diff --git a/ports/raspberrypi/Makefile b/ports/raspberrypi/Makefile
index b75d542325166..728a517480eb2 100644
--- a/ports/raspberrypi/Makefile
+++ b/ports/raspberrypi/Makefile
@@ -549,6 +549,7 @@ SRC_C += \
 ifeq ($(CIRCUITPY_USB_HOST), 1)
 SRC_C += \
 	lib/tinyusb/src/portable/raspberrypi/pio_usb/hcd_pio_usb.c \
+	lib/tinyusb/src/portable/raspberrypi/rp2040/hcd_rp2040.c \
 	lib/Pico-PIO-USB/src/pio_usb.c \
 	lib/Pico-PIO-USB/src/pio_usb_host.c \
 	lib/Pico-PIO-USB/src/usb_crc.c \
diff --git a/ports/raspberrypi/boards/olimex_rp2350pc/board.c b/ports/raspberrypi/boards/olimex_rp2350pc/board.c
new file mode 100644
index 0000000000000..f94a4cb3c3211
--- /dev/null
+++ b/ports/raspberrypi/boards/olimex_rp2350pc/board.c
@@ -0,0 +1,45 @@
+// This file is part of the CircuitPython project: https://circuitpython.org
+//
+// SPDX-FileCopyrightText: Copyright (c) 2021 Scott Shawcroft for Adafruit Industries
+//
+// SPDX-License-Identifier: MIT
+
+#include "common-hal/microcontroller/Pin.h"
+#include "hardware/gpio.h"
+#include "shared-bindings/usb_host/Port.h"
+#include "supervisor/board.h"
+
+#include "common-hal/picodvi/__init__.h"
+
+bool board_reset_pin_number(uint8_t pin_number) {
+    #if defined(DEFAULT_USB_HOST_5V_POWER)
+    if (pin_number == DEFAULT_USB_HOST_5V_POWER->number) {
+        // doing this (rather than gpio_init) in this specific order ensures no
+        // glitch if pin was already configured as a high output. gpio_init() temporarily
+        // configures the pin as an input, so the power enable value would potentially
+        // glitch.
+        gpio_put(pin_number, 1);
+        gpio_set_dir(pin_number, GPIO_OUT);
+        gpio_set_function(pin_number, GPIO_FUNC_SIO);
+
+        return true;
+    }
+    #endif
+    // Set I2S out of reset.
+    /*
+    if (pin_number == I2S_RESET_PIN_NUMBER) {
+        gpio_put(pin_number, 1);
+        gpio_set_dir(pin_number, GPIO_OUT);
+        gpio_set_function(pin_number, GPIO_FUNC_SIO);
+
+        return true;
+    }
+    */
+
+    return false;
+}
+
+void board_init(void) {
+    common_hal_usb_host_port_construct(0, 0);
+    picodvi_autoconstruct();
+}
diff --git a/ports/raspberrypi/boards/olimex_rp2350pc/mpconfigboard.h b/ports/raspberrypi/boards/olimex_rp2350pc/mpconfigboard.h
new file mode 100644
index 0000000000000..3c1e516a28fc8
--- /dev/null
+++ b/ports/raspberrypi/boards/olimex_rp2350pc/mpconfigboard.h
@@ -0,0 +1,46 @@
+// This file is part of the CircuitPython project: https://circuitpython.org
+//
