/packs/
+  chown -R root:st2packs st2tests/packs/
+fi
+
 cp -R --preserve st2tests/packs/* /opt/stackstorm/packs/
-cp -Rf --preserve /usr/share/doc/st2/examples /opt/stackstorm/packs/
 
 echo "Installing asserts, fixtures, tests and examples packs."
 st2 run packs.setup_virtualenv packs=examples,tests,asserts,fixtures,webui
@@ -136,6 +142,11 @@ do
         continue
     fi
 
+    if [[ " ${TESTS_TO_SKIP} " =~ " ${TEST} " ]]; then
+        echo "Skipping ${TEST}..."
+        continue
+    fi
+
     echo -n "Attempting Test ${TEST}..."
 
     START_TS=$(date +%s)
@@ -179,6 +190,9 @@ if [ $ERRORS -ne 0 ]; then
     echo "SELF CHECK FAILED!"
     echo "st2-self-check failed.  See above.  Also check the execution list for details."
     echo "st2 execution list"
+    if [ -n "${GITHUB_ACTIONS}" ]; then
+      exit 1
+    fi
 else
     echo "SELF CHECK SUCCEEDED!"
     echo -e "st2-self-check succeeded."
diff --git a/st2common/bin/st2ctl b/st2common/bin/st2ctl
index 26b404e0eb..a26f7bfb09 100755
--- a/st2common/bin/st2ctl
+++ b/st2common/bin/st2ctl
@@ -15,12 +15,12 @@
 # limitations under the License.
 
 COMPONENTS="st2actionrunner st2api st2stream st2auth st2garbagecollector st2notifier st2rulesengine st2sensorcontainer st2chatops st2timersengine st2workflowengine st2scheduler"
-ST2_CONF="/etc/st2/st2.conf"
+ST2_CONF="${ST2_CONF:-/etc/st2/st2.conf}"
 SYSTEMD_RELOADED=""
 
-# Ensure global environment is sourced if exists
+# Ensure global environment is sourced if exists and if not executed in the context of Github Actions
 # Does not happen consistently with all OSes we support.
-[ -r /etc/environment ] && source /etc/environment
+[ -z "${GITHUB_ACTIONS}" ] && [ -r /etc/environment ] && source /etc/environment
 
 # load in environment to allow override of COMPONENTS and ST2_CONF above
 # Ubuntu/Debian