+// SPDX-FileCopyrightText: Copyright (c) 2024 Scott Shawcroft for Adafruit Industries
+//
+// SPDX-License-Identifier: MIT
+
+#define MICROPY_HW_BOARD_NAME "Olimex RP2350pc"
+#define MICROPY_HW_MCU_NAME "rp2350b"
+
+#define MICROPY_HW_LED_STATUS (&pin_GPIO25)
+
+// Internal I2C bus (DVI, I2S), no user connection pins
+#define DEFAULT_I2C_BUS_SCL (&pin_GPIO33)
+#define DEFAULT_I2C_BUS_SDA (&pin_GPIO32)
+
+#define DEFAULT_SPI_BUS_SCK (&pin_GPIO6)
+#define DEFAULT_SPI_BUS_MOSI (&pin_GPIO7)
+#define DEFAULT_SPI_BUS_MISO (&pin_GPIO4)
+
+#define DEFAULT_UART_BUS_RX (&pin_GPIO1)
+#define DEFAULT_UART_BUS_TX (&pin_GPIO0)
+
+#define CIRCUITPY_CONSOLE_UART_RX DEFAULT_UART_BUS_RX
+#define CIRCUITPY_CONSOLE_UART_TX DEFAULT_UART_BUS_TX
+
+#define CIRCUITPY_PSRAM_CHIP_SELECT (&pin_GPIO8)
+
+#define DEFAULT_DVI_BUS_CLK_DN (&pin_GPIO15)
+#define DEFAULT_DVI_BUS_CLK_DP (&pin_GPIO14)
+#define DEFAULT_DVI_BUS_RED_DN (&pin_GPIO13)
+#define DEFAULT_DVI_BUS_RED_DP (&pin_GPIO12)
+#define DEFAULT_DVI_BUS_GREEN_DN (&pin_GPIO19)
+#define DEFAULT_DVI_BUS_GREEN_DP (&pin_GPIO18)
+#define DEFAULT_DVI_BUS_BLUE_DN (&pin_GPIO17)
+#define DEFAULT_DVI_BUS_BLUE_DP (&pin_GPIO16)
+
+#define DEFAULT_SD_SCK (&pin_GPIO10)
+#define DEFAULT_SD_MOSI (&pin_GPIO11)
+#define DEFAULT_SD_MISO (&pin_GPIO24)
+#define DEFAULT_SD_CS (&pin_GPIO9)
+#define DEFAULT_SD_CARD_DETECT (&pin_GPIO41)
+#define DEFAULT_SD_CARD_INSERTED true
+
+#define CIRCUITPY_DEBUG_TINYUSB 1
+
+// #define CIRCUITPY_SAVES_PARTITION_SIZE (2 * 1024 * 1024)
diff --git a/ports/raspberrypi/boards/olimex_rp2350pc/mpconfigboard.mk b/ports/raspberrypi/boards/olimex_rp2350pc/mpconfigboard.mk
new file mode 100644
index 0000000000000..aa16b8c471c20
--- /dev/null
+++ b/ports/raspberrypi/boards/olimex_rp2350pc/mpconfigboard.mk
@@ -0,0 +1,28 @@
+#USB_VID = 0x15BA
+#USB_PID = 0x0054
+CIRCUITPY_CREATOR_ID = 0x000c15BA
+CIRCUITPY_CREATION_ID = 0x00000054
+USB_PRODUCT = "RP2350pc"
+USB_MANUFACTURER = "Olimex"
+
+CHIP_VARIANT = RP2350
+CHIP_PACKAGE = B
+CHIP_FAMILY = rp2
+
+EXTERNAL_FLASH_DEVICES = "W25Q128JVxQ, P25Q16H"
+
+CIRCUITPY_USB_DEVICE=0
+CIRCUITPY_USB_IDENTIFICATION = 0
+CIRCUITPY_USB_VIDEO=0
+#CIRCUITPY_USB_MIDI=0
+#CIRCUITPY_USB_CDC = 0
+#CIRCUITPY_USB_HID = 0
+#CIRCUITPY_USB_MSC = 0
+
+CIRCUITPY_USB_HOST=1
+#CIRCUITPY_TINYUSB_HOST=1
+#CIRCUITPY_USB_HOST_INSTANCE = 0
+
+CIRCUITPY_BUILD_EXTENSIONS = uf2
+UF2_BOOTLOADER = 1
+#OPTIMIZATION_FLAGS = -Os
diff --git a/ports/raspberrypi/boards/olimex_rp2350pc/pico-sdk-configboard.h b/ports/raspberrypi/boards/olimex_rp2350pc/pico-sdk-configboard.h
new file mode 100644
index 0000000000000..2d9283a9192f2
--- /dev/null
+++ b/ports/raspberrypi/boards/olimex_rp2350pc/pico-sdk-configboard.h
@@ -0,0 +1,10 @@
+// This file is part of the CircuitPython project: https://circuitpython.org
+//
+// SPDX-FileCopyrightText: Copyright (c) 2021 Scott Shawcroft for Adafruit Industries
+//
+// SPDX-License-Identifier: MIT
+
+// Put board-specific pico-sdk definitions here. This file must exist.
+
+// Allow extra time for xosc to start.
+#define PICO_XOSC_STARTUP_DELAY_MULTIPLIER 64
diff --git a/ports/raspberrypi/boards/olimex_rp2350pc/pins.c b/ports/raspberrypi/boards/olimex_rp2350pc/pins.c
new file mode 100644
index 0000000000000..d60b1c4f1ee3a
--- /dev/null
+++ b/ports/raspberrypi/boards/olimex_rp2350pc/pins.c
@@ -0,0 +1,78 @@
+// This file is part of the CircuitPython project: https://circuitpython.org
+//
+// SPDX-FileCopyrightText: Copyright (c) 2024 Scott Shawcroft for Adafruit Industries
+//
+// SPDX-License-Identifier: MIT
+
+#include "shared-bindings/board/__init__.h"
+
+static const mp_rom_map_elem_t board_module_globals_table[] = {
+    CIRCUITPYTHON_BOARD_DICT_STANDARD_ITEMS
+
+    //  UEXT2 HEADER  Pin 1 - 3.3V, 2 - Gnd
+    { MP_OBJ_NEW_QSTR(MP_QSTR_D36), MP_ROM_PTR(&pin_GPIO36) }, // PIN 6
+    { MP_OBJ_NEW_QSTR(MP_QSTR_D37), MP_ROM_PTR(&pin_GPIO37) }, // 5
+    { MP_OBJ_NEW_QSTR(MP_QSTR_D38), MP_ROM_PTR(&pin_GPIO38) }, // 3
+    { MP_OBJ_NEW_QSTR(MP_QSTR_D39), MP_ROM_PTR(&pin_GPIO39) }, // 4
+    { MP_OBJ_NEW_QSTR(MP_QSTR_D42), MP_ROM_PTR(&pin_GPIO42) }, // 9
+    { MP_OBJ_NEW_QSTR(MP_QSTR_D43), MP_ROM_PTR(&pin_GPIO43) }, // 8
+    { MP_OBJ_NEW_QSTR(MP_QSTR_D44), MP_ROM_PTR(&pin_GPIO44) }, // 7
+    { MP_OBJ_NEW_QSTR(MP_QSTR_D45), MP_ROM_PTR(&pin_GPIO45) }, // 10
+
+//    { MP_OBJ_NEW_QSTR(MP_QSTR_SDA), MP_ROM_PTR(&pin_GPIO32) },
+    { MP_OBJ_NEW_QSTR(MP_QSTR_SDA0), MP_ROM_PTR(&pin_GPIO36) },
+    { MP_OBJ_NEW_QSTR(MP_QSTR_D36), MP_ROM_PTR(&pin_GPIO36) },
+//    { MP_OBJ_NEW_QSTR(MP_QSTR_SCL), MP_ROM_PTR(&pin_GPIO33) },
+    { MP_OBJ_NEW_QSTR(MP_QSTR_SCL0), MP_ROM_PTR(&pin_GPIO37) },
+    { MP_OBJ_NEW_QSTR(MP_QSTR_D37), MP_ROM_PTR(&pin_GPIO37) },
+
+    { MP_OBJ_NEW_QSTR(MP_QSTR_SDA1), MP_ROM_PTR(&pin_GPIO2) },
+    { MP_OBJ_NEW_QSTR(MP_QSTR_D2), MP_ROM_PTR(&pin_GPIO2) },
+    { MP_OBJ_NEW_QSTR(MP_QSTR_SCL1), MP_ROM_PTR(&pin_GPIO3) },
+    { MP_OBJ_NEW_QSTR(MP_QSTR_D3), MP_ROM_PTR(&pin_GPIO3) },
+
+    { MP_ROM_QSTR(MP_QSTR_D5), MP_ROM_PTR(&pin_GPIO5) },
+    { MP_ROM_QSTR(MP_QSTR_SCK), MP_ROM_PTR(&pin_GPIO6) },
+    { MP_ROM_QSTR(MP_QSTR_MOSI), MP_ROM_PTR(&pin_GPIO7) },
+    { MP_ROM_QSTR(MP_QSTR_MISO), MP_ROM_PTR(&pin_GPIO4) },
+
+    { MP_ROM_QSTR(MP_QSTR_SD_CS), MP_ROM_PTR(&pin_GPIO9) },
+    { MP_ROM_QSTR(MP_QSTR_SD_SCK), MP_ROM_PTR(&pin_GPIO10) },
+    { MP_ROM_QSTR(MP_QSTR_SD_MOSI), MP_ROM_PTR(&pin_GPIO11) },
+    { MP_ROM_QSTR(MP_QSTR_SD_MISO), MP_ROM_PTR(&pin_GPIO24) },
+
+    { MP_OBJ_NEW_QSTR(MP_QSTR_SD_CARD_DETECT), MP_ROM_PTR(&pin_GPIO41) },
+
+    { MP_ROM_QSTR(MP_QSTR_CKN), MP_ROM_PTR(&pin_GPIO15) },
+    { MP_ROM_QSTR(MP_QSTR_CKP), MP_ROM_PTR(&pin_GPIO14) },
+    { MP_ROM_QSTR(MP_QSTR_D0N), MP_ROM_PTR(&pin_GPIO13) }, // Red
+    { MP_ROM_QSTR(MP_QSTR_D0P), MP_ROM_PTR(&pin_GPIO12) },
+    { MP_ROM_QSTR(MP_QSTR_D1N), MP_ROM_PTR(&pin_GPIO19) }, // Green
+    { MP_ROM_QSTR(MP_QSTR_D1P), MP_ROM_PTR(&pin_GPIO18) },
+    { MP_ROM_QSTR(MP_QSTR_D2N), MP_ROM_PTR(&pin_GPIO17) }, // Blue
+    { MP_ROM_QSTR(MP_QSTR_D2P), MP_ROM_PTR(&pin_GPIO16) },
+
+    { MP_OBJ_NEW_QSTR(MP_QSTR_LED), MP_ROM_PTR(&pin_GPIO25) },
+    { MP_OBJ_NEW_QSTR(MP_QSTR_D25), MP_ROM_PTR(&pin_GPIO25) },
+
+    { MP_ROM_QSTR(MP_QSTR_PWM_SPK_L), MP_ROM_PTR(&pin_GPIO26) },
+    { MP_ROM_QSTR(MP_QSTR_PWM_SPK_R), MP_ROM_PTR(&pin_GPIO27) },
+
+    { MP_ROM_QSTR(MP_QSTR_I2S_PWR), MP_ROM_PTR(&pin_GPIO22) },
+
+    { MP_ROM_QSTR(MP_QSTR_I2S_DIN), MP_ROM_PTR(&pin_GPIO31) },
+    { MP_ROM_QSTR(MP_QSTR_I2S_MCLK), MP_ROM_PTR(&pin_GPIO23) },
+    { MP_ROM_QSTR(MP_QSTR_I2S_BCLK), MP_ROM_PTR(&pin_GPIO30) },
+    { MP_ROM_QSTR(MP_QSTR_I2S_WS), MP_ROM_PTR(&pin_GPIO29) },
+    { MP_ROM_QSTR(MP_QSTR_I2S_ASDOUT), MP_ROM_PTR(&pin_GPIO28) },
+
+    // AMP_VOL must be set high and AMP_SHDN set low to enable the PAM8003 amplifier
+    // There is an unpopulated potentiometer but without it AMP_VOL is only off/on
+    { MP_ROM_QSTR(MP_QSTR_AMP_VOL), MP_ROM_PTR(&pin_GPIO34) },
+    { MP_ROM_QSTR(MP_QSTR_AMP_SHDN), MP_ROM_PTR(&pin_GPIO35) },
+
+    { MP_ROM_QSTR(MP_QSTR_I2C), MP_ROM_PTR(&board_i2c_obj) },
+    { MP_ROM_QSTR(MP_QSTR_SPI), MP_ROM_PTR(&board_spi_obj) },
+    { MP_ROM_QSTR(MP_QSTR_UART), MP_ROM_PTR(&board_uart_obj) },
+};
+MP_DEFINE_CONST_DICT(board_module_globals, board_module_globals_table);
diff --git a/ports/raspberrypi/common-hal/usb_host/Port.c b/ports/raspberrypi/common-hal/usb_host/Port.c
index b8a49725030ea..53bfeef8314db 100644
--- a/ports/raspberrypi/common-hal/usb_host/Port.c
+++ b/ports/raspberrypi/common-hal/usb_host/Port.c
@@ -32,6 +32,7 @@
 
 usb_host_port_obj_t usb_host_instance;
 
+#if CIRCUITPY_USB_DEVICE
 volatile bool _core1_ready = false;
 
 static void __not_in_flash_func(core1_main)(void) {
@@ -109,16 +110,19 @@ static size_t get_usb_pio(void) {
     }
     mp_raise_RuntimeError(MP_ERROR_TEXT("All state machines in use"));
 }
-
+#endif
 
 usb_host_port_obj_t *common_hal_usb_host_port_construct(const mcu_pin_obj_t *dp, const mcu_pin_obj_t *dm) {
+    #if CIRCUITPY_USB_DEVICE
     if ((dp->number + 1 != dm->number)
         && (dp->number - 1 != dm->number)) {
         raise_ValueError_invalid_pins();
     }
+    #endif
     usb_host_port_obj_t *self = &usb_host_instance;
 
     // Return the singleton if given the same pins.
+    #if CIRCUITPY_USB_DEVICE
     if (self->dp != NULL) {
         if (self->dp != dp || self->dm != dm) {
             mp_raise_msg_varg(&mp_type_RuntimeError, MP_ERROR_TEXT("%q in use"), MP_QSTR_usb_host);
@@ -170,6 +174,18 @@ usb_host_port_obj_t *common_hal_usb_host_port_construct(const mcu_pin_obj_t *dp,
 
     tuh_configure(TUH_OPT_RHPORT, TUH_CFGID_RPI_PIO_USB_CONFIGURATION, &pio_cfg);
     tuh_init(TUH_OPT_RHPORT);
+    #else
+    #if CIRCUITPY_USB_HOST
+    // init host stack on configured roothub port
+    tusb_rhport_init_t host_init = {
+        .role = TUSB_ROLE_HOST,
+        .speed = TUSB_SPEED_AUTO
+    };
+    tusb_init(0, &host_init);
+
+    // tuh_init(0);
+    #endif
+    #endif
 
     return self;
 }
diff --git a/ports/raspberrypi/supervisor/port.c b/ports/raspberrypi/supervisor/port.c
index 66e63248c4810..48dcea6688791 100644
--- a/ports/raspberrypi/supervisor/port.c
+++ b/ports/raspberrypi/supervisor/port.c
@@ -552,10 +552,15 @@ void port_interrupt_after_ticks(uint32_t ticks) {
 void port_idle_until_interrupt(void) {
     #ifdef PICO_RP2040
     common_hal_mcu_disable_interrupts();
-    #if CIRCUITPY_USB_HOST
+    #if CIRCUITPY_USB_HOST && CIRCUITPY_USB_DEVICE
     if (!background_callback_pending() && !tud_task_event_ready() && !tuh_task_event_ready() && !_woken_up) {
     #else
+    #if CIRCUITPY_USB_HOST
+    if (!background_callback_pending() && !tuh_task_event_ready() && !_woken_up) {
+    #endif
+    #if CIRCUITPY_USB_DEVICE
     if (!background_callback_pending() && !tud_task_event_ready() && !_woken_up) {
+    #endif
         #endif
         __DSB();
         __WFI();
@@ -571,10 +576,15 @@ void port_idle_until_interrupt(void) {
     uint32_t oldBasePri = __get_BASEPRI();
     __set_BASEPRI(0);
     __isb();
-    #if CIRCUITPY_USB_HOST
+    #if CIRCUITPY_USB_HOST && CIRCUITPY_USB_DEVICE
     if (!background_callback_pending() && !tud_task_event_ready() && !tuh_task_event_ready() && !_woken_up) {
     #else
+    #if CIRCUITPY_USB_HOST
+    if (!background_callback_pending() && !tuh_task_event_ready() && !_woken_up) {
+    #endif
+    #if CIRCUITPY_USB_DEVICE
     if (!background_callback_pending() && !tud_task_event_ready() && !_woken_up) {
+    #endif
         #endif
         __DSB();
         __WFI();
diff --git a/supervisor/shared/usb/tusb_config.h b/supervisor/shared/usb/tusb_config.h
index ac2fd9f4f258c..babd9c87ac3e9 100644
--- a/supervisor/shared/usb/tusb_config.h
+++ b/supervisor/shared/usb/tusb_config.h
@@ -150,9 +150,9 @@ extern "C" {
 #if CIRCUITPY_USB_HOST || CIRCUITPY_MAX3421E
 #define CFG_TUH_ENABLED 1
 
-// Always use PIO to do host on RP2.
-#if !CIRCUITPY_MAX3421E
-#define CFG_TUH_RPI_PIO_USB 1
+// Don't use RP2 PIO to do host on MAX3421E or when USB device is disabled
+#if CIRCUITPY_MAX3421E || (CIRCUITPY_USB_HOST && !CIRCUITPY_USB_DEVICE)
+#define CFG_TUH_RPI_PIO_USB 0
 #else
 #define CFG_TUH_RPI_PIO_USB 1
 #endif
diff --git a/supervisor/shared/usb/usb.c b/supervisor/shared/usb/usb.c
index e67c15d022cc9..b56a650180e01 100644
--- a/supervisor/shared/usb/usb.c
+++ b/supervisor/shared/usb/usb.c
@@ -117,9 +117,11 @@ void usb_init(void) {
     usb_hid_build_report_descriptor();
     #endif
 
+    #if CIRCUITPY_USB_DEVICE
     // Only init device. Host gets inited by the `usb_host` module common-hal.
     tud_init(TUD_OPT_RHPORT);
     #endif
+    #endif
 
     post_usb_init();
 
@@ -181,7 +183,9 @@ void usb_setup_with_vm(void) {
 void usb_background(void) {
     if (usb_enabled()) {
         #if CFG_TUSB_OS == OPT_OS_NONE || CFG_TUSB_OS == OPT_OS_PICO
+        #if CIRCUITPY_USB_DEVICE
         tud_task();
+        #endif
         #if CIRCUITPY_USB_HOST || CIRCUITPY_MAX3421E
         tuh_task();
         #endif